-
1
-
-
33646476551
-
Osteoarthritis: Pathobiology-targets and ways for therapeutic intervention
-
Aigner, T., A. Sachse, P. M. Gebhard, and H. I. Roach. 2006. Osteoarthritis: pathobiology-targets and ways for therapeutic intervention. Adv. Drug Deliv. Rev. 58:128-149.
-
(2006)
Adv. Drug Deliv. Rev.
, vol.58
, pp. 128-149
-
-
Aigner, T.1
Sachse, A.2
Gebhard, P.M.3
Roach, H.I.4
-
2
-
-
0041328097
-
Role of eicosanoids in structural degradation in osteoarthritis
-
Laufer, S. 2003. Role of eicosanoids in structural degradation in osteoarthritis. Curr. Opin. Rheumatol. 15:623-627.
-
(2003)
Curr. Opin. Rheumatol.
, vol.15
, pp. 623-627
-
-
Laufer, S.1
-
3
-
-
0028348850
-
Interrelationships between interleukin (IL)-1, IL-6 and IL-8 in synovial fluid of various arthropathies
-
Bertazzolo, N., L. Punzi, M. P. Stefani, G. Cesaro, M. Pianon, B. Finco, and S. Todesco. 1994. Interrelationships between interleukin (IL)-1, IL-6 and IL-8 in synovial fluid of various arthropathies. Agents Actions 41:90-92.
-
(1994)
Agents Actions
, vol.41
, pp. 90-92
-
-
Bertazzolo, N.1
Punzi, L.2
Stefani, M.P.3
Cesaro, G.4
Pianon, M.5
Finco, B.6
Todesco, S.7
-
4
-
-
0031965384
-
Autocrine production of IL-1 beta by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8
-
Attur, M. G., I. R. Patel, R. N. Patel, S. B. Abramson, and A. R. Amin. 1998. Autocrine production of IL-1 beta by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8. Proc. Assoc. Am. Physicians 110:65-72.
-
(1998)
Proc. Assoc. Am. Physicians
, vol.110
, pp. 65-72
-
-
Attur, M.G.1
Patel, I.R.2
Patel, R.N.3
Abramson, S.B.4
Amin, A.R.5
-
5
-
-
0030945182
-
Superinduction of cyclooxygenase-2 activity in human osteoarthritis- affected cartilage. Influence of nitric oxide
-
Amin, A. R., M. Attur, R. N. Patel, G. D. Thakker, P. J. Marshall, J. Rediske, S. A. Stuchin, I. R. Patel, and S. B. Abramson. 1997. Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide. J. Clin. Invest. 99:1231-1237.
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 1231-1237
-
-
Amin, A.R.1
Attur, M.2
Patel, R.N.3
Thakker, G.D.4
Marshall, P.J.5
Rediske, J.6
Stuchin, S.A.7
Patel, I.R.8
Abramson, S.B.9
-
6
-
-
0034566271
-
COX-2, NO, and cartilage damage and repair
-
Amin, A. R., M. Dave, M. Attur, and S. B. Abramson. 2000. COX-2, NO, and cartilage damage and repair. Curr. Rheumatol. Rep. 2:447-453.
-
(2000)
Curr. Rheumatol. Rep.
, vol.2
, pp. 447-453
-
-
Amin, A.R.1
Dave, M.2
Attur, M.3
Abramson, S.B.4
-
7
-
-
0032589664
-
Microdetermination of prostaglandin E2 in joint fluid in rheumatoid arthritis patients using gas chromatography/selected ion monitoring
-
Hishinuma, T., H. Nakamura, T. Sawai, M. Uzuki, Y. Itabash, and M. Mizugaki. 1999. Microdetermination of prostaglandin E2 in joint fluid in rheumatoid arthritis patients using gas chromatography/selected ion monitoring. Prostaglandins Other Lipid Mediat. 58:179-186.
-
(1999)
Prostaglandins Other Lipid Mediat
, vol.58
, pp. 179-186
-
-
Hishinuma, T.1
Nakamura, H.2
Sawai, T.3
Uzuki, M.4
Itabash, Y.5
Mizugaki, M.6
-
8
-
-
33745266737
-
Prostaglandin E2 synthesis and secretion: The role of PGE2 synthases
-
Park, J. Y., M. H. Pillinger, and S. B. Abramson. 2006. Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. Clin. Immunol. 119:229-240.
-
(2006)
Clin. Immunol.
, vol.119
, pp. 229-240
-
-
Park, J.Y.1
Pillinger, M.H.2
Abramson, S.B.3
-
9
-
-
16644401116
-
Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis
-
Kojima, F., H. Naraba, S. Miyamoto, M. Beppu, H. Aoki, and S. Kawai. 2004. Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis. Arthritis Res. Ther. 6: R355-R365.
-
(2004)
Arthritis Res. Ther.
