Neuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl) piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro

European Journal of Pharmacology

Volumn 724, Issue 1, 2014, Pages 193-203

  Kaushal, Nidhi ^a   Robson, Matthew J ^a   Rosen, Abagail ^a   McCurdy, Christopher R ^b   Matsumoto, Rae R ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Apoptosis; Caspase; Methamphetamine; Necrosis; Reactive oxygen species; Sigma receptors

Indexed keywords

6 ACETYL 3 [4 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]BUTYL]BENZO[D]OXAZOL 2(3H)ONE; CASPASE 3; CASPASE 8; CASPASE 9; METHAMPHETAMINE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SIGMA RECEPTOR LIGAND; SN 79; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; IN VITRO STUDY; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL; TEMPERATURE;

APOPTOSIS; CASPASE; METHAMPHETAMINE; NECROSIS; REACTIVE OXYGEN SPECIES; SIGMA RECEPTORS;

ANIMALS; APOPTOSIS; BENZOXAZOLES; CASPASES; CELL LINE, TUMOR; EIF-2 KINASE; FEVER; LIGANDS; METHAMPHETAMINE; MICE; NECROSIS; NEUROPROTECTIVE AGENTS; PIPERAZINES; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; RECEPTORS, SIGMA;

EID: 84892566889     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.12.039     Document Type: Article

References (47)

