Low in situ expression of antioxidative enzymes in rat cerebellar granular cells susceptible to methylmercury

Archives of Toxicology

Volumn 88, Issue 1, 2014, Pages 109-113

  Fujimura, M ^a   Usuki, F ^a  

^a NATIONAL INSTITUTE FOR MINAMATA DISEASE   (Japan)

Author keywords

Antioxidative enzymes; Cerebellar neuron; Methylmercury; Microdissection; Susceptibility

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; EOSIN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE PEROXIDASE 1; HEMATOXYLIN; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; METHYLMERCURY; THIOREDOXIN REDUCTASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CEREBELLAR GRANULAR CELL; CEREBELLUM; CYTOTOXICITY; GRANULE CELL; IMMUNOHISTOCHEMISTRY; MICRODISSECTION; MOLECULAR LAYER NEURON; NEUROPATHOLOGY; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE CELL; RAT; REAL TIME POLYMERASE CHAIN REACTION; STAINING;

RATTUS;

ANIMALS; ANTIOXIDANTS; CATALASE; CEREBELLUM; ENZYMES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE PEROXIDASE; MALE; METHYLMERCURY COMPOUNDS; MICRODISSECTION; NEURONS; PURKINJE CELLS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; THIOREDOXIN REDUCTASE 1;

EID: 84892590625     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1089-2     Document Type: Article

References (18)

1. Bakir F, Damluji SF, Amin-Zaki L, Murtadha M, Khalidi A, al-Rawi NY, Tikriti S, Dahahir HI, Clarkson TW, Smith JC, Doherty RA (1973) Methylmercury poisoning in Iraq. Science 181:230-241
2. Colombrita C, Calabrese V, Stella AM, Mattei F, Alkon DL, Scapagnini G (2003) Regional rat brain distribution of heme oxygenase-1 and manganese superoxide dismutase mRNA: relevance of redox homeostasis in the aging processes. Exp Biol Med (Maywood) 228:517-524
3. Cumming RC, Dargusch R, Fischer WH, Schubert D (2007) Increase in expression levels and resistance to sulfhydryl oxidation of peroxiredoxin isoforms in amyloid beta-resistant nerve cells. J Biol Chem 282:30523-30534
4. de Haan JB, Bladier C, Griffiths P, Kelner M, O'Shea RD, Cheung NS, Bronson RT, Silvestro MJ, Wild S, Zheng SS, Beart PM, Hertzog PJ, Kola I (1998) Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide. J Biol Chem 273:22528-22536
5. Eto K, Takizawa Y, Akagi H, Haraguchi K, Asano S, Takahata N, Tokunaga H (1999) Differential diagnosis between organic and inorganic mercury poisoning in human cases - the pathologic point of view. Toxicol Pathol 27:664-671
6. Farina M, Campos F, Vendrell I, Berenguer J, Barzi M, Pons S, Suñol C (2009) Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells. Toxicol Sci 112:416-426
7. Fujimura M, Usuki F, Sawada M, Takashima A (2009) Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology 30:1000-1007
8. Fujimura M, Usuki F, Kawamura M, Izumo S (2011) Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure. Toxicol Appl Pharmacol 250:1-9
9. Gunasekar P, Li L, Prabhakaran K, Eybl V, Borowitz JL, Isom GE (2001) Mechanisms of the apoptotic and necrotic actions of trimethyltin in cerebellar granule cells. Toxicol Sci 64:83-89
10. Kaur P, Aschner M, Syversen T (2007) Role of glutathione in determining the differential sensitivity between the cortical and cerebellar regions towards mercury-induced oxidative stress. Toxicology 230:164-177
11. Naganuma A, Miura K, Tanaka-Kagawa T, Kitahara J, Seko Y, Toyama H, Imura N (1998) Overexpression of manganese-superoxide dismutase prevents methylmercury toxicity in Hela cells. Life Sci 62:157-161
12. Polunas M, Halladay A, Tjalkens RB, Philbert MA, Lowndes H, Reuhl K (2011) Role of oxidative stress and the mitochondrial permeability transition in methylmercury cytotoxicity. Neurotoxicology 32:526-534
13. Prohaska JR, Bailey WR (1993) Persistent regional changes in brain copper, cuproenzymes and catecholamines following perinatal copper deficiency in mice. J Nutr 123:1226-1234
14. Takeuchi T (1982) Pathology of Minamata disease. With special reference to its pathogenesis. Acta Pathol Jpn 32:73-99
15. Usuki F, Yasutake A, Umehara F, Tokunaga H, Matsumoto M, Eto K, Ishiura S, Higuchi I (2001) In vivo protection of a water-soluble derivative of vitamin E, Trolox, against methylmercury-intoxication in the rat. Neurosci Lett 304:199-203
16. Usuki F, Yamashita A, Fujimura M (2011) Post-transcriptional defect of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure. J Biol Chem 286:6641-6649
17. Wang WZ, Oeschger FM, Lee S, Molnár Z (2009) High quality RNA from multiple brain regions simultaneously acquired by laser capture microdissection. BMC Mol Biol 10:69
18. Yee S, Choi BH (1996) Oxidative stress in neurotoxic effects of methylmercury poisoning. Neurotoxicology 17:17-26