메뉴 건너뛰기




Volumn 8, Issue 12, 2013, Pages

Metabolomics of the tumor microenvironment in pediatric acute lymphoblastic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; 3 HYDROXYBUTYRIC ACID; ACETIC ACID; ACETOACETIC ACID; ACETONE; ASPARAGINASE MACROGOL; ASPARAGINE; ASPARTIC ACID; CHOLESTEROL ESTER; CHOLINE; DEXAMETHASONE; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLYCEROL; GLYCINE; HYPOXANTHINE; LACTIC ACID; LIPID; LYSINE; METHIONINE; PALMITIC ACID; PREDNISOLONE; PREDNISONE; TRIACYLGLYCEROL; UNINDEXED DRUG; UREA; URIDINE; VALINE; VINCRISTINE;

EID: 84892652350     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082859     Document Type: Article
Times cited : (49)

References (54)
  • 1
    • 2142819411 scopus 로고    scopus 로고
    • Mechanisms of disease: Acute lymphoblastic leukemia
    • doi:10.1056/NEJMra023001. PubMed: 15071128
    • Pui CH, Relling MV, Downing JR (2004) Mechanisms of disease: Acute lymphoblastic leukemia. N Engl J Med 350: 1535-1548. doi:10.1056/NEJMra023001. PubMed: 15071128.
    • (2004) N Engl J Med , vol.350 , pp. 1535-1548
    • Pui, C.H.1    Relling, M.V.2    Downing, J.R.3
  • 2
    • 33644798329 scopus 로고    scopus 로고
    • Childhood acute lymphoblastic leukaemia and relapse
    • doi:10.1111/j.1365-2141.2005.05773.x. PubMed: 16351633
    • Gaynon PS (2005) Childhood acute lymphoblastic leukaemia and relapse. Br J Haematol 131: 579-587. doi:10.1111/j.1365-2141.2005.05773.x. PubMed: 16351633.
    • (2005) Br J Haematol , vol.131 , pp. 579-587
    • Gaynon, P.S.1
  • 3
    • 78651337990 scopus 로고    scopus 로고
    • A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity
    • doi:10.1038/leu.2010.256. PubMed: 21072045
    • Chen SH, Yang W, Fan Y, Stocco G, Crews KR et al. (2011) A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity. Leukemia 25: 66-74. doi:10.1038/leu.2010.256. PubMed: 21072045.
    • (2011) Leukemia , vol.25 , pp. 66-74
    • Chen, S.H.1    Yang, W.2    Fan, Y.3    Stocco, G.4    Crews, K.R.5
  • 4
    • 84863116322 scopus 로고    scopus 로고
    • Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia
    • doi: 10.1182/blood-2011-09-381731. PubMed: 22117041
    • Kawedia JD, Liu CC, Pei DQ, Cheng C, Fernandez CA et al. (2012) Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia. Blood 119: 1658-1664. doi: 10.1182/blood-2011-09-381731. PubMed: 22117041.
    • (2012) Blood , vol.119 , pp. 1658-1664
    • Kawedia, J.D.1    Liu, C.C.2    Pei, D.Q.3    Cheng, C.4    Fernandez, C.A.5
  • 5
    • 84859534539 scopus 로고    scopus 로고
    • Outcomes after Induction Failure in Childhood Acute Lymphoblastic Leukemia
    • doi:10.1056/NEJMoa1110169. PubMed: 22494120
    • Martin Schrappe M, Hunger SP, Pui CH, Saha V, Gaynon PS et al. (2012) Outcomes after Induction Failure in Childhood Acute Lymphoblastic Leukemia. N Engl J Med 366: 1371-1381. doi:10.1056/NEJMoa1110169. PubMed: 22494120.
    • (2012) N Engl J Med , vol.366 , pp. 1371-1381
    • Martin Schrappe, M.1    Hunger, S.P.2    Pui, C.H.3    Saha, V.4    Gaynon, P.S.5
  • 7
    • 74049121331 scopus 로고    scopus 로고
    • Contribution of bone microenvironment to leukemogenesis and leukemia progression
    • doi:10.1038/leu.2009.175. PubMed: 19727127
    • Ayala F, Dewar R, Kieran M, Kalluri R (2009) Contribution of bone microenvironment to leukemogenesis and leukemia progression. Leukemia 23: 2233-2241. doi:10.1038/leu.2009.175. PubMed: 19727127.
