Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors

Free Radical Biology and Medicine

Volumn 50, Issue 6, 2011, Pages 689-699

  Rackham, Oliver ^a   Shearwood, Anne Marie J ^a   Thyer, Ross ^a   McNamara, Elyshia ^a   Davies, Stefan M K ^a   Callus, Bernard A ^b   Miranda Vizuete, Antonio ^c   Berners Price, Susan J ^d   Cheng, Qing ^e   Arnér, Elias S J ^e   Filipovska, Aleksandra ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^d GRIFFITH UNIVERSITY   (Australia)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Auranofin; Free radicals; Gold(I) compounds; Thioredoxin; Thioredoxin reductase

Indexed keywords

5,5' DITHIOBIS(2 NITROBENZOIC ACID); AURANOFIN; AUROTHIOGLUCOSE; CISPLATIN; GOLD COMPLEX; GOLD DERIVATIVE; ISOENZYME; JUGLONE; METAL DERIVATIVE; MITOCHONDRIAL ENZYME; OXIDOREDUCTASE INHIBITOR; PROTEIN BAK; PROTEIN BAX; QUINONE DERIVATIVE; THIOCTIC ACID; THIOREDOXIN REDUCTASE 1; THIOREDOXIN REDUCTASE 1 INHIBITOR; THIOREDOXIN REDUCTASE 2; THIOREDOXIN REDUCTASE 2 INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; CYTOTOXICITY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME SPECIFICITY; IN VITRO STUDY; INHIBITION KINETICS; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; ANTIOXIDANTS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CISPLATIN; CYTOSOL; DITHIONITROBENZOIC ACID; ENZYME INHIBITORS; HUMANS; MICE; MITOCHONDRIA; NAPHTHOQUINONES; ORGANOGOLD COMPOUNDS; OXIDATION-REDUCTION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THIOCTIC ACID; THIOREDOXIN REDUCTASE 1; THIOREDOXIN REDUCTASE 2; THIOREDOXINS;

MAMMALIA;

EID: 79951682393     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.12.015     Document Type: Article

References (55)

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