, vol.6
-
-
Kojima, F.1
Naraba, H.2
Miyamoto, S.3
Beppu, M.4
Aoki, H.5
Kawai, S.6
-
10
-
-
4344586823
-
Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: Critical roles of the ERK-1/2 and p38 signaling pathways
-
Masuko-Hongo, K., F. Berenbaum, L. Humbert, C. Salvat, M. B. Goldring, and S. Thirion. 2004. Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways. Arthritis Rheum. 50:2829-2838.
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 2829-2838
-
-
Masuko-Hongo, K.1
Berenbaum, F.2
Humbert, L.3
Salvat, C.4
Goldring, M.B.5
Thirion, S.6
-
11
-
-
18744408157
-
Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes
-
Li, X., H. Afif, S. Cheng, J. Martel-Pelletier, J. P. Pelletier, P. Ranger, and H. Fahmi. 2005. Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. J. Rheumatol. 32:887-895.
-
(2005)
J. Rheumatol.
, vol.32
, pp. 887-895
-
-
Li, X.1
Afif, H.2
Cheng, S.3
Martel-Pelletier, J.4
Pelletier, J.P.5
Ranger, P.6
Fahmi, H.7
-
12
-
-
2642545047
-
Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium
-
Westman, M., M. Korotkova, E. af Klint, A. Stark, L. P. Audoly, L. Klareskog, A. K. Ulfgren, and P. J. Jakobsson. 2004. Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium. Arthritis Rheum. 50:1774-1780.
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 1774-1780
-
-
Westman, M.1
Korotkova, M.2
Klint, E.A.3
Stark, A.4
Audoly, L.P.5
Klareskog, L.6
Ulfgren, A.K.7
Jakobsson, P.J.8
-
13
-
-
0036732016
-
Coexpression of microsomal prostaglandin E synthase with cyclooxygenase-2 in human rheumatoid synovial cells
-
Kojima, F., H. Naraba, Y. Sasaki, R. Okamoto, T. Koshino, and S. Kawai. 2002. Coexpression of microsomal prostaglandin E synthase with cyclooxygenase-2 in human rheumatoid synovial cells. J. Rheumatol. 29:1836-1842.
-
(2002)
J. Rheumatol.
, vol.29
, pp. 1836-1842
-
-
Kojima, F.1
Naraba, H.2
Sasaki, Y.3
Okamoto, R.4
Koshino, T.5
Kawai, S.6
-
14
-
-
0035400078
-
Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells
-
Stichtenoth, D. O., S. Thorén, H. Bian, M. Peters-Golden, P. J. Jakobsson, and L. J. Crofford. 2001. Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. J. Immunol. 167:469-474.
-
(2001)
J. Immunol.
, vol.167
, pp. 469-474
-
-
Stichtenoth, D.O.1
Thorén, S.2
Bian, H.3
Peters-Golden, M.4
Jakobsson, P.J.5
Crofford, L.J.6
-
15
-
-
4043169152
-
Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin E synthase-1
-
Kamei, D., K. Yamakawa, Y. Takegoshi, M. Mikami-Nakanishi, Y. Nakatani, S. Oh-Ishi, H. Yasui, Y. Azuma, N. Hirasawa, K. Ohuchi, et al. 2004. Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin E synthase-1. J. Biol. Chem. 279:33684-33695.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 33684-33695
-
-
Kamei, D.1
Yamakawa, K.2
Takegoshi, Y.3
Mikami-Nakanishi, M.4
Nakatani, Y.5
Oh-Ishi, S.6
Yasui, H.7
Azuma, Y.8
Hirasawa, N.9
Ohuchi, K.10
-
16
-
-
34247160020
-
Microsomal prostaglandin E synthase-1 deficiency is associated with elevated peroxisome proliferator-activated receptor gamma: Regulation by prostaglandin E2 via the phosphatidylinositol 3-kinase and Akt pathway
-
Kapoor, M., F. Kojima, M. Qian, L. Yang, and L. J. Crofford. 2007. Microsomal prostaglandin E synthase-1 deficiency is associated with elevated peroxisome proliferator-activated receptor gamma: regulation by prostaglandin E2 via the phosphatidylinositol 3-kinase and Akt pathway. J. Biol. Chem. 282:5356-5366.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 5356-5366
-
-
Kapoor, M.1
Kojima, F.2
Qian, M.3
Yang, L.4
Crofford, L.J.5
-
17
-
-
20444494334
-
Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages
-
Trebino, C. E., J. D. Eskra, T. S. Wachtmann, J. R. Perez, T. J. Carty, and L. P. Audoly. 2005. Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages. J. Biol. Chem. 280:16579-16585.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 16579-16585
-
-
Trebino, C.E.1
Eskra, J.D.2
Wachtmann, T.S.3
Perez, J.R.4
Carty, T.J.5
Audoly, L.P.6
-
18
-
-
0043261465
-
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase
-
Trebino, C. E., J. L. Stock, C. P. Gibbons, B. M. Naiman, T. S. Wachtmann, J. P. Umland, K. Pandher, J. M. Lapointe, S. Saha, M. L. Roach, et al. 2003. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc. Natl. Acad. Sci. USA 100:9044-9049.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 9044-9049
-
-
Trebino, C.E.1
Stock, J.L.2
Gibbons, C.P.3
Naiman, B.M.4
Wachtmann, T.S.5
Umland, J.P.6
Pandher, K.7
Lapointe, J.M.8
Saha, S.9
Roach, M.L.10
-
20
-
-
33744496575
-
The role of collagenolytic matrix metalloproteinases in the loss of articular cartilage in osteoarthritis
-
Smith, G. N., Jr. 2006. The role of collagenolytic matrix metalloproteinases in the loss of articular cartilage in osteoarthritis. Front. Biosci. 11:3081-3095.