    • (2009) Leukemia , vol.23 , pp. 2233-2241
    • Ayala, F.1    Dewar, R.2    Kieran, M.3    Kalluri, R.4
  • 8
    • 84864285794 scopus 로고    scopus 로고
    • Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
    • doi:10.1038/nature11183. PubMed: 22763439
    • Straussman R, Morikawa T, Shee K, Barzily-Rokni M, Qian ZR et al. (2012) Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 487: 500-504. doi:10.1038/nature11183. PubMed: 22763439.
    • (2012) Nature , vol.487 , pp. 500-504
    • Straussman, R.1    Morikawa, T.2    Shee, K.3    Barzily-Rokni, M.4    Qian, Z.R.5
  • 9
    • 84864286442 scopus 로고    scopus 로고
    • Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
    • doi:10.1038/nature11249. PubMed: 22763448
    • Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L et al. (2012) Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 487: 505-509. doi:10.1038/nature11249. PubMed: 22763448.
    • (2012) Nature , vol.487 , pp. 505-509
    • Wilson, T.R.1    Fridlyand, J.2    Yan, Y.3    Penuel, E.4    Burton, L.5
  • 10
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • doi:10.1038/nrc2981. PubMed: 21258394
    • Cairns RA, Harris IS, Mak TW (2011) Regulation of cancer cell metabolism. Nat Rev Cancer 11: 85-95. doi:10.1038/nrc2981. PubMed: 21258394.
    • (2011) Nat Rev Cancer , vol.11 , pp. 85-95
    • Cairns, R.A.1    Harris, I.S.2    Mak, T.W.3
  • 11
    • 81855226152 scopus 로고    scopus 로고
    • Choline metabolism in malignant transformation
    • PubMed: 22089420
    • Glunde K, Bhujwalla ZM, Ronen SM (2011) Choline metabolism in malignant transformation. Nat Rev Cancer 11: 835-848. PubMed: 22089420.
    • (2011) Nat Rev Cancer , vol.11 , pp. 835-848
    • Glunde, K.1    Bhujwalla, Z.M.2    Ronen, S.M.3
  • 12
    • 84872271709 scopus 로고    scopus 로고
    • Profiling metabolic networks to study cancer metabolism
    • doi:10.1016/j.copbio.2012.11.001. PubMed: 23206561
    • Hiller K, Metallo CM (2013) Profiling metabolic networks to study cancer metabolism. Curr Opin Biotechnol 24: 60-68. doi:10.1016/j.copbio.2012.11.001. PubMed: 23206561.
    • (2013) Curr Opin Biotechnol , vol.24 , pp. 60-68
    • Hiller, K.1    Metallo, C.M.2
  • 13
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • doi: 10.1073/pnas.0709747104. PubMed: 18032601
    • DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M et al. (2007) Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A 104: 19345-19350. doi: 10.1073/pnas.0709747104. PubMed: 18032601.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19345-19350
    • DeBerardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5
  • 14
    • 80052242132 scopus 로고    scopus 로고
    • Targeting cancer metabolism: A therapeutic window opens
    • doi:10.1038/nrd3504. PubMed: 21878982
    • Vander Heiden MG (2011) Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov 10: 671-684. doi:10.1038/nrd3504. PubMed: 21878982.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 671-684
    • Vander Heiden, M.G.1
  • 15
    • 36949081498 scopus 로고
    • Evidence that the L-Asparaginase Activity of Guinea Pig Serum is responsible for its Antilymphoma Effects
    • doi:10.1038/1911114a0
    • Broome JD (1961) Evidence that the L-Asparaginase Activity of Guinea Pig Serum is responsible for its Antilymphoma Effects. Nature 191: 1114-1115. doi:10.1038/1911114a0.
    • (1961) Nature , vol.191 , pp. 1114-1115
    • Broome, J.D.1
  • 16
    • 34548776939 scopus 로고    scopus 로고
    • Asparaginase (native ASNase or pegylated ASNase) in the treatment of acute lymphoblastic leukemia
    • PubMed: 17717965
    • Avramis VI, Tiwari PN (2006) Asparaginase (native ASNase or pegylated ASNase) in the treatment of acute lymphoblastic leukemia. Int J Nanomedicine 1: 241-254. PubMed: 17717965.
