Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta

Toxicology

Volumn 316, Issue 1, 2014, Pages 34-42

  Uno, Shigeyuki ^a   Sakurai, Kenichi ^a   Nebert, Daniel W ^b   Makishima, Makoto ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

Apoe( ) mice; Atherosclerosis; Benzo a pyrene; Cyp1a1( ) mice; DNA adduct formation; Reactive oxygen species

Indexed keywords

BENZO[A]PYRENE; CYTOCHROME P450 1A1; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROGENIC DIET; CONTROLLED STUDY; DETOXIFICATION; DISEASE EXACERBATION; DNA ADDUCT; EMBRYO; FIBROBLAST CULTURE; GENE EXPRESSION; HEART PROTECTION; MALE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; WILD TYPE;

APOE(-/-) MICE; ATHEROSCLEROSIS; BENZO[A]PYRENE; CYP1A1(-/-) MICE; DNA ADDUCT FORMATION; REACTIVE OXYGEN SPECIES;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; AORTA; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BENZO(A)PYRENE; CYTOCHROME P-450 CYP1A1; DNA ADDUCTS; ENVIRONMENTAL POLLUTANTS; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84892659191     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.12.005     Document Type: Article

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