-
(2006)
Front. Biosci.
, vol.11
, pp. 3081-3095
-
-
Smith Jr., G.N.1
-
21
-
-
0029766216
-
Metalloproteinase inhibitors and the prevention of connective tissue breakdown
-
Cawston, T. E. 1996. Metalloproteinase inhibitors and the prevention of connective tissue breakdown. Pharmacol. Ther. 70:163-182.
-
(1996)
Pharmacol. Ther.
, vol.70
, pp. 163-182
-
-
Cawston, T.E.1
-
22
-
-
0034615550
-
Tissue inhibitors of metalloproteinases: Evolution, structure and function
-
Brew, K., D. Dinakarpandian, and H. Nagase. 2000. Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim. Biophys. Acta 1477:267-283.
-
(2000)
Biochim. Biophys. Acta
, vol.1477
, pp. 267-283
-
-
Brew, K.1
Dinakarpandian, D.2
Nagase, H.3
-
24
-
-
32044475196
-
Cartilage breakdown in rheumatoid arthritis
-
Rannou, F., M. François, M. T. Corvol, and F. Berenbaum. 2006. Cartilage breakdown in rheumatoid arthritis. Joint Bone Spine 73:29-36.
-
(2006)
Joint Bone Spine
, vol.73
, pp. 29-36
-
-
Rannou, F.1
François, M.2
Corvol, M.T.3
Berenbaum, F.4
-
25
-
-
0029801511
-
Effects of indomethacin on the production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by human articular chondrocytes
-
Yamada, H., T. Kikuchi, O. Nemoto, K. Obata, H. Sato, M. Seiki, and M. Shinmei. 1996. Effects of indomethacin on the production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by human articular chondrocytes. J. Rheumatol. 23:1739-1743.
-
(1996)
J. Rheumatol.
, vol.23
, pp. 1739-1743
-
-
Yamada, H.1
Kikuchi, T.2
Nemoto, O.3
Obata, K.4
Sato, H.5
Seiki, M.6
Shinmei, M.7
-
26
-
-
43449100928
-
Celecoxib inhibits production of MMP and NO via down-regulation of NF-kappaB and JNK in a PGE2 independent manner in human articular chondrocytes
-
Tsutsumi, R., H. Ito, T. Hiramitsu, K. Nishitani, M. Akiyoshi, T. Kitaori, T. Yasuda, and T. Nakamura. 2008. Celecoxib inhibits production of MMP and NO via down-regulation of NF-kappaB and JNK in a PGE2 independent manner in human articular chondrocytes. Rheumatol. Int. 28:727-736.
-
(2008)
Rheumatol. Int.
, vol.28
, pp. 727-736
-
-
Tsutsumi, R.1
Ito, H.2
Hiramitsu, T.3
Nishitani, K.4
Akiyoshi, M.5
Kitaori, T.6
Yasuda, T.7
Nakamura, T.8
-
27
-
-
3242769159
-
Interleukin-1beta stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes
-
Choi, Y. A., D. J. Lee, H. K. Lim, J. H. Jeong, J. K. Sonn, S. S. Kang, and S. H. Baek. 2004. Interleukin-1beta stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes. Exp. Mol. Med. 36:226-232.
-
(2004)
Exp. Mol. Med.
, vol.36
, pp. 226-232
-
-
Choi, Y.A.1
Lee, D.J.2
Lim, H.K.3
Jeong, J.H.4
Sonn, J.K.5
Kang, S.S.6
Baek, S.H.7
-
28
-
-
0035985513
-
Evaluation of the influence of prostaglandin E2 on recombinant equine interleukin-1beta-stimulated matrix metalloproteinases 1, 3, and 13 and tissue inhibitor of matrix metalloproteinase 1 expression in equine chondrocyte cultures
-
Tung, J. T., C. E. Arnold, L. H. Alexander, V. Yuzbasiyan-Gurkan, P. J. Venta, D. W. Richardson, and J. P. Caron. 2002. Evaluation of the influence of prostaglandin E2 on recombinant equine interleukin-1beta-stimulated matrix metalloproteinases 1, 3, and 13 and tissue inhibitor of matrix metalloproteinase 1 expression in equine chondrocyte cultures. Am. J. Vet. Res. 63:987-993.
