-
1
-
-
0031005576
-
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
-
[PMID: 9108485 DOI: 10.1016/S0092-8674(00)80209-3]
-
Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Lüthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJ. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997; 89: 309-319 [PMID: 9108485 DOI: 10.1016/S0092-8674(00)80209-3]
-
(1997)
Cell
, vol.89
, pp. 309-319
-
-
Simonet, W.S.1
Lacey, D.L.2
Dunstan, C.R.3
Kelley, M.4
Chang, M.S.5
Lüthy, R.6
Nguyen, H.Q.7
Wooden, S.8
Bennett, L.9
Boone, T.10
Shimamoto, G.11
DeRose, M.12
Elliott, R.13
Colombero, A.14
Tan, H.L.15
Trail, G.16
Sullivan, J.17
Davy, E.18
Bucay, N.19
Renshaw-Gegg, L.20
Hughes, T.M.21
Hill, D.22
Pattison, W.23
Campbell, P.24
Sander, S.25
Van, G.26
Tarpley, J.27
Derby, P.28
Lee, R.29
Boyle, W.J.30
more..
-
2
-
-
0030989969
-
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis
-
[PMID: 9168977 DOI: 10.1006/bbrc.1997.6603]
-
Tsuda E, Goto M, Mochizuki S, Yano K, Kobayashi F, Morinaga T, Higashio K. Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 1997; 234: 137-142 [PMID: 9168977 DOI: 10.1006/bbrc.1997.6603]
-
(1997)
Biochem Biophys Res Commun
, vol.234
, pp. 137-142
-
-
Tsuda, E.1
Goto, M.2
Mochizuki, S.3
Yano, K.4
Kobayashi, F.5
Morinaga, T.6
Higashio, K.7
-
3
-
-
0009660825
-
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro
-
[PMID: 9492069 DOI: 10.1210/en.139.3.1329]
-
Yasuda H, Shima N, Nakagawa N, Mochizuki SI, Yano K, Fujise N, Sato Y, Goto M, Yamaguchi K, Kuriyama M, Kanno T, Murakami A, Tsuda E, Morinaga T, Higashio K. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology 1998; 139: 1329-1337 [PMID: 9492069 DOI: 10.1210/en.139.3.1329]
-
(1998)
Endocrinology
, vol.139
, pp. 1329-1337
-
-
Yasuda, H.1
Shima, N.2
Nakagawa, N.3
Mochizuki, S.I.4
Yano, K.5
Fujise, N.6
Sato, Y.7
Goto, M.8
Yamaguchi, K.9
Kuriyama, M.10
Kanno, T.11
Murakami, A.12
Tsuda, E.13
Morinaga, T.14
Higashio, K.15
-
4
-
-
0032584208
-
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
-
[PMID: 9520411 DOI: 10.1073/pnas.95.7.3597]
-
Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 1998; 95: 3597-3602 [PMID: 9520411 DOI: 10.1073/pnas.95.7.3597]
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3597-3602
-
-
Yasuda, H.1
Shima, N.2
Nakagawa, N.3
Yamaguchi, K.4
Kinosaki, M.5
Mochizuki, S.6
Tomoyasu, A.7
Yano, K.8
Goto, M.9
Murakami, A.10
Tsuda, E.11
Morinaga, T.12
Higashio, K.13
Udagawa, N.14
Takahashi, N.15
Suda, T.16
-
5
-
-
0032540319
-
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
-
[PMID: 9568710]
-
Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998; 93: 165-176 [PMID: 9568710]
-
(1998)
Cell
, vol.93
, pp. 165-176
-
-
Lacey, D.L.1
Timms, E.2
Tan, H.L.3
Kelley, M.J.4
Dunstan, C.R.5
Burgess, T.6
Elliott, R.7
Colombero, A.8
Elliott, G.9
Scully, S.10
Hsu, H.11
Sullivan, J.12
Hawkins, N.13
Davy, E.14
Capparelli, C.15
Eli, A.16
Qian, Y.X.17
Kaufman, S.18
Sarosi, I.19
Shalhoub, V.20
Senaldi, G.21
Guo, J.22
Delaney, J.23
Boyle, W.J.24
more..
-
6
-
-
0032545355
-
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis
-
[PMID: 9878548]
-
Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Yano K, Morinaga T, Higashio K. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem Biophys Res Commun 1998; 253: 395-400 [PMID: 9878548]
-
(1998)
Biochem Biophys Res Commun
, vol.253
, pp. 395-400
-
-
Nakagawa, N.1
Kinosaki, M.2
Yamaguchi, K.3
Shima, N.4
Yasuda, H.5
Yano, K.6
Morinaga, T.7
Higashio, K.8
-
7
-
-
13044316551
-
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
-
[PMID: 10097072]
-
Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia XZ, Elliott R, Chiu L, Black T, Scully S, Capparelli C, Morony S, Shimamoto G, Bass MB, Boyle WJ. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 1999; 96: 3540-3545 [PMID: 10097072]
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3540-3545
-
-
Hsu, H.1
Lacey, D.L.2
Dunstan, C.R.3
Solovyev, I.4
Colombero, A.5
Timms, E.6
Tan, H.L.7
Elliott, G.8
Kelley, M.J.9
Sarosi, I.10
Wang, L.11
Xia, X.Z.12
Elliott, R.13
Chiu, L.14
Black, T.15
Scully, S.16
Capparelli, C.17
Morony, S.18
Shimamoto, G.19
Bass, M.B.20
Boyle, W.J.21
more..
