Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila

FEBS Letters

Volumn 588, Issue 3, 2014, Pages 408-413

  Nagy, Péter ^a   Hegedus, Krisztina ^a   Pircs, Karolina ^a   Varga, Ágnes ^a   Juhász, Gábor ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Atg18; Atg2; Atg7; Atg8a; Atg9; Ref(2)P p62

Indexed keywords

INSECT PROTEIN; PROTEIN ATG8A; PROTEIN ATG9; PROTEIN FIP200; PROTEIN REF (2) P; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATG18 GENE; ATG2 GENE; ATG7 GENE; AUTOPHAGOSOME; AUTOPHAGY; DROSOPHILA; GENE MUTATION; GENE SILENCING; MICROBIAL GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; STARVATION; UBIQUITINATION;

ATG; ATG18; ATG2; ATG7; ATG8A; ATG9; AUTOPHAGY-RELATED; PAS; PHAGOPHORE ASSEMBLY SITE; PHOSPHATIDYLINOSITOL 3-PHOSPHATE; PI3P; REF(2)P; REF(2)P/P62; REFRACTORY TO SIGMA P; ULK; UNCOORDINATED-51 LIKE AUTOPHAGY KINASE; VACUOLAR PROTEIN SORTING; VPS; WD40 REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN; WIPI;

ANIMALS; AUTOPHAGY; CARRIER PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; MEMBRANE PROTEINS; MUTATION; PROTEIN TRANSPORT; PROTEOLYSIS; STARVATION; UBIQUITINATED PROTEINS;

EID: 84892810375     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.12.012     Document Type: Article

References (38)

1. N. Mizushima, B. Levine, A.M. Cuervo, and D.J. Klionsky Autophagy fights disease through cellular self-digestion Nature 451 2008 1069 1075 (Pubitemid 351317450)
2. S. Shaid, C.H. Brandts, H. Serve, and I. Dikic Ubiquitination and selective autophagy Cell Death Differ. 20 2013 21 30
3. T. Johansen, and T. Lamark Selective autophagy mediated by autophagic adapter proteins Autophagy 7 2011 279 296
4. Y. Ichimura et al. A ubiquitin-like system mediates protein lipidation Nature 408 2000 488 492
5. N. Mizushima, A. Yamamoto, M. Matsui, T. Yoshimori, and Y. Ohsumi In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker Mol. Biol. Cell 15 2004 1101 1111 (Pubitemid 38316219)
6. M. Komatsu et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice Cell 131 2007 1149 1163 (Pubitemid 350235021)
7. G. Bjorkoy, T. Lamark, A. Brech, H. Outzen, M. Perander, A. Overvatn, H. Stenmark, and T. Johansen P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death J. Cell Biol. 171 2005 603 614 (Pubitemid 41668720)
8. S. Pankiv et al. P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy J. Biol. Chem. 282 2007 24131 24145 (Pubitemid 47328003)
9. E. Itakura, and N. Mizushima P62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding J. Cell Biol. 192 2011 17 27
10. A. Orsi, M. Razi, H. Dooley, D. Robinson, A. Weston, L. Collinson, and S. Tooze Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, is required for autophagy Mol. Biol. Cell 23 2012 1860 1873
11. H. Yamamoto et al. Atg9 vesicles are an important membrane source during early steps of autophagosome formation J. Cell Biol. 198 2012 219 233
12. C. Puri, M. Renna, C.F. Bento, K. Moreau, and D.C. Rubinsztein Diverse autophagosome membrane sources coalesce in recycling endosomes Cell 154 2013 1285 1299
13. K. Suzuki, Y. Kubota, T. Sekito, and Y. Ohsumi Hierarchy of Atg proteins in pre-autophagosomal structure organization Genes Cells 12 2007 209 218 (Pubitemid 46152659)
14. E. Itakura, C. Kishi-Itakura, I. Koyama-Honda, and N. Mizushima Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy J. Cell Sci. 125 2012 1488 1499
15. F. Reggiori, K.A. Tucker, P.E. Stromhaug, and D.J. Klionsky The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure Dev. Cell 6 2004 79 90 (Pubitemid 38089207)
16. H.E. Polson, J. de Lartigue, D.J. Rigden, M. Reedijk, S. Urbe, M.J. Clague, and S.A. Tooze Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation Autophagy 6 2010 506 522
17. T. Proikas-Cezanne, S. Waddell, A. Gaugel, T. Frickey, A. Lupas, and A. Nordheim WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy Oncogene 23 2004 9314 9325 (Pubitemid 40069664)
18. Q. Lu et al. The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes Dev. Cell 21 2011 343 357
19. U. Nair, Y. Cao, Z. Xie, and D.J. Klionsky Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy J. Biol. Chem. 285 2010 11476 11488
20. R. Krick, S. Henke, J. Tolstrup, and M. Thumm Dissecting the localization and function of Atg18, Atg21 and Ygr223c Autophagy 4 2008 896 910
21. B. Erdi, P. Nagy, A. Zvara, A. Varga, K. Pircs, D. Menesi, L.G. Puskas, and G. Juhasz Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila Autophagy 8 2012 1124 1135
22. I.P. Nezis et al. Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain J. Cell Biol. 180 2008 1065 1071 (Pubitemid 351468465)
23. R.C. Scott, O. Schuldiner, and T.P. Neufeld Role and regulation of starvation-induced autophagy in the Drosophila fat body Dev. Cell 7 2004 167 178 (Pubitemid 39145023)
24. P. Low, A. Varga, K. Pircs, P. Nagy, Z. Szatmari, M. Sass, and G. Juhasz Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila BMC Cell Biol. 14 2013 29
25. P. Nagy, A. Varga, K. Pircs, K. Hegedus, and G. Juhasz Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster PLOS Genet. 9 2013 e1003664
26. K. Pircs, P. Nagy, A. Varga, Z. Venkei, B. Erdi, K. Hegedus, and G. Juhasz Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila PLoS One 7 2012 e44214
27. S. Takats et al. Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila J. Cell Biol. 201 2013 531 539
28. G. Juhasz, B. Erdi, M. Sass, and T.P. Neufeld Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila Genes Dev. 21 2007 3061 3066 (Pubitemid 350223523)
29. G. Juhasz, J.H. Hill, Y. Yan, M. Sass, E.H. Baehrecke, J.M. Backer, and T.P. Neufeld The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila J. Cell Biol. 181 2008 655 666 (Pubitemid 351717512)
30. A.K. Velikkakath, T. Nishimura, E. Oita, N. Ishihara, and N. Mizushima Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets Mol. Biol. Cell 23 2012 896 909
31. I. Koyama-Honda, E. Itakura, T.K. Fujiwara, and N. Mizushima Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site Autophagy 9 2013 1491 1499
32. E. Itakura, and N. Mizushima Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins Autophagy 6 2010 764 776
33. K. Obara, T. Sekito, K. Niimi, and Y. Ohsumi The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function J. Biol. Chem. 283 2008 23972 23980
34. P. Nagy et al. Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila Autophagy 10 3 2014 (in press)
35. T. Hara et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice Nature 441 2006 885 889
36. M. Komatsu et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice Nature 441 2006 880 884
37. E.A. Alemu et al. ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs J. Biol. Chem. 287 2012 39275 39290
38. E. Rieter, F. Vinke, D. Bakula, E. Cebollero, C. Ungermann, T. Proikas-Cezanne, and F. Reggiori Atg18 function in autophagy is regulated by specific sites within its beta-propeller J. Cell Sci. 126 2013 593 604