-
(2002)
Am. J. Vet. Res.
, vol.63
, pp. 987-993
-
-
Tung, J.T.1
Arnold, C.E.2
Alexander, L.H.3
Yuzbasiyan-Gurkan, V.4
Venta, P.J.5
Richardson, D.W.6
Caron, J.P.7
-
29
-
-
57349169432
-
Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: Evidence for signaling via the EP4 receptor
-
Attur, M., H. E. Al-Mussawir, J. Patel, A. Kitay, M. Dave, G. Palmer, M. H. Pillinger, and S. B. Abramson. 2008. Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor. J. Immunol. 181:5082-5088.
-
(2008)
J. Immunol.
, vol.181
, pp. 5082-5088
-
-
Attur, M.1
Al-Mussawir, H.E.2
Patel, J.3
Kitay, A.4
Dave, M.5
Palmer, G.6
Pillinger, M.H.7
Abramson, S.B.8
-
30
-
-
34648814090
-
Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: This involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy
-
Tchetina, E. V., J. A. di Battista, D. J. Zukor, J. Antoniou, and A. R. Poole. 2007. Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy. Arthritis Res. Ther. 9: R75.
-
(2007)
Arthritis Res. Ther.
, vol.9
-
-
Tchetina, E.V.1
Di Battista, J.A.2
Zukor, D.J.3
Antoniou, J.4
Poole, A.R.5
-
31
-
-
70249085277
-
Prostaglandin E2 differentially modulates proinflammatory/prodestructive effects of TNF-alpha on synovial fibroblasts via specific E prostanoid receptors/cAMP
-
Kunisch, E., A. Jansen, F. Kojima, I. Löffler, M. Kapoor, S. Kawai, I. Rubio, L. J. Crofford, and R. W. Kinne. 2009. Prostaglandin E2 differentially modulates proinflammatory/prodestructive effects of TNF-alpha on synovial fibroblasts via specific E prostanoid receptors/cAMP. J. Immunol. 183:1328-1336.
-
(2009)
J. Immunol.
, vol.183
, pp. 1328-1336
-
-
Kunisch, E.1
Jansen, A.2
Kojima, F.3
Löffler, I.4
Kapoor, M.5
Kawai, S.6
Rubio, I.7
Crofford, L.J.8
Kinne, R.W.9
-
32
-
-
0033922371
-
Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT)
-
Truett, G. E., P. Heeger, R. L. Mynatt, A. A. Truett, J. A. Walker, and M. L. Warman. 2000. Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT). Biotechniques 29:52-54.
-
(2000)
Biotechniques
, vol.29
, pp. 52-54
-
-
Truett, G.E.1
Heeger, P.2
Mynatt, R.L.3
Truett, A.A.4
Walker, J.A.5
Warman, M.L.6
-
33
-
-
50349096522
-
Primary culture and phenotyping of murine chondrocytes
-
Gosset, M., F. Berenbaum, S. Thirion, and C. Jacques. 2008. Primary culture and phenotyping of murine chondrocytes. Nat. Protoc. 3:1253-1260.
-
(2008)
Nat. Protoc.
, vol.3
, pp. 1253-1260
-
-
Gosset, M.1
Berenbaum, F.2
Thirion, S.3
Jacques, C.4
-
34
-
-
14044269575
-
Immature murine articular chondrocytes in primary culture: A new tool for investigating cartilage
-
Salvat, C., A. Pigenet, L. Humbert, F. Berenbaum, and S. Thirion. 2005. Immature murine articular chondrocytes in primary culture: a new tool for investigating cartilage. Osteoarthritis Cartilage 13:243-249.
-
(2005)
Osteoarthritis Cartilage
, vol.13
, pp. 243-249
-
-
Salvat, C.1
Pigenet, A.2
Humbert, L.3
Berenbaum, F.4
Thirion, S.5
-
35
-
-
0035799580
-
Matrix metalloproteinase-1,-3,-13 and aggrecanase-1 and-2 are differentially expressed in experimental osteoarthritis
-
Bluteau, G., T. Conrozier, P. Mathieu, E. Vignon, D. Herbage, and F. Mallein-Gerin. 2001. Matrix metalloproteinase-1,-3,-13 and aggrecanase-1 and-2 are differentially expressed in experimental osteoarthritis. Biochim. Biophys. Acta 1526:147-158.
-
(2001)
Biochim. Biophys. Acta
, vol.1526
, pp. 147-158
-
-
Bluteau, G.1
Conrozier, T.2
Mathieu, P.3
Vignon, E.4
Herbage, D.5
Mallein-Gerin, F.6
-
36
-
-
0030032444
-
Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage
-
Mitchell, P. G., H. A. Magna, L. M. Reeves, L. L. Lopresti-Morrow, S. A. Yocum, P. J. Rosner, K. F. Geoghegan, and J. E. Hambor. 1996. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J. Clin. Invest. 97:761-768.
