메뉴 건너뛰기




Volumn 74, Issue 2, 2014, Pages 471-483

Defective TGF-β signaling in bone marrow-derived cells prevents hedgehog-induced skin tumors

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2 ANTAGONIST; MONOCYTE CHEMOTACTIC PROTEIN 1; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84892942306     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-2134-T     Document Type: Article
Times cited : (45)

References (45)
  • 1
    • 84255196931 scopus 로고    scopus 로고
    • Immune microenvironments in solid tumors: New targets for therapy
    • Shiao SL, Ganesan AP, Rugo HS, Coussens LM. Immune microenvironments in solid tumors: new targets for therapy. Genes Dev 2011;25:2559-72.
    • (2011) Genes Dev , vol.25 , pp. 2559-2572
    • Shiao, S.L.1    Ganesan, A.P.2    Rugo, H.S.3    Coussens, L.M.4
  • 2
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012;21:309-22.
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 3
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009;9:162-74.
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 4
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 84862127053 scopus 로고    scopus 로고
    • Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression
    • Ostrand-Rosenberg S, Sinha P, Beury DW, Clements VK. Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression. Semin Cancer Biol 2012;22:275-81.
    • (2012) Semin Cancer Biol , vol.22 , pp. 275-281
    • Ostrand-Rosenberg, S.1    Sinha, P.2    Beury, D.W.3    Clements, V.K.4
  • 7
    • 79953113052 scopus 로고    scopus 로고
    • Transcription factors in myeloid-derived suppressor cell recruitment and function
    • Sonda N, Chioda M, Zilio S, Simonato F, Bronte V. Transcription factors in myeloid-derived suppressor cell recruitment and function. Curr Opin Immunol 2011;23:279-85.
    • (2011) Curr Opin Immunol , vol.23 , pp. 279-285
    • Sonda, N.1    Chioda, M.2    Zilio, S.3    Simonato, F.4    Bronte, V.5
  • 8
    • 52649111039 scopus 로고    scopus 로고
    • Basal cell carcinomas: Attack of the hedgehog
    • Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer 2008;8:743-54.
    • (2008) Nat Rev Cancer , vol.8 , pp. 743-754
    • Epstein, E.H.1
  • 9
    • 80955181031 scopus 로고    scopus 로고
    • The Hedgehog's tale: Developing strategies for targeting cancer
    • Ng JM, Curran T. The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer 2011;11:493-501.
    • (2011) Nat Rev Cancer , vol.11 , pp. 493-501
    • Ng, J.M.1    Curran, T.2
  • 10
    • 0035976543 scopus 로고    scopus 로고
    • Hedgehog signaling: A tale of two lipids
    • Ingham PW. Hedgehog signaling: a tale of two lipids. Science 2001;294:1879-81.
    • (2001) Science , vol.294 , pp. 1879-1881
    • Ingham, P.W.1
  • 11
    • 2942738996 scopus 로고    scopus 로고
    • The Hedgehog response network: Sensors, switches, and routers
    • Lum L, Beachy PA. The Hedgehog response network: sensors, switches, and routers. Science 2004;304:1755-9.
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 12
    • 75749139262 scopus 로고    scopus 로고
    • Activation of the hedgehog-signaling pathway in human cancer and the clinical implications
    • Yang L, Xie G, Fan Q, Xie J. Activation of the hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene 2010;29:469-81.
    • (2010) Oncogene , vol.29 , pp. 469-481
    • Yang, L.1    Xie, G.2    Fan, Q.3    Xie, J.4
  • 13
    • 78650756969 scopus 로고    scopus 로고
    • Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function
    • Condamine T, Gabrilovich DI. Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Trends Immunol 2011;32:19-25.
    • (2011) Trends Immunol , vol.32 , pp. 19-25
    • Condamine, T.1    Gabrilovich, D.I.2
  • 14
    • 80053336355 scopus 로고    scopus 로고
    • Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor
    • Toh B, Wang X, Keeble J, Sim WJ, Khoo K, Wong WC, et al. Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. PLoS Biol 2011;9:e1001162.
