Design and production of gentamicin/dextrans microparticles by supercritical assisted atomisation for the treatment of wound bacterial infections

International Journal of Pharmaceutics

Volumn 440, Issue 2, 2013, Pages 188-194

  Aquino, Rita P ^a   Auriemma, Giulia ^a   Mencherini, Teresa ^a   Russo, Paola ^a   Porta, Amalia ^a   Adami, Renata ^a   Liparoti, Sara ^a   Porta, Giovanna Della ^a   Reverchon, Ernesto ^a   Del Gaudio, Pasquale ^a  

^a UNIVERSITY OF SALERNO   (Italy)

Author keywords

Antimicrobial activity; Gentamicin; Microparticles; Supercritical assisted atomisation; Topical controlled release

Indexed keywords

ALGINIC ACID; DEXTRAN; GENTAMICIN; PECTIN;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; DISK DIFFUSION; DRUG DESIGN; DRUG FORMULATION; DRUG MANUFACTURE; DRUG RELEASE; MEMBRANE MICROPARTICLE; MICROENCAPSULATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STORAGE; SUPERCRITICAL ASSISTED ATOMIZATION; WATER CONTENT; WETTABILITY; WOUND DRESSING; WOUND INFECTION;

ADMINISTRATION, CUTANEOUS; ANTI-BACTERIAL AGENTS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, SUPERCRITICAL FLUID; DEXTRANS; DRUG CARRIERS; DRUG DESIGN; DRUG STABILITY; GENTAMICINS; MICROBIAL SENSITIVITY TESTS; PARTICLE SIZE; POWDERS; STAPHYLOCOCCUS AUREUS; WOUND INFECTION;

EID: 84872285418     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.07.074     Document Type: Article

References (34)

