Resveratrol directly affects in vitro lipolysis and glucose transport in human fat cells

Journal of Physiology and Biochemistry

Volumn 69, Issue 3, 2013, Pages 585-593

  Gomez Zorita, Saioa ^a   Tréguer, Karine ^b   Mercader, Josep ^b   Carpéné, Christian ^b  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b INSERM   (France)

Author keywords

Antioxidants; Benzylamine; Dietary supplements; Human adipocytes; Resveratrol

Indexed keywords

BENZYLAMINE; GLUCOSE; GLYCEROL; GLYCEROPHOSPHATE; INSULIN; ISOPRENALINE; LIBERASE; RESVERATROL; TRIACYLGLYCEROL;

ABDOMINAL SUBCUTANEOUS FAT; ADIPOCYTE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOLYSIS;

EID: 84892815877     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-012-0229-0     Document Type: Article

References (40)

1. Ajmo JM, Liang X, Rogers CQ, Pennock B, You M (2008) Resveratrol alleviates alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol 295:G833-G842
2. Akagawa M, Suyama K (2001) Amine oxidase-like activity of polyphenols. Mechanism and properties. Eur J Biochem 268:1953-1963
3. Alberdi G, Rodríguez VM, Miranda J, Macarulla MT, Arias N, Andrés-Lacueva C, Portillo MP (2011) Changes in white adipose tissue metabolism induced by resveratrol in rats. Nutr Metab (Lond) 8:29
4. Arias N, Macarulla MT, Aguirre L, Martínez-Castaño MG, Gómez-Zorita S, Miranda J, Martínez JA, Portillo MP (2011) The combination of resveratrol and conjugated linoleic acid is not useful in preventing obesity. J Physiol Biochem 67:471-477
5. Atgié C, Hadj-Sassi L, Bukowiecki L, Mauriège P (2009) High lipolytic activity and dyslipidemia in a spontaneous hypertensive/NIH corpulent (SHR/N-cp) rat: a genetic model of obesity and type 2 diabetes mellitus. J Physiol Biochem 65:33-42
6. Atgié C, Sauvant P, Ambid L, Carpéné C (2009) Possible mechanisms of weight loss of Siberian hamsters (Phodopus sungorus sungorus) exposed to short photoperiod. J Physiol Biochem 65:377-386
7. Baile CA, Yang JY, Rayalam S, Hartzell DL, Lai CY, Andersen C, Della-Fera MA (2011) Effect of resveratrol on fat mobilization. Ann N Y Acad Sci 1215:40-47
8. Breen DM, Sanli T, Giacca A, Tsiani E (2008) Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK. Biochem Biophys Res Commun 374:117-122
9. Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, Brown K, Steward WP, Gescher A, Brenner DE (2010) Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res 70:9003-9011
10. Costa CS, Rohden F, Hammes TO, Margis R, Bortolotto JW, Padoin AV, Mottin CC, Guaragna RM (2011) Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARγ1-3 mRNA expression in human visceral adipocytes. Obes Surg 21:356-361
11. Fischer-Posovszky P, Kukulus V, Tews D, Unterkircher T, Debatin KM, Fulda S, Wabitsch M (2010) Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Am J Clin Nutr 92:5-15
12. Floyd ZE, Wang ZQ, Kilroy G, Cefalu WT (2008) Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol. Metabolism 57:S32-S38
13. Gómez-Zorita S, Fernández-Quintela A, Macarulla MT, Aguirre L, Hijona E, Bujanda L, Milagro F, Martínez JA, Portillo MP (2012) Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress. Br J Nutr 107:202-210
14. Grès S, Bour S, Valet P, Carpéné C (2012) Benzylamine antihyperglycemic effect is abolished by AOC3 gene invalidation in mice but not rescued by semicarbazide-sensitive amine oxidase expression under the control of aP2 promoter. J Physiol Biochem 68:651-662
15. Iffiú-Soltész Z, Mercader J, Daviaud D, Boucher J, Carpéné C (2011) Increased primary amine oxidase expression and activity in white adipose tissue of obese and diabetic db-/-mice. J Neural Transm 118:1071-1077
16. Iglesias-Osma MC, Bour S, Garcia-Barrado MJ, Visentin V, Pastor MF, Testar X, Marti L, Enrique-Tarancon G, Valet P, Moratinos J, Carpéné C (2005) Methylamine but not mafenide mimics insulin-like actvity of the semicarbazidesensitive amine oxidase-substrate benzylamine on glucose tolerance and on human adipocyte metabolism. Pharmacol Res 52:475-484