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 761-768
-
-
Mitchell, P.G.1
Magna, H.A.2
Reeves, L.M.3
Lopresti-Morrow, L.L.4
Yocum, S.A.5
Rosner, P.J.6
Geoghegan, K.F.7
Hambor, J.E.8
-
37
-
-
0026736030
-
Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium
-
Okada, Y., M. Shinmei, O. Tanaka, K. Naka, A. Kimura, I. Nakanishi, M. T. Bayliss, K. Iwata, and H. Nagase. 1992. Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium. Lab. Invest. 66:680-690.
-
(1992)
Lab. Invest.
, vol.66
, pp. 680-690
-
-
Okada, Y.1
Shinmei, M.2
Tanaka, O.3
Naka, K.4
Kimura, A.5
Nakanishi, I.6
Bayliss, M.T.7
Iwata, K.8
Nagase, H.9
-
38
-
-
33747007085
-
The expression of collagenase 3 (MMP-13) mRNA in the synovial tissue is associated with histopathologic type II synovitis in rheumatoid arthritis
-
Wernicke, D., C. Seyfert, E. Gromnica-Ihle, and P. Stiehl. 2006. The expression of collagenase 3 (MMP-13) mRNA in the synovial tissue is associated with histopathologic type II synovitis in rheumatoid arthritis. Autoimmunity 39:307-313.
-
(2006)
Autoimmunity
, vol.39
, pp. 307-313
-
-
Wernicke, D.1
Seyfert, C.2
Gromnica-Ihle, E.3
Stiehl, P.4
-
39
-
-
0008741084
-
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis
-
Yoshihara, Y., H. Nakamura, K. Obata, H. Yamada, T. Hayakawa, K. Fujikawa, and Y. Okada. 2000. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann. Rheum. Dis. 59:455-461.
-
(2000)
Ann. Rheum. Dis.
, vol.59
, pp. 455-461
-
-
Yoshihara, Y.1
Nakamura, H.2
Obata, K.3
Yamada, H.4
Hayakawa, T.5
Fujikawa, K.6
Okada, Y.7
-
40
-
-
34250769704
-
Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction
-
Clements, D. N., S. D. Carter, J. F. Innes, W. E. Ollier, and P. J. Day. 2006. Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction. Arthritis Res. Ther. 8: R158.
-
(2006)
Arthritis Res. Ther.
, vol.8
-
-
Clements, D.N.1
Carter, S.D.2
Innes, J.F.3
Ollier, W.E.4
Day, P.J.5
-
41
-
-
0036714721
-
Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis
-
Flannelly, J., M. G. Chambers, J. Dudhia, R. M. Hembry, G. Murphy, R. M. Mason, and M. T. Bayliss. 2002. Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis. Osteoarthritis Cartilage 10:722-733.
-
(2002)
Osteoarthritis Cartilage
, vol.10
, pp. 722-733
-
-
Flannelly, J.1
Chambers, M.G.2
Dudhia, J.3
Hembry, R.M.4
Murphy, G.5
Mason, R.M.6
Bayliss, M.T.7
-
42
-
-
0032981531
-
Expression of the tissue inhibitor of metalloproteinases (TIMP) gene family in normal and osteoarthritic joints
-
Su, S., J. Grover, P. J. Roughley, J. A. DiBattista, J. Martel-Pelletier, J. P. Pelletier, and M. Zafarullah. 1999. Expression of the tissue inhibitor of metalloproteinases (TIMP) gene family in normal and osteoarthritic joints. Rheumatol. Int. 18:183-191.
-
(1999)
Rheumatol. Int.
, vol.18
, pp. 183-191
-
-
Su, S.1
Grover, J.2
Roughley, P.J.3
DiBattista, J.A.4
Martel-Pelletier, J.5
Pelletier, J.P.6
Zafarullah, M.7
-
43
-
-
4744343010
-
Effects of IL-1beta on gene expression in human rheumatoid synovial fibroblasts
-
Jeong, J. G., J. M. Kim, H. Cho, W. Hahn, S. S. Yu, and S. Kim. 2004. Effects of IL-1beta on gene expression in human rheumatoid synovial fibroblasts. Biochem. Biophys. Res. Commun. 324:3-7.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.324
, pp. 3-7
-
-
Jeong, J.G.1
Kim, J.M.2
Cho, H.3
Hahn, W.4
Yu, S.S.5
Kim, S.6
-
45
-
-
38149133229
-
Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders
-
Yamakawa, K., S. Kamekura, N. Kawamura, M. Saegusa, D. Kamei, M. Murakami, I. Kudo, S. Uematsu, S. Akira, U. I. Chung, et al. 2008. Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders. Arthritis Rheum. 58:172-183.
-
(2008)
Arthritis Rheum.