1. M.K. Bauer, M. Vogt, M. Los, J. Siegel, S. Wesselborg, and K. Schulze-Osthoff Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression J. Biol. Chem. 273 1998 8048 8055
2. T.V. Berghe, N. Vanlangenakker, E. Parthoens, W. Deckers, M. Devos, N. Festjens, C.J. Guerin, U.T. Brunk, W. Declercq, and P. Vandenabeele Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features Cell Death Differ. 17 2010 922 930
3. W.D. Bowen Sigma receptors: recent advances and new clinical potentials Pharm. Acta Helv. 74 2000 211 218
4. N. Cahuzac, W. Baum, V. Kirkin, F. Conchonaud, L. Wawrezinieck, D. Marguet, O. Janssen, M. Zornig, and A.O. Hueber Fas ligand is localized to membrane rafts, where it displays increased cell death-inducing activity Blood 107 2006 2384 2391
5. 2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells Cell Calcium 45 2009 340 345
6. K.W. Crawford, and W.D. Bowen Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines Cancer Res. 62 2002 313 322
7. C.C. Cruickshank, and K.R. Dyer A review of the clinical pharmacology of methamphetamine Addiction 104 2009 1085 1099
8. B. El Mchichi, A. Hadji, A. Vazquez, and G. Leca p38 MAPK and MSK1 mediate caspase-8 activation in manganese-induced mitochondria-dependent cell death Cell Death Differ. 14 2007 1826 1836
9. L. Formigli, L. Papucci, A. Tani, N. Schiavone, A. Tempestini, G.E. Orlandini, S. Capaccioli, and S.Z. Orlandini Aponecrosis: morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis J. Cell Physiol. 182 2000 41 49
10. C. Gajate, and F. Mollinedo Lipid rafts and Fas/CD95 signaling in cancer chemotherapy Recent Pat. Anticancer Drug Discovery 6 2011 274 283
11. L. Galluzzi, I. Vitale, J.M. Abrams, E.S. Alnemri, E.H. Barhrecke, M.V. Blagosklonny, T.M. Dawson, V.L. Dawson, W.S. El-Deiry, S. Fulda, E. Gottleib, D.R. Green, M.O. Hengartner, O. Kepp, R.A. Knight, S. Kumar, S.A. Lipton, X. Lu, F. Madeo, W. Malorni, P. Mehlen, G. Nunez, M.E. Peter, M. Piacentini, D.C. Rubinsztein, Y. Shi, H.-U. Simon, P. Vandenabeele, E. White, J. Yuan, B. Zhivotovsky, G. Melino, and G. Kroemer Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 Cell Death Differ. 19 2012 107 120
12. D. Gebreselassie, and W.D. Bowen Sigma-2 receptors are specifically localized to lipid rafts in rat liver membranes Eur. J. Pharmacol. 493 2004 19 28
13. B. Hamprecht, T. Glaser, G. Reiser, E. Bayer, and F. Propst Culture and characteristics of hormone-responsive neuroblastoma x glioma hybrid cells Methods Enzymol. 109 1985 316 341
14. 1 binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export J. Pharmacol. Exp. Ther. 306 2003 718 725
15. T. Hayashi, and T.P. Su Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival Cell 131 2007 596 610
16. J.R. Hornick, J. Xu, S. Vangveravong, Z. Tu, J.B. Mitchem, D. Spitzer, P. Goedegebuure, R.H. Mach, and W.G. Hawkins The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine Mol. Cancer 9 2010 298
17. S. Jayanthi, X. Deng, B. Ladenheim, M.T. McCoy, A. Cluster, N.S. Cai, and J.L. Cadet Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis Proc. Nat. Acad. Sci. U.S.A. 102 2005 868 873
18. Y.G. Jiang, Y. Peng, and K.S. Koussougbo Necroptosis: a novel therapeutic target for glioblastoma Med. Hypotheses 76 2011 350 352
19. S. Jonhede, A. Petersen, M. Zetterberg, and J.O. Karlsson Acute effects of the sigma-2 receptor agonist siramesine on lysosomal and extra-lysosomal proteolytic systems in lens epithelial cells Mol. Vis. 16 2010 819 827
20. B. Kadenbach, S. Arnold, I. Lee, and M. Huttemann The possible role of cytochrome c oxidase in stress-induced apoptosis and degenerative diseases Biochim. Biophys. Acta 1655 2004 400 408
21. N. Kaushal, and R.R. Matsumoto Role of sigma receptors in methamphetamine-induced neurotoxicity Curr. Neuropharmacol. 9 2011 54 57
22. Kaushal, N., McCurdy, C.R., Matsumoto, R.R., 2011b. SN79 Attenuates the Neurotoxic Effect of Methamphetamine: In Vivo and In Vitro Studies. Society for Neuroscience Meeting 2011 Program #367.03.
23. N. Kaushal, M.J. Robson, H. Vinnakota, S. Narayanan, B.A. Avery, C.R. McCurdy, and R.R. Matsumoto Synthesis and pharmacological evaluation of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a cocaine antagonist, in rodents AAPS J. 13 2011 336 346
24. N. Kaushal, M.J. Seminerio, J. Shaikh, M.A. Medina, C. Mesangeau, L.L. Wilson, C.R. McCurdy, and R.R. Matsumoto CM156, a high affinity sigma ligand, attenuates the stimulant and neurotoxic effects of methamphetamine in mice Neuropharmacology 61 2011 992 1000
