-
1
-
-
14544300321
-
Directive 2004/27/EEC of the European parliament and the council of 31 March 2004, amending directive 2001/83/EC on the community code relating to medicinal products for human use
-
Anon. 30.04.2004
-
Anon. (2004). Directive 2004/27/EEC of the European Parliament and the Council of 31 March 2004, amending Directive 2001/83/EC on the Community code relating to medicinal products for human use. Official Journal of the European Union L136, 30.04.2004, 34-57.
-
(2004)
Official Journal of the European Union
, vol.L136
, pp. 34-57
-
-
-
2
-
-
0042557758
-
-
Anon. Silver Spring, MD, USA: US Food and Drug Administration. (Accessed 11.10.13)
-
Anon. (2010). Federal Food, Drug and Cosmetics Act. Silver Spring, MD, USA: US Food and Drug Administration. Available at: http://www.fda.gov/ RegulatoryInformation/Legislation/FederalFood DrugandCosmeticActFDCAct/default. htm (Accessed 11.10.13).
-
(2010)
Federal Food, Drug and Cosmetics Act
-
-
-
3
-
-
0142209376
-
Attrition and translation
-
New York
-
Duyk, G. (2003). Attrition and translation. Science, New York 302, 603-605.
-
(2003)
Science
, vol.302
, pp. 603-605
-
-
Duyk, G.1
-
4
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola, I. & Landis, J. (2004). Can the pharmaceutical industry reduce attrition rates? Nature Reviews Drug Discovery 3, 711-715.
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
5
-
-
79551696589
-
Mind the gap
-
Aithal, G.P. (2010). Mind the gap. ATLA 38, Suppl. 1, 1-4.
-
(2010)
ATLA
, vol.38
, Issue.SUPPL. 1
, pp. 1-4
-
-
Aithal, G.P.1
-
7
-
-
84892881779
-
-
USDA. Riverdale, MD, USA: United States Department of Agriculture (USDA), Animal and Plant Health Inspection Service (APHIS). (Accessed 05.09. 13)
-
USDA (2011). Annual Report. Animal Usage by Fiscal Year - Fiscal Year 2010, 2pp. Riverdale, MD, USA: United States Department of Agriculture (USDA), Animal and Plant Health Inspection Service (APHIS). Available at: http://www.aphis. usda.gov/animal-welfare/efoia/downloads/2010-Animals-Used-In- Research.pdf (Accessed 05.09. 13).
-
(2011)
Annual Report. Animal Usage by Fiscal Year - Fiscal Year 2010
, pp. 2
-
-
-
9
-
-
0033771951
-
Concordance of the toxicity of pharmaceuticals in humans and in animals
-
Olson, H., Betton, G., Robinson, D., Thomas, K., Monro, A., Kolaja, G., Lilly, P., Sanders, J., Sipes, G., Bracken, W., Dorato, M., Van Deun, K., Smith, P., Berger, B. & Heller, A. (2000). Concordance of the toxicity of pharmaceuticals in humans and in animals. Regulatory Toxicology & Pharmacology 32, 56-67.
-
(2000)
Regulatory Toxicology & Pharmacology
, vol.32
, pp. 56-67
-
-
Olson, H.1
Betton, G.2
Robinson, D.3
Thomas, K.4
Monro, A.5
Kolaja, G.6
Lilly, P.7
Sanders, J.8
Sipes, G.9
Bracken, W.10
Dorato, M.11
Van Deun, K.12
Smith, P.13
Berger, B.14
Heller, A.15
-
11
-
-
84892845965
-
-
Anon. Oxford, UK: Centre for Evidence Based Medicine (CEBM). (Accessed 10.10.13)
-
Anon. (2012). Likelihood Ratios. Oxford, UK: Centre for Evidence Based Medicine (CEBM). Available at: http://www.cebm.net/index.aspx?o= 1043 (Accessed 10.10.13).
