메뉴 건너뛰기




Volumn 69, Issue 3, 2013, Pages 319-326

Medication prescribing in frail older people

Author keywords

Frail elderly; Inappropriate prescribing; Pharmacokinetics; Polypharmacy

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CEFTRIAXONE; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LIDOCAINE; LORAZEPAM; NAPROXEN; PARACETAMOL; PHENYTOIN; SPIRONOLACTONE; THIOPENTAL; VALPROIC ACID; VERAPAMIL; WARFARIN;

EID: 84877152350     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-012-1387-2     Document Type: Review
Times cited : (171)

References (89)
  • 1
    • 27744437158 scopus 로고    scopus 로고
    • Extraordinary longevity: Individual and societal issues
    • 16131362 10.1111/j.1532-5415.2005.53499.x
    • Louria DB (2005) Extraordinary longevity: individual and societal issues. J Am Geriatr Soc 53:S317-S319
    • (2005) J Am Geriatr Soc , vol.53
    • Louria, D.B.1
  • 2
    • 70349495203 scopus 로고    scopus 로고
    • Ageing populations: The challenges ahead
    • 19801098 10.1016/S0140-6736(09)61460-4
    • Christensen K, Doblhammer G, Rau R, Vaupel JW (2009) Ageing populations: the challenges ahead. Lancet 374:1196-1208
    • (2009) Lancet , vol.374 , pp. 1196-1208
    • Christensen, K.1    Doblhammer, G.2    Rau, R.3    Vaupel, J.W.4
  • 4
    • 33744925926 scopus 로고    scopus 로고
    • Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70
    • 16776795 10.1111/j.1532-5415.2006.00738.x
    • Rockwood K, Mitnitski A, Song X, Steen B, Skoog I (2006) Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J Am Geriatr Soc 54:975-979
    • (2006) J Am Geriatr Soc , vol.54 , pp. 975-979
    • Rockwood, K.1    Mitnitski, A.2    Song, X.3    Steen, B.4    Skoog, I.5
  • 5
    • 2442699834 scopus 로고    scopus 로고
    • Frailty in older adults: Evidence for a phenotype
    • 10.1093/gerona/56.3.M146 1:STN:280:DC%2BD3M7osFejuw%3D%3D
    • Fried LP, Tangen CM, Walston J et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol Biol Med Sci 56:M146-M156
    • (2001) J Gerontol Biol Med Sci , vol.56
    • Fried, L.P.1    Tangen, C.M.2    Walston, J.3
  • 6
    • 79956110208 scopus 로고    scopus 로고
    • Changes in relative fitness and frailty across the adult lifespan: Evidence from the Canadian National Population Health Survey
    • 10.1503/cmaj.101271
    • Rockwood K, Song X, Mitnitski A (2011) Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey. Can Med Assoc J 183:E487-E494
    • (2011) Can Med Assoc J , vol.183
    • Rockwood, K.1    Song, X.2    Mitnitski, A.3
  • 7
    • 80054906742 scopus 로고    scopus 로고
    • Association between inflammatory-related disease burden and frailty: Results from the Women's Health and Aging Studies (WHAS) i and II
    • 21763008 10.1016/j.archger.2011.05.020
    • Chang SS, Weiss CO, Xue QL, Fried LP (2012) Association between inflammatory-related disease burden and frailty: results from the Women's Health and Aging Studies (WHAS) I and II. Arch Gerontol Geriatr 54:9-15
    • (2012) Arch Gerontol Geriatr , vol.54 , pp. 9-15
    • Chang, S.S.1    Weiss, C.O.2    Xue, Q.L.3    Fried, L.P.4
  • 8
    • 33745473295 scopus 로고    scopus 로고
    • Short- and long-term outcomes of older patients in intermediate care units
    • 16791668 10.1007/s00134-006-0170-1
    • Torres OH, Francia E, Longobardi V, Gich I, Benito S, Ruiz D (2006) Short- and long-term outcomes of older patients in intermediate care units. Intensive Care Med 32:1052-1059
    • (2006) Intensive Care Med , vol.32 , pp. 1052-1059
    • Torres, O.H.1    Francia, E.2    Longobardi, V.3    Gich, I.4    Benito, S.5    Ruiz, D.6
  • 9
  • 10
    • 33646014444 scopus 로고    scopus 로고
    • Phenotype of frailty: Characterization in the women's health and aging studies
    • 16567375 10.1093/gerona/61.3.262
    • Bandeen-Roche K, Xue QL, Ferrucci L et al (2006) Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci 61:262-266
    • (2006) J Gerontol A Biol Sci Med Sci , vol.61 , pp. 262-266
    • Bandeen-Roche, K.1    Xue, Q.L.2    Ferrucci, L.3
  • 11
    • 77950478147 scopus 로고    scopus 로고
    • Trajectories of disability in the last year of life
    • 20357280 10.1056/NEJMoa0909087 1:CAS:528:DC%2BC3cXkt1Cns7o%3D
    • Gill TM, Gahbauer EA, Han L, Allore HG (2010) Trajectories of disability in the last year of life. N Engl J Med 362:1173-1180
    • (2010) N Engl J Med , vol.362 , pp. 1173-1180
    • Gill, T.M.1    Gahbauer, E.A.2    Han, L.3    Allore, H.G.4
  • 12
    • 58849134906 scopus 로고    scopus 로고
    • Characterising frailty in the clinical setting - A comparison of different approaches
    • 19008304 10.1093/ageing/afn252
    • Hubbard RE, O'Mahony MS, Woodhouse KW (2009) Characterising frailty in the clinical setting - a comparison of different approaches. Age Ageing 38:115-119
    • (2009) Age Ageing , vol.38 , pp. 115-119
    • Hubbard, R.E.1    O'Mahony, M.S.2    Woodhouse, K.W.3
  • 13
    • 33748045402 scopus 로고    scopus 로고
    • Content validation of a frailty checklist derived from comprehensive geriatric assessment
    • 10.1159/000052785