    • (2006) Int J Nanomedicine , vol.1 , pp. 241-254
    • Avramis, V.I.1    Tiwari, P.N.2
  • 17
    • 2442528894 scopus 로고    scopus 로고
    • Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases In vivo (CCG-1961)
    • PubMed: 15154634
    • Panosyan EH, Grigoryan RS, Avramis IA, Seibel NL, Gaynon PS et al. (2004) Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases In vivo (CCG-1961). Anticancer Res 24: 1121-1125. PubMed: 15154634.
    • (2004) Anticancer Res , vol.24 , pp. 1121-1125
    • Panosyan, E.H.1    Grigoryan, R.S.2    Avramis, I.A.3    Seibel, N.L.4    Gaynon, P.S.5
  • 18
    • 0037085747 scopus 로고    scopus 로고
    • A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: A Children's Cancer Group study
    • doi:10.1182/blood.V99.6.1986. PubMed: 11877270
    • Avramis VI, Sencer S, Periclou AP, Sather H, Bostrom BC et al. (2002) A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study. Blood 99: 1986-1994. doi:10.1182/blood.V99.6.1986. PubMed: 11877270.
    • (2002) Blood , vol.99 , pp. 1986-1994
    • Avramis, V.I.1    Sencer, S.2    Periclou, A.P.3    Sather, H.4    Bostrom, B.C.5
  • 19
  • 20
    • 59449097019 scopus 로고    scopus 로고
    • Clinical applications of metabolomics in oncology: A review
    • doi: 10.1158/1078-0432.CCR-08-1059. PubMed: 19147747
    • Spratlin JL, Serkova NJ, Eckhardt SG (2009) Clinical applications of metabolomics in oncology: a review. Clin Cancer Res 15: 431-440. doi: 10.1158/1078-0432.CCR-08-1059. PubMed: 19147747.
    • (2009) Clin Cancer Res , vol.15 , pp. 431-440
    • Spratlin, J.L.1    Serkova, N.J.2    Eckhardt, S.G.3
  • 21
    • 78449285472 scopus 로고    scopus 로고
    • Early Detection of Recurrent Breast Cancer Using Metabolite Profiling
    • doi: 10.1158/0008-5472.CAN-10-1319. PubMed: 20959483
    • Asiago VM, Alvarado LZ, Shanaiah N, Gowda GAN, Owusu-Sarfo K et al. (2010) Early Detection of Recurrent Breast Cancer Using Metabolite Profiling. Cancer Res 70: 8309-8318. doi: 10.1158/0008-5472.CAN-10-1319. PubMed: 20959483.
    • (2010) Cancer Res , vol.70 , pp. 8309-8318
    • Asiago, V.M.1    Alvarado, L.Z.2    Shanaiah, N.3    Gowda, G.A.N.4    Owusu-Sarfo, K.5
  • 22
    • 78149356687 scopus 로고    scopus 로고
    • Lipidomics reveals a remarkable diversity of lipids in human plasma
    • doi:10.1194/jlr.M009449. PubMed: 20671299
    • Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS et al. (2010) Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res 51: 3299-3305. doi:10.1194/jlr.M009449. PubMed: 20671299.
    • (2010) J Lipid Res , vol.51 , pp. 3299-3305
    • Quehenberger, O.1    Armando, A.M.2    Brown, A.H.3    Milne, S.B.4    Myers, D.S.5
  • 23
    • 80052922354 scopus 로고    scopus 로고
    • The Emerging Field of Quantitative Blood Metabolomics for Biomarker Discovery in Critical Illnesses
    • doi:10.1164/rccm.201103-0474CI. PubMed: 21680948
    • Serkova NJ, Standiford TJ, Stringer KA (2011) The Emerging Field of Quantitative Blood Metabolomics for Biomarker Discovery in Critical Illnesses. Am J Respir Crit Care Med 184: 647-655. doi:10.1164/rccm.201103-0474CI. PubMed: 21680948.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 647-655
    • Serkova, N.J.1    Standiford, T.J.2    Stringer, K.A.3
  • 24
    • 62549138339 scopus 로고    scopus 로고
    • Early Stage Diagnosis of Oral Cancer Using 1H NMR-Based Metabolomics
    • PubMed: 19242608
    • Tiziani S, Lopes V, Günther UL (2009) Early Stage Diagnosis of Oral Cancer Using 1H NMR-Based Metabolomics. Neoplasia 11: 269-U269. PubMed: 19242608.