-
(2012)
Likelihood Ratios
-
-
-
12
-
-
84873355257
-
Systematic reviews of animal models: Methodology versus epistemology
-
Greek, R. & Menache, A. (2013). Systematic reviews of animal models: Methodology versus epistemology. International Journal of Medical Sciences 10, 206-221.
-
(2013)
International Journal of Medical Sciences
, vol.10
, pp. 206-221
-
-
Greek, R.1
Menache, A.2
-
13
-
-
17844402965
-
Refining clinical diagnosis with likelihood ratios
-
Grimes, D.A. & Schulz, K.F. (2005). Refining clinical diagnosis with likelihood ratios. Lancet 365, 1500-1505.
-
(2005)
Lancet
, vol.365
, pp. 1500-1505
-
-
Grimes, D.A.1
Schulz, K.F.2
-
14
-
-
84455181545
-
Critical evaluation of the use of dogs in biomedical research and testing in Europe
-
Hasiwa, N., Bailey, J., Clausing, P., Daneshian, M., Eileraas, M., Farkas, S., Gyertyan, I., Hubrecht, R., Kobel, W., Krummenacher, G., Leist, M., Lohi, H., Miklosi, A., Ohl, F., Olejniczak, K., Schmitt, G., Sinnett-Smith, P., Smith, D., Wagner, K., Yager, J.D., Zurlo, J. & Hartung, T. (2011). Critical evaluation of the use of dogs in biomedical research and testing in Europe. ALTEX 28, 326-340.
-
(2011)
ALTEX
, vol.28
, pp. 326-340
-
-
Hasiwa, N.1
Bailey, J.2
Clausing, P.3
Daneshian, M.4
Eileraas, M.5
Farkas, S.6
Gyertyan, I.7
Hubrecht, R.8
Kobel, W.9
Krummenacher, G.10
Leist, M.11
Lohi, H.12
Miklosi, A.13
Ohl, F.14
Olejniczak, K.15
Schmitt, G.16
Sinnett-Smith, P.17
Smith, D.18
Wagner, K.19
Yager, J.D.20
Zurlo, J.21
Hartung, T.22
more..
-
15
-
-
84868305913
-
The ability of animal studies to detect serious post marketing adverse events is limited
-
van Meer, P.J., Kooijman, M., Gispen-de Wied, C.C., Moors, E.H. & Schellekens, H. (2012). The ability of animal studies to detect serious post marketing adverse events is limited. Regulatory Toxicology & Pharmacology 64, 345-349.
-
(2012)
Regulatory Toxicology & Pharmacology
, vol.64
, pp. 345-349
-
-
Van Meer, P.J.1
Kooijman, M.2
Gispen-De Wied, C.C.3
Moors, E.H.4
Schellekens, H.5
-
16
-
-
0029012739
-
Predictability of clinical adverse reactions of drugs by general pharmacology studies
-
Igarashi, T., Nakane, S. & Kitagawa, T. (1995). Predictability of clinical adverse reactions of drugs by general pharmacology studies. Journal of Toxicological Sciences 20, 77-92.
-
(1995)
Journal of Toxicological Sciences
, vol.20
, pp. 77-92
-
-
Igarashi, T.1
Nakane, S.2
Kitagawa, T.3
-
17
-
-
0004082597
-
-
Nottingham, UK: Fund for the Replacement of Animals in Medical Experiments (FRAME)
-
Broadhead, C.L., Jennings, M. & Combes, R. (1999). A Critical Evaluation of the Use of Dogs in the Regulatory Toxicity Testing of Pharmaceuticals, 106pp. Nottingham, UK: Fund for the Replacement of Animals in Medical Experiments (FRAME).
