Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux

Biochemical Pharmacology

Volumn 87, Issue 3, 2014, Pages 445-455

  Samarasinghe, Buddhini ^a   Wales, Christina T K ^a   Taylor, Frederick R ^a   Jacobs, Aaron T ^a,b  

^a UNIVERSITY OF HAWAII AT HILO   (United States)

^b UNIVERSITY OF HAWAII CANCER CENTER   (United States)

Author keywords

Autophagy; Cancer; HSF1; Hsp90; p62 SQSTM1

Indexed keywords

3 METHYLADENINE; BAFILOMYCIN A1; BECLIN 1; GELDANAMYCIN; HEAT SHOCK PROTEIN 90 INHIBITOR; HEAT SHOCK TRANSCRIPTION FACTOR 1; PROTEIN; PROTEIN P62; SEQUESTOSOME 1; SMALL INTERFERING RNA; TANESPIMYCIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER RESISTANCE; CELL DEATH; CHEMOSENSITIVITY; CONTROLLED STUDY; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

17-AAG; 17-N-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN; ATG; AUTOPHAGY; AUTOPHAGY-RELATED GENE; CANCER; DIMETHYL SULFOXIDE; DMSO; HEAT SHOCK ELEMENT; HEAT SHOCK FACTOR 1; HEAT SHOCK PROTEIN; HSE; HSF1; HSP; HSP90; LC3; MICROTUBULE-ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; P62/SQSTM1; SEQUESTESOME 1; SQSTM1;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AUTOPHAGY; CELL LINE, TUMOR; CELL SURVIVAL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENE SILENCING; HSP90 HEAT-SHOCK PROTEINS; HUMANS; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS;

EID: 84892921475     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.11.014     Document Type: Article

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