Medical progress depends on animal models - Doesn't it?

Journal of the Royal Society of Medicine

Volumn 101, Issue 2, 2008, Pages 95-98

  Matthews, Robert A J ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MODEL; HEALTH PRACTITIONER; HEALTH SERVICE; HUMAN; MEDICAL PRACTICE; MEDICAL RESEARCH; MEDICAL SOCIETY; REVIEW; UNIVERSITY HOSPITAL; VALIDATION STUDY;

EID: 41849108479     PISSN: 01410768     EISSN: None     Source Type: Journal    
DOI: 10.1258/jrsm.2007.070164     Document Type: Review

References (17)

1. US Department of Public Health. The Physiologist 1994;37:107
2. Royal Society. Statement of the Royal Society's Position on the Use of Animals in Research. London: Royal Society, 2002. See http://www.royalsoc. org/displaypagedoc.asp?id=11471
3. UK Department of Health. Memorandum for House of Lords Select Committee on Animals In Scientific Procedures. London: DoH, 2001
4. RDS petition.. See http://www.rds-online.org.uk/upload/docs/ Declaration%202005.pdf
5. RDS Timeline. See http://www.rds-online.org.uk/pages/page.asp? i_ToolbarID=3&i_PageID=37
6. Comroe JH, Dripps RD. Scientific basis for the support of biomedical science. Science 1976;192:105-11
7. Grant J, Green L, Mason B. From Bedside to Bench: Comroe and Dripps Revisited. London: Brunel University, 2003. (Health Economics Research Group Research Report No 30). See http://www.brunel.ac.uk/3289/Herg1/RR30.pdf
8. Paton W. Man & Mouse: Animals in Medical Research. 2nd edn. Oxford: Oxford University Press, 1993
9. Paulos JA. Innumeracy: Mathematical Illiteracy and its Consequences. London: Viking, 1989
10. Deeks JJ, Altman DG. Diagnostic tests 4: likelihood ratios. BMJ 2004;329:168-9. See http://www.bmj.com/cgi/content/full/329/7458/168
11. Schein PS, Davis RD, Carter S, Newman J, Schein DR, Rall DP. The evaluation of anticancer drugs in dogs and monkeys for the prediction of qualitative toxicities in man. Clin Pharmacol Ther 1970;11:3-10
12. Heywood R. Target organ toxicity. Toxic Lett 1981;8:349-58
13. Greaves P, Williams A, Eve M. First dose of potential new medicines to humans: how animals help. Nature Rev Drug Discov 2004;3:226-36
14. Nuffield Council on Bioethics. The Ethics of Research Involving Animals 265. London: Nuffield Council on Bioethics, 2005. See http://www.nuffieldbioethics.org/fileLibrary/pdf/RIA_Report_FINAL-opt.pdf
15. House of Lords Select Committee on Animals in Scientific Procedures Report 2002. Chapter 4, sections 4.28. London: TSO, 2002. See http://www.parliament.the-stationery-office.co.uk/pa/ld200102/ldselect/ldanimal/ 150/15001.htm
16. Olson H, Betton G, Robinson D, et al. Concordance of the toxicity of pharmaceuticals in humans and animals. Regul Toxicol Pharmacol 2000;32:56-67
17. Hottendorf GH. Species differences in toxic lesions in human risk assessment. In: Roloff MV, (ed.) The Role of Animal Selection and Extrapolation. London: Taylor & Francis, 1987, 87-96