-
(1999)
A Critical Evaluation of the Use of Dogs in the Regulatory Toxicity Testing of Pharmaceuticals
, pp. 106
-
-
Broadhead, C.L.1
Jennings, M.2
Combes, R.3
-
18
-
-
0001107637
-
Symposium on clinical drug evaluation and human pharmacology. XVI. Evaluation of the safety of new drugs by means of tests in animals
-
Litchfield, J.T.J. (1962). Symposium on clinical drug evaluation and human pharmacology. XVI. Evaluation of the safety of new drugs by means of tests in animals. Clinical Pharmacology & Thera-peutics 3, 665-672.
-
(1962)
Clinical Pharmacology & Thera-peutics
, vol.3
, pp. 665-672
-
-
Litchfield, J.T.J.1
-
19
-
-
59849123600
-
Developmental toxicity testing: Protecting future generations?
-
Bailey, J. (2008). Developmental toxicity testing: Protecting future generations? ATLA 36, 718-721.
-
(2008)
ATLA
, vol.36
, pp. 718-721
-
-
Bailey, J.1
-
20
-
-
0003396336
-
-
3rd edn, Boca Raton, FL, USA: CRC Press
-
Schardein, J. (2000). Chemically Induced Birth Defects, 3rd edn, 1019pp. Boca Raton, FL, USA: CRC Press.
-
(2000)
Chemically Induced Birth Defects
, pp. 1019
-
-
Schardein, J.1
-
21
-
-
70449570242
-
-
Cambridge, UK: Biowisdom Ltd. (Accessed 10.10.13)
-
Spanhaak, S., Cook, D., Barnes, J. & Reynolds, J. (2008). Species Concordance for Liver Injury, 6pp. Cambridge, UK: Biowisdom Ltd. Available at: http://www.biowisdom.com/files/SIP-Board-Species -Concordance.pdf (Accessed 10.10.13).
-
(2008)
Species Concordance for Liver Injury
, pp. 6
-
-
Spanhaak, S.1
Cook, D.2
Barnes, J.3
Reynolds, J.4
-
22
-
-
41849108479
-
Medical progress depends on animal models - Doesn't it?
-
Matthews, R.A. (2008). Medical progress depends on animal models - doesn't it? Journal of the Royal Society of Medicine 101, 95-98.
-
(2008)
Journal of the Royal Society of Medicine
, vol.101
, pp. 95-98
-
-
Matthews, R.A.1
-
23
-
-
84892871496
-
-
Cambridge, UK: Biowisdom Ltd. (Accessed 10.10.13)
-
Barnes, J.C., Matis, S., Kenna, G., Swinton, J., Bradley, P.M., Day, N.C., Reed, J.Z., Reynolds, J. & Cook, D. (2008). The Safety Intelligence Program: An Intelligence Network for Drug-induced Liver Injury, 2pp. Cambridge, UK: Biowisdom Ltd. Available at: http://bioblog.instem.com/downloads/Carboxylic- acids-A4.pdf (Accessed 10.10.13).
-
(2008)
The Safety Intelligence Program: An Intelligence Network for Drug-induced Liver Injury
, pp. 2
-
-
Barnes, J.C.1
Matis, S.2
Kenna, G.3
Swinton, J.4
Bradley, P.M.5
Day, N.C.6
Reed, J.Z.7
Reynolds, J.8
Cook, D.9
-
24
-
-
84892874279
-
-
Macclesfield, UK: Safety Assessment, AstraZeneca. (Accessed 10.10.13)
-
Sidaway, J.R.M., Roberts, S., Huby, R., Nicholson, A., Pemberton, J., South, M., Noeske, T., Engkvist, O., Bradley, P. & Reed, J. (2012). Drug Toxicities Associated With Pharmacological Activity: Using Harmonised Data to Make the 'Known' Visible, 2pp. Macclesfield, UK: Safety Assessment, AstraZeneca. Available at: http://bioblog.instem.com/wp-content/uploads/downloads/2012/03/ SOT2012-make-theknown-visible-poster.pdf (Accessed 10.10.13).