, vol.58
, pp. 172-183
-
-
Yamakawa, K.1
Kamekura, S.2
Kawamura, N.3
Saegusa, M.4
Kamei, D.5
Murakami, M.6
Kudo, I.7
Uematsu, S.8
Akira, S.9
Chung, U.I.10
-
46
-
-
33847683870
-
Regulation of matrix metalloproteinase gene expression
-
Yan, C., and D. D. Boyd. 2007. Regulation of matrix metalloproteinase gene expression. J. Cell. Physiol. 211:19-26.
-
(2007)
J. Cell. Physiol.
, vol.211
, pp. 19-26
-
-
Yan, C.1
Boyd, D.D.2
-
47
-
-
0242655673
-
Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation
-
Jiménez, M. J., M. Balbín, J. M. López, J. Alvarez, T. Komori, and C. López-Otín. 1999. Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol. Cell. Biol. 19:4431-4442.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 4431-4442
-
-
Jiménez, M.J.1
Balbín, M.2
López, J.M.3
Alvarez, J.4
Komori, T.5
López-Otín, C.6
-
48
-
-
0033590648
-
Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone
-
Porte, D., J. Tuckermann, M. Becker, B. Baumann, S. Teurich, T. Higgins, M. J. Owen, M. Schorpp-Kistner, and P. Angel. 1999. Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone. Oncogene 18:667-678.
-
(1999)
Oncogene
, vol.18
, pp. 667-678
-
-
Porte, D.1
Tuckermann, J.2
Becker, M.3
Baumann, B.4
Teurich, S.5
Higgins, T.6
Owen, M.J.7
Schorpp-Kistner, M.8
Angel, P.9
-
49
-
-
0035504250
-
IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: Requirement for Runx-2 and activation by p38 MAPK and JNK pathways
-
Mengshol, J. A., M. P. Vincenti, and C. E. Brinckerhoff. 2001. IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways. Nucleic Acids Res. 29:4361-4372.
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 4361-4372
-
-
Mengshol, J.A.1
Vincenti, M.P.2
Brinckerhoff, C.E.3
-
50
-
-
33748940904
-
Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx/RD/Cbfa sites alters bone remodeling in vivo
-
Selvamurugan, N., S. C. Jefcoat, S. Kwok, R. Kowalewski, J. A. Tamasi, and N. C. Partridge. 2006. Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx/RD/Cbfa sites alters bone remodeling in vivo. J. Cell. Biochem. 99:545-557.
-
(2006)
J. Cell. Biochem.
, vol.99
, pp. 545-557
-
-
Selvamurugan, N.1
Jefcoat, S.C.2
Kwok, S.3
Kowalewski, R.4
Tamasi, J.A.5
Partridge, N.C.6
-
51
-
-
33748779541
-
Estrogen receptor alpha regulates matrix metalloproteinase-13 promoter activity primarily through the AP-1 transcriptional regulatory site
-
Lu, T., Y. Achari, P. Sciore, and D. A. Hart. 2006. Estrogen receptor alpha regulates matrix metalloproteinase-13 promoter activity primarily through the AP-1 transcriptional regulatory site. Biochim. Biophys. Acta 1762:719-731.
-
(2006)
Biochim. Biophys. Acta
, vol.1762
, pp. 719-731
-
-
Lu, T.1
Achari, Y.2
Sciore, P.3
Hart, D.A.4
-
52
-
-
38349050125
-
Nucleolin binds specifically to an AP-1 DNA sequence and represses AP1-dependent transactivation of the matrix metalloproteinase-13 gene
-
Samuel, S., J. C. Twizere, K. K. Beifuss, and L. R. Bernstein. 2008. Nucleolin binds specifically to an AP-1 DNA sequence and represses AP1-dependent transactivation of the matrix metalloproteinase-13 gene. Mol. Carcinog. 47:34-46.
-
(2008)
Mol. Carcinog
, vol.47
, pp. 34-46
-
-
Samuel, S.1
Twizere, J.C.2
Beifuss, K.K.3
Bernstein, L.R.4
-
53
-
-
0036228958
-
Metabolism of human articular chondrocytes cultured in alginate beads. Longterm effects of interleukin 1beta and nonsteroidal antiinflammatory drugs
-
Sanchez, C., M. M. Mateus, M. P. Defresne, J. M. Crielaard, J. Y. Reginster, and Y. E. Henrotin. 2002. Metabolism of human articular chondrocytes cultured in alginate beads. Longterm effects of interleukin 1beta and nonsteroidal antiinflammatory drugs. J. Rheumatol. 29:772-782.
-
(2002)
J. Rheumatol.
, vol.29
, pp. 772-782
-
-
Sanchez, C.1
Mateus, M.M.2
Defresne, M.P.3
Crielaard, J.M.4
Reginster, J.Y.5
Henrotin, Y.E.6
-
54
-
-
0032823306
-
Prostanoid receptors: Structures, properties, and functions
-
Narumiya, S., Y. Sugimoto, and F. Ushikubi. 1999. Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79:1193-1226.
-
(1999)
Physiol. Rev.
