Inhibition of Rab1 GTPase and endoplasmic reticulum-to-golgi trafficking underlies statin's toxicity in rat skeletal myofibers

Journal of Pharmacology and Experimental Therapeutics

Volumn 338, Issue 1, 2011, Pages 62-69

  Sakamoto, Kazuho ^a   Wada, Ikuo ^a   Kimura, Junko ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BREFELDIN A; CALNEXIN; FLUINDOSTATIN; RAB PROTEIN; RAB1A PROTEIN; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MEMBRANE; CELL MIGRATION; CELL NUCLEUS; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; FLEXOR DIGITORUM BREVIS MUSCLE; FLEXOR MUSCLE; GOLGI COMPLEX; IMMUNOFLUORESCENCE; MALE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SKELETAL MYOTOXICITY; TOXICITY; UNFOLDED PROTEIN RESPONSE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CELLS, CULTURED; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL; PROTEIN TRANSPORT; RAB1 GTP-BINDING PROTEINS; RATS; RATS, WISTAR;

EID: 79959512148     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.179762     Document Type: Article

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