Time-course microarrays reveal modulation of developmental, lipid metabolism and immune gene networks in intrascapular brown adipose tissue during the development of diet-induced obesity

International Journal of Obesity

Volumn 37, Issue 12, 2013, Pages 1524-1531

  McGregor, R A ^a,b   Kwon, E Y ^a   Shin, S K ^a   Jung, U J ^a   Kim, E ^c   Park, J H Y ^d   Yu, R ^e   Yun, J W ^f   Choi, M S ^a  

^a Kyungpook National University   (South Korea)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c Catholic University of Daegu   (South Korea)

^d Hallym University   (South Korea)

^e University of Ulsan   (South Korea)

^f Daegu University   (South Korea)

Author keywords

brown adipocyte; diet induced obesity; inflammation; microarray; PRDM16; UCP

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CD68 GENE; COL1A1 GENE; CONTROLLED STUDY; DOWN REGULATION; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE TARGETING; GLUCOSE BLOOD LEVEL; HSD11B1 GENE; IMMUNE RESPONSE; INSULIN BLOOD LEVEL; LIPID METABOLISM; MALE; MICROARRAY ANALYSIS; MOUSE; MUSCLE DEVELOPMENT; NONHUMAN; OBESITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SKELETAL MUSCLE; SUBCUTANEOUS FAT; TIME; TNNC1 GENE; UPREGULATION; VALIDATION STUDY; WEIGHT GAIN;

MUS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADAPTIVE IMMUNITY; ADIPOSE TISSUE, BROWN; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; COLLAGEN TYPE I; DIET, HIGH-FAT; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORKS; INSULIN RESISTANCE; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; OBESITY; TENASCIN; TIME FACTORS; UP-REGULATION;

EID: 84892613505     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2013.52     Document Type: Article

References (47)

1. Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9-1 million participants. Lancet 2011; 377: 557-567.
2. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 2009; 9: 88.
3. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004; 84: 277-359. (Pubitemid 38054374)
4. Nedergaard J, Bengtsson T, Cannon B. Three years with adult human brown adipose tissue. Ann N Y Acad Sci 2010; 1212: E20-E36.
5. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360: 1509-1517.
6. Pfannenberg C, Werner MK, Ripkens S, Stef I, Deckert A, Schmadl M et al. Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans. Diabetes 2010; 59: 1789-1793.
7. Wang Q, Zhang M, Ning G, Gu W, Su T, Xu M et al. Brown adipose tissue in humans is activated by elevated plasma catecholamines levels and is inversely related to central obesity. PloS One 2011; 6: e21006.
8. Vijgen GHEJ Bouvy ND, Teule GJJ, Brans B, Schrauwen P, van Marken Lichtenbelt WD. Brown adipose tissue in morbidly obese subjects. PloS One 2011; 6: e17247.
9. Mercer SW, Trayhurn P. Effect of high fat diets on energy balance and thermogenesis in brown adipose tissue of lean and genetically obese ob/ob mice. J Nutr 1987; 117: 2147-2153. (Pubitemid 18030601)
10. Tulp OL, Frink R, Danforth E. Effect of cafeteria feeding on brown and white adipose tissue cellularity, thermogenesis, and body composition in rats. J Nutr 1982; 112: 2250-2260. (Pubitemid 13186546)
11. Schmid GM, Converset V, Walter N, Sennitt MV, Leung K-Y, Byers H et al. Effect of high-fat diet on the expression of proteins in muscle, adipose tissues, and liver of C57BL/6 mice. Proteomics 2004; 4: 2270-2282. (Pubitemid 39025327)
12. Fitzgibbons TP, Kogan S, Aouadi M, Hendricks GM, Straubhaar J, Czech MP. Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol 2011; 301: H1425-1437.
13. Hamann A, Flier JS, Lowell BB. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology 1996; 137: 21-29. (Pubitemid 26004968)
14. Bachman ES, Dhillon H, Zhang C-Y, Cinti S, Bianco AC, Kobilka BK et al. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science 2002; 297: 843-845. (Pubitemid 34839635)
15. Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ et al. A networkbased analysis of systemic inflammation in humans. Nature 2005; 437: 1032-1037. (Pubitemid 41486985)
16. Oh H-Y, Shin S-K, Heo H-S, Ahn J-S, Kwon E-Y, Park JHY et al. Time-dependent network analysis reveals molecular targets underlying the development of dietinduced obesity and non-alcoholic steatohepatitis. Genes Nutr 2013; e-pub ahead of print 13 November 2012; doi:10.1007/s12263-012-0322-6.
17. Baranova A, Schlauch K, Elariny H, Jarrar M, Bennett C, Nugent C et al. Gene expression patterns in hepatic tissue and visceral adipose tissue of patients with non-alcoholic fatty liver disease. Obes Surg 2007; 17: 1111-1118. (Pubitemid 350042936)
18. Do G-M, Oh HY, Kwon E-Y, Cho Y-Y, Shin S-K, Park H-J et al. Long-term adaptation of global transcription and metabolism in the liver of high-fat diet-fed C57BL/6J mice. Mol Nutr Food Res 2011; 55: 173-185.
19. Do G-M, Kwon E-Y, Kim E, Kim H-S, Choi M-S. Hepatic transcription response to high-fat treatment in mice: microarray comparison of individual vs. pooled RNA samples. Biotechnol J 2010; 5: 970-973.
20. Kim E-J, Kim E-J, Seo S-W, Hur C-G, McGregor R, Choi M. Meta-review of proteinprotein interactions between validated obesity candidate genes in the white adipose tissue of high-fat diet induced obese C57BL/6J mice. Crit Rev Food Sci Nutr 2013; doi:10.1080/10408398.2011.619283.
21. Shin S-K, Ha T-Y, McGregor RA, Choi M-S. Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism. Mol Nutr Food Res 2011; 55: 1829-1840.
22. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008; 3: 1101-1108. (Pubitemid 351818697)
23. Kwon E-Y, Shin S-K, Cho Y-Y, Jung UJ, Kim E, Park T et al. Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet-induced obesity. BMC Genomics 2012; 13: 450.
24. Fromme T, Klingenspor M. Uncoupling protein 1 expression and high-fat diets. Am J Physiol Regul Integr Comp Physiol 2011; 300: R1-R8.
25. Feldmann HM, Golozoubova V, Cannon B, Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 2009; 9: 203-209.
26. Seale P, Kajimura S, Spiegelman BM. Transcriptional control of brown adipocyte development and physiological function-of mice and men. Genes Dev 2009; 23: 788-797.
27. Timmons JA, Wennmalm K, Larsson O, Walden TB, Lassmann T, Petrovic N et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad SciUSA 2007; 104: 4401-4406. (Pubitemid 47186238)
28. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008; 454: 961-967.
29. Sampey BP, Vanhoose AM, Winfield HM, Freemerman AJ, Muehlbauer MJ, Fueger PT et al. Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obesity (Silver Spring) 2011; 19: 1109-1117.
30. Rosenblat M, Coleman R, Reddy ST, Aviram M. Paraoxonase 2 attenuates macrophage triglyceride accumulation via inhibition of diacylglycerol acyltransferase 1. J Lipid Res 2009; 50: 870-879.
31. Zhang Y, Li Y, Niepel MW, Kawano Y, Han S, Liu S et al. Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance. Proc Natl Acad SciUSA 2012; 109: 5417-5422.
32. Cinti S, Frederich RC, Zingaretti MC, De Matteis R, Flier JS, Lowell BB. Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue. Endocrinology 1997; 138: 797-804. (Pubitemid 27110934)
33. Lee YS, Li P, Huh JY, Hwang IJ, Lu M, Kim JI et al. Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes 2011; 60: 2474-2483.
34. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112: 1821-1830. (Pubitemid 38063705)
35. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011; 29: 415-445.
36. Nisoli E, Briscini L, Giordano A, Tonello C, Wiesbrock SM, Uysal KT et al. Tumor necrosis factor a mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. Proc Natl Acad Sci USA 2000; 97: 8033-8038. (Pubitemid 30460768)
37. Sun K, Kusminski CM, Scherer PE. Adipose tissue remodeling and obesity. J Clin Invest 2011; 121: 2094-2101.
38. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005; 115: 209-218. (Pubitemid 40385459)
39. Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N et al. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol 2009; 29: 1575-1591.
40. Relaix F, Wei XJ, Wu X, Sassoon DA. Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. Nat Genet 1998; 18: 287-291. (Pubitemid 28117271)
41. Repnik U, Stoka V, Turk V, Turk B. Lysosomes and lysosomal cathepsins in cell death. Biochim Biophys Acta 2012; 1824: 22-33.
42. Morton NM, Ramage L, Seckl JR. Down-regulation of adipose 11b-hydroxysteroid dehydrogenase type 1 by high-fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease. Endocrinology 2004; 145: 2707-2712. (Pubitemid 38686218)
43. Desbriere R, Vuaroqueaux V, Achard V, Boullu-Ciocca S, Labuhn M, Dutour A et al. 11beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients. Obesity 2006; 14: 794-798. (Pubitemid 46219720)
44. Pereira CD, Azevedo I, Monteiro R, Martins MJ, Pereira CD, Azevedo I et al. 11b-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus. Diabetes Obes Metab 2012; 14: 869-881.
45. Kershaw EE, Morton NM, Dhillon H, Ramage L, Seckl JR, Flier JS. Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity. Diabetes 2005; 54: 1023-1031. (Pubitemid 40446315)
46. Nixon M, Wake DJ, Livingstone DE, Stimson RH, Esteves CL, Seckl JR et al. Salicylate downregulates 11b-hsd1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. Diabetes 2012; 61: 790-796.
47. McGregor RA, Choi MS. microRNAs in the regulation of adipogenesis and obesity. Curr Mol Med 2011; 11: 304-316.