, vol.79
, pp. 1193-1226
-
-
Narumiya, S.1
Sugimoto, Y.2
Ushikubi, F.3
-
55
-
-
33644915535
-
Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage
-
Sato, T., K. Konomi, S. Yamasaki, S. Aratani, K. Tsuchimochi, M. Yokouchi, K. Masuko-Hongo, N. Yagishita, H. Nakamura, S. Komiya, et al. 2006. Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage. Arthritis Rheum. 54:808-817.
-
(2006)
Arthritis Rheum.
, vol.54
, pp. 808-817
-
-
Sato, T.1
Konomi, K.2
Yamasaki, S.3
Aratani, S.4
Tsuchimochi, K.5
Yokouchi, M.6
Masuko-Hongo, K.7
Yagishita, N.8
Nakamura, H.9
Komiya, S.10
-
56
-
-
61549117532
-
PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage
-
Otsuka, S., T. Aoyama, M. Furu, K. Ito, Y. Jin, A. Nasu, K. Fukiage, Y. Kohno, T. Maruyama, T. Kanaji, et al. 2009. PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage. Osteoarthritis Cartilage 17:529-538.
-
(2009)
Osteoarthritis Cartilage
, vol.17
, pp. 529-538
-
-
Otsuka, S.1
Aoyama, T.2
Furu, M.3
Ito, K.4
Jin, Y.5
Nasu, A.6
Fukiage, K.7
Kohno, Y.8
Maruyama, T.9
Kanaji, T.10
-
57
-
-
0036732019
-
The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
-
McCoy, J. M., J. R. Wicks, and L. P. Audoly. 2002. The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis. J. Clin. Invest. 110:651-658.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 651-658
-
-
McCoy, J.M.1
Wicks, J.R.2
Audoly, L.P.3
-
58
-
-
74949085350
-
PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes
-
Nishitani, K., H. Ito, T. Hiramitsu, R. Tsutsumi, S. Tanida, T. Kitaori, H. Yoshitomi, M. Kobayashi, and T. Nakamura. 2010. PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes. J. Cell. Biochem. 109:425-433.
-
(2010)
J. Cell. Biochem.
, vol.109
, pp. 425-433
-
-
Nishitani, K.1
Ito, H.2
Hiramitsu, T.3
Tsutsumi, R.4
Tanida, S.5
Kitaori, T.6
Yoshitomi, H.7
Kobayashi, M.8
Nakamura, T.9
-
59
-
-
77949524833
-
Prostaglandin E2 regulates the expression of connective tissue growth factor (CTGF/CCN2) in human osteoarthritic chondrocytes via the EP4 receptor
-
Masuko, K., M. Murata, K. Yudoh, H. Shimizu, M. Beppu, H. Nakamura, and T. Kato. 2010. Prostaglandin E2 regulates the expression of connective tissue growth factor (CTGF/CCN2) in human osteoarthritic chondrocytes via the EP4 receptor. BMC Res. Notes 3:5.
-
(2010)
BMC Res. Notes
, vol.3
, pp. 5
-
-
Masuko, K.1
Murata, M.2
Yudoh, K.3
Shimizu, H.4
Beppu, M.5
Nakamura, H.6
Kato, T.7
-
60
-
-
13444271580
-
Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs
-
Kobayashi, T., K. Notoya, T. Naito, S. Unno, A. Nakamura, J. Martel-Pelletier, and J. P. Pelletier. 2005. Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs. Arthritis Rheum. 52:479-487.
-
(2005)
Arthritis Rheum.
, vol.52
, pp. 479-487
-
-
Kobayashi, T.1
Notoya, K.2
Naito, T.3
Unno, S.4
Nakamura, A.5
Martel-Pelletier, J.6
Pelletier, J.P.7
-
61
-
-
0035083913
-
Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes
-
Fahmi, H., J. A. di Battista, J. P. Pelletier, F. Mineau, P. Ranger, and J. Martel-Pelletier. 2001. Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes. Arthritis Rheum. 44:595-607.
-
(2001)
Arthritis Rheum.
, vol.44
, pp. 595-607
-
-
Fahmi, H.1
Di Battista, J.A.2
Pelletier, J.P.3
Mineau, F.4
Ranger, P.5
Martel-Pelletier, J.6
-
62
-
-
0036714690
-
Effects of agonists of peroxisome proliferator-activated receptor gamma on proteoglycan degradation and matrix metalloproteinase production in rat cartilage in vitro
-
Sabatini, M., A. Bardiot, C. Lesur, N. Moulharat, M. Thomas, I. Richard, and A. Fradin. 2002. Effects of agonists of peroxisome proliferator-activated receptor gamma on proteoglycan degradation and matrix metalloproteinase production in rat cartilage in vitro. Osteoarthritis Cartilage 10:673-679.
