The ω3-polyunsaturated fatty acid derivatives AVX001 and AVX002 directly inhibit cytosolic phospholipase A2 and suppress PGE 2 formation in mesangial cells

British Journal of Pharmacology

Volumn 167, Issue 8, 2012, Pages 1691-1701

  Huwiler, Andrea ^a   Feuerherm, Astrid J ^b   Sakem, Benjamin ^a   Pastukhov, Oleksandr ^a   Filipenko, Iuliia ^a   Nguyen, Thuy ^b   Johansen, Berit ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

AVX001; AVX002; cPLA2; inflammation; kidney; mesangial cell; prostaglandins

Indexed keywords

AVX 001; AVX 002; DOCOSAHEXAENOIC ACID; ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; OMEGA 3 FATTY ACID; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; DOWN REGULATION; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; IC 50; IN VITRO STUDY; INFLAMMATORY DISEASE; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; CYTOSOL; DINOPROSTONE; ENZYME INHIBITORS; FATTY ACIDS, OMEGA-3; MESANGIAL CELLS; NF-KAPPA B; PHOSPHOLIPASES A2; RATS;

EID: 84870556593     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02114.x     Document Type: Article

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