-
(2012)
Drug Toxicities Associated with Pharmacological Activity: Using Harmonised Data to Make the 'Known' Visible
, pp. 2
-
-
Sidaway, J.R.M.1
Roberts, S.2
Huby, R.3
Nicholson, A.4
Pemberton, J.5
South, M.6
Noeske, T.7
Engkvist, O.8
Bradley, P.9
Reed, J.10
-
25
-
-
75149175715
-
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species
-
Fourches, D., Barnes, J.C., Day, N.C., Bradley, P., Reed, J.Z. & Tropsha, A. (2010). Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical Research in Toxicology 23, 171-183.
-
(2010)
Chemical Research in Toxicology
, vol.23
, pp. 171-183
-
-
Fourches, D.1
Barnes, J.C.2
Day, N.C.3
Bradley, P.4
Reed, J.Z.5
Tropsha, A.6
-
26
-
-
84868250727
-
Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation
-
Greco, I., Day, N., Riddoch-Contreras, J., Reed, J., Soininen, H., Kloszewska, I., Tsolaki, M., Vellas, B., Spenger, C., Mecocci, P., Wahlund, L.O., Simmons, A., Barnes, J. & Lovestone, S. (2012). Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation. Journal of Translational Medicine 10, 217.
-
(2012)
Journal of Translational Medicine
, vol.10
, pp. 217
-
-
Greco, I.1
Day, N.2
Riddoch-Contreras, J.3
Reed, J.4
Soininen, H.5
Kloszewska, I.6
Tsolaki, M.7
Vellas, B.8
Spenger, C.9
Mecocci, P.10
Wahlund, L.O.11
Simmons, A.12
Barnes, J.13
Lovestone, S.14
-
27
-
-
34547730344
-
Bias in toxicology
-
Wandall, B., Hansson, S.O. & Ruden, C. (2007). Bias in toxicology. Archives of Toxicology 81, 605-617.
-
(2007)
Archives of Toxicology
, vol.81
, pp. 605-617
-
-
Wandall, B.1
Hansson, S.O.2
Ruden, C.3
-
28
-
-
33846702343
-
Translating animal research into clinical benefit
-
Hackam, D.G. (2007). Translating animal research into clinical benefit. British Medical Journal 334, 163-164.
-
(2007)
British Medical Journal
, vol.334
, pp. 163-164
-
-
Hackam, D.G.1
-
29
-
-
84866040246
-
Publication bias in laboratory animal research: A survey on magnitude, drivers, consequences and potential solutions
-
ter Riet, G., Korevaar, D.A., Leenaars, M., Sterk, P.J., Van Noorden, C.J., Bouter, L.M., Lutter, R., Elferink, R.P. & Hooft, L. (2012). Publication bias in laboratory animal research: A survey on magnitude, drivers, consequences and potential solutions. PLoS One 7, e43404.
-
(2012)
PLoS One
, vol.7
-
-
Ter Riet, G.1
Korevaar, D.A.2
Leenaars, M.3
Sterk, P.J.4
Van Noorden, C.J.5
Bouter, L.M.6
Lutter, R.7
Elferink, R.P.8
Hooft, L.9
-
30
-
-
84883852488
-
Publication bias in animal research: A systematic review protocol
-
Briel, M., Muller, K.F., Meerpohl, J.J., von Elm, E., Lang, B., Motschall, E., Gloy, V., Lamontagne, F., Schwarzer, G. & Bassler, D. (2013). Publication bias in animal research: A systematic review protocol. Systematic Reviews 2, 23.
-
(2013)
Systematic Reviews
, vol.2
, pp. 23
-
-
Briel, M.1
Muller, K.F.2
Meerpohl, J.J.3
Von Elm, E.4
Lang, B.5
Motschall, E.6
Gloy, V.7
Lamontagne, F.8
Schwarzer, G.9
Bassler, D.10
-
31
-
-
77950679333
-
Can animal models of disease reliably inform human studies?