    • (2011) PLoS Biol , vol.9
    • Toh, B.1    Wang, X.2    Keeble, J.3    Sim, W.J.4    Khoo, K.5    Wong, W.C.6
  • 15
    • 78449258451 scopus 로고    scopus 로고
    • Requirement of TGF{beta} signaling for SMO-mediated carcinogenesis
    • Fan Q, He M, Sheng T, Zhang X, Sinha M, Luxon B, et al. Requirement of TGF{beta} Signaling for SMO-mediated Carcinogenesis. J Biol Chem 2010;285:36570-6.
    • (2010) J Biol Chem , vol.285 , pp. 36570-36576
    • Fan, Q.1    He, M.2    Sheng, T.3    Zhang, X.4    Sinha, M.5    Luxon, B.6
  • 16
    • 23744484146 scopus 로고    scopus 로고
    • Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells
    • Chen M, O'Connor KL. Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells. Oncogene 2005;24:5125-30.
    • (2005) Oncogene , vol.24 , pp. 5125-5130
    • Chen, M.1    O'Connor, K.L.2
  • 17
    • 84871109342 scopus 로고    scopus 로고
    • Suppressionof vaccineimmunity by inflammatory monocytes
    • MitchellL A, Henderson AJ, Dow SW. Suppressionof vaccineimmunity by inflammatory monocytes. J Immunol 2012;189:5612-21.
    • (2012) J Immunol , vol.189 , pp. 5612-5621
    • MitchellL, A.1    Henderson, A.J.2    Dow, S.W.3
  • 18
    • 84856723000 scopus 로고    scopus 로고
    • The MCP-1/CCR2 axis in podocytes is involved in apoptosis induced by diabetic conditions
    • Nam BY, Paeng J, Kim SH, Lee SH, Kim do H, Kang HY, et al. The MCP-1/CCR2 axis in podocytes is involved in apoptosis induced by diabetic conditions. Apoptosis 2012;17:1-13.
    • (2012) Apoptosis , vol.17 , pp. 1-13
    • Nam, B.Y.1    Paeng, J.2    Kim, S.H.3    Lee, S.H.4    Do, H.K.5    Kang, H.Y.6
  • 19
    • 84880052558 scopus 로고    scopus 로고
    • CXCR4-targeted therapy inhibits VEGF expression and chondrosarcoma angiogenesis and metastasis
    • Sun X, Charbonneau C, Wei L, Yang W, Chen Q, Terek RM. CXCR4-targeted therapy inhibits VEGF expression and chondrosarcoma angiogenesis and metastasis. Mol Cancer Ther 2013;12:1163-70.
    • (2013) Mol Cancer Ther , vol.12 , pp. 1163-1170
    • Sun, X.1    Charbonneau, C.2    Wei, L.3    Yang, W.4    Chen, Q.5    Terek, R.M.6
  • 20
    • 84868332807 scopus 로고    scopus 로고
    • A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis
    • Gu D, Fan Q, Zhang X, Xie J. A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. J Biol Chem 2012;287:38356-66.
    • (2012) J Biol Chem , vol.287 , pp. 38356-38366
    • Gu, D.1    Fan, Q.2    Zhang, X.3    Xie, J.4
  • 21
    • 33750543972 scopus 로고    scopus 로고
    • A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway
    • Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, et al. A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res 2006;66:10171-8.
    • (2006) Cancer Res , vol.66 , pp. 10171-10178
    • Mao, J.1    Ligon, K.L.2    Rakhlin, E.Y.3    Thayer, S.P.4    Bronson, R.T.5    Rowitch, D.6
  • 22
    • 79955508675 scopus 로고    scopus 로고
    • Basal cell carcinomas in mice arise from hairfollicle stem cells and multiple epithelial progenitor populations
    • Grachtchouk M, Pero J, Yang SH, Ermilov AN, Michael LE, Wang A, et al. Basal cell carcinomas in mice arise from hairfollicle stem cells and multiple epithelial progenitor populations. J Clin Invest 2011;121:1768-81.
    • (2011) J Clin Invest , vol.121 , pp. 1768-1781
    • Grachtchouk, M.1    Pero, J.2    Yang, S.H.3    Ermilov, A.N.4    Michael, L.E.5    Wang, A.6
  • 23
    • 78651467232 scopus 로고    scopus 로고
    • Basal cell carcinomas arise from hair follicle stem cells in Ptch1 (+/-) mice
    • Wang GY, Wang J, Mancianti ML, Epstein EH Jr. Basal cell carcinomas arise from hair follicle stem cells in Ptch1 (+/-) mice. Cancer Cell 2011;19:114-24.