    • Rolfson DB, Majumdar SR, Tahir AS, Tsuyuki RT (2001) Content validation of a frailty checklist derived from comprehensive geriatric assessment. Gerontology 47:119
    • (2001) Gerontology , vol.47 , pp. 119
    • Rolfson, D.B.1    Majumdar, S.R.2    Tahir, A.S.3    Tsuyuki, R.T.4
  • 14
    • 4444352300 scopus 로고    scopus 로고
    • Clinical Global Impression of Change in Physical Frailty: Development of a measure based on clinical judgment
    • 15341562 10.1111/j.1532-5415.2004.52423.x
    • Studenski S, Hayes RP, Leibowitz RQ et al (2004) Clinical Global Impression of Change in Physical Frailty: development of a measure based on clinical judgment. J Am Geriatr Soc 52:1560-1566
    • (2004) J Am Geriatr Soc , vol.52 , pp. 1560-1566
    • Studenski, S.1    Hayes, R.P.2    Leibowitz, R.Q.3
  • 15
    • 34548395418 scopus 로고    scopus 로고
    • Frailty in relation to the accumulation of deficits
    • 17634318 10.1093/gerona/62.7.722
    • Rockwood K, Mitnitski A (2007) Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci 62:722-727
    • (2007) J Gerontol A Biol Sci Med Sci , vol.62 , pp. 722-727
    • Rockwood, K.1    Mitnitski, A.2
  • 17
    • 84857205309 scopus 로고    scopus 로고
    • Predictors of adverse outcome on an acute geriatric rehabilitation ward
    • 22301571 10.1093/ageing/afr179
    • Singh I, Davis K, Gallacher J, Johansen A, Eeles EMP, Hubbard RE (2012) Predictors of adverse outcome on an acute geriatric rehabilitation ward. Age Ageing 41:242-246
    • (2012) Age Ageing , vol.41 , pp. 242-246
    • Singh, I.1    Davis, K.2    Gallacher, J.3    Johansen, A.4    Eeles, E.M.P.5    Hubbard, R.E.6
  • 18
    • 83655163860 scopus 로고    scopus 로고
    • Assessing balance and mobility to track illness and recovery in older inpatients
    • 21845488 10.1007/s11606-011-1821-7
    • Hubbard RE, Eeles EM, Rockwood MR et al (2011) Assessing balance and mobility to track illness and recovery in older inpatients. J Gen Intern Med 26:1471-1478
    • (2011) J Gen Intern Med , vol.26 , pp. 1471-1478
    • Hubbard, R.E.1    Eeles, E.M.2    Rockwood, M.R.3
  • 20
    • 69949102187 scopus 로고    scopus 로고
    • Nonlinear multisystem physiological dysregulation associated with frailty in older women: Implications for etiology and treatment
    • 19567825 10.1093/gerona/glp076
    • Fried LP, Xue QL, Cappola AR et al (2009) Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci 64:1049-1057
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , pp. 1049-1057
    • Fried, L.P.1    Xue, Q.L.2    Cappola, A.R.3
  • 22
    • 33947498821 scopus 로고    scopus 로고
    • Eligibility criteria of randomised controlled trials published in high-impact general medical journals: A systematic sampling review
    • 17374817 10.1001/jama.297.11.1233
    • Van Spall HG, Toren A, Kiss A et al (2007) Eligibility criteria of randomised controlled trials published in high-impact general medical journals: a systematic sampling review. JAMA 297:1233-1240
    • (2007) JAMA , vol.297 , pp. 1233-1240
    • Van Spall, H.G.1    Toren, A.2    Kiss, A.3
  • 23
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomised Aldactone Evaluation Study
    • 10.1056/NEJM199909023411001 1:CAS:528:DyaK1MXmtVyrurk%3D
    • Pitt B, Zannad F, Remme WJ et al (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomised Aldactone Evaluation Study. N Eng J Med 341:709-717
    • (1999) N Eng J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 24
    • 0037438820 scopus 로고    scopus 로고
    • Complications of inappropriate use of spironolactone; When an old medicine spirals out of new guidelines
    • 12535810 10.1016/S0735-1097(02)02694-3 1:CAS:528:DC%2BD3sXht1Srs7w%3D
    • Bozkurt B, Agoston I, Knowlton AA (2003) Complications of inappropriate use of spironolactone; when an old medicine spirals out of new guidelines. J Am Coll Cardiol 41:211-214
    • (2003) J Am Coll Cardiol , vol.41 , pp. 211-214
    • Bozkurt, B.1    Agoston, I.2    Knowlton, A.A.3
  • 25
    • 0242637043 scopus 로고    scopus 로고
    • Hyperkalaemia and impaired renal function in patients taking spironolactone for congestive heart failure; Retrospective study
    • 10.1136/bmj.327.7424.1141
    • Svensson M, Gustafsson F, Galatius S, Hildebrandt PR, Atar D (2003) Hyperkalaemia and impaired renal function in patients taking spironolactone for congestive heart failure; retrospective study. Br Med J 327:1141-1142
    • (2003) Br Med J , vol.327 , pp. 1141-1142
    • Svensson, M.1    Gustafsson, F.2    Galatius, S.3    Hildebrandt, P.R.4    Atar, D.5
  • 26
    • 26944459667 scopus 로고    scopus 로고
    • Tolerability of spironolactone as adjunctive treatment for heart failure in patients over 75 years of age
    • 15955761 10.1093/ageing/afi104
    • Dinsdale C, Wani M, Steward J, O'Mahony MS (2005) Tolerability of spironolactone as adjunctive treatment for heart failure in patients over 75 years of age. Age Ageing 34:395-398
    • (2005) Age Ageing , vol.34 , pp. 395-398
    • Dinsdale, C.1    Wani, M.2    Steward, J.3    O'Mahony, M.S.4
  • 27
    • 41249101169 scopus 로고    scopus 로고
    • Frailty: Different tools for different purposes?
