Synthesis and pharmacological evaluation of 6-acetyl-3-(4-(4-(4- fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a cocaine antagonist, in rodents

AAPS Journal

Volumn 13, Issue 3, 2011, Pages 336-346

  Kaushal, Nidhi ^a   Robson, Matthew J ^a   Vinnakota, Harsha ^b   Narayanan, Sanju ^c   Avery, Bonnie A ^b   McCurdy, Christopher R ^c   Matsumoto, Rae R ^a,d  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c UNIVERSITY OF MISSISSIPPI   (United States)

^d NONE   (United States)

Author keywords

behavior; cocaine; monoamine transporter; pharmacokinetics; sigma receptor

Indexed keywords

6 ACETYL 3 [4 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]BUTYL]BENZO[D]OXAZOL 2(3H)ONE; CENTRAL DEPRESSANT AGENT; COCAINE; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; SEROTONIN 2 RECEPTOR; SIGMA OPIATE RECEPTOR; SN 79; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER;

ADVERSE OUTCOME; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CONVULSION; COORDINATION DISORDER; DOSE RESPONSE; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFECT; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; HYPERACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; OPEN FIELD BEHAVIOR; RAT; RECEPTOR AFFINITY; REPEATED DRUG DOSE; ROTAROD TEST; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 80052586797     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-011-9274-9     Document Type: Article

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