The preclinical efficacy, selectivity and pharmacologic profile of MK-5932, an insulin-sparing selective glucocorticoid receptor modulator

European Journal of Pharmacology

Volumn 724, Issue 1, 2014, Pages 102-111

  Brandish, Philip E ^a   Anderson, Kenneth ^a   Baltus, Gretchen A ^a   Bai, Chang ^a   Bungard, Christopher J ^a   Bunting, Patricia ^a   Byford, Alan ^a   Chiu, Chi Sung ^a   Cicmil, Milenko ^a   Corcoran, Halea ^a   Euler, Danielle ^a   Fisher, John E ^a   Gambone, Carlo ^a   Hasbun Manning, Martha ^a   Kuklin, Nelly ^a   Landis, Elizabeth ^a   Lifsted, Traci Q ^a   McElwee Witmer, Sheila ^a   McIntosh, Ian S ^a   Meissner, Robert S ^a   Miao, John ^a   Mitchell, Helen J ^a   Musselman, Amy ^a   Schmidt, Azriel ^a   Shin, John ^a   Szczerba, Peter ^a   Thompson, Charles D ^a   Tribouley, Catherine ^a   Vogel, Robert L ^a   Warrier, Sudha ^a   Hershey, James C ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Diabetes; Glucocorticoid; Glucocorticoid receptor; Glucose; MK 5932

Indexed keywords

GAMMA INTERFERON; GLUCOCORTICOID; GLUCOSE; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; METHYLPREDNISOLONE; MK 5932; PREDNISONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; AREA UNDER THE CURVE; ARTHRITIS; ARTICLE; BINDING AFFINITY; CONTACT DERMATITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOG; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG EXPOSURE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; MALE; NEUTROPHIL COUNT; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS INHIBITION; RAT;

DIABETES; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOSE; MK-5932;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; BENZAMIDES; CELL LINE, TUMOR; COLLAGEN; CYTOKINES; DERMATITIS, CONTACT; DOGS; EDEMA; FEMALE; HELA CELLS; HUMANS; INDAZOLES; INSULIN; LIPOPOLYSACCHARIDES; MALE; METHYLPREDNISOLONE; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID;

EID: 84892583837     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.12.031     Document Type: Article

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