    • 18349007 10.1093/ageing/afn011
    • Martin FC, Brighton P (2008) Frailty: different tools for different purposes? Age Ageing 37(2):129-131
    • (2008) Age Ageing , vol.37 , Issue.2 , pp. 129-131
    • Martin, F.C.1    Brighton, P.2
  • 28
    • 0028307648 scopus 로고
    • Inappropriate drug prescribing for the community-dwelling elderly
    • 8028142 10.1001/jama.1994.03520040054040 1:STN:280:DyaK2czgtVOmtQ%3D%3D
    • Willcox SM, Himmelstein DU, Woolhandler S (1994) Inappropriate drug prescribing for the community-dwelling elderly. JAMA 272:292-296
    • (1994) JAMA , vol.272 , pp. 292-296
    • Willcox, S.M.1    Himmelstein, D.U.2    Woolhandler, S.3
  • 29
    • 38549109081 scopus 로고    scopus 로고
    • Inappropriate prescribing in an acutely ill population of elderly patients as determined by Beers' Criteria
    • 17933759 10.1093/ageing/afm116
    • Gallagher PF, Barry PJ, Ryan C, Hartigan I, O'Mahony D (2008) Inappropriate prescribing in an acutely ill population of elderly patients as determined by Beers' Criteria. Age Ageing 37:96-101
    • (2008) Age Ageing , vol.37 , pp. 96-101
    • Gallagher, P.F.1    Barry, P.J.2    Ryan, C.3    Hartigan, I.4    O'Mahony, D.5
  • 31
    • 0034253924 scopus 로고    scopus 로고
    • Incidence and preventability of adverse drug events in nursing homes
    • 10967148 10.1016/S0002-9343(00)00451-4 1:STN:280:DC%2BD3cvosV2nsA%3D%3D
    • Gurwitz JH, Field TS, Avorn J et al (2000) Incidence and preventability of adverse drug events in nursing homes. Am J Med 109:87-94
    • (2000) Am J Med , vol.109 , pp. 87-94
    • Gurwitz, J.H.1    Field, T.S.2    Avorn, J.3
  • 32
    • 84859857179 scopus 로고    scopus 로고
    • American Geriatrics Society updated beers criteria for potentially inappropriate medication use in older adults
    • The American Geriatrics Society 2012 Beers Criteria Update Expert Panel 10.1111/j.1532-5415.2012.03923.x
    • The American Geriatrics Society 2012 Beers Criteria Update Expert Panel (2012) American Geriatrics Society updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 60:616-631
    • (2012) J Am Geriatr Soc , vol.60 , pp. 616-631
  • 33
    • 33846042587 scopus 로고    scopus 로고
    • Is inappropriate medication use a major cause of adverse drug reactions in the elderly?
