Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 3, 2014, Pages 1186-1191

  Chang, Ming Jin ^a   Zhong, Fei ^a   Lavik, Andrew R ^a   Parys, Jan B ^b   Berridge, Michael J ^c   Distelhorst, Clark W ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^c BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Calcium; Cancer; Lymphocyte; Signal transduction; Signaling

Indexed keywords

B LYMPHOCYTE RECEPTOR; CALCINEURIN; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; PHOSPHOPROTEIN DARPP 32; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN BCL 2; SERINE; SMALL INTERFERING RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; DEVELOPMENTAL STAGE; FEEDBACK SYSTEM; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; LEUKEMIA CELL LINE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

CALCIUM; CANCER; LYMPHOCYTE; SIGNAL TRANSDUCTION; SIGNALING;

ANIMALS; APOPTOSIS; BRAIN; CALCINEURIN; CALCIUM; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; GENE EXPRESSION REGULATION; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; JURKAT CELLS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MICE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84892910489     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1323098111     Document Type: Article

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