25. N. Kaushal, M. Elliott, M.J. Robson, A.K. Iyer, Y. Rojanasakul, A. Coop, and R.R. Matsumoto AC927, a σ receptor ligand, blocks methamphetamine- induced release of dopamine and generation of reactive oxygen species in NG108-15 cells Mol. Pharmacol. 81 2012 299 308
26. I.N. Krasnova, and J.L. Cadet Methamphetamine toxicity and messengers of death Brain Res. Rev. 60 2009 379 407
27. G. Kroemer, L. Galluzzi, P. Vandenabeele, J. Abrams, E.S. Alnemri, E.H. Baehrecke, M.V. Blagosklonny, W.S. El-Deiry, P. Golstein, D.R. Green, M. Hengartner, R.A. Knight, S. Kumar, S.A. Lipton, W. Malorni, G. Nunez, M.E. Peter, J. Tschopp, J. Yuan, M. Piacentini, B. Zhivotovsky, and G. Melino Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 Cell. Death Differ. 16 2009 3 11
28. H. Li, H. Zhu, C.J. Xu, and J. Yuan Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis Cell 94 1998 491 501
29. W. Ma, J.J. Prancrazio, M. Coulombe, J. Dumm, R. Sathanoori, J.L. Barker, V.C. Kowtha, D.A. Stenger, and J.J. Hickman Neuronal and glial epitopes and transmitter-synthesizing enzymes appear in parallel with membrane excitability during neuroblastoma x glioma hybrid differentiation Brain Res. Dev. Brain Res. 106 1998 155 163
30. A. Marrazzo, J. Fiorito, L. Zappala, O. Prezzavento, S. Ronsisvalle, L. Pasquinucci, G.M. Scoto, R. Bernardini, and G. Ronsisvalle Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(+/-)-MRJF4] in prostate cancer cells Eur. J. Med. Chem. 46 2011 433 438
31. R.R. Matsumoto, J. Shaikh, L.L. Wilson, S. Vedam, and A. Coop Attenuation of methamphetamine-induced effects through the antagonism of sigma (σ) receptors: evidence from in vivo and in vitro studies Eur. Neuropsychopharmacol. 18 2008 871 881
32. D.J. McCann, A.D. Weissman, and T.P. Su Sigma-1 and sigma-2 sites in rat brain: comparison of regional, ontogenetic, and subcellular patterns Synapse 17 1994 182 189
33. P. Nicotera, and G. Melino Regulation of the apoptosis-necrosis switch Oncogene 23 2004 2757 2765
34. M.S. Ostenfeld, N. Fehrenbacher, M. Hoyer-Hansen, C. Thomsen, T. Farkas, and M. Jaattela Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress Cancer Res. 65 2005 8975 8983
35. A. Pal, D. Fontanilla, A. Gopalakrishnan, Y.-K. Chae, J.L. Markley, and A.E. Ruoho The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements Eur. J. Pharmacol. 682 2012 12 20
36. M.J. Robson, M.J. Seminerio, C.R. McCurdy, A. Coop, and R.R. Matsumoto σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation Pharmacol. Rep. 65 2013 343 349
37. M.J. Seminerio, N. Kaushal, J. Shaikh, J.D. Huber, A. Coop, and R.R. Matsumoto Sigma (σ) receptor ligand, AC927 (N-phenethylpiperidine oxalate), attenuates methamphetamine-induced hyperthermia and serotonin damage in mice Pharmacol. Biochem. Behav. 98 2011 12 20
38. J.R. Suchard Recovery from severe hyperthermia (45 degrees C) and rhabdomyolysis induced by methamphetamine body-stuffing West. J. Emerg. Med. 8 2007 93 95
39. C. Soti, A.S. Sreedhar, and P. Csermely Apoptosis, necrosis and cellular senescence: chaperone occupancy as a potential switch Aging Cell 2 2003 39 45
40. S.Y. Tsai, T. Hayashi, T. Mori, and T.P. Su Sigma-1 receptor chaperones and diseases Cent. Nerv. Syst. Agents Med. Chem. 9 2009 184 189
41. K. Vagnerova, P.D. Hurn, A. Bhardwaj, and J.R. Kirsch Sigma 1 receptor agonists act as neuroprotective drugs through inhibition of inducible nitric oxide synthase Anesth. Analg. 103 2006 430 434
42. B.J. Vilner, B.R. de Costa, and W.D. Bowen Cytotoxic effects of sigma ligands: sigma receptor-mediated alterations in cellular morphology and viability J. Neurosci. 15 1995 117 134
43. B.J. Vilner, and W.D. Bowen Modulation of cellular calcium by sigma-2 receptors: release from intracellular stores in human SK-N-SH neuroblastoma cells J. Pharmacol. Exp. Ther. 292 2000 900 911
44. X. Wang, and W.D. Bowen Sigma-2 receptors mediate apoptosis in SK-N-SH neuroblastoma cells via caspase-10-dependent Bid cleavage and mitochondrial release of endonuclease G and apoptosis-inducing factor Soc. Neurosci. Abstr. #90.1 2006
45. 2 receptor system and Bcl-XS Pharmacogen. J. 6 2006 279 288
46. Z.J. Yang, E.L. Carter, M.T. Torbey, L.J. Martin, and R.C. Koehler Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons Exp. Neurol. 221 2010 166 174
47. C. Zeng, S. Vangveravong, J. Xu, K.C. Chang, R.S. Hotchkiss, K.T. Wheeler, D. Shen, Z.P. Zhuang, H.F. Kung, and R.H. Mach Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy Cancer Res. 67 2007 6708 6716