β-arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Simard, Elie ^a   Kovacs, Jeffrey J ^c   Miller, William E ^d   Kim, Jihee ^c   Grandbois, Michel ^a,b   Lefkowitz, Robert J ^c  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN DERIVATIVE; ANGIOTENSIN TYPE 1A RECEPTOR; BETA ARRESTIN; BETA ARRESTIN 1; BETA ARRESTIN 2; LIGAND; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN PHOSPHATASE TARGETING SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; ATOMIC FORCE MICROSCOPY; CELL CONTRACTION; CELL MIGRATION; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CHEMOTAXIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; PROTEIN DEPHOSPHORYLATION; PROTEIN DEPLETION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION;

AMINO ACID SEQUENCE; ANGIOTENSIN II; ARRESTINS; CELL LINE; CELL MOVEMENT; HUMANS; MOLECULAR SEQUENCE DATA; MYOCYTES, SMOOTH MUSCLE; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; RECEPTOR, ANGIOTENSIN, TYPE 1; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84892617010     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080532     Document Type: Article

References (27)

1. Kolodney MS, Thimgan MS, Honda HM, Tsai G, Yee HF (1999) Ca2+-independent myosin II phosphorylation and contraction in chicken embryo fibroblasts. J Physiol Lond 515 (1): 87-92. doi:10.1111/j.1469-7793.1999.087ad.x. PubMed: 9925880.
2. Tang DD, Anfinogenova Y (2008) Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle. J Cardiovasc Pharmacol Ther 13: 130-140. doi:10.1177/1074248407313737. PubMed: 18212360.
3. de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T (2000) International union of pharmacology. XXIII. the angiotensin II receptors. Pharmacol Rev 52: 415-472. PubMed: 10977869.
4. Kim S, Iwao H (2000) Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacol Rev 52: 11-34. PubMed: 10699153.
5. Barnes WG, Reiter E, Violin JD, Ren XR, Milligan G et al. (2005) Beta-arrestin 1 and galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J Biol Chem 280: 8041-8050. PubMed: 15611106.
6. Goodman OB Jr, Krupnick JG, Santini F, Gurevich VV, Penn RB et al. (1996) Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature 383: 447-450. doi:10.1038/383447a0. PubMed: 8837779.
7. Laporte SA, Oakley RH, Zhang J, Holt JA, Ferguson SS et al. (1999) The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Proc Natl Acad Sci U S A 96: 3712-3717. doi:10.1073/pnas.96.7.3712. PubMed: 10097102.
8. Xiao K, McClatchy DB, Shukla AK, Chen YZaM et al Shenoy SK. (2007) Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A 104: 12011-12016. doi:10.1073/pnas. 0704849104. PubMed: 17620599. doi:10.1073/pnas.0704849104 PubMed: 17620599
9. Wei H, Ahn S, Barnes WG, Lefkowitz RJ (2004) Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. J Biol Chem 279: 48255-48261. doi:10.1074/jbc.M406205200. PubMed: 15355986.
10. Ikebe R, Reardon S, Mitsui T, Ikebe M (1999) Role of the N-terminal region of the regulatory light chain in the dephosphorylation of myosin by myosin light chain phosphatase. J Biol Chem 274: 30122-30126. doi:10.1074/jbc.274.42.30122. PubMed: 10514500.
11. Matsumura F, Hartshorne DJ (2008) Myosin phosphatase target subunit: Many roles in cell function. Biochem Biophys Res Commun 369: 149-156. doi:10.1016/j.bbrc.2007.12.090. PubMed: 18155661.
12. Lincoln TM (2007) Myosin phosphatase regulatory pathways: Different functions or redundant functions? Circ Res 100: 10-12. doi:10.1161/01.RES. 0000255894.25293.82. PubMed: 17204659.
13. Amano M, Ito M, Kimura K, Fukata Y, Chihara K et al. (1996) Phosphorylation and activation of myosin by rho-associated kinase (rho-kinase). J Biol Chem 271: 20246-20249. doi:10.1074/jbc.271.34.20246. PubMed: 8702756.
14. Godin CM, Ferguson SSG (2010) The angiotensin II type 1 receptor induces membrane blebbing by coupling to rho A, rho kinase, and myosin light chain kinase. Mol Pharmacol 77: 903-911. doi:10.1124/mol.110.063859. PubMed: 20181817.
15. Hunton DL, Barnes WG, Kim J, Ren XR, Violin JD et al. (2005) Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. Mol Pharmacol 67: 1229-1236. doi:10.1124/mol.104.006270. PubMed: 15635042.
16. Ren XR, Reiter E, Ahn S, Kim J, Chen W et al. (2005) Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. Proc Natl Acad Sci U S A 102: 1448-1453. doi:10.1073/pnas.0409534102. PubMed: 15671180.
17. Kim J, Ahn S, Rajagopal K, Lefkowitz RJ (2009) Independent beta-arrestin2 and gq/protein kinase czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. J Biol Chem 284: 11953-11962. doi:10.1074/jbc.M808176200. PubMed: 19254952.
18. Luttrell LM, Roudabush FL, Choy EW, Miller WE, Field ME et al. (2001) Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proc Natl Acad Sci U S A 98: 2449-2454. doi:10.1073/pnas.041604898. PubMed: 11226259.
19. Kim J, Ahn S, Ren XR, Whalen EJ, Reiter E et al. (2005) Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin- mediated angiotensin II receptor signaling. Proc Natl Acad Sci U S A 102: 1442-1447. doi:10.1073/pnas.0409532102. PubMed: 15671181.
20. Eguchi A, Dowdy SF (2010) Efficient siRNA delivery by novel PTD-DRBD fusion proteins. Cell Cycle 9: 424-425. doi:10.4161/cc.9.3.10693. PubMed: 20090414.
21. Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD et al. (2006) Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. J Biol Chem 281: 10856-10864. doi:10.1074/jbc.M513380200. PubMed: 16492667.
22. Attramadal H, Arriza JL, Aoki C, Dawson TM, Codina J et al. (1992) Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. J Biol Chem 267: 17882-17890. PubMed: 1517224.
23. Cuerrier CM, Benoit M, Guillemette G, Gobeil F Jr, Grandbois M (2009) Real-time monitoring of angiotensin II-induced contractile response and cytoskeleton remodeling in individual cells by atomic force microscopy. Pflugers Arch 457: 1361-1372. doi:10.1007/s00424-008-0596-0. PubMed: 18953565.
24. Mehta PK, Griendling KK (2007) Angiotensin II cell signaling: Physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 292: C82-C97. PubMed: 16870827.
25. Auger-Messier M, Turgeon ES, Leduc R, Escher E, Guillemette G (2005) The constitutively active N111G-AT1 receptor for angiotensin II modifies the morphology and cytoskeletal organization of HEK-293 cells. Exp Cell Res 308: 188-195. doi:10.1016/j.yexcr.2005.04.015. PubMed: 15896777.
26. D'Angelo G, Adam LP (2002) Inhibition of ERK attenuates force development by lowering myosin light chain phosphorylation. Am J Physiol Heart Circ Physiol 282: H602-H610. PubMed: 11788408.
27. Vicente-Manzanares M, Ma X, Adelstein RS, Horwitz AR (2009) Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat Rev Mol Cell Biol 10: 778-790. doi:10.1038/nrm2786. PubMed: 19851336.