-
8
-
-
0033057784
-
A novel molecular mechanism modulating osteoclast differentiation and function
-
[PMID: 10423033 DOI: 10.1016/S8756-3282(99)00121-0]
-
Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Goto M, Mochizuki SI, Tsuda E, Morinaga T, Udagawa N, Takahashi N, Suda T, Higashio K. A novel molecular mechanism modulating osteoclast differentiation and function. Bone 1999; 25: 109-113 [PMID: 10423033 DOI: 10.1016/S8756-3282(99)00121-0]
-
(1999)
Bone
, vol.25
, pp. 109-113
-
-
Yasuda, H.1
Shima, N.2
Nakagawa, N.3
Yamaguchi, K.4
Kinosaki, M.5
Goto, M.6
Mochizuki, S.I.7
Tsuda, E.8
Morinaga, T.9
Udagawa, N.10
Takahashi, N.11
Suda, T.12
Higashio, K.13
-
9
-
-
0033304730
-
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
-
[PMID: 10368775 DOI: 10.1210/er.20.3.345]
-
Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 1999; 20: 345-357 [PMID: 10368775 DOI: 10.1210/er.20.3.345]
-
(1999)
Endocr Rev
, vol.20
, pp. 345-357
-
-
Suda, T.1
Takahashi, N.2
Udagawa, N.3
Jimi, E.4
Gillespie, M.T.5
Martin, T.J.6
-
10
-
-
0037673945
-
Osteoclast differentiation and activation
-
[PMID: 12748652 DOI: 10.1038/nature01658]
-
Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature 2003; 423: 337-342 [PMID: 12748652 DOI: 10.1038/nature01658]
-
(2003)
Nature
, vol.423
, pp. 337-342
-
-
Boyle, W.J.1
Simonet, W.S.2
Lacey, D.L.3
-
11
-
-
34347341433
-
Vitamin D and osteoclastigenesis
-
Feldman D, Pike JW, Glorieux FH, editors, Vitamin D, 2nd ed. New York: Elsevier/Academic Press
-
Yasuda H, Higashio K, Suda T. Vitamin D and osteoclastigenesis. In: Feldman D, Pike JW, Glorieux FH, editors. Vitamin D. 2nd ed. New York: Elsevier/Academic Press, 2005: 665-685
-
(2005)
, pp. 665-685
-
-
Yasuda, H.1
Higashio, K.2
Suda, T.3
-
12
-
-
0023928381
-
Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures
-
[PMID: 3345718 DOI: 10.1210/endo-122-4-1373]
-
Takahashi N, Yamana H, Yoshiki S, Roodman GD, Mundy GR, Jones SJ, Boyde A, Suda T. Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 1988; 122: 1373-1382 [PMID: 3345718 DOI: 10.1210/endo-122-4-1373]
-
(1988)
Endocrinology
, vol.122
, pp. 1373-1382
-
-
Takahashi, N.1
Yamana, H.2
Yoshiki, S.3
Roodman, G.D.4
Mundy, G.R.5
Jones, S.J.6
Boyde, A.7
Suda, T.8
-
13
-
-
0024435957
-
The bone marrowderived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells
-
[PMID: 2676473 DOI: 10.1210/endo-125-4-1805]
-
Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin TJ, Suda T. The bone marrowderived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 1989; 125: 1805-1813 [PMID: 2676473 DOI: 10.1210/endo-125-4-1805]
-
(1989)
Endocrinology
, vol.125
, pp. 1805-1813
-
-
Udagawa, N.1
Takahashi, N.2
Akatsu, T.3
Sasaki, T.4
Yamaguchi, A.5
Kodama, H.6
Martin, T.J.7
Suda, T.8
-
14
-
-
0025171006
-
Identity of a tumor cytotoxic factor from human fibroblasts and hepatocyte growth factor
-
[PMID: 2142596 DOI: 10.1016/0006-291X(90)91287-3]
-
Higashio K, Shima N, Goto M, Itagaki Y, Nagao M, Yasuda H, Morinaga T. Identity of a tumor cytotoxic factor from human fibroblasts and hepatocyte growth factor. Biochem Biophys Res Commun 1990; 170: 397-404 [PMID: 2142596 DOI: 10.1016/0006-291X(90)91287-3]
-
(1990)
Biochem Biophys Res Commun
, vol.170
, pp. 397-404
-
-
Higashio, K.1
Shima, N.2
Goto, M.3
Itagaki, Y.4
Nagao, M.5
Yasuda, H.6
Morinaga, T.7
-
15
-
-
85003152202
-
Modulation of osteoclast differentiation
-
[PMID: 1555533 DOI: 10.1210/edrv-13-1-66]
-
Suda T, Takahashi N, Martin TJ. Modulation of osteoclast differentiation. Endocr Rev 1992; 13: 66-80 [PMID: 1555533 DOI: 10.1210/edrv-13-1-66]
-
(1992)
Endocr Rev
, vol.13
, pp. 66-80
-
-
Suda, T.1
Takahashi, N.2
Martin, T.J.3
-
16
-
-
14444272043
-
TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells
-
[PMID: 9312132 DOI: 10.1074/jbc.272.40.25190]
-
Wong BR, Rho J, Arron J, Robinson E, Orlinick J, Chao M, Kalachikov S, Cayani E, Bartlett FS, Frankel WN, Lee SY, Choi Y. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J Biol Chem 1997; 272: 25190-25194 [PMID: 9312132 DOI: 10.1074/jbc.272.40.25190]
-
(1997)
J Biol Chem
, vol.272
, pp. 25190-25194
-
-
Wong, B.R.1
Rho, J.2
Arron, J.3
Robinson, E.4
Orlinick, J.5
Chao, M.6
Kalachikov, S.7
Cayani, E.8
Bartlett, F.S.9
Frankel, W.N.10
Lee, S.Y.11
Choi, Y.12
-
17
-
-
0030714605
-
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
-
[PMID: 9367155 DOI: 10.1038/36593]
-
Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 1997; 390: 175-179 [PMID: 9367155 DOI: 10.1038/36593]
-
(1997)
Nature
, vol.390
, pp. 175-179
-
-
Anderson, D.M.1
Maraskovsky, E.2
Billingsley, W.L.3
Dougall, W.C.4
Tometsko, M.E.5
Roux, E.R.6
Teepe, M.C.7
DuBose, R.F.8
Cosman, D.9
Galibert, L.10
-
18
-
-
0033711760
-
Proposed standard nomenclature for new tumor necrosis factor family members involved in the regulation of bone resorption. The American Society for Bone and Mineral Research President's Committee on Nomenclature
-
[PMID: 11127193]
-