-
(2002)
Osteoarthritis Cartilage
, vol.10
, pp. 673-679
-
-
Sabatini, M.1
Bardiot, A.2
Lesur, C.3
Moulharat, N.4
Thomas, M.5
Richard, I.6
Fradin, A.7
-
63
-
-
0034707105
-
Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis
-
VIGOR Study Group, 2 p following 1528
-
Bombardier, C., L. Laine, A. Reicin, D. Shapiro, R. Burgos-Vargas, B. Davis, R. Day, M. B. Ferraz, C. J. Hawkey, M. C. Hochberg, et al; VIGOR Study Group. 2000. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. N. Engl. J. Med. 343:1520-1528, 2 p following 1528.
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 1520-1528
-
-
Bombardier, C.1
Laine, L.2
Reicin, A.3
Shapiro, D.4
Burgos-Vargas, R.5
Davis, B.6
Day, R.7
Ferraz, M.B.8
Hawkey, C.J.9
Hochberg, M.C.10
-
64
-
-
0034644396
-
Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: The CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study
-
Silverstein, F. E., G. Faich, J. L. Goldstein, L. S. Simon, T. Pincus, A. Whelton, R. Makuch, G. Eisen, N. M. Agrawal, W. F. Stenson, et al. 2000. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA 284:1247-1255.
-
(2000)
JAMA
, vol.284
, pp. 1247-1255
-
-
Silverstein, F.E.1
Faich, G.2
Goldstein, J.L.3
Simon, L.S.4
Pincus, T.5
Whelton, A.6
Makuch, R.7
Eisen, G.8
Agrawal, N.M.9
Stenson, W.F.10
-
65
-
-
19744380776
-
Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial
-
Adenomatous Polyp Prevention on Vioxx APPROVe Trial Investigators
-
Bresalier, R. S., R. S. Sandler, H. Quan, J. A. Bolognese, B. Oxenius, K. Horgan, C. Lines, R. Riddell, D. Morton, A. Lanas, et al; Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators. 2005. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N. Engl. J. Med. 352:1092-1102.
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 1092-1102
-
-
Bresalier, R.S.1
Sandler, R.S.2
Quan, H.3
Bolognese, J.A.4
Oxenius, B.5
Horgan, K.6
Lines, C.7
Riddell, R.8
Morton, D.9
Lanas, A.10
-
66
-
-
20144365496
-
Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention
-
Adenoma Prevention with Celecoxib APC Study Investigators
-
Solomon, S. D., J. J. McMurray, M. A. Pfeffer, J. Wittes, R. Fowler, P. Finn, W. F. Anderson, A. Zauber, E. Hawk, M. Bertagnolli; Adenoma Prevention with Celecoxib (APC) Study Investigators. 2005. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N. Engl. J. Med. 352:1071-1080.
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 1071-1080
-
-
Solomon, S.D.1
McMurray, J.J.2
Pfeffer, M.A.3
Wittes, J.4
Fowler, R.5
Finn, P.6
Anderson, W.F.7
Zauber, A.8
Hawk, E.9
Bertagnolli, M.10
-
67
-
-
35848954713
-
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors
-
Côté, B., L. Boulet, C. Brideau, D. Claveau, D. Ethier, R. Frenette, M. Gagnon, A. Giroux, J. Guay, S. Guiral, et al. 2007. Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. Bioorg. Med. Chem. Lett. 17:6816-6820.
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 6816-6820
-
-
Côté, B.1
Boulet, L.2
Brideau, C.3
Claveau, D.4
Ethier, D.5
Frenette, R.6
Gagnon, M.7
Giroux, A.8
Guay, J.9
Guiral, S.10
-
68
-
-
53849098967
-
MF63 [2-(6-chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)-isophthalonitrile] , a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation
-
Xu, D., S. E. Rowland, P. Clark, A. Giroux, B. Côté, S. Guiral, M. Salem, Y. Ducharme, R. W. Friesen, N. Méthot, et al. 2008. MF63 [2-(6-chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. J. Pharmacol. Exp. Ther. 326:754-763.
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.326
, pp. 754-763
-
-
Xu, D.1
Rowland, S.E.2
Clark, P.3
Giroux, A.4
Côté, B.5
Guiral, S.6
Salem, M.7
Ducharme, Y.8
Friesen, R.W.9
Méthot, N.10
-
69
-
-
34247881867
-
PGE synthase inhibitors as an alternative to COX-2 inhibitors
-
Jachak, S. M. 2007. PGE synthase inhibitors as an alternative to COX-2 inhibitors. Curr. Opin. Investig. Drugs 8:411-415.
-
(2007)
Curr. Opin. Investig. Drugs
, vol.8
, pp. 411-415
-
-
Jachak, S.M.1
-
70
-
-
34748817976
-
Membrane prostaglandin E synthase-1: A novel therapeutic target
-
Samuelsson, B., R. Morgenstern, and P. J. Jakobsson. 2007. Membrane prostaglandin E synthase-1: a novel therapeutic target. Pharmacol. Rev. 59:207-224.
-
(2007)
Pharmacol. Rev.
, vol.59
, pp. 207-224
-
-
Samuelsson, B.1
Morgenstern, R.2
Jakobsson, P.J.3
|