Cross-linking of thioredoxin reductase by the sulfur mustard analogue mechlorethamine (methylbis(2-chloroethyl)amine) in human lung epithelial cells and rat lung: Selective inhibition of disulfide reduction but not redox cycling

Chemical Research in Toxicology

Volumn 27, Issue 1, 2014, Pages 61-75

  Jan, Yi Hua ^a   Heck, Diane E ^b   Malaviya, Rama ^c   Casillas, Robert P ^d   Laskin, Debra L ^c   Laskin, Jeffrey D ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d MRIGlobal   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORMETHINE; CYSTEINE; DIMER; MUSTARD GAS DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SELENOCYSTEINE; THIOREDOXIN REDUCTASE 1; THIOREDOXIN REDUCTASE 2; CROSS LINKING REAGENT; DISULFIDE; THIOREDOXIN REDUCTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOLIC FRACTION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LUNG ALVEOLUS EPITHELIUM; MALE; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN CROSS LINKING; RAT; REDOX STRESS; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; EPITHELIUM CELL; LUNG; METABOLISM; WISTAR RAT;

ANIMALS; CELLS, CULTURED; CROSS-LINKING REAGENTS; DISULFIDES; EPITHELIAL CELLS; HUMANS; LUNG; MALE; MECHLORETHAMINE; MODELS, MOLECULAR; OXIDATION-REDUCTION; RATS; RATS, WISTAR; THIOREDOXIN-DISULFIDE REDUCTASE;

EID: 84892843411     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx400329a     Document Type: Article

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