Proposed standard nomenclature for new tumor necrosis factor family members involved in the regulation of bone resorption. The American Society for Bone and Mineral Research President's Committee on Nomenclature. J Bone Miner Res 2000; 15: 2293-2296 [PMID: 11127193]
-
(2000)
J Bone Miner Res
, vol.15
, pp. 2293-2296
-
-
-
19
-
-
0032079445
-
osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
-
[PMID: 9573043]
-
Bucay N, Sarosi I, Dunstan CR, Morony S, Tarpley J, Capparelli C, Scully S, Tan HL, Xu W, Lacey DL, Boyle WJ, Simonet WS. osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998; 12: 1260-1268 [PMID: 9573043]
-
(1998)
Genes Dev
, vol.12
, pp. 1260-1268
-
-
Bucay, N.1
Sarosi, I.2
Dunstan, C.R.3
Morony, S.4
Tarpley, J.5
Capparelli, C.6
Scully, S.7
Tan, H.L.8
Xu, W.9
Lacey, D.L.10
Boyle, W.J.11
Simonet, W.S.12
-
20
-
-
0032577903
-
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin
-
[PMID: 9647741]
-
Mizuno A, Amizuka N, Irie K, Murakami A, Fujise N, Kanno T, Sato Y, Nakagawa N, Yasuda H, Mochizuki S, Gomibuchi T, Yano K, Shima N, Washida N, Tsuda E, Morinaga T, Higashio K, Ozawa H. Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun 1998; 247: 610-615 [PMID: 9647741]
-
(1998)
Biochem Biophys Res Commun
, vol.247
, pp. 610-615
-
-
Mizuno, A.1
Amizuka, N.2
Irie, K.3
Murakami, A.4
Fujise, N.5
Kanno, T.6
Sato, Y.7
Nakagawa, N.8
Yasuda, H.9
Mochizuki, S.10
Gomibuchi, T.11
Yano, K.12
Shima, N.13
Washida, N.14
Tsuda, E.15
Morinaga, T.16
Higashio, K.17
Ozawa, H.18
-
21
-
-
0033611467
-
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
-
[PMID: 9950424 DOI: 10.1038/16852]
-
Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999; 397: 315-323 [PMID: 9950424 DOI: 10.1038/16852]
-
(1999)
Nature
, vol.397
, pp. 315-323
-
-
Kong, Y.Y.1
Yoshida, H.2
Sarosi, I.3
Tan, H.L.4
Timms, E.5
Capparelli, C.6
Morony, S.7
Oliveira-dos-Santos, A.J.8
Van, G.9
Itie, A.10
Khoo, W.11
Wakeham, A.12
Dunstan, C.R.13
Lacey, D.L.14
Mak, T.W.15
Boyle, W.J.16
Penninger, J.M.17
-
22
-
-
0033568341
-
RANK is essential for osteoclast and lymph node development
-
[PMID: 10500098 DOI: 10.1101/gad.13.18.2412]
-
Dougall WC, Glaccum M, Charrier K, Rohrbach K, Brasel K, De Smedt T, Daro E, Smith J, Tometsko ME, Maliszewski CR, Armstrong A, Shen V, Bain S, Cosman D, Anderson D, Morrissey PJ, Peschon JJ, Schuh J. RANK is essential for osteoclast and lymph node development. Genes Dev 1999; 13: 2412-2424 [PMID: 10500098 DOI: 10.1101/gad.13.18.2412]
-
(1999)
Genes Dev
, vol.13
, pp. 2412-2424
-
-
Dougall, W.C.1
Glaccum, M.2
Charrier, K.3
Rohrbach, K.4
Brasel, K.5
De Smedt, T.6
Daro, E.7
Smith, J.8
Tometsko, M.E.9
Maliszewski, C.R.10
Armstrong, A.11
Shen, V.12
Bain, S.13
Cosman, D.14
Anderson, D.15
Morrissey, P.J.16
Peschon, J.J.17
Schuh, J.18
-
23
-
-
12944262423
-
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
-
[PMID: 10677500 DOI: 10.1073/pnas.97.4.1566]
-
Li J, Sarosi I, Yan XQ, Morony S, Capparelli C, Tan HL, McCabe S, Elliott R, Scully S, Van G, Kaufman S, Juan SC, Sun Y, Tarpley J, Martin L, Christensen K, McCabe J, Kostenuik P, Hsu H, Fletcher F, Dunstan CR, Lacey DL, Boyle WJ. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci USA 2000; 97: 1566-1571 [PMID: 10677500 DOI: 10.1073/pnas.97.4.1566]
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1566-1571
-
-
Li, J.1
Sarosi, I.2
Yan, X.Q.3
Morony, S.4
Capparelli, C.5
Tan, H.L.6
McCabe, S.7
Elliott, R.8
Scully, S.9
Van, G.10
Kaufman, S.11
Juan, S.C.12
Sun, Y.13
Tarpley, J.14
Martin, L.15
Christensen, K.16
McCabe, J.17
Kostenuik, P.18
Hsu, H.19
Fletcher, F.20
Dunstan, C.R.21
Lacey, D.L.22
Boyle, W.J.23
more..
-
24
-
-
18444379071
-
Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis
-
[PMID: 12434161 DOI: 10.1007/s007740200049]
-
Mizuno A, Kanno T, Hoshi M, Shibata O, Yano K, Fujise N, Kinosaki M, Yamaguchi K, Tsuda E, Murakami A, Yasuda H, Higashio K. Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis. J Bone Miner Metab 2002; 20: 337-344 [PMID: 12434161 DOI: 10.1007/s007740200049]
-
(2002)
J Bone Miner Metab
, vol.20
, pp. 337-344
-
-
Mizuno, A.1
Kanno, T.2
Hoshi, M.3
Shibata, O.4
Yano, K.5
Fujise, N.6
Kinosaki, M.7
Yamaguchi, K.8
Tsuda, E.9
Murakami, A.10
Yasuda, H.11
Higashio, K.12
-
25
-
-
0024548933
-
The aged rat model of ovarian hormone deficiency bone loss
-
[PMID: 2909382 DOI: 10.1210/endo-124-1-7]
-
Kalu DN, Liu CC, Hardin RR, Hollis BW. The aged rat model of ovarian hormone deficiency bone loss. Endocrinology 1989; 124: 7-16 [PMID: 2909382 DOI: 10.1210/endo-124-1-7]
-
(1989)
Endocrinology
, vol.124
, pp. 7-16
-
-
Kalu, D.N.1
Liu, C.C.2
Hardin, R.R.3
Hollis, B.W.4
-
26
-
-
0025002221
-
The ovariectomized, lactating rat as an experimental model for osteopenia: calcium metabolism and bone changes
-
[PMID: 2268738 DOI: 10.1016/0169-6009(90)90014-7]
-
Anderson JJ, Garner SC, Mar MH, Boass A, Toverud SU, Parikh I. The ovariectomized, lactating rat as an experimental model for osteopenia: calcium metabolism and bone changes. Bone Miner 1990; 11: 43-53 [PMID: 2268738 DOI: 10.1016/0169-6009(90)90014-7]
-
(1990)
Bone Miner
, vol.11
, pp. 43-53
-
-
Anderson, J.J.1
Garner, S.C.2
Mar, M.H.3
Boass, A.4
Toverud, S.U.5
