TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

Annals of Neurology

Volumn 74, Issue 6, 2013, Pages 837-847

  Flinn, Laura J ^a,b   Keatinge, Marcus ^a,b   Bretaud, Sandrine ^a,b   Mortiboys, Heather ^b   Matsui, Hideaki ^c   De Felice, Elena ^a,b,d   Woodroof, Helen I ^e   Brown, Lucy ^a,b   McTighe, Aimee ^a,b   Soellner, Rosemarie ^f   Allen, Claire E ^a   Heath, Paul R ^b   Milo, Marta ^f   Muqit, Miratul M K ^e   Reichert, Andreas S ^g,h   Köster, Reinhard W ^c,f   Ingham, Philip W ^a,i   Bandmann, Oliver ^a,b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^d UNIVERSITY OF MESSINA   (Italy)

^e UNIVERSITY OF DUNDEE   (United Kingdom)

^f INSTITUTE OF EPIDEMIOLOGY   (Germany)

^g Buchmann Institute for Molecular Life Sciences   (Germany)

^h GOETHE UNIVERSITY   (Germany)

ⁱ NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; PHOSPHOTRANSFERASE; PTEN INDUCED KINASE 1 PROTEIN; REGULATOR PROTEIN; TP53 INDUCED GLYCOLYSIS AND APOPTOSIS REGULATOR B PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL LOSS; CELL STRUCTURE; CELLULAR PARAMETERS; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOPAMINERGIC NERVE CELL; EMBRYO; ENZYME DEFICIENCY; GENE EXPRESSION; GENETIC ASSOCIATION; LARVA; MICROGLIA; MOLECULAR DYNAMICS; MUTANT; NERVE CELL DIFFERENTIATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; ZEBRA FISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOSIS REGULATORY PROTEINS; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; LARVA; MICROGLIA; MITOCHONDRIA; MITOCHONDRIAL DISEASES; PARKINSON DISEASE; PROTEIN-SERINE-THREONINE KINASES; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84892909862     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.23999     Document Type: Article

References (44)

