Cytosolic phospholipase A2 regulates TNF-induced production of joint destructive effectors in synoviocytes

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Sommerfelt, Randi M ^a   Feuerherm, Astrid J ^a   Jones, Kymry ^a,b   Johansen, Berit ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; ARACHIDONOYL COENZYME A; CYCLOOXYGENASE 2; CYTOSOLIC PHOSPHOLIPASE A2; INTERLEUKIN 6; PROSTAGLANDIN E2; STROMELYSIN; TUMOR NECROSIS FACTOR;

ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; PATHOGENESIS; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE;

ARTHRITIS, RHEUMATOID; CELL LINE; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GROUP IV PHOSPHOLIPASES A2; HUMANS; INFLAMMATION MEDIATORS; SYNOVIAL MEMBRANE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84892562024     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083555     Document Type: Article

References (52)

1. Harris ED, Budd RC, Firestein GS, Genovese MC, Sergent JS et al. (2005) Kelley's textbook of rheumatology - Volume I. 7 ed. Philadelphia: Elseviers Saunders.
2. Bartok B, Firestein GS (2010) Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev 233: 233-255. doi:10.1111/j.0105- 2896.2009.00859.x. PubMed: 20193003.
3. Choy EHS, Panayi GS (2001) Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis. N Engl J Med 344: 907-916. doi: 10.1056/ NEJM200103223441207. PubMed: 11259725.
4. Feldmann M, Brennan FM, Maini RN (1996) Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14: 397-440. doi:10.1146/annurev.immunol.14.1.397. PubMed: 8717520.
5. Choy E (2012) Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology 51: v3-v11
6. Clark JD, Lin LL, Kriz RW, Ramesha CS, Sultzman LA et al. (1991) A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+- dependent translocation domain with homology to PKC and GAP. Cell 65: 1043-1051. doi:10.1016/0092-8674(91)90556-E. PubMed: 1904318.
7. Sapirstein A, Bonventre JV (2000) Specific physiological roles of cytosolic phospholipase A2 as defined by gene knockouts. Biochim Biophys Acta 1488: 139-148. doi:10.1016/S1388-1981(00)00116-5. PubMed: 11080683.
8. Dieter P, Kolada A, Kamionka S, Schadow A, Kaszkin M (2002) Lipopolysaccharide-induced release of arachidonic acid and prostaglandins in liver macrophages: Regulation by Group IV cytosolic phospholipase A2, but not by Group V and Group IIA secretory phospholipase A2. Cell Signal 14: 199-204. doi:10.1016/S0898-6568(01)00243-1. PubMed: 11812647.
9. Walters JN, Bickford JS, Beachy DE, Newsom KJ, Herlihy JDH et al. (2011) cPLA2α gene activation by IL-1β is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: A positive feedback loop. Cell Signal 23: 1944-1951. doi: 10.1016/j.cellsig.2011. 07.002. PubMed: 21771656.
10. Dennis EA, Cao J, Hsu YH, Magrioti V, Kokotos G (2011) Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention. Chem Rev 111: 6130-6185. doi:10.1021/cr200085w. PubMed: 21910409.
11. Haeggström JZ, Rinaldo-Matthis A, Wheelock CE, Wetterholm A (2010) Advances in eicosanoid research, novel therapeutic implications. Biochem Biophys Res Commun 396: 135-139. doi:10.1016/j.bbrc.2010.03.140. PubMed: 20494126.
12. Funk CD (2001) Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology. Science 294: 1871-1875. doi:10.1126/science.294.5548.1871. PubMed: 11729303.
13. Crofford LJ (2002) Specific cyclooxygenase-2 inhibitors: what have we learned since they came into widespread clinical use? Curr Opin Rheumatol 14: 225-230. doi:10.1097/00002281-200205000-00005. PubMed: 11981317.
14. Mukherjee D, Nissen SE, Topol EJ (2001) Risk of cardiovascular events associated with selective COX-2 inhibitors. JAMA 286: 954-959. doi:10.1001/jama.286.8.954. PubMed: 11509060.
15. Laine L, Bombardier C, Hawkey CJ, Davis B, Shapiro D et al. (2002) Stratifying the risk of NSAID-related upper gastrointestinal clinical events: Results of a double-blind outcomes study in patients with rheumatoid arthritis. Gastroenterology 123: 1006-1012. doi:10.1053/gast.2002.36013. PubMed: 12360461.
16. Vuolteenaho K, Moilanen T, Moilanen E (2008) Non-steroidal anti-inflammatory drugs, cyclooxygenase-2 and the bone healing process. Basic Clin Pharmacol Toxicol 102: 10-14. PubMed: 17973900.
17. Suryaprasad AG, Prindiville T (2003) The biology of TNF blockade. Autoimmun Rev 2: 346-357. doi:10.1016/S1568-9972(03)00048-X. PubMed: 14550876.