    • (2011) Cancer Cell , vol.19 , pp. 114-124
    • Wang, G.Y.1    Wang, J.2    Mancianti, M.L.3    Epstein Jr., E.H.4
  • 24
    • 79951793550 scopus 로고    scopus 로고
    • In vivo suppressive function of myeloid-derived suppressor cells is limited to the inflammatory site
    • Haverkamp JM, Crist SA, Elzey BD, Cimen C, Ratliff TL. In vivo suppressive function of myeloid-derived suppressor cells is limited to the inflammatory site. Eur J Immunol 2011;41:749-59.
    • (2011) Eur J Immunol , vol.41 , pp. 749-759
    • Haverkamp, J.M.1    Crist, S.A.2    Elzey, B.D.3    Cimen, C.4    Ratliff, T.L.5
  • 25
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo CA, Condamine T, Lu L, Cotter MJ, Youn JI, Cheng P, et al. HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med 2010;207:2439-53.
    • (2010) J Exp Med , vol.207 , pp. 2439-2453
    • Corzo, C.A.1    Condamine, T.2    Lu, L.3    Cotter, M.J.4    Youn, J.I.5    Cheng, P.6
  • 27
    • 0035945639 scopus 로고    scopus 로고
    • Smads mediate signaling of the TGFbeta superfamily in normal keratinocytes but are lost during skin chemical carcinogenesis
    • He W, Cao T, Smith DA, Myers TE, Wang XJ. Smads mediate signaling of the TGFbeta superfamily in normal keratinocytes but are lost during skin chemical carcinogenesis. Oncogene 2001;20:471-83.
    • (2001) Oncogene , vol.20 , pp. 471-483
    • He, W.1    Cao, T.2    Smith, D.A.3    Myers, T.E.4    Wang, X.J.5
  • 28
    • 84866742560 scopus 로고    scopus 로고
    • TGFbeta signalling in context
    • Massague J. TGFbeta signalling in context. Nat Rev Mol Cell Biol 2012;13:616-30.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 616-630
    • Massague, J.1
  • 29
    • 3142664714 scopus 로고    scopus 로고
    • Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer
    • Biswas S, Chytil A, Washington K, Romero-Gallo J, Gorska AE, Wirth PS, et al. Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. Cancer Res 2004;64:4687-92.
    • (2004) Cancer Res , vol.64 , pp. 4687-4692
    • Biswas, S.1    Chytil, A.2    Washington, K.3    Romero-Gallo, J.4    Gorska, A.E.5    Wirth, P.S.6
  • 30
    • 33846000938 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling inhibits hairfollicle anagen nduction by restricting epithelial stem/progenitor cell activation and expansion
    • Zhang J, He XC, Tong WG, Johnson T, Wiedemann LM, Mishina Y, et al. Bone morphogenetic protein signaling inhibits hairfollicle anagen nduction by restricting epithelial stem/progenitor cell activation and expansion. Stem Cells 2006;24:2826-39.
    • (2006) Stem Cells , vol.24 , pp. 2826-2839
    • Zhang, J.1    He, X.C.2    Tong, W.G.3    Johnson, T.4    Wiedemann, L.M.5    Mishina, Y.6
  • 32
    • 16644369882 scopus 로고    scopus 로고
    • Flow cytometric analysis of hematopoietic development
    • Srour EF, Yoder MC. Flow cytometric analysis of hematopoietic development. Methods Mol Med 2005;105:65-80.
    • (2005) Methods Mol Med , vol.105 , pp. 65-80
    • Srour, E.F.1    Yoder, M.C.2
  • 33
    • 79960933117 scopus 로고    scopus 로고
    • Functions of skin-resident gammadelta T cells
    • Macleod AS, Havran WL. Functions of skin-resident gammadelta T cells. Cell Mol Life Sci 2011;68:2399-408.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 2399-2408
    • Macleod, A.S.1    Havran, W.L.2
  • 34
    • 0034682767 scopus 로고    scopus 로고
    • Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: Binding to a common chemokine receptor motif within the helical bundle
    • Mirzadegan T, Diehl F, Ebi B, Bhakta S, Polsky I, McCarley D, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem 2000;275:25562-71.