    • 17166186 10.1111/j.1365-2125.2006.02831.x
    • Laroche ML, Charmes JP, Nouaille Y, Picard N, Merle L (2007) Is inappropriate medication use a major cause of adverse drug reactions in the elderly? Br J Clin Pharmacol 63(2):177-186
    • (2007) Br J Clin Pharmacol , vol.63 , Issue.2 , pp. 177-186
    • Laroche, M.L.1    Charmes, J.P.2    Nouaille, Y.3    Picard, N.4    Merle, L.5
  • 34
    • 77951689108 scopus 로고    scopus 로고
    • Problems of nonadherence in cardiology and proposals to improve outcomes
    • 20451702 10.1016/j.amjcard.2009.12.077
    • Garner JB (2010) Problems of nonadherence in cardiology and proposals to improve outcomes. Am J Cardiol 105(10):1495-1501
    • (2010) Am J Cardiol , vol.105 , Issue.10 , pp. 1495-1501
    • Garner, J.B.1
  • 35
    • 84861305959 scopus 로고    scopus 로고
    • Adverse drug reactions in hospital in-patients: A prospective analysis of 3695 patient-episodes
    • 10.1371/journal.pone.0004439
    • Davies EC, Green CF, Taylor S et al (2009) Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes. PLoS One 4:4439
    • (2009) PLoS One , vol.4 , pp. 4439
    • Davies, E.C.1    Green, C.F.2    Taylor, S.3
  • 36
    • 0032447083 scopus 로고    scopus 로고
    • Delirium in hospitalized older patients: Recognition and risk factors
    • 9894730 1:STN:280:DyaK1M7htVShsw%3D%3D
    • Inouye SK (1998) Delirium in hospitalized older patients: recognition and risk factors. J Geriatr Psychiatry Neurol 11(3):118-125
    • (1998) J Geriatr Psychiatry Neurol , vol.11 , Issue.3 , pp. 118-125
    • Inouye, S.K.1
  • 37
    • 74549140992 scopus 로고    scopus 로고
    • The patient who falls: "it's always a trade-off
    • 20085954 10.1001/jama.2009.2024 1:CAS:528:DC%2BC3cXptFSqsg%3D%3D
    • Tinetti ME, Kumar C (2010) The patient who falls: "It's always a trade-off". JAMA 303(3):258-266
    • (2010) JAMA , vol.303 , Issue.3 , pp. 258-266
    • Tinetti, M.E.1    Kumar, C.2
  • 38
    • 84874423767 scopus 로고    scopus 로고
    • Physiology of aging
    • H.M. Fillit K. Rockwood K. Woodhouse (eds) 7 Elsevier Philadelphia 10.1016/B978-1-4160-6231-8.10009-1
    • Masoro EJ (2010) Physiology of aging. In: Fillit HM, Rockwood K, Woodhouse K (eds) Brocklehurst's textbook of geriatric medicine and gerontology, 7th edn. Elsevier, Philadelphia, pp 51-59
    • (2010) Brocklehurst's Textbook of Geriatric Medicine and Gerontology , pp. 51-59
    • Masoro, E.J.1
  • 39
    • 70149103802 scopus 로고    scopus 로고
    • Pharmacokinetics and drug metabolism in the elderly
    • 19514965 10.1080/03602530902722679 1:CAS:528:DC%2BD1MXnsVagsrc%3D
    • Klotz U (2009) Pharmacokinetics and drug metabolism in the elderly. Drug Metab Rev 41:67-76
    • (2009) Drug Metab Rev , vol.41 , pp. 67-76
    • Klotz, U.1
  • 40
    • 15044344552 scopus 로고    scopus 로고
    • Pharmacokinetics in older persons
    • 15903286 10.1016/j.amjopharm.2004.12.005 1:CAS:528:DC%2BD2MXktlajs7s%3D
    • Cusack BJ (2004) Pharmacokinetics in older persons. Am J Geriatr Pharmacother 2:274-302
    • (2004) Am J Geriatr Pharmacother , vol.2 , pp. 274-302
    • Cusack, B.J.1
  • 41
    • 44349160069 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic alterations in the geriatric patient
    • 18454589 10.4140/TCP.n.2008.324
    • Delafuente JC (2008) Pharmacokinetic and pharmacodynamic alterations in the geriatric patient. Consult Pharm 23:324-334
    • (2008) Consult Pharm , vol.23 , pp. 324-334
    • Delafuente, J.C.1
  • 42
    • 34748874678 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic crisis in the elderly
    • 10.1097/01.mjt.0000183719.84390.4d
    • El Desoky ES (2007) Pharmacokinetic-pharmacodynamic crisis in the elderly. Am J Ther 14:488-498
    • (2007) Am J Ther , vol.14 , pp. 488-498
    • El Desoky, E.S.1
  • 43
    • 0347319044 scopus 로고    scopus 로고
    • Age-related changes in pharmacokinetics and pharmacodynamics: Basic principles and practical applications
    • 10.1046/j.1365-2125.2003.02007.x
    • Mangoni AA, Jackson SHD (2003) Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol 57:6-14
    • (2003) Br J Clin Pharmacol , vol.57 , pp. 6-14
    • Mangoni, A.A.1    Jackson, S.H.D.2
  • 44
    • 80053479046 scopus 로고    scopus 로고
    • Pharmacokinetic considerations for digoxin in older people
    • 21769303 10.2174/1874192401105010130 1:CAS:528:DC%2BC3MXhtV2ju7zO
    • Currie GM, Wheat JM, Kiat H (2011) Pharmacokinetic considerations for digoxin in older people. Open Cardiovasc Med J 5:130-135
    • (2011) Open Cardiovasc Med J , vol.5 , pp. 130-135