    • (2009) Neoplasia , vol.11
    • Tiziani, S.1    Lopes, V.2    Günther, U.L.3
  • 25
    • 84874196888 scopus 로고    scopus 로고
    • Proton NMR-Based Metabolite Analyses of Archived Serial Paired Serum and Urine Samples from Myeloma Patients at Different Stages of Disease Activity Identifies Acetylcarnitine as a Novel Marker of Active Disease
    • PubMed: 23431376
    • Lodi A, Tiziani S, Khanim FL, Günther UL, Viant MR et al. (2013) Proton NMR-Based Metabolite Analyses of Archived Serial Paired Serum and Urine Samples from Myeloma Patients at Different Stages of Disease Activity Identifies Acetylcarnitine as a Novel Marker of Active Disease. PLOS ONE 8: e56422. PubMed: 23431376.
    • (2013) PLOS ONE , vol.8
    • Lodi, A.1    Tiziani, S.2    Khanim, F.L.3    Günther, U.L.4    Viant, M.R.5
  • 26
    • 77950944945 scopus 로고    scopus 로고
    • Serum metabolome analysis by (1)H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups
    • doi:10.1038/leu.2009.295. PubMed: 20090781
    • MacIntyre DA, Jiménez B, Lewintre EJ, Martín CR, Schäfer H et al. (2010) Serum metabolome analysis by (1)H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups. Leukemia 24: 788-797. doi:10.1038/leu.2009.295. PubMed: 20090781.
    • (2010) Leukemia , vol.24 , pp. 788-797
    • MacIntyre, D.A.1    Jiménez, B.2    Lewintre, E.J.3    Martín, C.R.4    Schäfer, H.5
  • 27
    • 0002329771 scopus 로고    scopus 로고
    • Automated analysis of bone marrow: Routine implementation and differences from peripheral blood
    • D'Onofrio G, Zini G, Tommasi M, Laurenti L, Van Hove L et al. (1998) Automated analysis of bone marrow: Routine implementation and differences from peripheral blood. Laboratory Hematology 4: 71-79.
    • (1998) Laboratory Hematology , vol.4 , pp. 71-79
    • D'Onofrio, G.1    Zini, G.2    Tommasi, M.3    Laurenti, L.4    Van Hove, L.5
  • 28
    • 33750490093 scopus 로고    scopus 로고
    • Normal structure, function, and histology of the bone marrow
    • doi:10.1080/01926230600939856. PubMed: 17067943
    • Travlos GS (2006) Normal structure, function, and histology of the bone marrow. Toxicol Pathol 34: 548-565. doi:10.1080/01926230600939856. PubMed: 17067943.
    • (2006) Toxicol Pathol , vol.34 , pp. 548-565
    • Travlos, G.S.1
  • 29
    • 43049140446 scopus 로고    scopus 로고
    • Optimized metabolite extraction from blood serum for 1H nuclear magnetic resonance spectroscopy
    • doi: 10.1016/j.ab.2008.01.037. PubMed: 18312846
    • Tiziani S, Einwas AH, Lodi A, Ludwig C, Bunce CM et al. (2008) Optimized metabolite extraction from blood serum for 1H nuclear magnetic resonance spectroscopy. Anal Biochem 377: 16-23. doi: 10.1016/j.ab.2008.01.037. PubMed: 18312846.
    • (2008) Anal Biochem , vol.377 , pp. 16-23
    • Tiziani, S.1    Einwas, A.H.2    Lodi, A.3    Ludwig, C.4    Bunce, C.M.5
  • 31
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • PubMed: 13428781
    • Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509. PubMed: 13428781.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 32
    • 80052654387 scopus 로고    scopus 로고
    • MetaboLab - advanced NMR data processing and analysis for metabolomics
    • doi:10.1186/1471-2105-12-366. PubMed: 21914187
    • Ludwig C, Günther UL (2011) MetaboLab - advanced NMR data processing and analysis for metabolomics. BMC Bioinformatics 12: 366. doi:10.1186/1471- 2105-12-366. PubMed: 21914187.
