Modulation of Wnt/β-catenin signaling attenuates periapical bone lesions

Journal of Dental Research

Volumn 93, Issue 2, 2014, Pages 175-182

  Tang, Y ^a   Zhou, X ^a,a   Gao, B ^a   Xu, X ^a   Sun, J ^a   Cheng, L ^a   Zheng, L ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

catenin; BMMSCs; LPS; osteoblast; osteogenesis; Wnt3a

Indexed keywords

ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; LIPOPOLYSACCHARIDE; LITHIUM CHLORIDE; OSTEOCALCIN; OSTERIX PROTEIN, RAT; RUNX2 PROTEIN, RAT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; WNT3A PROTEIN;

ALVEOLAR BONE LOSS; ANIMAL; ARTICLE; BMMSCS; BONE DEVELOPMENT; BONE MARROW CELL; BONE MINERALIZATION; BONE REMODELING; COMPARATIVE STUDY; CULTURE TECHNIQUE; DRUG ANTAGONISM; DRUG EFFECT; JAW DISEASE; MESENCHYMAL STROMA CELL; METHODOLOGY; MICRO-COMPUTED TOMOGRAPHY; OSTEOBLAST; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PORPHYROMONAS GINGIVALIS; RANDOMIZATION; RAT; SPRAGUE DAWLEY RAT; TOOTH PERIAPICAL DISEASE; WNT SIGNALING PATHWAY; WNT3A; Β-CATENIN;

BMMSCS; LPS; OSTEOBLAST; OSTEOGENESIS; WNT3A; Β-CATENIN;

ALVEOLAR BONE LOSS; ANIMALS; BONE MARROW CELLS; BONE REMODELING; CALCIFICATION, PHYSIOLOGIC; CELL CULTURE TECHNIQUES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; LIPOPOLYSACCHARIDES; LITHIUM CHLORIDE; MANDIBULAR DISEASES; MESENCHYMAL STROMAL CELLS; OSTEOCALCIN; OSTEOGENESIS; PERIAPICAL PERIODONTITIS; PHOSPHORYLATION; PORPHYROMONAS GINGIVALIS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTORS; WNT SIGNALING PATHWAY; WNT3A PROTEIN; X-RAY MICROTOMOGRAPHY;

EID: 84892775819     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034513512507     Document Type: Article

References (28)

1. Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer. 2013 ; 13: 11-26
2. Baksh D, Boland GM, Tuan RS. Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation. J Cell Biochem. 2007 ; 101: 1109-1124 (Pubitemid 47253714)
3. Bodine PV. Wnt signaling control of bone cell apoptosis. Cell Res. 2008 ; 18: 248-253 (Pubitemid 351206161)
4. Bonsignore LA, Anderson JR, Lee Z, Goldberg VM, Greenfield EM. Adherent lipopolysaccharide inhibits the osseointegration of orthopedic implants by impairing osteoblast differentiation. Bone. 2013 ; 52: 93-101
5. Chang J, Liu F, Lee M, Wu B, Ting K, Zara JN, et al. NF-kappaB inhibits osteogenic differentiation of mesenchymal stem cells by promoting beta-catenin degradation. Proc Natl Acad Sci USA. 2013 ; 110: 9469-9474
6. Chen Y, Whetstone HC, Lin AC, Nadesan P, Wei Q, Poon R, et al. Beta-catenin signaling plays a disparate role in different phases of fracture repair implications for therapy to improve bone healing. PloS One. 2007 ; 4: e249
7. Cho YD, Kim WJ, Yoon WJ, Woo KM, Baek JH, Lee G, et al. Wnt3a stimulates Mepe, matrix extracellular phosphoglycoprotein, expression directly by the activation of the canonical Wnt signaling pathway and indirectly through the stimulation of autocrine Bmp-2 expression. J Cell Physiol. 2012 ; 227: 2287-2296
8. Clement-Lacroix P, Ai M, Morvan F, Roman-Roman S, Vayssiere B, Belleville C, et al. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci USA. 2005 ; 102: 17406-17411 (Pubitemid 41740879)
9. Duan Y, Liao AP, Kuppireddi S, Ye Z, Ciancio MJ, Sun J. beta-Catenin activity negatively regulates bacteria-induced inflammation. Lab Invest. 2007 ; 87: 613-624 (Pubitemid 46788789)
10. Gao B, Chen W, Hao L, Zhu G, Feng S, Ci H, et al. Inhibiting periapical lesions through AAV-RNAi silencing of cathepsin K. J Dent Res. 2013 ; 92: 180-186
11. Gao S-S, Zhang Y-R, Zhu Z-L, Yu H-Y. Micromotions and combined damages at the dental implant/bone interface. Int J Oral Science. 2012 ; 4: 182-188
12. Glass DA, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005 ; 8: 751-764 (Pubitemid 40585297)
13. Jackson A, Vayssiere B, Garcia T, Newell W, Baron R, Roman-Roman S, et al. Gene array analysis of Wnt-regulated genes in C3H10T1/2 cells. Bone. 2005 ; 36: 585-598 (Pubitemid 40602252)
14. Kim JS, Yeo S, Shin DG, Bae YS, Lee JJ, Chin BR, et al. Glycogen synthase kinase 3beta and beta-catenin pathway is involved in Toll-like receptor 4-mediated NADPH oxidase 1 expression in macrophages. FEBS J. 2010 ; 277: 2830-2837
15. Krause U, Harris S, Green A, Ylostalo J, Zeitouni S, Lee N, et al. Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy. Proc Natl Acad Sci USA. 2010 ; 107: 4147-4152
16. Leclerc N, Noh T, Cogan J, Samarawickrama DB, Smith E, Frenkel B. Opposing effects of glucocorticoids and Wnt signaling on Krox20 and mineral deposition in osteoblast cultures. J Cell Biochem. 2008 ; 103: 1938-1951 (Pubitemid 351501923)
17. Li J, Khavandgar Z, Lin SH, Murshed M. Lithium chloride attenuates BMP-2 signaling and inhibits osteogenic differentiation through a novel WNT/GSK3- independent mechanism. Bone. 2011 ; 48: 321-331
18. Li X, Liu P, Liu W, Maye P, Zhang J, Zhang Y, et al. Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet. 2005 ; 37: 945-952 (Pubitemid 43086150)
19. Liu L, Zhang C, Hu Y, Peng B. Protective effect of metformin on periapical lesions in rats by decreasing the ratio of receptor activator of nuclear factor kappa B ligand/osteoprotegerin. J Endod. 2012 ; 38: 943-947
20. Maupin K, Droscha C, Williams B. A comprehensive overview of skeletal phenotypes associated with alterations in Wnt/β-catenin signaling in humans and mice. Bone Res. 2013 ; 1: 27-71
21. Moon RT, Kohn AD, De Ferrari GV, Kaykas A. WNT and beta-catenin signalling: diseases and therapies. Nat Rev Genet. 2004 ; 5: 691-701 (Pubitemid 39150127)
22. Nonnenmacher C, Dalpke A, Rochon J, Flores-de-Jacoby L, Mutters R, Heeg K. Real-time polymerase chain reaction for detection and quantification of bacteria in periodontal patients. J Periodontol. 2005 ; 76: 1542-1549 (Pubitemid 41479373)
23. Okahashi N, Inaba H, Nakagawa I, Yamamura T, Kuboniwa M, Nakayama K, et al. Porphyromonas gingivalis induces receptor activator of NF-κB ligand expression in osteoblasts through the activator protein 1 pathway. Infect Immun. 2004 ; 72: 1706-1714 (Pubitemid 38263795)
24. Tang GH, Xu J, Chen RJ, Qian YF, Shen G. Lithium delivery enhances bone growth during midpalatal expansion. J Dent Res. 2011 ; 90: 336-340
25. Tang Y, Sun F, Li X, Zhou Y, Yin S, Zhou X. Porphyromonas endodontalis lipopolysaccharides induce RANKL by mouse osteoblast in a way different from that of Escherichia coli lipopolysaccharide. J Endod. 2011 ; 37: 1653-1658
26. Wang J, Dai J, Liu B, Gu S, Cheng L, Liang J. Porphyromonas gingivalis lipopolysaccharide activates canonical Wnt/beta-catenin and p38 MAPK signalling in stem cells from the apical papilla. Inflammation. 2013 ;:
27. Zamani A, Omrani GR, Nasab MM. Lithium's effect on bone mineral density. Bone. 2009 ; 44: 331-334
28. Zeng YT, Fu B, Tang GH, Zhang L, Qian YF. Effects of lithium on extraction socket healing in rats assessed with micro-computed tomography. Acta Odontol Scand. 2013 ; 71: 1335-1340