The definition of the toxicologically relevant applicability domain for the SNAr reaction for substituted pyridines and pyrimidines

SAR and QSAR in Environmental Research

Volumn 24, Issue 5, 2013, Pages 385-392

  Enoch, S J ^a   Cronin, M T D ^a   Schultz, T W ^b  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

adverse outcome pathways; electrophilic reaction chemistry; in chemico; structural alerts

Indexed keywords

CHEMICAL ACTIVATION;

ADVERSE OUTCOME PATHWAY; ADVERSE OUTCOMES; ELECTROPHILIC REACTION; ELECTROPHILIC REACTION CHEMISTRY; GLUTHATHIONE; IN CHEMICO; MECHANISTICS; NUCLEOPHILIC AROMATIC SUBSTITUTION; REACTION CHEMISTRY; STRUCTURAL ALERT;

PYRIDINE;

GLUTATHIONE; PROTEIN BINDING; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

CHEMISTRY; HUMAN; METABOLISM; PROCEDURES; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL MODEL; TOXICITY; TOXICOLOGY;

GLUTATHIONE; HUMANS; MODELS, STATISTICAL; PROTEIN BINDING; PYRIDINES; PYRIMIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TOXICOLOGY;

EID: 84892638261     PISSN: 1062936X     EISSN: 1029046X     Source Type: Journal    
DOI: 10.1080/1062936X.2013.773377     Document Type: Article

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