Biopharmaceutical characterization of nanocrystalline solid dispersion of coenzyme Q10 prepared with cold wet-milling system

European Journal of Pharmaceutical Sciences

Volumn 53, Issue 1, 2014, Pages 118-125

  Onoue, Satomi ^a   Terasawa, Naohiko ^a   Nakamura, Tatsuya ^a   Yuminoki, Kayo ^b   Hashimoto, Naofumi ^b   Yamada, Shizuo ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b SETSUNAN UNIVERSITY   (Japan)

Author keywords

Bioavailability; Coenzyme Q10; Dissolution; Hepatoprotection

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; NANOCRYSTAL; NUTRACEUTICAL; UBIDECARENONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CRYSTALLIZATION; DISPERSION; DISSOLUTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EXPOSURE; DRUG STABILITY; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; MORPHOLOGY; NANOCRYSTALLINE SOLID DISPERSION; NONHUMAN; PARTICLE SIZE; PHOTODEGRADATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT;

BIOAVAILABILITY; COENZYME Q(10); DISSOLUTION; HEPATOPROTECTION;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CARBON TETRACHLORIDE; CRYSTALLIZATION; DRUG COMPOUNDING; DRUG STABILITY; DRUG-INDUCED LIVER INJURY; LIGHT; MALE; NANOPARTICLES; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; UBIQUINONE;

EID: 84892686330     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.12.013     Document Type: Article

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