1. R. Adami, L.S. Osséo, and E. Reverchon Micronization of lysozyme by supercritical assisted atomization Biotechnol. Bioeng. 104 2009 1162 1170
2. G. Auriemma, P. Del Gaudio, A.A. Barba, M. d'Amore, and R.P. Aquino A combined technique based on prilling and microwave assisted treatments for the production of ketoprofen controlled release dosage forms Int. J. Pharm. 415 2011 196 205
3. M. Aviv, I. Berdicevsky, and M. Zilberman Gentamicin-loaded bioresorbable films for prevention of bacterial infections associated with orthopedic implants J. Biomed. Mater. Res. A 83 2007 10 19
4. S. Baranoski Choosing a wound dressing, part 1 Nursing (Lond.) 38 2008 60 61
5. S. Baranoski Choosing a wound dressing, part 2 Nursing (Lond.) 38 2008 14 15
6. S. Baranoski, and E. Ayello Wound Care Essentials: Practice Principles 3rd ed. 2011 Wolter Kluwer Health, Lippincott Williams & Wilkins
7. A.L. Barry, W.A. Craig, H. Nadler, L.B. Reller, C.C. Sanders, and J.M. Swenson National Committee for Clinical Laboratory Standards. Methods for Determining Bactericidal Activity of Antimicrobial Agents; Approved Guideline 1999 National Committee for Clinical Laboratory Standards Wayne, PA
8. J.S. Boateng, K.H. Matthews, H.N.E. Stevens, and G.M. Eccleston Wound healing dressings and drug delivery systems: a review J. Pharm. Sci. 97 2008 2892 2923
9. B.D. Davis Mechanism of bactericidal action of aminoglycosides Microbiol. Rev. 51 1987 341 350
10. P. Del Gaudio, P. Russo, M. Rosaria Lauro, P. Colombo, and R. Aquino Encapsulation of ketoprofen and ketoprofen lysinate by prilling for controlled drug release AAPS PharmSciTech 10 2009 1178 1185
11. G. Della Porta, R. Adami, P. Del Gaudio, L. Prota, R. Aquino, and E. Reverchon Albumin/gentamicin microspheres produced by supercritical assisted atomization: optimization of size, drug loading and release J. Pharm. Sci. 99 2010 4720 4729
12. J. Fletcher Understanding wound dressings: alginates Nurs. Times 101 2005 53 54
13. A. Forge, and J. Schacht Aminoglycoside antibiotics Audiol. Neurootol. 5 2000 3 22
14. W. Friess, and M. Schlapp Release mechanisms from gentamicin loaded poly(lactic-co-glycolic acid) (PLGA) microparticles J. Pharm. Sci. 91 2002 845 855
15. V. Iannuccelli, G. Coppi, M. Bondi, M. Pinelli, A. Mingione, and R. Cameroni Biodegradable intraoperative system for bone infection treatment II. In vivo evaluation Int. J. Pharm. 143 1996 187 194
16. Y. Jia, H. Joly, and A. Omri Liposomes as a carrier for gentamicin delivery: development and evaluation of the physicochemical properties Int. J. Pharm. 359 2008 254 263
17. Y. Kawashima, T. Serigano, T. Hino, H. Yamamoto, and H. Takeuchi Effect of surface morphology of carrier lactose on dry powder inhalation property of pranlukast hydrate Int. J. Pharm. 172 1998 179 188
18. R.W. Korsmeyer, R. Gurny, E. Doelker, P. Buri, and N.A. Peppas Mechanisms of solute release from porous hydrophilic polymers Int. J. Pharm. 15 1983 25 35
19. P.S. McKinnon, and S.L. Davis Pharmacokinetic and pharmacodynamic issues in the treatment of bacterial infectious diseases Eur. J. Clin. Microbiol. Infect. Dis. 23 2004 271 288
20. ®) in the treatment of peri-implantitis. I: microbiological outcomes Clin. Oral Implants Res. 17 2006 386 393
21. E. Reverchon, R. Adami, S. Cardea, and G.D. Porta Supercritical fluids processing of polymers for pharmaceutical and medical applications J. Supercrit. Fluids 47 2009 484 492
22. E. Reverchon, and A. Antonacci Polymer microparticles production by supercritical assisted atomization J. Supercrit. Fluids 39 2007 444 452
23. E. Reverchon, and I. De Marco Supercritical fluid extraction and fractionation of natural matter J. Supercrit. Fluids 38 2006 146 166
24. M. Reza Dextrans for targeted and sustained delivery of therapeutic and imaging agents J. Control. Release 69 2000 1 25
25. C. Sandolo, S. Péchiné, A. Le Monnier, S. Hoys, C. Janoir, T. Coviello, F. Alhaique, A. Collignon, E. Fattal, and N. Tsapis Encapsulation of Cwp84 into pectin beads for oral vaccination against Clostridium difficile Eur. J. Pharm. Biopharm. 79 2011 566 573
26. F. Sansone, R.P. Aquino, P. Del Gaudio, P. Colombo, and P. Russo Physical characteristics and aerosol performance of naringin dry powders for pulmonary delivery prepared by spray-drying Eur. J. Pharm. Biopharm. 72 2009 206 213
27. J. Schnieders, U. Gbureck, R. Thull, and T. Kissel Controlled release of gentamicin from calcium phosphate-poly(lactic acid-co-glycolic acid) composite bone cement Biomaterials 27 2006 4239 4249
28. I. Soriano, and C. Evora Formulation of calcium phosphates/poly(d,l- lactide) blends containing gentamicin for bone implantation J. Control. Release 68 2000 121 134
29. C. Strobel, N. Bormann, A. Kadow-Romacker, G. Schmidmaier, and B. Wildemann Sequential release kinetics of two (gentamicin and BMP-2) or three (gentamicin, IGF-I and BMP-2) substances from a one-component polymeric coating on implants J. Control. Release 156 2011 37 45
30. A. Thomas, K.G. Harding, and K. Moore Alginates from wound dressings activate human macrophages to secrete tumour necrosis factor-alpha Biomaterials 21 2000 1797 1802
31. H. Vester, B. Wildemann, G. Schmidmaier, U. Stöckle, and M. Lucke Gentamycin delivered from a PDLLA coating of metallic implants: in vivo and in vitro characterisation for local prophylaxis of implant-related osteomyelitis Injury 41 2010 1053 1059
32. M.A. Wikler Clinical and Laboratory Standard Institute. Performance Standards for Antimicrobial Susceptibility Testing. 18th Informational Supplement 2008 Clinical and Laboratory Standards Institute Wayne, PA
33. S.-H. Yoo, Y.-B. Song, P.-S. Chang, and H.G. Lee Microencapsulation of α-tocopherol using sodium alginate and its controlled release properties Int. J. Biol. Macromol. 38 2006 25 30
34. C.G. Zalavras, M.J. Patzakis, and P. Holtom Local antibiotic therapy in the treatment of open fractures and osteomyelitis Clin. Orthop. Relat. Res. 427 2004 86 93