Effect of age and sex on plasma cortisol and dehydroepiandrosterone concentrations in the dog (Canis familiaris)

Research in Veterinary Science

Volumn 96, Issue 1, 2014, Pages 33-38

  Mongillo, P ^a   Prana, E ^a   Gabai, G ^a   Bertotto, D ^a   Marinelli, L ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Age; Cortisol; Dehydroepiandrosterone; Dog; Sex

Indexed keywords

HYDROCORTISONE; PRASTERONE;

ADRENAL GLAND; ADULT; AGE; ANDROGEN BLOOD LEVEL; ANDROGEN RELEASE; ARTICLE; CONTROLLED STUDY; DOG; HYDROCORTISONE BLOOD LEVEL; MALE; NONHUMAN; OVARY; SEX DIFFERENCE; TESTIS;

CANIS FAMILIARIS;

AGE; CORTISOL; DEHYDROEPIANDROSTERONE; DOG; SEX;

AGE FACTORS; ANIMALS; DEHYDROEPIANDROSTERONE; DOGS; FEMALE; HYDROCORTISONE; MALE; SEX FACTORS;

EID: 84892558223     PISSN: 00345288     EISSN: 15322661     Source Type: Journal    
DOI: 10.1016/j.rvsc.2013.10.010     Document Type: Article

References (50)