    • (2000) J Biol Chem , vol.275 , pp. 25562-25571
    • Mirzadegan, T.1    Diehl, F.2    Ebi, B.3    Bhakta, S.4    Polsky, I.5    McCarley, D.6
  • 36
    • 84855465218 scopus 로고    scopus 로고
    • Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis
    • Yiakouvaki A, Dimitriou M, Karakasiliotis I, Eftychi C, Theocharis S, Kontoyiannis DL. Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis. J Clin Invest 2012;122:48-61.
    • (2012) J Clin Invest , vol.122 , pp. 48-61
    • Yiakouvaki, A.1    Dimitriou, M.2    Karakasiliotis, I.3    Eftychi, C.4    Theocharis, S.5    Kontoyiannis, D.L.6
  • 37
    • 84884556145 scopus 로고    scopus 로고
    • History of myeloid-derived suppressor cells
    • Talmadge JE, Gabrilovich DI. History of myeloid-derived suppressor cells. Nat Rev Cancer 2013;13:739-52.
    • (2013) Nat Rev Cancer , vol.13 , pp. 739-752
    • Talmadge, J.E.1    Gabrilovich, D.I.2
  • 39
    • 16844373628 scopus 로고    scopus 로고
    • Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis
    • Forrester E, Chytil A, Bierie B, Aakre M, Gorska AE, Sharif-Afshar AR, et al. Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. Cancer Res 2005;65:2296-302.
    • (2005) Cancer Res , vol.65 , pp. 2296-2302
    • Forrester, E.1    Chytil, A.2    Bierie, B.3    Aakre, M.4    Gorska, A.E.5    Sharif-Afshar, A.R.6
  • 40
    • 37349100945 scopus 로고    scopus 로고
    • Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
    • Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M, et al. Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 2008;13:23-35.
    • (2008) Cancer Cell , vol.13 , pp. 23-35
    • Yang, L.1    Huang, J.2    Ren, X.3    Gorska, A.E.4    Chytil, A.5    Aakre, M.6
  • 41
    • 84866018690 scopus 로고    scopus 로고
    • TGF-betamiR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma
    • Yang P, Li QJ, Feng Y, Zhang Y, Markowitz GJ, Ning S, et al. TGF-betamiR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell 2012;22:291-303.
    • (2012) Cancer Cell , vol.22 , pp. 291-303
    • Yang, P.1    Li, Q.J.2    Feng, Y.3    Zhang, Y.4    Markowitz, G.J.5    Ning, S.6
  • 42
    • 84872681454 scopus 로고    scopus 로고
    • Absence of signaling into CD4 (+) cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3 (+) regulatory T cells
    • Strainic MG, Shevach EM, An F, Lin F, Medof ME. Absence of signaling into CD4 (+) cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3 (+) regulatory T cells. Nat Immunol 2013;14:162-71.
    • (2013) Nat Immunol , vol.14 , pp. 162-171
    • Strainic, M.G.1    Shevach, E.M.2    An, F.3    Lin, F.4    Medof, M.E.5
  • 43
    • 84866403123 scopus 로고    scopus 로고
    • Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut
    • Schlenner SM, Weigmann B, Ruan Q, Chen Y, von Boehmer H. Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J Exp Med 2012;209:1529-35.
    • (2012) J Exp Med , vol.209 , pp. 1529-1535
    • Schlenner, S.M.1    Weigmann, B.2    Ruan, Q.3    Chen, Y.4    Von Boehmer, H.5
  • 44
    • 64249115813 scopus 로고    scopus 로고
    • Induction of myeloid-derived suppressor cells by tumor exosomes
    • Xiang X, Poliakov A, Liu C, Liu Y, Deng ZB, Wang J, et al. Induction of myeloid-derived suppressor cells by tumor exosomes. Int J Cancer 2009;124:2621-33.
    • (2009) Int J Cancer , vol.124 , pp. 2621-2633
    • Xiang, X.1    Poliakov, A.2    Liu, C.3    Liu, Y.4    Deng, Z.B.5    Wang, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.