    • (2011) BMC Bioinformatics , vol.12 , pp. 366
    • Ludwig, C.1    Günther, U.L.2
  • 33
    • 84876148784 scopus 로고    scopus 로고
    • HMDB 3.0 - The Human Metabolome Database in 2013
    • doi:10.1093/nar/gks1065. PubMed: 23161693
    • Wishart DS, Jewison T, Guo AC, Wilson M, Knox C et al. (2013) HMDB 3.0 - The Human Metabolome Database in 2013. Nucleic Acids Res 41: D801-D807. doi:10.1093/nar/gks1065. PubMed: 23161693.
    • (2013) Nucleic Acids Res , vol.41
    • Wishart, D.S.1    Jewison, T.2    Guo, A.C.3    Wilson, M.4    Knox, C.5
  • 35
    • 59949086432 scopus 로고    scopus 로고
    • minet: A R/Bioconductor package for inferring large transcriptional networks using mutual information
    • doi:10.1186/1471-2105-9-461. PubMed: 18959772
    • Meyer PE, Lafitte F, Bontempi G (2008) minet: A R/Bioconductor package for inferring large transcriptional networks using mutual information. BMC Bioinformatics 9: 461. doi:10.1186/1471-2105-9-461. PubMed: 18959772.
    • (2008) BMC Bioinformatics , vol.9 , pp. 461
    • Meyer, P.E.1    Lafitte, F.2    Bontempi, G.3
  • 36
    • 33947305781 scopus 로고    scopus 로고
    • ARACNE: An algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context
    • doi:10.1186/1471-2105-7-S2-S7. PubMed: 16723010
    • Margolin AA, Nemenman I, Basso K, Wiggins C, Stolovitzky G et al. (2006) ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context. BMC Bioinformatics 7 Suppl 1: S7. doi:10.1186/1471-2105-7-S2-S7. PubMed: 16723010.
    • (2006) BMC Bioinformatics , vol.7 , Issue.SUPPL. 1
    • Margolin, A.A.1    Nemenman, I.2    Basso, K.3    Wiggins, C.4    Stolovitzky, G.5
  • 37
    • 16844376909 scopus 로고    scopus 로고
    • Reverse engineering of regulatory networks in human B cells
    • doi:10.1038/ng1532. PubMed: 15778709
    • Basso K, Margolin AA, Stolovitzky G, Klein U, Dalla-Favera R et al. (2005) Reverse engineering of regulatory networks in human B cells. Nat Genet 37: 382-390. doi:10.1038/ng1532. PubMed: 15778709.
    • (2005) Nat Genet , vol.37 , pp. 382-390
    • Basso, K.1    Margolin, A.A.2    Stolovitzky, G.3    Klein, U.4    Dalla-Favera, R.5
  • 38
    • 84855846735 scopus 로고    scopus 로고
    • Comparing statistical methods for constructing large scale gene networks
    • doi:10.1371/journal.pone.0029348. PubMed: 22272232
    • Allen JD, Xie Y, Chen M, Girard L, Xiao G (2012) Comparing statistical methods for constructing large scale gene networks. PLOS ONE 7: e29348. doi:10.1371/journal.pone.0029348. PubMed: 22272232.
    • (2012) PLOS ONE , vol.7
    • Allen, J.D.1    Xie, Y.2    Chen, M.3    Girard, L.4    Xiao, G.5
  • 39
    • 79958036116 scopus 로고    scopus 로고
    • The long-term impact of in vitro drug sensitivity on risk stratification and treatment outcome in acute lymphoblastic leukemia of childhood (CoALL 06-97)
    • doi:10.3324/haematol.2010.039735. PubMed: 21330320
    • Escherich G, Tröger A, Göbel U, Graubner U, Pekrun A et al. (2011) The long-term impact of in vitro drug sensitivity on risk stratification and treatment outcome in acute lymphoblastic leukemia of childhood (CoALL 06-97). Haematologica 96: 854-862. doi:10.3324/haematol.2010.039735. PubMed: 21330320.
    • (2011) Haematologica , vol.96 , pp. 854-862
    • Escherich, G.1    Tröger, A.2    Göbel, U.3    Graubner, U.4    Pekrun, A.5
  • 40
    • 80052001030 scopus 로고    scopus 로고
    • American Society of Clinical Oncology clinical practice guideline update on the use of chemotherapy sensitivity and resistance assays
    • doi:10.1200/JCO.2011.36.0354. PubMed: 21788567
    • Burstein HJ, Mangu PB, Somerfield MR, Schrag D, Samson D et al. (2011) American Society of Clinical Oncology clinical practice guideline update on the use of chemotherapy sensitivity and resistance assays. J Clin Oncol 29: 3328-3330. doi:10.1200/JCO.2011.36.0354. PubMed: 21788567.
