Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 3, 2014, Pages 1126-1131

  Alaganan, Aditi ^a   Fentress, Sarah J ^a   Tang, Keliang ^a   Wang, Qiuling ^a   Sibley, L David ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cooperative polymerization; Innate immunity; Pathogenesis

Indexed keywords

DENSE GRANULE PROTEIN 7; GAMMA INTERFERON; GUANOSINE TRIPHOSPHATASE; IMMUNITY RELATED GTPASE A6; PROTEIN SERINE THREONINE KINASE; PROTOZOAL PROTEIN; RHOPTRY PROTEIN 18; RHOPTRY PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DELETION MUTANT; ENZYME METABOLISM; IN VITRO STUDY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PARASITE CLEARANCE; PARASITE VIRULENCE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; TOXOPLASMA GONDII;

COOPERATIVE POLYMERIZATION; INNATE IMMUNITY; PATHOGENESIS;

ANIMALS; ANTIGENS, PROTOZOAN; DIMERIZATION; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GTP PHOSPHOHYDROLASES; GUANOSINE TRIPHOSPHATE; HOST-PARASITE INTERACTIONS; HYDROLYSIS; IMMUNITY, INNATE; INTERFERON-GAMMA; MACROPHAGES; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTOZOAN PROTEINS; TIME FACTORS; TOXOPLASMA; VIRULENCE;

EID: 84892910206     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1313501111     Document Type: Article

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