Parikh, I.6
-
27
-
-
0024422508
-
Bone response to normal weight bearing after a period of skeletal unloading
-
[PMID: 2801939]
-
Sessions ND, Halloran BP, Bikle DD, Wronski TJ, Cone CM, Morey-Holton E. Bone response to normal weight bearing after a period of skeletal unloading. Am J Physiol 1989; 257: E606-E610 [PMID: 2801939]
-
(1989)
Am J Physiol
, vol.257
-
-
Sessions, N.D.1
Halloran, B.P.2
Bikle, D.D.3
Wronski, T.J.4
Cone, C.M.5
Morey-Holton, E.6
-
28
-
-
0032953761
-
Bone and hormonal changes induced by skeletal unloading in the mature male rat
-
[PMID: 9886951]
-
Dehority W, Halloran BP, Bikle DD, Curren T, Kostenuik PJ, Wronski TJ, Shen Y, Rabkin B, Bouraoui A, Morey-Holton E. Bone and hormonal changes induced by skeletal unloading in the mature male rat. Am J Physiol 1999; 276: E62-E69 [PMID: 9886951]
-
(1999)
Am J Physiol
, vol.276
-
-
Dehority, W.1
Halloran, B.P.2
Bikle, D.D.3
Curren, T.4
Kostenuik, P.J.5
Wronski, T.J.6
Shen, Y.7
Rabkin, B.8
Bouraoui, A.9
Morey-Holton, E.10
-
29
-
-
0024263371
-
The effects of tamoxifen on the osteopenia induced by sciatic neurotomy in the rat: a histomorphometric study
-
[PMID: 3146428 DOI: 10.1007/BF02553283]
-
Wakley GK, Baum BL, Hannon KS, Turner RT. The effects of tamoxifen on the osteopenia induced by sciatic neurotomy in the rat: a histomorphometric study. Calcif Tissue Int 1988; 43: 383-388 [PMID: 3146428 DOI: 10.1007/BF02553283]
-
(1988)
Calcif Tissue Int
, vol.43
, pp. 383-388
-
-
Wakley, G.K.1
Baum, B.L.2
Hannon, K.S.3
Turner, R.T.4
-
30
-
-
0026319878
-
Tamoxifen prevents bone loss in ovariectomized mice
-
[PMID: 1813035]
-
Broulik PD. Tamoxifen prevents bone loss in ovariectomized mice. Endocr Regul 1991; 25: 217-219 [PMID: 1813035]
-
(1991)
Endocr Regul
, vol.25
, pp. 217-219
-
-
Broulik, P.D.1
-
31
-
-
0023320347
-
The effects of ovariectomy and 17 beta-estradiol on cortical bone histomorphometry in growing rats
-
[PMID: 3455160 DOI: 10.1002/jbmr.5650020206]
-
Turner RT, Vandersteenhoven JJ, Bell NH. The effects of ovariectomy and 17 beta-estradiol on cortical bone histomorphometry in growing rats. J Bone Miner Res 1987; 2: 115-122 [PMID: 3455160 DOI: 10.1002/jbmr.5650020206]
-
(1987)
J Bone Miner Res
, vol.2
, pp. 115-122
-
-
Turner, R.T.1
Vandersteenhoven, J.J.2
Bell, N.H.3
-
32
-
-
39749180445
-
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals
-
[PMID: 18329366 DOI: 10.1016/j.cell.2007.12.037]
-
Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell 2008; 132: 794-806 [PMID: 18329366 DOI: 10.1016/j.cell.2007.12.037]
-
(2008)
Cell
, vol.132
, pp. 794-806
-
-
Shinohara, M.1
Koga, T.2
Okamoto, K.3
Sakaguchi, S.4
Arai, K.5
Yasuda, H.6
Takai, T.7
Kodama, T.8
Morio, T.9
Geha, R.S.10
Kitamura, D.11
Kurosaki, T.12
Ellmeier, W.13
Takayanagi, H.14
-
33
-
-
70349116967
-
Evaluation of pharmaceuticals with a novel 50-hour animal model of bone loss
-
[PMID: 19257825 DOI: 10.1359/jbmr.090217]
-
Tomimori Y, Mori K, Koide M, Nakamichi Y, Ninomiya T, Udagawa N, Yasuda H. Evaluation of pharmaceuticals with a novel 50-hour animal model of bone loss. J Bone Miner Res 2009; 24: 1194-1205 [PMID: 19257825 DOI: 10.1359/jbmr.090217]
-
(2009)
J Bone Miner Res
, vol.24
, pp. 1194-1205
-
-
Tomimori, Y.1
Mori, K.2
Koide, M.3
Nakamichi, Y.4
Ninomiya, T.5
Udagawa, N.6
Yasuda, H.7
-
34
-
-
71749110216
-
Identification of a novel L-serine analog that suppresses osteoclastogenesis in vitro and bone turnover in vivo
-
[PMID: 19837662 DOI: 10.1074/jbc. M109.058933]
-
Bahtiar A, Matsumoto T, Nakamura T, Akiyama M, Yogo K, Ishida-Kitagawa N, Ogawa T, Takeya T. Identification of a novel L-serine analog that suppresses osteoclastogenesis in vitro and bone turnover in vivo. J Biol Chem 2009; 284: 34157-34166 [PMID: 19837662 DOI: 10.1074/jbc. M109.058933]
-
(2009)
J Biol Chem
, vol.284
, pp. 34157-34166
-
-
Bahtiar, A.1
Matsumoto, T.2
Nakamura, T.3
Akiyama, M.4
Yogo, K.5
Ishida-Kitagawa, N.6
Ogawa, T.7
Takeya, T.8
-
35
-
-
43149095800
-
Skeletal deterioration induced by RANKL infusion: a model for high-turnover bone disease
-
[PMID: 18038244 DOI: 10.1007/s00198-007-0509-7]
-
Yuan YY, Kostenuik PJ, Ominsky MS, Morony S, Adamu S, Simionescu DT, Basalyga DM, Asuncion FJ, Bateman TA. Skeletal deterioration induced by RANKL infusion: a model for high-turnover bone disease. Osteoporos Int 2008; 19: 625-635 [PMID: 18038244 DOI: 10.1007/s00198-007-0509-7]
-
(2008)
Osteoporos Int
, vol.19
, pp. 625-635
-
-
Yuan, Y.Y.1
Kostenuik, P.J.2
Ominsky, M.S.3
Morony, S.4
Adamu, S.5
Simionescu, D.T.6
Basalyga, D.M.7
Asuncion, F.J.8
Bateman, T.A.9
-
36
-
-
45849117956
-
Soluble RANKL induces high bone turnover and decreases bone volume, density, and strength in mice
-
[PMID: 18465074 DOI: 10.1007/s00223-008-9133-6]
-
Lloyd SA, Yuan YY, Kostenuik PJ, Ominsky MS, Lau AG, Morony S, Stolina M, Asuncion FJ, Bateman TA. Soluble RANKL induces high bone turnover and decreases bone volume, density, and strength in mice. Calcif Tissue Int 2008; 82: 361-372 [PMID: 18465074 DOI: 10.1007/s00223-008-9133-6]
-
(2008)
Calcif Tissue Int
, vol.82
, pp. 361-372
