A novel gastroretentive porous microparticle for anti-Helicobacter pylori therapy: Preparation, in vitro and in vivo evaluation

International Journal of Pharmaceutics

Volumn 463, Issue 1, 2014, Pages 10-21

  Hao, Shilei ^a   Wang, Yazhou ^a   Wang, Bochu ^a   Zou, Quanming ^b   Zeng, Hao ^b   Chen, Xiaoliang ^c   Liu, Xi ^a   Liu, Junyu ^a   Yu, Songke ^c  

^a CHONGQING UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c Chongqing Cancer Institute   (China)

Author keywords

Electrospray; Helicobacter pylori; Local delivery; Porous microparticles; SPECT CT tomography

Indexed keywords

EUDRAGIT RS; IODINE 131; METRONIDAZOLE;

ADULT; ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL THERAPY; ARTICLE; BACTERIAL COUNT; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG SCREENING; DRUG SYNTHESIS; ELECTROSPRAY; FEMALE; FLOW RATE; GAMMA SCINTIGRAPHY; GROWTH INHIBITION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROSCOPY; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; RABBIT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STOMACH; STOMACH CONTENT; SUSTAINED DRUG RELEASE; X RAY DIFFRACTION; ZETA POTENTIAL;

ELECTROSPRAY; EUDRAGIT RS (PUBCHEM CID: 104931); HELICOBACTER PYLORI; IODINE-131 (PUBCHEM CID: 24855); LOCAL DELIVERY; METRONIDAZOLE (PUBCHEM CID: 4173); POROUS MICROPARTICLES; SPECT/CT TOMOGRAPHY;

ACRYLIC RESINS; ANIMALS; ANTI-INFECTIVE AGENTS; CELL LINE; CELL SURVIVAL; COLONY COUNT, MICROBIAL; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; FEMALE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; METRONIDAZOLE; MICE; MICE, INBRED C57BL; POROSITY; STOMACH;

EID: 84892753373     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.12.052     Document Type: Article

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