-
van der Worp, H.B., Howells, D.W., Sena, E.S., Porritt, M.J., Rewell, S., O'Collins, V. & Macleod, M.R. (2010). Can animal models of disease reliably inform human studies? PLoS Medicine 7, e1000245.
-
(2010)
PLoS Medicine
, vol.7
-
-
Van Der Worp, H.B.1
Howells, D.W.2
Sena, E.S.3
Porritt, M.J.4
Rewell, S.5
O'Collins, V.6
MacLeod, M.R.7
-
32
-
-
77950572352
-
Publication bias in reports of animal stroke studies leads to major overstatement of efficacy
-
Sena, E.S., van der Worp, H.B., Bath, P.M., Howells, D.W. & Macleod, M.R. (2010). Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biology 8, e1000344.
-
(2010)
PLoS Biology
, vol.8
-
-
Sena, E.S.1
Van Der Worp, H.B.2
Bath, P.M.3
Howells, D.W.4
MacLeod, M.R.5
-
33
-
-
33846677129
-
Comparison of treatment effects between animal experiments and clinical trials: Systematic review
-
Perel, P., Roberts, I., Sena, E., Wheble, P., Briscoe, C., Sandercock, P., Macleod, M., Mignini, L.E., Jayaram, P. & Khan, K.S. (2007). Comparison of treatment effects between animal experiments and clinical trials: Systematic review. British Medical Journal 334, 197.
-
(2007)
British Medical Journal
, vol.334
, pp. 197
-
-
Perel, P.1
Roberts, I.2
Sena, E.3
Wheble, P.4
Briscoe, C.5
Sandercock, P.6
MacLeod, M.7
Mignini, L.E.8
Jayaram, P.9
Khan, K.S.10
-
34
-
-
77952688070
-
The financing of drug trials by pharmaceutical companies and its consequences. Part 1: A qualitative, systematic review of the literature on possible influences on the findings, protocols, and quality of drug trials
-
Schott, G., Pachl, H., Limbach, U., Gundert-Remy, U., Ludwig, W.D. & Lieb, K. (2010). The financing of drug trials by pharmaceutical companies and its consequences. Part 1: A qualitative, systematic review of the literature on possible influences on the findings, protocols, and quality of drug trials. Deutsches Arzteblatt International 107, 279-285.
-
(2010)
Deutsches Arzteblatt International
, vol.107
, pp. 279-285
-
-
Schott, G.1
Pachl, H.2
Limbach, U.3
Gundert-Remy, U.4
Ludwig, W.D.5
Lieb, K.6
-
35
-
-
76849104977
-
Survey of the quality of experimental design, statistical analysis and reporting of research using animals
-
Kilkenny, C., Parsons, N., Kadyszewski, E., Festing, M.F., Cuthill, I.C., Fry, D., Hutton, J. & Altman, D.G. (2009). Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS One 4, e7824.
-
(2009)
PLoS One
, vol.4
-
-
Kilkenny, C.1
Parsons, N.2
Kadyszewski, E.3
Festing, M.F.4
Cuthill, I.C.5
Fry, D.6
Hutton, J.7
Altman, D.G.8
-
36
-
-
79957595848
-
Directive 2010/63/EU of the European parliament and of the council of 22 September 2010 on the protection of animals used for scientific purposes
-
Anon. 20.10.2010
-
Anon. (2010). Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. Official Journal of the European Union L276, 20.10.2010, 33-79.
-
(2010)
Official Journal of the European Union
, vol.L276
, pp. 33-79
-
-
-
37
-
-
2542641907
-
-
US FDA, Silver Spring, MD, USA: US Department of Health and Human Services, Food and Drug Administration. (Accessed 10.10.13)
-
US FDA (2004). Innovation or Stagnation: Challenge and Opportunity on the Critical Path to New Medical Products, 12pp. Silver Spring, MD, USA: US Department of Health and Human Services, Food and Drug Administration. Available at: http://www.fda.gov/ScienceResearch/Special Topics/CriticalPath Initiative/CriticalPathOpportunitiesReports/ucm077 262.htm (Accessed 10.10.13).