-
-
Lloyd, S.A.1
Yuan, Y.Y.2
Kostenuik, P.J.3
Ominsky, M.S.4
Lau, A.G.5
Morony, S.6
Stolina, M.7
Asuncion, F.J.8
Bateman, T.A.9
-
37
-
-
77953365526
-
The pivotal role of the alternative NF-kappaB pathway in maintenance of basal bone homeostasis and osteoclastogenesis
-
[PMID: 19839765]
-
Soysa NS, Alles N, Weih D, Lovas A, Mian AH, Shimokawa H, Yasuda H, Weih F, Jimi E, Ohya K, Aoki K. The pivotal role of the alternative NF-kappaB pathway in maintenance of basal bone homeostasis and osteoclastogenesis. J Bone Miner Res 2010; 25: 809-818 [PMID: 19839765]
-
(2010)
J Bone Miner Res
, vol.25
, pp. 809-818
-
-
Soysa, N.S.1
Alles, N.2
Weih, D.3
Lovas, A.4
Mian, A.H.5
Shimokawa, H.6
Yasuda, H.7
Weih, F.8
Jimi, E.9
Ohya, K.10
Aoki, K.11
-
38
-
-
84856837846
-
Tetracyclines convert the osteoclasticdifferentiation pathway of progenitor cells to produce dendritic cell-like cells
-
[PMID: 22250082 DOI: 10.4049/jimmunol.1101174]
-
Kinugawa S, Koide M, Kobayashi Y, Mizoguchi T, Ninomiya T, Muto A, Kawahara I, Nakamura M, Yasuda H, Takahashi N, Udagawa N. Tetracyclines convert the osteoclasticdifferentiation pathway of progenitor cells to produce dendritic cell-like cells. J Immunol 2012; 188: 1772-1781 [PMID: 22250082 DOI: 10.4049/jimmunol.1101174]
-
(2012)
J Immunol
, vol.188
, pp. 1772-1781
-
-
Kinugawa, S.1
Koide, M.2
Kobayashi, Y.3
Mizoguchi, T.4
Ninomiya, T.5
Muto, A.6
Kawahara, I.7
Nakamura, M.8
Yasuda, H.9
Takahashi, N.10
Udagawa, N.11
-
39
-
-
0025751703
-
Parathyroid hormone-related protein: elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer
-
[PMID: 1955513 DOI: 10.1210/jcem-73-6-1309]
-
Grill V, Ho P, Body JJ, Johanson N, Lee SC, Kukreja SC, Moseley JM, Martin TJ. Parathyroid hormone-related protein: elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer. J Clin Endocrinol Metab 1991; 73: 1309-1315 [PMID: 1955513 DOI: 10.1210/jcem-73-6-1309]
-
(1991)
J Clin Endocrinol Metab
, vol.73
, pp. 1309-1315
-
-
Grill, V.1
Ho, P.2
Body, J.J.3
Johanson, N.4
Lee, S.C.5
Kukreja, S.C.6
Moseley, J.M.7
Martin, T.J.8
-
40
-
-
0024420892
-
Parathyroid hormone-related protein in hypercalcaemia of malignancy
-
[PMID: 2697477 DOI: 10.1111/j.1365-2265.1989. tb01288.x]
-
Martin TJ, Suva LJ. Parathyroid hormone-related protein in hypercalcaemia of malignancy. Clin Endocrinol (Oxf) 1989; 31: 631-647 [PMID: 2697477 DOI: 10.1111/j.1365-2265.1989. tb01288.x]
-
(1989)
Clin Endocrinol (Oxf)
, vol.31
, pp. 631-647
-
-
Martin, T.J.1
Suva, L.J.2
-
41
-
-
0033305222
-
Breast cancer cells interact with osteoblasts to support osteoclast formation
-
[PMID: 10499498 DOI: 10.1210/en.140.10.4451]
-
Thomas RJ, Guise TA, Yin JJ, Elliott J, Horwood NJ, Martin TJ, Gillespie MT. Breast cancer cells interact with osteoblasts to support osteoclast formation. Endocrinology 1999; 140: 4451-4458 [PMID: 10499498 DOI: 10.1210/en.140.10.4451]
-
(1999)
Endocrinology
, vol.140
, pp. 4451-4458
-
-
Thomas, R.J.1
Guise, T.A.2
Yin, J.J.3
Elliott, J.4
Horwood, N.J.5
Martin, T.J.6
Gillespie, M.T.7
-
42
-
-
2342631887
-
The high rate of bone resorption in multiple myeloma is due to RANK (receptor activator of nuclear factor-kappaB) and RANK Ligand expression
-
[PMID: 15359989 DOI: 10.1080/10428194310001593193]
-
Roux S, Mariette X. The high rate of bone resorption in multiple myeloma is due to RANK (receptor activator of nuclear factor-kappaB) and RANK Ligand expression. Leuk Lymphoma 2004; 45: 1111-1118 [PMID: 15359989 DOI: 10.1080/10428194310001593193]
-
(2004)
Leuk Lymphoma
, vol.45
, pp. 1111-1118
-
-
Roux, S.1
Mariette, X.2
-
43
-
-
38449090761
-
Hypercalcemia
-
[PMID: 18004092 DOI: 10.1097/MAJ.0b013e31812f4947]
-
Shepard MM, Smith JW. Hypercalcemia. Am J Med Sci 2007; 334: 381-385 [PMID: 18004092 DOI: 10.1097/MAJ.0b013e31812f4947]
-
(2007)
Am J Med Sci
, vol.334
, pp. 381-385
-
-
Shepard, M.M.1
Smith, J.W.2
-
44
-
-
0041667871
-
Current management strategies for hypercalcemia
-
[PMID: 15966562 DOI: 10.2165/00024677-200302040-00005]
-
Pecherstorfer M, Brenner K, Zojer N. Current management strategies for hypercalcemia. Treat Endocrinol 2003; 2: 273-292 [PMID: 15966562 DOI: 10.2165/00024677-200302040-00005]
-
(2003)
Treat Endocrinol
, vol.2
, pp. 273-292
-
-
Pecherstorfer, M.1
Brenner, K.2
Zojer, N.3
-
45
-
-
80052490261
-
Establishment of a new murine model of hypercalcemia with anorexia by overexpression of soluble receptor activator of NF-κB ligand using an adenovirus vector
-
[PMID: 21063739 DOI: 10.1007/s00774-010-0235-7]
-
Enomoto T, Furuya Y, Tomimori Y, Mori K, Miyazaki J, Yasuda H. Establishment of a new murine model of hypercalcemia with anorexia by overexpression of soluble receptor activator of NF-κB ligand using an adenovirus vector. J Bone Miner Metab 2011; 29: 414-421 [PMID: 21063739 DOI: 10.1007/s00774-010-0235-7]
-
(2011)
J Bone Miner Metab
, vol.29
, pp. 414-421
-
-
Enomoto, T.1
Furuya, Y.2
Tomimori, Y.3
Mori, K.4
Miyazaki, J.5
Yasuda, H.6
-
46
-
-
0024359184
-
Role of bone and kidney in parathyroid hormone-related peptide-induced hypercalcemia in rats
-
