Mechanism of statin-induced rhabdomyolysis

Journal of Pharmacological Sciences

Volumn 123, Issue 4, 2013, Pages 289-294

  Sakamoto, Kazuho ^a   Kimura, Junko ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Prenylation; Rhabdomyolysis; Skeletal muscle; Small GTPase; Statin

Indexed keywords

BREFELDIN A; FARNESYL DIPHOSPHATE; FLUINDOSTATIN; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPENTENYL DIPHOSPHATE; MEVALONIC ACID; MEVINOLIN; PRAVASTATIN; RAB PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

APOPTOSIS; CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); ENZYME INHIBITION; HUMAN; IN VITRO STUDY; MYOTUBE; NONHUMAN; PRENYLATION; PROTEIN DEPLETION; REVIEW; RHABDOMYOLYSIS; SKINNED MUSCLE FIBER; TOXICITY TESTING;

ANTICHOLESTEREMIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MUSCLE, SKELETAL; RAB GTP-BINDING PROTEINS; RHABDOMYOLYSIS; RHO GTP-BINDING PROTEINS;

EID: 84892633429     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.13R06CP     Document Type: Review

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