    • (2011) J Clin Oncol , vol.29 , pp. 3328-3330
    • Burstein, H.J.1    Mangu, P.B.2    Somerfield, M.R.3    Schrag, D.4    Samson, D.5
  • 41
    • 0017849252 scopus 로고
    • Uniformity in sensitivity test media
    • doi:10.1093/jac/4.1.4. PubMed: 415034
    • Waterworth PM (1978) Uniformity in sensitivity test media. J Antimicrob Chemother 4: 4-6. doi:10.1093/jac/4.1.4. PubMed: 415034.
    • (1978) J Antimicrob Chemother , vol.4 , pp. 4-6
    • Waterworth, P.M.1
  • 42
    • 34250196824 scopus 로고    scopus 로고
    • Evaluation of methods for trace-element determination with emphasis on their usability in the clinical routine laboratory
    • doi:10.1080/00365510601095281. PubMed: 17558890
    • Bolann BJ, Rahil-Khazen R, Henriksen H, Isrenn R, Ulvik RJ (2007) Evaluation of methods for trace-element determination with emphasis on their usability in the clinical routine laboratory. Scand J Clin Lab Invest 67: 353-366. doi:10.1080/00365510601095281. PubMed: 17558890.
    • (2007) Scand J Clin Lab Invest , vol.67 , pp. 353-366
    • Bolann, B.J.1    Rahil-Khazen, R.2    Henriksen, H.3    Isrenn, R.4    Ulvik, R.J.5
  • 43
    • 0019170218 scopus 로고
    • Serum-free cell culture: A unifying approach
    • doi:10.1016/0092-8674(80)90540-1. PubMed: 7460009
    • Barnes D, Sato G (1980) Serum-free cell culture: a unifying approach. Cell 22: 649-655. doi:10.1016/0092-8674(80)90540-1. PubMed: 7460009.
    • (1980) Cell , vol.22 , pp. 649-655
    • Barnes, D.1    Sato, G.2
  • 44
    • 38949184922 scopus 로고    scopus 로고
    • The oncoprotein H-RasV12 increases mitochondrial metabolism
    • doi:10.1186/1476-4598-6-77. PubMed: 18053146
    • Telang S, Lane AN, Nelson KK, Arumugam S, Chesney J (2007) The oncoprotein H-RasV12 increases mitochondrial metabolism. Mol Cancer 6: 77. doi:10.1186/1476-4598-6-77. PubMed: 18053146.
    • (2007) Mol Cancer , vol.6 , pp. 77
    • Telang, S.1    Lane, A.N.2    Nelson, K.K.3    Arumugam, S.4    Chesney, J.5
  • 45
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell metabolism: Warburg and beyond
    • doi:10.1016/j.cell.2008.08.021. PubMed: 18775299
    • Hsu PP, Sabatini DM (2008) Cancer cell metabolism: Warburg and beyond. Cell 134: 703-707. doi:10.1016/j.cell.2008.08.021. PubMed: 18775299.
    • (2008) Cell , vol.134 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 46
    • 43749083041 scopus 로고    scopus 로고
    • Brick by brick: Metabolism and tumor cell growth
    • doi:10.1016/j.gde.2008.02.003. PubMed: 18387799
    • Deberardinis RJ, Sayed N, Ditsworth D, Thompson CB (2008) Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev 18: 54-61. doi:10.1016/j.gde.2008.02.003. PubMed: 18387799.
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 54-61
    • Deberardinis, R.J.1    Sayed, N.2    Ditsworth, D.3    Thompson, C.B.4
  • 47
    • 79951879368 scopus 로고    scopus 로고
    • Hypoxia Triggers Major Metabolic Changes in AML Cells without Altering Indomethacin-Induced TCA Cycle Deregulation
    • doi:10.1021/cb900300j. PubMed: 20886892
    • Lodi A, Tiziani S, Khanim FL, Drayson MT, Günther UL et al. (2011) Hypoxia Triggers Major Metabolic Changes in AML Cells without Altering Indomethacin-Induced TCA Cycle Deregulation. ACS Chem Biol 6: 169-175. doi:10.1021/cb900300j. PubMed: 20886892.