[PMID: 2554691 DOI: 10.1002/jbmr.5650040516]
-
Rizzoli R, Caverzasio J, Chapuy MC, Martin TJ, Bonjour JP. Role of bone and kidney in parathyroid hormone-related peptide-induced hypercalcemia in rats. J Bone Miner Res 1989; 4: 759-765 [PMID: 2554691 DOI: 10.1002/jbmr.5650040516]
-
(1989)
J Bone Miner Res
, vol.4
, pp. 759-765
-
-
Rizzoli, R.1
Caverzasio, J.2
Chapuy, M.C.3
Martin, T.J.4
Bonjour, J.P.5
-
47
-
-
0027743456
-
Mechanisms of paraneoplastic syndromes of colon-26: involvement of interleukin 6 in hypercalcemia
-
[PMID: 8142602 DOI: 10.1016/1043-4666(93)90037-6]
-
Strassmann G, Jacob CO, Fong M, Bertolini DR. Mechanisms of paraneoplastic syndromes of colon-26: involvement of interleukin 6 in hypercalcemia. Cytokine 1993; 5: 463-468 [PMID: 8142602 DOI: 10.1016/1043-4666(93)90037-6]
-
(1993)
Cytokine
, vol.5
, pp. 463-468
-
-
Strassmann, G.1
Jacob, C.O.2
Fong, M.3
Bertolini, D.R.4
-
48
-
-
0031888574
-
Effects of YM175, a new-generation bisphosphonate, on hypercalcemia induced by tumorderived bone resorbing factors in rats
-
[PMID: 9541278 DOI: 10.1254/jjp.76.155]
-
Takahashi K, Shirahata A, Fukushima S, Kokubo S, Teramura K, Usuda S. Effects of YM175, a new-generation bisphosphonate, on hypercalcemia induced by tumorderived bone resorbing factors in rats. Jpn J Pharmacol 1998; 76: 155-163 [PMID: 9541278 DOI: 10.1254/jjp.76.155]
-
(1998)
Jpn J Pharmacol
, vol.76
, pp. 155-163
-
-
Takahashi, K.1
Shirahata, A.2
Fukushima, S.3
Kokubo, S.4
Teramura, K.5
Usuda, S.6
-
49
-
-
0242552436
-
Treatment of malignancy-associated hypercalcemia and cachexia with humanized anti-parathyroid hormone-related protein antibody
-
[PMID: 14613038 DOI: 10.1053/j.seminoncol.2003.08.019]
-
Sato K, Onuma E, Yocum RC, Ogata E. Treatment of malignancy-associated hypercalcemia and cachexia with humanized anti-parathyroid hormone-related protein antibody. Semin Oncol 2003; 30: 167-173 [PMID: 14613038 DOI: 10.1053/j.seminoncol.2003.08.019]
-
(2003)
Semin Oncol
, vol.30
, pp. 167-173
-
-
Sato, K.1
Onuma, E.2
Yocum, R.C.3
Ogata, E.4
-
50
-
-
69049083492
-
Denosumab for prevention of fractures in postmenopausal women with osteoporosis
-
[PMID: 19671655 DOI: 10.1056/NEJMoa0809493]
-
Cummings SR, San Martin J, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 2009; 361: 756-765 [PMID: 19671655 DOI: 10.1056/NEJMoa0809493]
-
(2009)
N Engl J Med
, vol.361
, pp. 756-765
-
-
Cummings, S.R.1
San Martin, J.2
McClung, M.R.3
Siris, E.S.4
Eastell, R.5
Reid, I.R.6
Delmas, P.7
Zoog, H.B.8
Austin, M.9
Wang, A.10
Kutilek, S.11
Adami, S.12
Zanchetta, J.13
Libanati, C.14
Siddhanti, S.15
Christiansen, C.16
-
51
-
-
69049105440
-
Denosumab in men receiving androgen-deprivation therapy for prostate cancer
-
[PMID: 19671656 DOI: 10.1056/NEJMoa0809003]
-
Smith MR, Egerdie B, Hernández Toriz N, Feldman R, Tammela TL, Saad F, Heracek J, Szwedowski M, Ke C, Kupic A, Leder BZ, Goessl C. Denosumab in men receiving androgen-deprivation therapy for prostate cancer. N Engl J Med 2009; 361: 745-755 [PMID: 19671656 DOI: 10.1056/NEJMoa0809003]
-
(2009)
N Engl J Med
, vol.361
, pp. 745-755
-
-
Smith, M.R.1
Egerdie, B.2
Hernández Toriz, N.3
Feldman, R.4
Tammela, T.L.5
Saad, F.6
Heracek, J.7
Szwedowski, M.8
Ke, C.9
Kupic, A.10
Leder, B.Z.11
Goessl, C.12
-
52
-
-
79551568488
-
Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study
-
[PMID: 21060033 DOI: 10.1200/JCO.2010.29.7101]
-
Stopeck AT, Lipton A, Body JJ, Steger GG, Tonkin K, de Boer RH, Lichinitser M, Fujiwara Y, Yardley DA, Viniegra M, Fan M, Jiang Q, Dansey R, Jun S, Braun A. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J Clin Oncol 2010; 28: 5132-5139 [PMID: 21060033 DOI: 10.1200/JCO.2010.29.7101]
-
(2010)
J Clin Oncol
, vol.28
, pp. 5132-5139
-
-
Stopeck, A.T.1
Lipton, A.2
Body, J.J.3
Steger, G.G.4
Tonkin, K.5
de Boer, R.H.6
Lichinitser, M.7
Fujiwara, Y.8
Yardley, D.A.9
Viniegra, M.10
Fan, M.11
Jiang, Q.12
Dansey, R.13
Jun, S.14
Braun, A.15
-
53
-
-
79952360832
-
Denosumab versus zoledronic acid for treatment of bone metastases in men with castrationresistant prostate cancer: a randomised, double-blind study
-
[PMID: 21353695]
-
Fizazi K, Carducci M, Smith M, Damião R, Brown J, Karsh L, Milecki P, Shore N, Rader M, Wang H, Jiang Q, Tadros S, Dansey R, Goessl C. Denosumab versus zoledronic acid for treatment of bone metastases in men with castrationresistant prostate cancer: a randomised, double-blind study. Lancet 2011; 377: 813-822 [PMID: 21353695]
-
(2011)
Lancet
, vol.377
, pp. 813-822
-
-
Fizazi, K.1
Carducci, M.2
Smith, M.3
Damião, R.4
Brown, J.5
Karsh, L.6
Milecki, P.7
Shore, N.8
Rader, M.9
Wang, H.10
Jiang, Q.11
Tadros, S.12
Dansey, R.13
Goessl, C.14
-
54
-
-
79952761418
-
Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma
-
[PMID: 21343556 DOI: 10.1200/JCO.2010.31.3304]
-
Henry DH, Costa L, Goldwasser F, Hirsh V, Hungria V, Prausova J, Scagliotti GV, Sleeboom H, Spencer A, Vadhan-Raj S, von Moos R, Willenbacher W, Woll PJ, Wang J, Jiang Q, Jun S, Dansey R, Yeh H. Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. J Clin Oncol 2011; 29: 1125-1132 [PMID: 21343556 DOI: 10.1200/JCO.2010.31.3304]