18. Feldmann M, Maini RN (2001) Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol 19: 163-196. doi: 10.1146/annurev.immunol.19.1.163. PubMed: 11244034.
19. Bongartz TA, Sutton J, Sweeting MJ, Buchan I, Matteson EL et al. (2006) Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 295: 2275-2285. doi:10.1001/jama.295.19.2275. PubMed: 16705109.
20. Courties G, Baron M, Presumey J, Escriou V, van Lent P et al. (2011) Cytosolic phospholipase A2α gene silencing in the myeloid lineage alters development of Th1 responses and reduces disease severity in collagen-induced arthritis. Arthritis Rheum 63: 681-690. doi:10.1002/art.30174. PubMed: 21360497.
21. Hegen M, Sun L, Uozumi N, Kume K, Goad ME et al. (2003) Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis. J Exp Med 197: 1297-1302. doi:10.1084/jem.20030016. PubMed: 12743172.
22. Raichel L, Berger S, Hadad N, Kachko L, Karter M et al. (2008) Reduction of cPLA2a overexpression: An efficient anti-inflammatory therapy for collagen-induced arthritis. Eur J Immunol 38: 2905-2915. doi:10.1002/eji. 200838545. PubMed: 18825749.
23. Tai N, Kuwabara K, Kobayashi M, Yamada K, Ono T et al. (2010) Cytosolic phospholipase A2 alpha inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model. Inflamm Res 59: 53-62. doi:10.1007/s00011-009-0069-8. PubMed: 19655230.
24. Anthonsen MW, Andersen S, Solhaug A, Johansen B (2001) Atypical λ/ιPKC Conveys 5-Lipoxygenase/Leukotriene B4-mediated Cross-talk between Phospholipase A2s Regulating NF-κB Activation in Response to Tumor Necrosis Factor-α and Interleukin-1β. J Biol Chem 276: 35344-35351. doi:10.1074/jbc.M105264200. PubMed: 11445585.
25. Huwiler A, Feuerherm AJ, Sakem B, Pastukhov O, Filipenko I et al. (2012) The ω3-polyunsaturated fatty acid derivatives AVX001 and AVX002 directly inhibit cytosolic phospholipase A2 and suppress prostaglandin E2 formation in mesangial cells. Br J Pharmacol 168: 1691-1701.
26. Wijkander J, Sundler R (1991) An 100-kDa arachidonate-mobilizing phospholipase A2 in mouse spleen and the macrophage cell line J774. Eur J Biochem 202: 873-880. doi:10.1111/j.1432-1033.1991.tb16445.x. PubMed: 1662616.
27. Lucas KK, Dennis EA (2005) Distinguishing phospholipase A2 types in biological samples by employing group-specific assays in the presence of inhibitors. Prostaglandins Other Lipid Mediat 77: 235-248. doi: 10.1016/j.prostaglandins.2005.02.004. PubMed: 16099408.
28. Pfaffl MW, Horgan GW, Dempfle L (2002) Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30: e36. doi:10.1093/nar/30.9.e36. PubMed: 11972351.
29. Ruijter JM, Ramakers C, Hoogaars WMH, Karlen Y, Bakker O et al. (2009) Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data. Nucleic Acids Res 37: e45. doi:10.1093/nar/gkp045. PubMed: 19237396.
30. Yamanaka H, Matsuda Y, Tanaka M, Sendo W, Nakajima H et al. (2000) Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis. Arthritis Rheum 43: 852-858. doi: 10.1002/1529-0131(200004)43:4. PubMed: 10765930.
31. Koch AE, Polverini PJ, Kunkel SL, Harlow LA, DiPietro LA et al. (1992) Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258: 1798-1801. doi:10.1126/science.1281554. PubMed: 1281554.
32. Tchetverikov I, Ronday HK, van El B, Kiers GH, Verzijl N et al. (2004) MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis. Ann Rheum Dis 63: 881-883. doi:10.1136/ard.2003.013243. PubMed: 15194590.
33. Das ST, Rajagopalan L, Guerrero-Plata A, Sai J, Richmond A, Garofalo RP, Rajarathnam K (2010) Monomeric and dimeric CXCL8 are both essential for in vivo neutrophil recruitment. PLOS ONE 5: e11754. doi: 10.1371/journal.pone.0011754. PubMed: 20668677.
34. Tian J, Chen JW, Gao JS, Li L, Xie X (2013) Resveratrol inhibits TNF-α-induced IL-1β, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway. Rheumatol Int 33: 1829-1835. doi:10.1007/s00296-012-2657-0. PubMed: 23328930.
35. Street IP, Lin HK, Laliberté F, Ghomashchi F, Wang Z et al. (1993) Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2. Biochemistry 32: 5935-5940. doi:10.1021/bi00074a003. PubMed: 8018213.
36. Chenevier-Gobeaux C, Simonneau C, Therond P, Bonnefont-Rousselot D, Poiraudeau S et al. (2007) Implication of cytosolic phospholipase A2 (cPLA2) in the regulation of human synoviocyte NADPH oxidase (Nox2) activity. Life Sci 81: 1050-1058. doi:10.1016/j.lfs.2007.08.018. PubMed: 17869312.