1. Valente EM, Abou-Sleiman PM, Caputo V, et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004; 21: 304: 1158-1160.
2. Gandhi S, Muqit MM, Stanyer L, et al. PINK1 protein in normal human brain and Parkinson's disease. Brain 2006; 129: 1720-1731.
3. Hoepken HH, Gispert S, Morales B, et al. Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol Dis 2007; 25: 401-411.
4. Morais VA, Verstreken P, Roethig A, et al. Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med 2009; 1: 99-111.
5. Gautier CA, Kitada T, Shen J,. Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci U S A 2008; 105: 11364-11369.
6. Dawson TM, Ko HS, Dawson VL,. Genetic animal models of Parkinson's disease. Neuron 2010; 66: 646-661.
7. Bandmann O, Burton EA,. Genetic zebrafish models of neurodegenerative diseases. Neurobiol Dis 2010; 40: 58-65.
8. Panula P, Chen YC, Priyadarshini M, et al. The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases. Neurobiol Dis 2010; 40: 46-57.
9. Bill BR, Petzold AM, Clark KJ, et al. A primer for morpholino use in zebrafish. Zebrafish 2009; 6: 69-77.
10. Anichtchik O, Diekmann H, Fleming A, et al. Loss of PINK1 function affects development and results in neurodegeneration in zebrafish. J Neurosci 2008; 28: 8199-8207.
11. Sallinen V, Kolehmainen J, Priyadarshini M, et al. Dopaminergic cell damage and vulnerability to MPTP in Pink1 knockdown zebrafish. Neurobiol Dis 2010; 40: 93-101.
12. Xi Y, Ryan J, Noble S, et al. Impaired dopaminergic neuron development and locomotor function in zebrafish with loss of pink1 function. Eur J Neurosci 2010; 31: 623-633.
13. Bensaad K, Tsuruta A, Selak MA, et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 2006; 126: 107-120.
14. Woodroof HI, Pogson JH, Begley M, et al. Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations. Open Biol 2011; 1: 110012.
15. Thisse C, Thisse B,. High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat Protoc 2008; 3: 59-69.
16. Flinn L, Mortiboys H, Volkmann K, et al. Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio). Brain 2009; 132: 1613-1623.
17. Peri F, Nusslein-Volhard C,. Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo. Cell 2008; 133: 916-927.
18. Su F, Juarez MA, Cooke CL, et al. Differential regulation of primitive myelopoiesis in the zebrafish by Spi-1/Pu.1 and C/ebp1. Zebrafish 2007; 4: 187-199.
19. Kondapalli C, Kazlauskaite A, Zhang N, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol 2012; 2: 120080.
20. Rink E, Wullimann MF,. The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum). Brain Res 2001; 889: 316-330.
21. Rink E, Wullimann MF,. Connections of the ventral telencephalon and tyrosine hydroxylase distribution in the zebrafish brain (Danio rerio) lead to identification of an ascending dopaminergic system in a teleost. Brain Res Bull 2002; 57: 385-387.
22. Schweitzer J, Lohr H, Filippi A, Driever W,. Dopaminergic and noradrenergic circuit development in zebrafish. Dev Neurobiol 2012; 72: 256-268.
23. Del Giacco L, Sordino P, Pistocchi A, et al. Differential regulation of the zebrafish orthopedia 1 gene during fate determination of diencephalic neurons. BMC Dev Biol 2006; 6: 50.
24. Pfeffer PL, Gerster T, Lun K, et al. Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function. Development 1998; 125: 3063-3074.
25. Ryu S, Mahler J, Acampora D, et al. Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development. Curr Biol 2007; 17: 873-880.
26. Scholpp S, Wolf O, Brand M, Lumsden A,. Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon. Development 2006; 133: 855-864.
27. Viktorin G, Chiuchitu C, Rissler M, et al. Emx3 is required for the differentiation of dorsal telencephalic neurons. Dev Dyn 2009; 238: 1984-1998.
28. Voiculescu O, Taillebourg E, Pujades C, et al. Hindbrain patterning: Krox20 couples segmentation and specification of regional identity. Development 2001; 128: 4967-4978.
29. Akundi RS, Huang Z, Eason J, et al. Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PLoS One 2011; 6: e16038.
30. Samaranch L, Lorenzo-Betancor O, Arbelo JM, et al. PINK1-linked parkinsonism is associated with Lewy body pathology. Brain 2010; 133 (pt 4): 1128-1142.
31. Levesque S, Wilson B, Gregoria V, et al. Reactive microgliosis: extracellular micro-calpain and microglia-mediated dopaminergic neurotoxicity. Brain 2010; 133 (pt 3): 808-821.
32. Rhodes J, Hagen A, Hsu K, et al. Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish. Dev Cell 2005; 8: 97-108.
33. Hardy J,. Genetic analysis of pathways to Parkinson disease. Neuron 2010; 68: 201-206.
34. Shin JH, Ko HS, Kang H, et al. PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease. Cell 2011; 144: 689-702.
35. Rink E, Wullimann MF,. Development of the catecholaminergic system in the early zebrafish brain: an immunohistochemical study. Brain Res Dev Brain Res 2002; 137: 89-100.
36. Tay TL, Ronneberger O, Ryu S, et al. Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems. Nat Commun 2011; 25: 2: 171.
37. Bretaud S, Lee S, Guo S,. Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease. Neurotoxicol Teratol 2004; 26: 857-864.
38. Li H, Jogl G,. Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator). J Biol Chem 2009; 284: 1748-1754.
39. Gandhi S, Wood-Kaczmar A, Yao Z, et al. PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell 2009; 33: 627-638.
40. Hoshino A, Matoba S, Iwai-Kanai E, et al. p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia. J Mol Cell Cardiol 2012; 52: 175-184.
41. Vives-Bauza C, Przedborski S,. Mitophagy: the latest problem for Parkinson's disease. Trends Mol Med 2011; 17: 158-165.
42. Narendra DP, Jin SM, Tanaka A, et al. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 2010; 8: e1000298.
43. Green DR, Chipuk JE,. p53 and metabolism: inside the TIGAR. Cell 2006; 126: 30-32.
44. Plun-Favreau H, Lewis PA, Hardy J, et al. Cancer and neurodegeneration: between the devil and the deep blue sea. PLoS Genet 2010; 6: e1001257.