Acute effects of the sigma-2 receptor agonist siramesine on lysosomal and extra-lysosomal proteolytic systems in lens epithelial cells

Molecular Vision

Volumn 16, Issue , 2010, Pages 819-827

  Jonhede, S ^a   Petersen, A ^a   Zetterberg, M ^b   Karlsson, J O ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CALCEIN; CALPAIN; CASPASE 3; OPIATE AGONIST; PROTEASOME; SIRAMESINE; UNCLASSIFIED DRUG;

ACIDITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL FUNCTION; CELL GROWTH; CELL PH; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; LENS EPITHELIUM; LENS NUCLEUS; LYSOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ACIDS; CASPASES; CELL SURVIVAL; CELLS, CULTURED; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EPITHELIAL CELLS; HUMANS; INDOLES; LENS, CRYSTALLINE; LYSOSOMES; PEPTIDE HYDROLASES; RECEPTORS, SIGMA; SPIRO COMPOUNDS;

EID: 77955626426     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Vilner BJ, de Costa BR, Bowen WD. Cytotoxic effects of sigma ligands: sigma receptor-mediated alterations in cellular morphology and viability. J Neurosci 1995; 15:117-34.
2. Hashimoto K, Ishiwata K. Sigma receptor ligands: possible application as therapeutic drugs and as radiopharmaceuticals. Curr Pharm Des 2006; 12:3857-76.
3. Mach RH, Smith CR, al-Nabulsi I, Whirrett BR, Childers SR, Wheeler KT. Sigma 2 receptors as potential biomarkers of proliferation in breast cancer. Cancer Res 1997; 57:156-61.
4. Crawford KW, Bowen WD. Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines. Cancer Res 2002; 62:313-22.
5. Colabufo NA, Berardi F, Contino M, Niso M, Abate C, Perrone R, Tortorella V. Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines. Naunyn Schmiedebergs Arch Pharmacol 2004; 370:106-13.
6. Crawford KW, Coop A, Bowen WD. sigma(2) Receptors regulate changes in sphingolipid levels in breast tumor cells. Eur J Pharmacol 2002; 443:207-9.
7. Ostenfeld MS, Fehrenbacher N, Hoyer-Hansen M, Thomsen C, Farkas T, Jaattela M. Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress. Cancer Res 2005; 65:8975-83.
8. Azzariti A, Colabufo NA, Berardi F, Porcelli L, Niso M, Simone GM, Perrone R, Paradiso A. Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer. Mol Cancer Ther 2006; 5:1807-16.
9. Cassano G, Gasparre G, Contino M, Niso M, Berardi F, Perrone R, Colabufo NA. The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells. Cell Calcium 2006; 40:23-8.
10. Monassier L, Manoury B, Bellocq C, Weissenburger J, Greney H, Zimmermann D, Erhardt JD, Jaillon P, Baró I, Bousquet P. sigma(2)-receptor ligand-mediated inhibition of inwardly rectifying K(+) channels in the heart. J Pharmacol Exp Ther 2007; 322:341-50.
11. Zeng C, Vangveravong S, Xu J, Chang KC, Hotchkiss RS, Wheeler KT, Shen D, Zhuang ZP, Kung HF, Mach RH. Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer Res 2007; 67:6708-16.
12. Parry MJ, Alakoskela JM, Khandelia H, Kumar SA, Jaattela M, Mahalka AK, Kinnunen PK. High-affinity small moleculephospholipid complex formation: binding of siramesine to phosphatidic acid. J Am Chem Soc 2008; 130:12953-60.
13. Perregaard J, Moltzen EK, Meier E, Sanchez C. Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. J Med Chem 1995; 38:1998-2008.
14. Soby KK, Mikkelsen JD, Meier E, Thomsen C. Lu 28-179 labels a sigma(2)-site in rat and human brain. Neuropharmacology 2002; 43:95-100.
15. Groth-Pedersen L, Ostenfeld MS, Hoyer-Hansen M, Nylandsted J, Jaattela M. Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosomedestabilizing siramesine. Cancer Res 2007; 67:2217-25.
16. Brent PJ, Pang GT. Sigma binding site ligands inhibit cell proliferation in mammary and colon carcinoma cell lines and melanoma cells in culture. Eur J Pharmacol 1995; 278:151-60.
17. Spruce BA, Campbell LA, McTavish N, Cooper MA, Appleyard MV, O'Neill M, Howie J, Samson J, Watt S, Murray K, McLean D, Leslie NR, Safrany ST, Ferguson MJ, Peters JA, Prescott AR, Box G, Hayes A, Nutley B, Raynaud F, Dawnes CP, Lambert JJ, Thompson AM, Eccles S. Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res 2004; 64:4875-86.
18. Wang L, Prescott AR, Spruce BA, Sanderson J, Duncan G. Sigma receptor antagonists inhibit human lens cell growth and induce pigmentation. Invest Ophthalmol Vis Sci 2005; 46:1403-8.
19. Heading C, Siramesine H. Lundbeck. Curr Opin Investig Drugs 2001; 2:266-70.
20. Petersen A, Zetterberg M, Sjostrand J, Palsson AZ, Karlsson JO. Potential protective effects of NSAIDs/ASA in oxidatively stressed human lens epithelial cells and intact mouse lenses in culture. Ophthalmic Res 2005; 37:318-27.
21. Karlsson JO, Andersson M, Kling-Petersen A, Sjostrand J. Proteolysis in human lens epithelium determined by a cellpermeable substrate. Invest Ophthalmol Vis Sci 1999; 40:261-4.
22. Awasthi N, Guo S, Wagner BJ. Posterior capsular opacification: a problem reduced but not yet eradicated. Arch Ophthalmol 2009; 127:555-62.
23. Findl O, Buehl W, Bauer P, Sycha T. Interventions for preventing posterior capsule opacification. Cochrane database of systematic reviews. 2007. http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD003738/frame.html
24. Ostenfeld MS, Hoyer-Hansen M, Bastholm L, Fehrenbacher N, Olsen OD, Groth-Pedersen L, Puustinen P, Kirkegaard-Sørensen T, Nylandsted J, Farkas T, Jäättelä M. Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Autophagy 2008; 4:487-99.
25. Burq MA, Taqui AM. Frequency of retinal detachment and other complications after neodymium:Yag laser capsulotomy. J Pak Med Assoc 2008; 58:550-2.
26. Ranta P, Tommila P, Kivela T. Retinal breaks and detachment after neodymium: YAG laser posterior capsulotomy: fiveyear incidence in a prospective cohort. J Cataract Refract Surg 2004; 30:58-66.