-
(2011)
J Clin Oncol
, vol.29
, pp. 1125-1132
-
-
Henry, D.H.1
Costa, L.2
Goldwasser, F.3
Hirsh, V.4
Hungria, V.5
Prausova, J.6
Scagliotti, G.V.7
Sleeboom, H.8
Spencer, A.9
Vadhan-Raj, S.10
von Moos, R.11
Willenbacher, W.12
Woll, P.J.13
Wang, J.14
Jiang, Q.15
Jun, S.16
Dansey, R.17
Yeh, H.18
-
55
-
-
79958772395
-
Decreased bone remodeling and porosity are associated with improved bone strength in ovariectomized cynomolgus monkeys treated with denosumab, a fully human RANKL antibody
-
[PMID: 21457806 DOI: 10.1016/j.bone.2011.03.769]
-
Kostenuik PJ, Smith SY, Jolette J, Schroeder J, Pyrah I, Ominsky MS. Decreased bone remodeling and porosity are associated with improved bone strength in ovariectomized cynomolgus monkeys treated with denosumab, a fully human RANKL antibody. Bone 2011; 49: 151-161 [PMID: 21457806 DOI: 10.1016/j.bone.2011.03.769]
-
(2011)
Bone
, vol.49
, pp. 151-161
-
-
Kostenuik, P.J.1
Smith, S.Y.2
Jolette, J.3
Schroeder, J.4
Pyrah, I.5
Ominsky, M.S.6
-
56
-
-
79958772773
-
Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys
-
[PMID: 21497676 DOI: 10.1016/j.bone.2011.04.001]
-
Ominsky MS, Stouch B, Schroeder J, Pyrah I, Stolina M, Smith SY, Kostenuik PJ. Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys. Bone 2011; 49: 162-173 [PMID: 21497676 DOI: 10.1016/j.bone.2011.04.001]
-
(2011)
Bone
, vol.49
, pp. 162-173
-
-
Ominsky, M.S.1
Stouch, B.2
Schroeder, J.3
Pyrah, I.4
Stolina, M.5
Smith, S.Y.6
Kostenuik, P.J.7
-
57
-
-
58649113384
-
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL
-
[PMID: 19016581 DOI: 10.1359/jbmr.081112]
-
Kostenuik PJ, Nguyen HQ, McCabe J, Warmington KS, Kurahara C, Sun N, Chen C, Li L, Cattley RC, Van G, Scully S, Elliott R, Grisanti M, Morony S, Tan HL, Asuncion F, Li X, Ominsky MS, Stolina M, Dwyer D, Dougall WC, Hawkins N, Boyle WJ, Simonet WS, Sullivan JK. Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL. J Bone Miner Res 2009; 24: 182-195 [PMID: 19016581 DOI: 10.1359/jbmr.081112]
-
(2009)
J Bone Miner Res
, vol.24
, pp. 182-195
-
-
Kostenuik, P.J.1
Nguyen, H.Q.2
McCabe, J.3
Warmington, K.S.4
Kurahara, C.5
Sun, N.6
Chen, C.7
Li, L.8
Cattley, R.C.9
Van, G.10
Scully, S.11
Elliott, R.12
Grisanti, M.13
Morony, S.14
Tan, H.L.15
Asuncion, F.16
Li, X.17
Ominsky, M.S.18
Stolina, M.19
Dwyer, D.20
Dougall, W.C.21
Hawkins, N.22
Boyle, W.J.23
Simonet, W.S.24
Sullivan, J.K.25
more..
-
58
-
-
80054683416
-
Increased bone mass in mice after single injection of anti-receptor activator of nuclear factor-kappaB ligand-neutralizing antibody: evidence for bone anabolic effect of parathyroid hormone in mice with few osteoclasts
-
[PMID: 21862583 DOI: 10.1074/jbc.M111.246280]
-
Furuya Y, Mori K, Ninomiya T, Tomimori Y, Tanaka S, Takahashi N, Udagawa N, Uchida K, Yasuda H. Increased bone mass in mice after single injection of anti-receptor activator of nuclear factor-kappaB ligand-neutralizing antibody: evidence for bone anabolic effect of parathyroid hormone in mice with few osteoclasts. J Biol Chem 2011; 286: 37023-37031 [PMID: 21862583 DOI: 10.1074/jbc.M111.246280]
-
(2011)
J Biol Chem
, vol.286
, pp. 37023-37031
-
-
Furuya, Y.1
Mori, K.2
Ninomiya, T.3
Tomimori, Y.4
Tanaka, S.5
Takahashi, N.6
Udagawa, N.7
Uchida, K.8
Yasuda, H.9
-
59
-
-
0027070472
-
Bone and haematopoietic defects in mice lacking c-fos
-
[PMID: 1465144]
-
Wang ZQ, Ovitt C, Grigoriadis AE, Möhle-Steinlein U, Rüther U, Wagner EF. Bone and haematopoietic defects in mice lacking c-fos. Nature 1992; 360: 741-745 [PMID: 1465144]
-
(1992)
Nature
, vol.360
, pp. 741-745
-
-
Wang, Z.Q.1
Ovitt, C.2
Grigoriadis, A.E.3
Möhle-Steinlein, U.4
Rüther, U.5
Wagner, E.F.6
-
60
-
-
0025332897
-
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
-
[PMID: 2188141 DOI: 10.1038/345442a0]
-
Yoshida H, Hayashi S, Kunisada T, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD, Nishikawa S. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 1990; 345: 442-444 [PMID: 2188141 DOI: 10.1038/345442a0]
-
(1990)
Nature
, vol.345
, pp. 442-444
-
-
Yoshida, H.1
Hayashi, S.2
Kunisada, T.3
Ogawa, M.4
Nishikawa, S.5
Okamura, H.6
Sudo, T.7
Shultz, L.D.8
Nishikawa, S.9
-
61
-
-
70849096810
-
Central control of fever and female body temperature by RANKL/RANK
-
[PMID: 19940926 DOI: 10.1038/nature08596]
-
Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, Trichereau J, Paolino M, Qadri F, Plehm R, Klaere S, Komnenovic V, Mimata H, Yoshimatsu H, Takahashi N, von Haeseler A, Bader M, Kilic SS, Ueta Y, Pifl C, Narumiya S, Penninger JM. Central control of fever and female body temperature by RANKL/RANK. Nature 2009; 462: 505-509 [PMID: 19940926 DOI: 10.1038/nature08596]
-
(2009)
Nature
, vol.462
, pp. 505-509
-
-
Hanada, R.1
Leibbrandt, A.2
Hanada, T.3
Kitaoka, S.4
Furuyashiki, T.5
Fujihara, H.6
Trichereau, J.7
Paolino, M.8
Qadri, F.9
Plehm, R.10
Klaere, S.11
Komnenovic, V.12
Mimata, H.13
Yoshimatsu, H.14
Takahashi, N.15
von Haeseler, A.16
Bader, M.17
Kilic, S.S.18
Ueta, Y.19
Pifl, C.20
Narumiya, S.21
Penninger, J.M.22
more..
