Constitutive TLR4 signalling in intestinal epithelium reduces tumor load by increasing apoptosis in APC Min/+ mice

Oncogene

Volumn 33, Issue 3, 2014, Pages 369-377

  Li, Y ^a,b   Teo, W L ^c   Low, M J ^c   Meijer, L ^a   Sanderson, I ^d   Pettersson, S ^a,c,e   Greicius, G ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b AGENCY FOR SCIENCE   (Singapore)

^c DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

APCMin +; apoptosis; Cox 2; Paneth cells; TLR4; tumorigenesis

Indexed keywords

APC; BETA INTERFERON; CASPASE 3; CD4 ANTIGEN; CYCLOOXYGENASE 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; EX VIVO STUDY; INTESTINE CRYPT; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENE; TUMOR VOLUME;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; APOPTOSIS; CASPASE 3; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; FEMALE; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTERFERON-BETA; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; ORGANOIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR BURDEN;

EID: 84892661403     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.581     Document Type: Article

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