1. Adams B., Chan A., Callahan H., Milgram N.W. The canine as a model of human cognitive aging: recent developments. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2000, 24:675-692.
2. Aly H.F., Metwally F.M., Ahmed H.H. Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimer's disease. Acta Biochimica Polonica 2011, 58:513-520.
3. Azkona G., Garcia-Belenguer S., Chacon G., Rosado B., Leon M., Palacio J. Prevalence and risk factors of behavioural changes associated with age-related cognitive impairment in geriatric dogs. Journal of Small Animal Practice 2009, 50:87-91.
4. Baulieu E.E. Neurosteroids: a novel function of the brain. Psychoneuroendocrinology 1998, 23:963-987.
5. Casson P.R., ElkindHirsch K.E., Buster J.E., Hornsby P.J., Carson S.A., Snabes M.C. Effect of postmenopausal estrogen replacement on circulating androgens. Obstetrics and Gynecology 1997, 90:995-998.
6. Cumming D.C., Rebar R.W., Hopper B.R., Yen S.S. Evidence for an influence of the ovary on circulating dehydroepiandrosterone sulfate levels. Journal of Clinical Endocrinology and Metabolism 1982, 54:1069-1071.
7. Cutler G.B., Glenn M., Bush M., Hodgen G.D., Graham C.E., Loriaux D.L. Adrenarche: a survey of rodents, domestic animals, and primates. Endocrinology 1978, 103:2112-2118.
8. Davies E., MacKenzie S.M. Extra-adrenal production of corticosteroids. Clinical and Experimental Pharmacology and Physiology 2003, 30:437-445.
9. Depaoli J., Eik-Nes B. Metabolism in vivo of (7alpha-3h) pregnenolone by the dog ovary. Biochimica et biophysica acta 1963, 78.
10. Ferrari E., Cravello L., Muzzoni B., Casarotti D., Paltro M., Solerte S.B., Fioravanti M., Cuzzoni G., Pontiggia B., Magri F. Age-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates. European Journal of Endocrinology 2001, 144:319-329.
11. Frank L.A., Rohrbach B.W., Bailey E.M., West J.R., Oliver J.W. Steroid hormone concentration profiles in healthy intact and neutered dogs before and after cosyntropin administration. Domestic Animal Endocrinology 2003, 24.
12. Garnier F., Benoit E., Virat M., Ochoa R., Delatour P. Adrenal-cortical response in clinically normal dogs before and after adaptation to a housing environment. Laboratory Animals 1990, 24:40-43.
13. Giordano R., Di Vito L., Lanfranco F., Broglio F., Benso A., Gianotti L., Grottoli S., Ghigo E., Arvat E. Elderly subjects show severe impairment of dehydroepiandrosterone sulphate and reduced sensitivity of cortisol and aldosterone response to the stimulatory effect of ACTH(1-24). Clinical Endocrinology 2001, 55:259-265.
14. Goel R.M., Cappola A.R. Dehydroepiandrosterone sulfate and postmenopausal women. Current Opinion in Endocrinology Diabetes and Obesity 2011, 18:171-176.
15. Goy-Thollot I., Decosne-Junot C., Bonnet J.-M. Influence of aging on adrenal responsiveness in a population of eleven healthy beagles. Research in Veterinary Science 2007, 82:195-201.
16. Hennessy M.B., Davis H.N., Williams M.T., Mellott C., Douglas C.W. Plasma cortisol levels of dogs at a county animal shelter. Physiology & Behavior 1997, 62:485-490.
17. Hornsby P.J. Aging of the human adrenal cortex. Ageing Research Reviews 2002, 1.
18. Kimonides V.G., Khatibi N.H., Svendsen C.N., Sofroniew M.V., Herbert J. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:1852-1857.
19. Kirschbaum C., Wust S., Hellhammer D. Consistent sex-differences in cortisol responses to psychological stress. Psychosomatic Medicine 1992, 54.
20. Knochenhauer E., Azziz R. Ovarian hormones and adrenal androgens during a woman's lifespan. Journal of the American Academy of Dermatology 2001, 45:S105-S115.
21. Kroboth P.D., Salek F.S., Pittenger A.L., Fabian T.J., Frye R.F. DHEA and DHEA-S: a review. Journal of Clinical Pharmacology 1999, 39:327-348.
22. Kurata K., Takebayashi M., Morinobu S., Yamawaki S. Beta-estradiol, dehydroepiandrosterone, and dehydroepiandrosterone sulfate protect against N-methyl-D-aspartate-induced neurotoxicity in rat hippocampal neurons by different mechanisms. Journal of Pharmacology and Experimental Therapeutics 2004, 311:237-245.
23. Lacoste D., Dube D., Trudel C., Belanger A., Labrie F. Normal gonadal functions and fertility after 23 months of treatment of prepubertal male and female dogs with the gnrh agonist d-trp6, des-gly-nh210 gnrh ethylamide. Journal of Andrology 1989, 10.
24. Landsberg G. Therapeutic agents for the treatment of cognitive dysfunction syndrome in senior dogs. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2005, 29:471-479.
25. Laughlin G.A., Barrett-Connor E. Sexual dimorphism in the influence of advanced aging on adrenal hormone levels: the Rancho Bernardo Study. Journal of Clinical Endocrinology & Metabolism 2000, 85:3561-3568.
26. Marinelli L., Gabai G., Simontacchi C., Bono G. Effect of aging and reproductive condition on dehydroepiandrosterone plasma levels in the bitch. Veterinary Research Communications 2007, 31:169-172.
27. Marinelli L., Trevisi E., Da Dalt L., Merlo M., Bertoni G., Gabai G. Dehydroepiandrosterone secretion in dairy cattle is episodic and unaffected by ACTH stimulation. Journal of Endocrinology 2007, 194:627-635.
