Epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk

Journal of the American College of Cardiology

Volumn 59, Issue 11, 2012, Pages 1017-1025

  Mann, Stefan A ^a   Otway, Robyn ^a   Guo, Guanglan ^a   Soka, Magdalena ^a   Karlsdotter, Lina ^a   Trivedi, Gunjan ^a   Ohanian, Monique ^a   Zodgekar, Poonam ^a   Smith, Robert A ^b   Wouters, Merridee A ^a   Subbiah, Rajesh ^c   Walker, Bruce ^c   Kuchar, Dennis ^c   Sanders, Prashanthan ^d   Griffiths, Lyn ^b   Vandenberg, Jamie I ^a,e   Fatkin, Diane ^a,c,e  

^a VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^b GRIFFITH UNIVERSITY   (Australia)

^c ST VINCENT S HOSPITAL   (Australia)

^d UNIVERSITY OF ADELAIDE   (Australia)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

atrial cell modeling; familial atrial fibrillation; genetics; potassium channels

Indexed keywords

POTASSIUM CHANNEL;

ACTION POTENTIAL; ADULT; AGED; AMINO ACID SEQUENCE; ANIMAL CELL; ARRHYTHMOGENESIS; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; EFFECT SIZE; FEMALE; GENE; GENE FREQUENCY; GENE MUTATION; GENETIC EPISTASIS; GENETIC VARIABILITY; HEART ATRIUM FIBRILLATION; HEART REPOLARIZATION; HUMAN; KCNA5 GENE; KCND3 GENE; KCNE1 GENE; KCNE2 GENE; KCNE3 GENE; KCNE4 GENE; KCNE5 GENE; KCNH2 GENE; KCNIP2 GENE; KCNJ14 GENE; KCNJ2 GENE; KCNJ4 GENE; KCNQ1 GENE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PATCH CLAMP; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS;

ACTION POTENTIALS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ATRIAL FIBRILLATION; CASE-CONTROL STUDIES; EPISTASIS, GENETIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HEART CONDUCTION SYSTEM; HUMANS; MALE; MIDDLE AGED; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; SEQUENCE ANALYSIS, DNA; YOUNG ADULT;

EID: 84863230453     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.11.039     Document Type: Article

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