    • (2011) ACS Chem Biol , vol.6 , pp. 169-175
    • Lodi, A.1    Tiziani, S.2    Khanim, F.L.3    Drayson, M.T.4    Günther, U.L.5
  • 48
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • doi:10.1038/nature04871. PubMed: 16724055
    • Pouysségur J, Dayan F, Mazure NM (2006) Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441: 437-443. doi:10.1038/nature04871. PubMed: 16724055.
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouysségur, J.1    Dayan, F.2    Mazure, N.M.3
  • 49
    • 0033655775 scopus 로고    scopus 로고
    • Mutual information relevance networks: Functional genomic clustering using pairwise entropy measurements
    • PubMed: 10902190
    • Butte AJ, Kohane IS (2000) Mutual information relevance networks: functional genomic clustering using pairwise entropy measurements. Pac Symp Biocomput: 418-429. PubMed: 10902190.
    • (2000) Pac Symp Biocomput , pp. 418-429
    • Butte, A.J.1    Kohane, I.S.2
  • 50
    • 84863837081 scopus 로고    scopus 로고
    • Lipid metabolism in cancer
    • doi:10.1111/j.1742-4658.2012.08644.x. PubMed: 22621751
    • Santos CR, Schulze A (2012) Lipid metabolism in cancer. FEBS J 279: 2610-2623. doi:10.1111/j.1742-4658.2012.08644.x. PubMed: 22621751.
    • (2012) FEBS J , vol.279 , pp. 2610-2623
    • Santos, C.R.1    Schulze, A.2
  • 51
    • 84868550230 scopus 로고    scopus 로고
    • Statin use and reduced cancer-related mortality
    • doi: 10.1056/NEJMoa1201735. PubMed: 23134381
    • Nielsen SF, Nordestgaard BG, Bojesen SE (2012) Statin use and reduced cancer-related mortality. N Engl J Med 367: 1792-1802. doi: 10.1056/ NEJMoa1201735. PubMed: 23134381.
    • (2012) N Engl J Med , vol.367 , pp. 1792-1802
    • Nielsen, S.F.1    Nordestgaard, B.G.2    Bojesen, S.E.3
  • 52
    • 79551625096 scopus 로고    scopus 로고
    • Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity
    • doi:10.1182/blood-2010-07-298422. PubMed: 21106986
    • Offman MN, Krol M, Patel N, Krishnan S, Liu J et al. (2011) Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity. Blood 117: 1614-1621. doi:10.1182/blood-2010-07-298422. PubMed: 21106986.
    • (2011) Blood , vol.117 , pp. 1614-1621
    • Offman, M.N.1    Krol, M.2    Patel, N.3    Krishnan, S.4    Liu, J.5
  • 53
    • 1842841753 scopus 로고    scopus 로고
    • Changes of amino acid serum levels in pediatric patients with higher-risk acute lymphoblastic leukemia (CCG-1961)
    • PubMed: 15113036
    • Grigoryan RS, Panosyan EH, Seibel NL, Gaynon PS, Avramis IA et al. (2004) Changes of amino acid serum levels in pediatric patients with higher-risk acute lymphoblastic leukemia (CCG-1961). In Vivo 18: 107-112. PubMed: 15113036.
    • (2004) In Vivo , vol.18 , pp. 107-112
    • Grigoryan, R.S.1    Panosyan, E.H.2    Seibel, N.L.3    Gaynon, P.S.4    Avramis, I.A.5
  • 54
    • 10744233565 scopus 로고    scopus 로고
    • LAsparagine depletion levels and L-asparaginase activity in plasma of children with acute lymphoblastic leukemia under asparaginase treatment
    • doi:10.1007/s00280-003-0734-5. PubMed: 14634792
    • Tsurusawa M, Chin M, Iwai A, Nomura K, Maeba H et al. (2004) LAsparagine depletion levels and L-asparaginase activity in plasma of children with acute lymphoblastic leukemia under asparaginase treatment. Cancer Chemother Pharmacol 53: 204-208. doi:10.1007/s00280-003-0734-5. PubMed: 14634792.
    • (2004) Cancer Chemother Pharmacol , vol.53 , pp. 204-208
    • Tsurusawa, M.1    Chin, M.2    Iwai, A.3    Nomura, K.4    Maeba, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.