17. Kang W, Hong HJ, Guan J, Kim DG, Yang EJ, Koh G, Park D, Han CH, Lee YJ, Lee DH (2012) Resveratrol improves insulin signaling in a tissue-specific manner under insulinresistant conditions only: in vitro and in vivo experiments in rodents. Metabolism 61:424-433
18. Kennedy A, Overman A, Lapoint K, Hopkins R, West T, Chuang CC, Martinez K, Bell D, McIntosh M (2009) Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol. J Lipid Res 50:225-232
19. Krawczyk SA, Haller JF, Ferrante T, Zoeller RA, Corkey BE (2012) Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes. PLoS One 7:e34904
20. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127:1109-1122
21. Lasa A, Churruca I, Eseberri I, Andrés-Lacueva C, Portillo MP (2012) Delipidating effect of resveratrol metabolites in 3T3-L1 adipocytes. Mol Nutr Food Res 56:1559-1568
22. Lasa A, Schweiger M, Kotzbeck P, Churruca I, Simón E, Zechner R, Del Puy PM (2012) Resveratrol regulates lipolysis via adipose triglyceride lipase. J Nutr Biochem 23:379-384
23. Maraculla MT, Alberdi G, Gomez S, Tueros I, Bald C, Rodriguez VM, Martinez JA, Portillo MP (2009) Effects of different doses of resveratrol on body fat and serum parameters in rats fed a hypercaloric diet. J Physiol Biochem 65:369-376
24. Mercader J, Iffiú-Soltesz Z, Brenachot X, Földi A, Dunkel P, Balogh B, Attané C, Valet P, Mátyus P, Carpéné C (2010) SSAO substrates exhibiting insulin-like effects in adipocytes as a promising treatment option for metabolic disorders. Future Med Chem 2:1735-1749
25. Mercader J, Palou A, Bonet ML (2011) Resveratrol enhances fatty acid oxidation capacity and reduces resistin and retinol-binding protein 4 expression in white adipocytes. J Nutr Biochem 22:828-834
26. Mercader J, Wanecq E, Chen J, Carpéné C (2011) Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium. J Physiol Biochem 67:443-452
27. Olholm J, Paulsen SK, Cullberg KB, Richelsen B, Pedersen SB (2010) Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants. Int J Obes (Lond) 34:1546-1553
28. Park HJ, Yang JY, Ambati S, Della-Fera MA, Hausman DB, Rayalam S, Baile CA (2008) Combined effects of genistein, quercetin, and resveratrol in human and 3T3-L1 adipocytes. J Med Food 11:773-783
29. Pedersen SB, Ølholm J, Paulsen SK, Bennetzen MF, Richelsen B (2008) Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women. Int J Obes (Lond) 32:1250-1255
30. Rayalam S, Yang J-Y, Ambati S, Della-Fera MA, Baile CA (2008) Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes. Phytother Res 22:1367-1371
31. Rivera L, Moron R, Zarzuelo A, Galisteo M (2009) Longterm resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochem Pharmacol 77:1053-1063
32. Serrano J, Jové M, Boada J, Bellmunt MJ, Pamplona R, Portero-Otín M (2009) Dietary antioxidants interfere with Amplex Red-coupled-fluorescence assays. Biochem Biophys Res Commun 388:443-449
33. Su HC, Hung LM, Chen JK (2006) Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocininduced diabetic rats. Am J Physiol Endocrinol Metab 290:E1339-E1346
34. Szkudelska K, Nogowski L, Szkudelski T (2009) Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and antilipolytic action of insulin in isolated rat adipocytes. J Steroid Biochem Mol Biol 113:17-24
35. Szkudelska K, Nogowski L, Szkudelski T (2011) Resveratrol and genistein as adenosine triphosphate-depleting agents in fat cells. Metabolism 60:720-729
36. Szkudelski T, Szkudelska K (2011) Anti-diabetic effects of resveratrol. Ann N Y Acad Sci 1215:34-39
37. Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens G, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink M, Kunz I, Schrauwen-Hinderling V, Blaak E, Auwerx J, Schrauwen P (2011) Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 14:612-622
38. Wanecq E, Prévot D, Carpéné C (2009) Lack of direct insulin-like action of visfatin/Nampt/PBEF1 in human adipocytes. J Physiol Biochem 65:351-360
39. Yang JY, Della-Fera MA, Rayalam S, Ambati S, Hartzell DL, Park HJ, Baile CA (2008) Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci 82:1032-1039
40. Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai SI, Schechtman KB, Gu C, Kunz I, Fanelli FR, Patterson BW, Klein S (2012) Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab 16:658-664