    • Currie, G.M.1    Wheat, J.M.2    Kiat, H.3
  • 46
    • 34247489795 scopus 로고    scopus 로고
    • Intestinal malabsorption in the elderly
    • 17468550 10.1159/000099479
    • Holt PR (2007) Intestinal malabsorption in the elderly. Dig Dis 25:144-150
    • (2007) Dig Dis , vol.25 , pp. 144-150
    • Holt, P.R.1
  • 48
    • 47149118354 scopus 로고    scopus 로고
    • How does obesity affect residence time dispersion and the shape of drug disposition curves? Thiopental as an example
    • 18465214 10.1007/s10928-008-9090-8 1:CAS:528:DC%2BD1cXosVGiu7o%3D
    • Weiss M (2008) How does obesity affect residence time dispersion and the shape of drug disposition curves? Thiopental as an example. J Pharmacokinet Pharmacodyn 35(3):325-336
    • (2008) J Pharmacokinet Pharmacodyn , vol.35 , Issue.3 , pp. 325-336
    • Weiss, M.1
  • 50
    • 0025245869 scopus 로고
    • The association of age and frailty with paracetamol conjugation in man
    • 2285011 10.1093/ageing/19.6.419 1:STN:280:DyaK3M7jsFGntw%3D%3D
    • Wynne HA, Cope L, Herd B, James OFW, Rawlins MD, Woodhouse KW (1990) The association of age and frailty with paracetamol conjugation in man. Age Ageing 19:419-424
    • (1990) Age Ageing , vol.19 , pp. 419-424
    • Wynne, H.A.1    Cope, L.2    Herd, B.3    James, O.F.W.4    Rawlins, M.D.5    Woodhouse, K.W.6
  • 51
    • 0027179625 scopus 로고
    • The association of age and frailty with the pharmacokinetics and pharmacodynamics of metoclopramide
    • 8237626 10.1093/ageing/22.5.354 1:STN:280:DyaK2c%2FlsF2rtQ%3D%3D
    • Wynne HA, Yelland C, Cope LH, Boddy A, Woodhouse KW, Bateman DN (1993) The association of age and frailty with the pharmacokinetics and pharmacodynamics of metoclopramide. Age Ageing 22:354-359
    • (1993) Age Ageing , vol.22 , pp. 354-359
    • Wynne, H.A.1    Yelland, C.2    Cope, L.H.3    Boddy, A.4    Woodhouse, K.W.5    Bateman, D.N.6
  • 52
    • 0023223018 scopus 로고
    • Serum enzymes of drug metabolism
    • 3310046 10.1016/0163-7258(87)90094-5 1:CAS:528:DyaL2sXmt1yhsr4%3D
    • Williams FM (1987) Serum enzymes of drug metabolism. Pharmacol Ther 34(1):99-109
    • (1987) Pharmacol Ther , vol.34 , Issue.1 , pp. 99-109
    • Williams, F.M.1
  • 53
    • 0019801671 scopus 로고
    • Clinical pharmacokinetics of antithyroid drugs
    • 6172233 10.2165/00003088-198106060-00001 1:STN:280:DyaL38%2FpsVSksQ%3D%3D
    • Kampmann JP, Hansen JM (1981) Clinical pharmacokinetics of antithyroid drugs. Clin Pharmacokinet 6(6):401-428
    • (1981) Clin Pharmacokinet , vol.6 , Issue.6 , pp. 401-428
    • Kampmann, J.P.1    Hansen, J.M.2
  • 54
    • 0021998682 scopus 로고
    • Clinical pharmacokinetics of the angiotensin converting enzyme inhibitors
    • 2994938 10.2165/00003088-198510050-00001 1:STN:280:DyaL28%2FgtlWlsg%3D%3D
    • Kubo SH, Cody RJ (1985) Clinical pharmacokinetics of the angiotensin converting enzyme inhibitors. Clin Pharmacokinet 10(5):377-391
    • (1985) Clin Pharmacokinet , vol.10 , Issue.5 , pp. 377-391
    • Kubo, S.H.1    Cody, R.J.2
  • 55
    • 0026025379 scopus 로고
    • The association of age with aspirin esterase activity in human liver
    • 2028845 10.1093/ageing/20.1.16 1:STN:280:DyaK3M3ivV2jtw%3D%3D
    • Yelland C, Summerbell J, Nicholson E, Herd B, Wynne H, Woodhouse KW (1991) The association of age with aspirin esterase activity in human liver. Age Ageing 20(1):16-18
    • (1991) Age Ageing , vol.20 , Issue.1 , pp. 16-18
    • Yelland, C.1    Summerbell, J.2    Nicholson, E.3    Herd, B.4    Wynne, H.5    Woodhouse, K.W.6
  • 56
    • 0035069664 scopus 로고    scopus 로고
    • Relationship between age and plasma esterases
    • 11322671 10.1093/ageing/30.1.41 1:STN:280:DC%2BD3M3jtVGgtA%3D%3D
    • Abou-Hatab K, O'Mahony MS, Patel S, Woodhouse K (2001) Relationship between age and plasma esterases. Age Ageing 30(1):41-45
    • (2001) Age Ageing , vol.30 , Issue.1 , pp. 41-45
    • Abou-Hatab, K.1    O'Mahony, M.S.2    Patel, S.3    Woodhouse, K.4
  • 57
    • 0028285776 scopus 로고
    • Plasma aspirin esterase activity in elderly patients undergoing elective hip replacement and with fractured neck of femur
    • 10.1093/ageing/23.4.338
    • O'Mahony MS, George G, Westlake H, Woodhouse K (1994) Plasma aspirin esterase activity in elderly patients undergoing elective hip replacement and with fractured neck of femur. Age Ageing 23:338-341
    • (1994) Age Ageing , vol.23 , pp. 338-341
    • O'Mahony, M.S.1    George, G.2    Westlake, H.3    Woodhouse, K.4
  • 58
    • 28244482382 scopus 로고    scopus 로고