37. Hulkower KI, Wertheimer SJ, Levin W, Coffey JW, Anderson CM et al. (1994) Interleukin-1β induces cytosolic phospholipase A2 and prostaglandin H synthase in rheumatoid synovial fibroblasts. Arthritis Rheum 37: 653-661. doi:10.1002/art.1780370508. PubMed: 8185692.
38. Thommesen L, Sjursen W, Gåsvik K, Hanssen W, Brekke OL et al. (1998) Selective inhibitors of cytosolic or secretory phospholipase A2 block TNF-induced activation of transcription factor nuclear factor-kappa B and expression of ICAM-1. J Immunol 161: 3421-3430. PubMed: 9759860.
39. Anthonsen MW, Solhaug A, Johansen B (2001) Functional coupling between secretory and cytosolic phospholipase A2 modulates tumor necrosis factor-alpha- and interleukin-1beta-induced NF-kappa B activation. J Biol Chem 276: 30527-30536. doi:10.1074/jbc.M008481200. PubMed: 11390371.
40. Sjursen W, Brekke OL, Johansen B (2000) Secretory and cytosolic phospholipase A2 regulate the long-term cytokine-induced eicosanoid production in human keratinocytes. Cytokine 12: 1189-1194. doi: 10.1006/cyto.1999.0727. PubMed: 10930295.
41. Gentile LB, Piva B, Capizzani BC, Furlaneto LGB, Moreira LS et al. (2010) Hypertonic environment elicits cyclooxygenase-2-driven prostaglandin E2 generation by colon cancer cells: Role of cytosolic phospholipase A2-α and kinase signaling pathways. Prostaglandins, Leukot, Essent Fatty Acids 82: 131-139. doi:10.1016/j.plefa.2009.11.005.
42. Sugimoto Y, Narumiya S (2007) Prostaglandin E Receptors. J Biol Chem 282: 11613-11617. PubMed: 17329241.
43. McCoy JM, Wicks JR, Audoly LP (2002) The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis. J Clin Invest 110: 651-658. doi:10.1172/JCI0215528. PubMed: 12208866.
44. Gosset M, Pigenet A, Salvat C, Berenbaum F, Jacques C (2010) Inhibition of Matrix Metalloproteinase-3 and -13 Synthesis Induced by IL-1β in Chondrocytes from Mice Lacking Microsomal Prostaglandin E Synthase-1. J Immunol 185: 6244-6252. doi:10.4049/jimmunol.0903315. PubMed: 20943996.
45. Miyaura C, Inada M, Matsumoto C, Ohshiba T, Uozumi N et al. (2003) An Essential Role of Cytosolic Phospholipase A2α in Prostaglandin E2-mediated Bone Resorption Associated with Inflammation. J Exp Med 197: 1303-1310. doi:10.1084/jem.20030015. PubMed: 12743173.
46. Sacco K, Portelli M, Pollacco J, Schembri-Wismayer P, Calleja-Agius J (2012) The role of prostaglandin E2 in endometriosis. Gynecol Endocrinol 28: 134-138. doi:10.3109/09513590.2011.588753. PubMed: 22003899.
47. Lee J, Banu SK, Subbarao T, Starzinski-Powitz A, Arosh JA (2011) Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases. Mol Cell Endocrinol 332: 306-313. doi:10.1016/j.mce.2010.11.022. PubMed: 21111772.
48. Sapirstein A, Saito H, Texel SJ, Samad TA, O'Leary E et al. (2005) Cytosolic phospholipase A2α regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation. Am J Physiol Regul Integr Comp Physiol 288: R1774-R1782. doi:10.1152/ajpregu.00815.2004. PubMed: 15718387.
49. Cunnane G, Fitzgerald O, Beeton C, Cawston TE, Bresnihan B (2001) Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis. Arthritis Rheum 44: 2263-2264. doi: 10.1002/1529-0131(200110)44:10. PubMed: 11665967.
50. Pawliczak R, Logun C, Madara P, Lawrence M, Woszczek G et al. (2004) Cytosolic phospholipase A2 group IVα but not secreted phospholipase A2 group IIA, V, or X induces interleukin-8 and cyclooxygenase-2 gene and protein expression through peroxisome proliferator-activated receptors γ 1 and 2 in human lung cells. J Biol Chem 279: 48550-48561. doi:10.1074/jbc.M408926200. PubMed: 15331599.
51. Chi PL, Chen YW, Hsiao LD, Chen YL, Yang CM (2012) Heme oxygenase 1 attenuates interleukin-1β-induced cytosolic phospholipase A2 expression via a decrease in NADPH oxidase/reactive oxygen species/activator protein 1 activation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 64: 2114-2125. doi: 10.1002/art.34371. PubMed: 22231145.
52. Malaviya R, Ansell J, Hall L, Fahmy M, Argentieri RL et al. (2006) Targeting cytosolic phospholipase A2 by arachidonyl trifluoromethyl ketone prevents chronic inflammation in mice. Eur J Pharmacol 539: 195-204. doi:10.1016/j.ejphar.2006.03.018. PubMed: 16712837.