-
62
-
-
0018352747
-
Epididymitis in rams: studies on vaccine efficacy
-
[PMID: 110515]
-
McGowan B, Harrold DR. Epididymitis in rams: studies on vaccine efficacy. Cornell Vet 1979; 69: 73-76 [PMID: 110515]
-
(1979)
Cornell Vet
, vol.69
, pp. 73-76
-
-
McGowan, B.1
Harrold, D.R.2
-
63
-
-
77953384898
-
Control of mammary stem cell function by steroid hormone signalling
-
[PMID: 20383121 DOI: 10.1038/nature09027]
-
Asselin-Labat ML, Vaillant F, Sheridan JM, Pal B, Wu D, Simpson ER, Yasuda H, Smyth GK, Martin TJ, Lindeman GJ, Visvader JE. Control of mammary stem cell function by steroid hormone signalling. Nature 2010; 465: 798-802 [PMID: 20383121 DOI: 10.1038/nature09027]
-
(2010)
Nature
, vol.465
, pp. 798-802
-
-
Asselin-Labat, M.L.1
Vaillant, F.2
Sheridan, J.M.3
Pal, B.4
Wu, D.5
Simpson, E.R.6
Yasuda, H.7
Smyth, G.K.8
Martin, T.J.9
Lindeman, G.J.10
Visvader, J.E.11
-
64
-
-
77953388315
-
Progesterone induces adult mammary stem cell expansion
-
[PMID: 20445538 DOI: 10.1038/nature09091]
-
Joshi PA, Jackson HW, Beristain AG, Di Grappa MA, Mote PA, Clarke CL, Stingl J, Waterhouse PD, Khokha R. Progesterone induces adult mammary stem cell expansion. Nature 2010; 465: 803-807 [PMID: 20445538 DOI: 10.1038/nature09091]
-
(2010)
Nature
, vol.465
, pp. 803-807
-
-
Joshi, P.A.1
Jackson, H.W.2
Beristain, A.G.3
Di Grappa, M.A.4
Mote, P.A.5
Clarke, C.L.6
Stingl, J.7
Waterhouse, P.D.8
Khokha, R.9
-
65
-
-
78149284013
-
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
-
[PMID: 20881962 DOI: 10.1038/nature09387]
-
Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, Penninger JM. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature 2010; 468: 98-102 [PMID: 20881962 DOI: 10.1038/nature09387]
-
(2010)
Nature
, vol.468
, pp. 98-102
-
-
Schramek, D.1
Leibbrandt, A.2
Sigl, V.3
Kenner, L.4
Pospisilik, J.A.5
Lee, H.J.6
Hanada, R.7
Joshi, P.A.8
Aliprantis, A.9
Glimcher, L.10
Pasparakis, M.11
Khokha, R.12
Ormandy, C.J.13
Widschwendter, M.14
Schett, G.15
Penninger, J.M.16
-
66
-
-
78149284767
-
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis
-
[PMID: 20881963 DOI: 10.1038/nature09495]
-
Gonzalez-Suarez E, Jacob AP, Jones J, Miller R, Roudier-Meyer MP, Erwert R, Pinkas J, Branstetter D, Dougall WC. RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis. Nature 2010; 468: 103-107 [PMID: 20881963 DOI: 10.1038/nature09495]
-
(2010)
Nature
, vol.468
, pp. 103-107
-
-
Gonzalez-Suarez, E.1
Jacob, A.P.2
Jones, J.3
Miller, R.4
Roudier-Meyer, M.P.5
Erwert, R.6
Pinkas, J.7
Branstetter, D.8
Dougall, W.C.9
-
67
-
-
84862936378
-
Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization
-
[PMID: 22006978]
-
Miyamoto K, Yoshida S, Kawasumi M, Hashimoto K, Kimura T, Sato Y, Kobayashi T, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Hao W, Morioka H, Chiba K, Kobayashi T, Yasuda H, Penninger JM, Toyama Y, Suda T, Miyamoto T. Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med 2011; 208: 2175-2181 [PMID: 22006978]
-
(2011)
J Exp Med
, vol.208
, pp. 2175-2181
-
-
Miyamoto, K.1
Yoshida, S.2
Kawasumi, M.3
Hashimoto, K.4
Kimura, T.5
Sato, Y.6
Kobayashi, T.7
Miyauchi, Y.8
Hoshi, H.9
Iwasaki, R.10
Miyamoto, H.11
Hao, W.12
Morioka, H.13
Chiba, K.14
Kobayashi, T.15
Yasuda, H.16
Penninger, J.M.17
Toyama, Y.18
Suda, T.19
Miyamoto, T.20
more..
-
68
-
-
51349111243
-
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and selftolerance
-
[PMID: 18799149]
-
Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and selftolerance. Immunity 2008; 29: 423-437 [PMID: 18799149]
-
(2008)
Immunity
, vol.29
, pp. 423-437
-
-
Akiyama, T.1
Shimo, Y.2
Yanai, H.3
Qin, J.4
Ohshima, D.5
Maruyama, Y.6
Asaumi, Y.7
Kitazawa, J.8
Takayanagi, H.9
Penninger, J.M.10
Matsumoto, M.11
Nitta, T.12
Takahama, Y.13
Inoue, J.14
-
69
-
-
0037978900
-
Organogenesis of lymphoid tissues
-
[PMID: 12669020 DOI: 10.1038/nri1054]
-
Mebius RE. Organogenesis of lymphoid tissues. Nat Rev Immunol 2003; 3: 292-303 [PMID: 12669020 DOI: 10.1038/nri1054]
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 292-303
-
-
Mebius, R.E.1
-
70
-
-
33845543666
-
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells
-
[PMID: 17143276 DOI: 10.1038/nm1518]
-
Loser K, Mehling A, Loeser S, Apelt J, Kuhn A, Grabbe S, Schwarz T, Penninger JM, Beissert S. Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med 2006; 12: 1372-1379 [PMID: 17143276 DOI: 10.1038/nm1518]
-
(2006)
Nat Med
, vol.12
, pp. 1372-1379
-
-
Loser, K.1
Mehling, A.2
Loeser, S.3
Apelt, J.4
Kuhn, A.5
Grabbe, S.6
Schwarz, T.7
Penninger, J.M.8
Beissert, S.9
-
71
-
-
77950491661
-
RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium
-
[PMID: 19828638]
-
Knoop KA, Kumar N, Butler BR, Sakthivel SK, Taylor RT, Nochi T, Akiba H, Yagita H, Kiyono H, Williams IR. RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium. J Immunol 2009; 183: 5738-5747 [PMID: 19828638]
-
(2009)
J Immunol
, vol.183
, pp. 5738-5747
-
-
Knoop, K.A.1
Kumar, N.2
Butler, B.R.3
Sakthivel, S.K.4
Taylor, R.T.5
Nochi, T.6
Akiba, H.7
Yagita, H.8
Kiyono, H.9
Williams, I.R.10
-
72
-
-
84860364397
-
Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab
-
[PMID: 22543469 DOI: 10.1038/nrd3705]
-
Lacey DL, Boyle WJ, Simonet WS, Kostenuik PJ, Dougall WC, Sullivan JK, San Martin J, Dansey R. Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab. Nat Rev Drug Discov 2012; 11: 401-419 [PMID: 22543469 DOI: 10.1038/nrd3705]
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 401-419
-
-
Lacey, D.L.1
Boyle, W.J.2
Simonet, W.S.3
Kostenuik, P.J.4
Dougall, W.C.5
Sullivan, J.K.6
San Martin, J.7
Dansey, R.8
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