    • Enzymes of drug metabolism during delirium
    • 16267186 10.1093/ageing/afi189
    • White S, Calver BL, Newsway V et al (2005) Enzymes of drug metabolism during delirium. Age Ageing 34(6):603-608
    • (2005) Age Ageing , vol.34 , Issue.6 , pp. 603-608
    • White, S.1    Calver, B.L.2    Newsway, V.3
  • 60
    • 0034542616 scopus 로고    scopus 로고
    • Plasma esterase activities in young and old patients undergoing open inguinal hernia repair
    • 11154773 10.1016/S0167-4943(00)00073-X 1:CAS:528:DC%2BD3MXitlyqsQ%3D%3D
    • Abou-Hatab K, O'Mahony MS, Patel S, Carey D, Woodhouse K (2000) Plasma esterase activities in young and old patients undergoing open inguinal hernia repair. Arch Gerontol Geriatr 31:193-198
    • (2000) Arch Gerontol Geriatr , vol.31 , pp. 193-198
    • Abou-Hatab, K.1    O'Mahony, M.S.2    Patel, S.3    Carey, D.4    Woodhouse, K.5
  • 61
    • 0025305695 scopus 로고
    • The kinetics of plasma aspirin esterase in relation to old age and frailty
    • 2337009 10.1093/ageing/19.2.128 1:STN:280:DyaK3c3kslWrtQ%3D%3D
    • Summerbell J, Yelland C, Woodhouse KW (1990) The kinetics of plasma aspirin esterase in relation to old age and frailty. Age Ageing 19:128-130
    • (1990) Age Ageing , vol.19 , pp. 128-130
    • Summerbell, J.1    Yelland, C.2    Woodhouse, K.W.3
  • 62
    • 50849090598 scopus 로고    scopus 로고
    • Plasma esterases and inflammation in ageing and frailty
    • 18506436 10.1007/s00228-008-0499-1 1:CAS:528:DC%2BD1cXhtVKju7nK
    • Hubbard RE, O'Mahony MS, Calver BL, Woodhouse KW (2008) Plasma esterases and inflammation in ageing and frailty. Eur J Clin Pharmacol 64(9):895-900
    • (2008) Eur J Clin Pharmacol , vol.64 , Issue.9 , pp. 895-900
    • Hubbard, R.E.1    O'Mahony, M.S.2    Calver, B.L.3    Woodhouse, K.W.4
  • 63
    • 0031409592 scopus 로고    scopus 로고
    • Regulation of cytochrome p450 during inflammation and infection
    • 9421688 10.3109/03602539709002246 1:CAS:528:DyaK1cXhtlGqsw%3D%3D
    • Morgan ET (1997) Regulation of cytochrome p450 during inflammation and infection. Drug Metab Rev 29:1129-1188
    • (1997) Drug Metab Rev , vol.29 , pp. 1129-1188
    • Morgan, E.T.1
  • 64
    • 0024350454 scopus 로고
    • The effect of age and frailty upon acetonilide clearance in man
    • 2629492 10.1093/ageing/18.6.415 1:STN:280:DyaK3c7psFOhtg%3D%3D
    • Wynne HA, Cope LH, James OFW, Rawlins MD, Woodhouse KW (1989) The effect of age and frailty upon acetonilide clearance in man. Age Ageing 18:415-418
    • (1989) Age Ageing , vol.18 , pp. 415-418
    • Wynne, H.A.1    Cope, L.H.2    James, O.F.W.3    Rawlins, M.D.4    Woodhouse, K.W.5
  • 65
    • 0017230772 scopus 로고
    • The effect of age on creatinine clearance in men: A cross-sectional and longitudinal study
    • 1249404 10.1093/geronj/31.2.155 1:CAS:528:DyaE28XktlWjsbs%3D
    • Rowe JW, Andres R, Tobin JD, Norris AM, Shock NW (1976) The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study. J Gerontol 31:155-163
    • (1976) J Gerontol , vol.31 , pp. 155-163
    • Rowe, J.W.1    Andres, R.2    Tobin, J.D.3    Norris, A.M.4    Shock, N.W.5
  • 66
    • 0021910427 scopus 로고
    • Longitudinal studies on the rate of decline in renal function with age
    • 3989190 1:STN:280:DyaL2M7otlKgsw%3D%3D
    • Lindeman RD, Tobin J, Shock NW (1985) Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 33:278-285
    • (1985) J Am Geriatr Soc , vol.33 , pp. 278-285
    • Lindeman, R.D.1    Tobin, J.2    Shock, N.W.3
  • 68
    • 67649814915 scopus 로고    scopus 로고
    • Frailty and chronic kidney disease: The Third National Health and Nutrition Evaluation Survey
    • 19559169 10.1016/j.amjmed.2009.01.026 e2
    • Wilhelm-Leen ER, Hall YN, Tamura MK, Chertow GM (2009) Frailty and chronic kidney disease: the Third National Health and Nutrition Evaluation Survey. Am J Med 122(7):664-671, e2
    • (2009) Am J Med , vol.122 , Issue.7 , pp. 664-671
    • Wilhelm-Leen, E.R.1    Hall, Y.N.2    Tamura, M.K.3    Chertow, G.M.4
  • 69
    • 84864417018 scopus 로고    scopus 로고
    • Frailty, dialysis initiation, and mortality in end-stage renal disease
    • 22733312 10.1001/archinternmed.2012.3020 1:CAS:528:DC%2BC38Xht1Cht7%2FJ
    • Bao Y, Dalrymple L, Chertow GM, Kaysen GA, Johansen KL (2012) Frailty, dialysis initiation, and mortality in end-stage renal disease. Arch Intern Med 172:1071-1077
    • (2012) Arch Intern Med , vol.172 , pp. 1071-1077
    • Bao, Y.1    Dalrymple, L.2    Chertow, G.M.3    Kaysen, G.A.4    Johansen, K.L.5