-
(2004)
Innovation or Stagnation: Challenge and Opportunity on the Critical Path to New Medical Products
, pp. 12
-
-
-
38
-
-
35348840852
-
Drug withdrawals in the United States: A systematic review of the evidence and analysis of trends
-
Issa, A.M., Phillips, K.A., Van Bebber, S., Nidamarthy, H.G., Lasser, K.E., Haas, J.S., Alldredge, B.K., Wachter, R.M. & Bates, D.W. (2007). Drug withdrawals in the United States: A systematic review of the evidence and analysis of trends. Current Drug Safety 2, 177-185.
-
(2007)
Current Drug Safety
, vol.2
, pp. 177-185
-
-
Issa, A.M.1
Phillips, K.A.2
Van Bebber, S.3
Nidamarthy, H.G.4
Lasser, K.E.5
Haas, J.S.6
Alldredge, B.K.7
Wachter, R.M.8
Bates, D.W.9
-
39
-
-
80052831391
-
Drug discovery in the next decade: Innovation needed ASAP
-
Bennani, Y.L. (2011). Drug discovery in the next decade: Innovation needed ASAP. Drug Discovery Today 16, 779-792.
-
(2011)
Drug Discovery Today
, vol.16
, pp. 779-792
-
-
Bennani, Y.L.1
-
40
-
-
77951872182
-
New drug approval success rate in Europe in 2009
-
Eichler, H.G., Aronsson, B., Abadie, E. & Salmonson, T. (2010). New drug approval success rate in Europe in 2009. Nature Reviews Drug Discovery 9, 355-356.
-
(2010)
Nature Reviews Drug Discovery
, vol.9
, pp. 355-356
-
-
Eichler, H.G.1
Aronsson, B.2
Abadie, E.3
Salmonson, T.4
-
41
-
-
39049161143
-
2007 FDA drug approvals: A year of flux
-
Hughes, B. (2008). 2007 FDA drug approvals: A year of flux. Nature Reviews Drug Discovery 7, 107-109.
-
(2008)
Nature Reviews Drug Discovery
, vol.7
, pp. 107-109
-
-
Hughes, B.1
-
42
-
-
67650445156
-
Toxicology for the twenty-first century
-
London
-
Hartung, T. (2009). Toxicology for the twenty-first century. Nature, London 460, 208-212.
-
(2009)
Nature
, vol.460
, pp. 208-212
-
-
Hartung, T.1
-
43
-
-
29444441547
-
More compounds failing phase I. FDA chief warns that high drug attrition rate is pushing up the cost of drug development
-
6 August 2004. (Accessed 10.10.13)
-
Harding, A. (2004). More compounds failing phase I. FDA chief warns that high drug attrition rate is pushing up the cost of drug development. The Scientist, 6 August 2004. Available at: http://www.the-scientist.com/?articles. view/articleNo/23003/title/More-compounds-failing-Phase-I/ (Accessed 10.10.13).
-
(2004)
The Scientist
-
-
Harding, A.1
-
44
-
-
33746699651
-
Access before approval - A right to take experimental drugs?
-
Okie, S. (2006). Access before approval - a right to take experimental drugs? New England Journal of Medicine 355, 437-440.
-
(2006)
New England Journal of Medicine
, vol.355
, pp. 437-440
-
-
Okie, S.1
-
46
-
-
0003392834
-
-
Anon. GAO/PEMD-90-15, Washington, DC, USA: US General Accounting Office. (Accessed 10.10.13)
-
Anon. (1990). FDA Drug Review: Post Approval Risks 1976-1985. GAO/PEMD-90-15, 132pp. Washington, DC, USA: US General Accounting Office. Available at: http://161.203.16.4/d24t8/141456.pdf (Accessed 10.10.13).