28. McKenna T.J., Fearon U., Clarke D., Cunningham S.K. A critical review of the origin and control of adrenal androgens. Baillieres Clinical Obstetrics and Gynaecology 1997, 11:229-248.
29. Mialot J.P., Thibier M., Toublanc J.E., Castanier M., Scholler R. Plasma-concentration of luteinizing-hormone, testosterone, dehydroepiandrosterone, androstenedione between birth and one year in the male dog - longitudinal study and hcg stimulation. Andrologia 1988, 20:145-154.
30. Miller T.P., Taylor J., Rogerson S., Mauricio M., Kennedy Q., Schatzberg A., Tinklenberg J., Yesavage J. Cognitive and noncognitive symptoms in dementia patients: relationship to cortisol and dehydroepiandrosterone. International Psychogeriatrics/IPA 1998, 10:85-96.
31. Obrien J.T., Ames D., Schweitzer I., Colman P., Desmond P., Tress B. Clinical and magnetic resonance imaging correlates of hypothalamic-pituitary-adrenal axis function in depression and Alzheimer's disease. British Journal of Psychiatry 1996, 168:679-687.
32. Obrien J.T., Ames D., Schweitzer I., Mastwyk M., Colman P. Enhanced adrenal sensitivity to adrenocorticotrophic hormone (ACTH) is evidence of HPA axis hyperactivity in Alzheimer's disease. Psychological Medicine 1996, 26:7-14.
33. Orentreich N., Brind J.L., Rizer R.L., Vogelman J.H. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. Journal of Clinical Endocrinology and Metabolism 1984, 59:551-555.
34. Palazzolo D.L., Quadri S.K. Plasma thyroxine and cortisol under basal conditions and during cold stress in the aging dog. Proceedings of the Society for Experimental Biology and Medicine 1987, 185:305-311.
35. Parker C.R., Slayden S.M., Azziz R., Crabbe S.L., Hines G.A., Boots L.R., Bae S. Effects of aging on adrenal function in the human: responsiveness and sensitivity of adrenal androgens and cortisol to adrenocorticotropin in premenopausal and postmenopausal women. Journal of Clinical Endocrinology & Metabolism 2000, 85:48-54.
36. Peters M.A.J., de Jong F.H., Teerds K.J., de Rooij D.G., Dieleman S.J., van Sluijs F.J. Ageing, testicular tumours and the pituitary-testis axis in dogs. Journal of Endocrinology 2000, 166.
37. Reimers T.J., Lawler D.F., Sutaria P.M., Correa M.T., Erb H.N. Effects of age, sex, and body size on serum concentrations of thyroid and adrenocortical hormones in dogs. American Journal of Veterinary Research 1990, 51:454-457.
38. Reul J., Rothuizen J., Dekloet E.R. Age-related-changes in the dog hypothalamic pituitary adrenocortical system - neuroendocrine activity and corticosteroid receptors. Journal of Steroid Biochemistry and Molecular Biology 1991, 40.
39. Rosado B., Garcia-Belenguer S., Leon M., Chacon G., Villegas A., Palacio J. Blood concentrations of serotonin, cortisol and dehydroepiandrosterone in aggressive dogs. Applied Animal Behaviour Science 2010, 123:124-130.
40. Rothuizen J., Reul J.M.H., Vansluijs F.J., Mol J.A., Rijnberk A., Dekloet E.R. Increased neuroendocrine reactivity and decreased brain mineralocorticoid receptor-binding capacity in aged dogs. Endocrinology 1993, 132:161-168.
41. Schiebinger R.J., Albertson B.D., Barnes K.M., Cutler G.B., Loriaux D.L. Developmental changes in rabbit and dog adrenal function: a possible homologue of adrenarche in the dog. American Journal of Physiology 1981, 240:E694-E699.
42. Sher L., Oquendo M.A., Galfalvy H.C., Cooper T.B., Mann J.J. Age effects on cortisol levels in depressed patients with and without comorbid post-traumatic stress disorder, and healthy volunteers. Journal of Affective Disorders 2004, 82:53-59.
43. Sluijmer A.V., Heineman M.J., Dejong F.H., Evers J.L.H. Endocrine activity of the postmenopausal ovary - the effects of pituitary down-regulation and oophorectomy. Journal of Clinical Endocrinology & Metabolism 1995, 80:2163-2167.
44. Strasser A., Niedermuller H., Hofecker G., Laber G. The effect of aging on laboratory values in dogs. Journal of Veterinary Medicine, Series a-Zentralblatt Fur Veterinarmedizin Reihe a-Physiology Pathology Clinical Medicine 1993, 40:720-730.
45. Studzinski C.M., Araujo J.A., Milgram N.W. The canine model of human cognitive aging and dementia: pharmacological validity of the model for assessment of human cognitive-enhancing drugs. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2005, 29:489-498.
46. Uhart M., Chong R.Y., Oswald L., Lin P.I., Wand G.S. Gender differences in hypothalamic-pituitary-adrenal (HPA) axis reactivity. Psychoneuroendocrinology 2006, 31.
47. Van Cauter, E., Turek, F.W. (Eds.),1995. Endocrine and other biological rhythms. In: Endocrinology. Saunders, Philadelphia, pp. 2487-2548.
48. VanCauter E., Leproult R., Kupfer D.J. Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. Journal of Clinical Endocrinology & Metabolism 1996, 81.
49. Wudy S.A., Hartmann M.F., Remer T. Sexual dimorphism in cortisol secretion starts after age 10 in healthy children: urinary cortisol metabolite excretion rates during growth. American Journal of Physiology-Endocrinology and Metabolism 2007, 293:E970-E976.
50. Zhao Z.Y., Lu F.H., Xie Y., Fu Y.R., Bogdan A., Touitou Y. Cortisol secretion in the elderly. Influence of age, sex and cardiovascular disease in a Chinese population. Steroids 2003, 68.