  • 70
    • 35848952748 scopus 로고    scopus 로고
    • Significance of frailty among dialysis patients
    • 17942958 10.1681/ASN.2007020221
    • Johansen KL, Chertow GM, Jin C, Kutner NG (2007) Significance of frailty among dialysis patients. J Am Soc Nephrol 18:2960-2967
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2960-2967
    • Johansen, K.L.1    Chertow, G.M.2    Jin, C.3    Kutner, N.G.4
  • 71
    • 0016916438 scopus 로고
    • Prediction of creatinine clearance from serum creatinine
    • 1244564 10.1159/000180580 1:STN:280:DyaE28%2FnsF2isw%3D%3D
    • Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16:31-41
    • (1976) Nephron , vol.16 , pp. 31-41
    • Cockcroft, D.W.1    Gault, M.H.2
  • 72
    • 0036227238 scopus 로고    scopus 로고
    • Serum cystatin C is not a better marker of creatinine or digoxin clearance than serum creatinine
    • 11966673 10.1046/j.1365-2125.2002.01549.x
    • O'Riordan S, Ouldred E, Brice S, Jackson SH, Swift CG (2002) Serum cystatin C is not a better marker of creatinine or digoxin clearance than serum creatinine. Br J Clin Pharmacol 53:398-402
    • (2002) Br J Clin Pharmacol , vol.53 , pp. 398-402
    • O'Riordan, S.1    Ouldred, E.2    Brice, S.3    Jackson, S.H.4    Swift, C.G.5
  • 73
    • 0033574249 scopus 로고    scopus 로고
    • A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group
    • 10075613 1:CAS:528:DyaK1MXitFChs7k%3D
    • Levey AS, Bosch J, Lewis JB, Greene T, Rogers N, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130:461-470
    • (1999) Ann Intern Med , vol.130 , pp. 461-470
    • Levey, A.S.1    Bosch, J.2    Lewis, J.B.3    Greene, T.4    Rogers, N.5    Roth, D.6
  • 74
    • 20544448298 scopus 로고    scopus 로고
    • Predictive performance of the Modification of Diet in Renal Disease and Cockcroft-Gault equations for estimating renal function
    • 15659562 10.1681/ASN.2004070549
    • Froissart M, Rossert J, Jaquot C, Paillard M, Houillier P (2005) Predictive performance of the Modification of Diet in Renal Disease and Cockcroft-Gault equations for estimating renal function. J Am Soc Nephrol 16:763-773
    • (2005) J Am Soc Nephrol , vol.16 , pp. 763-773
    • Froissart, M.1    Rossert, J.2    Jaquot, C.3    Paillard, M.4    Houillier, P.5
  • 75
    • 79961039191 scopus 로고    scopus 로고
    • Age-related changes in pharmacodynamics: Focus on drugs acting on central nervous and cardiovascular systems
    • 21495972 10.2174/138920011796504473 1:CAS:528:DC%2BC3MXhsVCks7%2FL
    • Trifiro G, Spina E (2011) Age-related changes in pharmacodynamics: focus on drugs acting on central nervous and cardiovascular systems. Curr Drug Metab 12(7):611-620
    • (2011) Curr Drug Metab , vol.12 , Issue.7 , pp. 611-620
    • Trifiro, G.1    Spina, E.2
  • 76
    • 0018421704 scopus 로고
    • Factors affecting warfarin requirements. A prospective population study
    • 378674 10.1007/BF00558434 1:STN:280:DyaE1M3htlGiuw%3D%3D
    • Routledge PA, Chapman PH, Davies DM, Rawlins MD (1979) Factors affecting warfarin requirements. A prospective population study. Eur J Clin Pharmacol 15(5):319-322
    • (1979) Eur J Clin Pharmacol , vol.15 , Issue.5 , pp. 319-322
    • Routledge, P.A.1    Chapman, P.H.2    Davies, D.M.3    Rawlins, M.D.4
  • 77
    • 0036187613 scopus 로고    scopus 로고
    • Impact of age, gender and cognitive functioning on pain perception
    • 11867935 10.1159/000048937
    • Pickering G, Jourdan D, Eschalier A, Dubray C (2002) Impact of age, gender and cognitive functioning on pain perception. Gerontology 48:112-118
    • (2002) Gerontology , vol.48 , pp. 112-118
    • Pickering, G.1    Jourdan, D.2    Eschalier, A.3    Dubray, C.4
  • 78
    • 79251621724 scopus 로고    scopus 로고
    • Clinical pharmacology of analgesic medicines in older people: Impact of frailty and cognitive impairment
    • 21284694 10.1111/j.1365-2125.2010.03847.x 1:CAS:528:DC%2BC3MXjvFSnurs%3D
    • McLachlan AJ, Bath S, Naganathan V et al (2011) Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. Br J Clin Pharmacol 71(3):351-364
    • (2011) Br J Clin Pharmacol , vol.71 , Issue.3 , pp. 351-364
    • McLachlan, A.J.1    Bath, S.2    Naganathan, V.3
  • 79
    • 33645469743 scopus 로고    scopus 로고
    • Reconsidering medication appropriateness for patients late in life
    • 16567597 10.1001/archinte.166.6.605
    • Holmes HM, Hayley DC, Alexander GC, Sachs GA (2006) Reconsidering medication appropriateness for patients late in life. Arch Intern Med 166:605-609
    • (2006) Arch Intern Med , vol.166 , pp. 605-609