-
(1990)
FDA Drug Review: Post Approval Risks 1976-1985
, pp. 132
-
-
-
47
-
-
0032522873
-
Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies
-
Lazarou, J., Pomeranz, B.H. & Corey, P.N. (1998). Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies. Journal of the American Medical Association 279, 1200-1205.
-
(1998)
Journal of the American Medical Association
, vol.279
, pp. 1200-1205
-
-
Lazarou, J.1
Pomeranz, B.H.2
Corey, P.N.3
-
49
-
-
84876561670
-
Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics
-
Martinez, M.N., Antonovic, L., Court, M., Dacasto, M., Fink-Gremmels, J., Kukanich, B., Locuson, C., Mealey, K., Myers, M.J. & Trepanier, L. (2013). Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics. Drug Metabolism Reviews 45, 218-230.
-
(2013)
Drug Metabolism Reviews
, vol.45
, pp. 218-230
-
-
Martinez, M.N.1
Antonovic, L.2
Court, M.3
Dacasto, M.4
Fink-Gremmels, J.5
Kukanich, B.6
Locuson, C.7
Mealey, K.8
Myers, M.J.9
Trepanier, L.10
-
50
-
-
17744387700
-
Prospects for reducing and refining the use of dogs in the regulatory toxicity testing of pharmaceuticals
-
Broadhead, C.L., Betton, G., Combes, R., Damment, S., Everett, D., Garner, C., Godsafe, Z., Healing, G., Heywood, R., Jennings, M., Lumley, C., Oliver, G., Smith, D., Straughan, D., Topham, J., Wallis, R., Wilson, S. & Buckley, P. (2000). Prospects for reducing and refining the use of dogs in the regulatory toxicity testing of pharmaceuticals. Human & Experimental Toxicology 19, 440-447.
-
(2000)
Human & Experimental Toxicology
, vol.19
, pp. 440-447
-
-
Broadhead, C.L.1
Betton, G.2
Combes, R.3
Damment, S.4
Everett, D.5
Garner, C.6
Godsafe, Z.7
Healing, G.8
Heywood, R.9
Jennings, M.10
Lumley, C.11
Oliver, G.12
Smith, D.13
Straughan, D.14
Topham, J.15
Wallis, R.16
Wilson, S.17
Buckley, P.18
-
51
-
-
84892891464
-
-
Berlin, Germany: Institute of Pharmacy, Free University of Berlin. (Accessed 10.10.13)
-
Spielmann, H., Kral, V., Schäfer-Korting, M., Seidle, T., McIvor, E., Rowan, A. & Schoeters, G. (2011). The AXLR8 Consortium. Alternative Testing Strategies, Progress Report 2011, 364pp. Berlin, Germany: Institute of Pharmacy, Free University of Berlin. Available at: http://scrtox.eu/~scrtox/ images/stories/AXLR8-2011.pdf (Accessed 10.10.13).
-
(2011)
The AXLR8 Consortium. Alternative Testing Strategies, Progress Report 2011
, pp. 364
-
-
Spielmann, H.1
Kral, V.2
Schäfer-Korting, M.3
Seidle, T.4
McIvor, E.5
Rowan, A.6
Schoeters, G.7
-
53
-
-
0004028916
-
-
Anon, London, UK: European Coalition to End Animal Experiments. (Accessed 10.10.13)
-
Anon. (2009). Public Opinion. London, UK: European Coalition to End Animal Experiments. Available at: http://www.eceae.org/en/what-we-do/campaigns/ 12-million-reasons/public-opinion (Accessed 10.10.13).
-
(2009)
Public Opinion
-
-
-
54
-
-
0037159691
-
The domestication of social cognition in dogs
-
New York
-
Hare, B., Brown, M., Williamson, C. & Tomasello, M. (2002). The domestication of social cognition in dogs. Science, New York 298, 1634-1636.
-
(2002)
Science
, vol.298
, pp. 1634-1636
-
-
Hare, B.1
Brown, M.2
Williamson, C.3
Tomasello, M.4
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