    • Holmes, H.M.1    Hayley, D.C.2    Alexander, G.C.3    Sachs, G.A.4
  • 80
    • 84862777885 scopus 로고    scopus 로고
    • Minimizing inappropriate medications in older populations: A 10-step conceptual framework
    • 22385783 10.1016/j.amjmed.2011.09.021
    • Scott IA, Gray LC, Martin JH, Mitchell CA (2012) Minimizing inappropriate medications in older populations: a 10-step conceptual framework. Am J Med 125(6):529-537
    • (2012) Am J Med , vol.125 , Issue.6 , pp. 529-537
    • Scott, I.A.1    Gray, L.C.2    Martin, J.H.3    Mitchell, C.A.4
  • 81
    • 79251471118 scopus 로고    scopus 로고
    • Respecting frailty
    • 21097941 10.1136/jme.2010.040147
    • Mallery LH, Moorhouse P (2011) Respecting frailty. J Med Ethics 37(2):126-128
    • (2011) J Med Ethics , vol.37 , Issue.2 , pp. 126-128
    • Mallery, L.H.1    Moorhouse, P.2
  • 82
    • 77951021284 scopus 로고    scopus 로고
    • Cautionary tales in the interpretation of clinical studies involving older persons
    • 20386001 10.1001/archinternmed.2010.18
    • Scott IA, Guyatt GH (2010) Cautionary tales in the interpretation of clinical studies involving older persons. Arch Intern Med 170(7):587-595
    • (2010) Arch Intern Med , vol.170 , Issue.7 , pp. 587-595
    • Scott, I.A.1    Guyatt, G.H.2
  • 83
    • 4544287574 scopus 로고    scopus 로고
    • Frailty and the geriatrician
    • 15315912 10.1093/ageing/afh153
    • Rockwood K, Hubbard R (2004) Frailty and the geriatrician. Age Ageing 33(5):429-430
    • (2004) Age Ageing , vol.33 , Issue.5 , pp. 429-430
    • Rockwood, K.1    Hubbard, R.2
  • 84
    • 0030978954 scopus 로고    scopus 로고
    • Use of goal attainment scaling in measuring clinically important change in cognitive rehabilitation patients
    • 9180650 10.1016/S0895-4356(97)00014-0 1:STN:280:DyaK2szisVGntw%3D%3D
    • Rockwood K, Joyce B, Stolee P (1997) Use of goal attainment scaling in measuring clinically important change in cognitive rehabilitation patients. J Clin Epidemiol 50(5):581-588
    • (1997) J Clin Epidemiol , vol.50 , Issue.5 , pp. 581-588
    • Rockwood, K.1    Joyce, B.2    Stolee, P.3
  • 85
    • 79957577017 scopus 로고    scopus 로고
    • Effects of benefits and harms on older persons' willingness to take medication for primary cardiovascular prevention
    • 21357797 10.1001/archinternmed.2011.32
    • Fried TR, Tinetti ME, Towle V, O'Leary JR, Iannone L (2011) Effects of benefits and harms on older persons' willingness to take medication for primary cardiovascular prevention. Arch Intern Med 171:923-928
    • (2011) Arch Intern Med , vol.171 , pp. 923-928
    • Fried, T.R.1    Tinetti, M.E.2    Towle, V.3    O'Leary, J.R.4    Iannone, L.5
  • 86
    • 84860508263 scopus 로고    scopus 로고
    • The impact of frailty and delirium on mortality in older inpatients
    • 22391613 10.1093/ageing/afs021
    • Eeles EMP, White SV, O'Mahony MS, Bayer AJ, Hubbard RE (2012) The impact of frailty and delirium on mortality in older inpatients. Age Ageing 41(3):412-416
    • (2012) Age Ageing , vol.41 , Issue.3 , pp. 412-416
    • Eeles, E.M.P.1    White, S.V.2    O'Mahony, M.S.3    Bayer, A.J.4    Hubbard, R.E.5
  • 87
    • 79958192032 scopus 로고    scopus 로고
    • Lipid-lowering drug therapy in elderly patients
    • 21418034 10.2174/138161211795428803 1:CAS:528:DC%2BC3MXlvFykt7s%3D
    • Berthold HK, Gouni-Berthold I (2011) Lipid-lowering drug therapy in elderly patients. Curr Pharm Des 17:877-893
    • (2011) Curr Pharm des , vol.17 , pp. 877-893
    • Berthold, H.K.1    Gouni-Berthold, I.2
  • 88
    • 83555176128 scopus 로고    scopus 로고
    • Potentially harmful drug-drug interactions in the elderly: A review
    • 22078863 10.1016/j.amjopharm.2011.10.004 1:CAS:528:DC%2BC3MXhs1Skt7fN
    • Hines LE, Murphy JE (2011) Potentially harmful drug-drug interactions in the elderly: a review. Am J Geriatr Pharmacother 9(6):364-377
    • (2011) Am J Geriatr Pharmacother , vol.9 , Issue.6 , pp. 364-377
    • Hines, L.E.1    Murphy, J.E.2
  • 89
    • 79959481579 scopus 로고    scopus 로고
    • Role of bisphosphonates in the management of postmenopausal osteoporosis: An update on recent safety anxieties
    • 21693503 10.1258/mi.2011.011014
    • Hollick RJ, Reid DM (2011) Role of bisphosphonates in the management of postmenopausal osteoporosis: an update on recent safety anxieties. Menopause Int 17(2):66-72
    • (2011) Menopause Int , vol.17 , Issue.2 , pp. 66-72
    • Hollick, R.J.1    Reid, D.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.