Prevalence and risk factors of behavioural changes associated with age-related cognitive impairment in geriatric dogs: PAPER

Journal of Small Animal Practice

Volumn 50, Issue 2, 2009, Pages 87-91

  Azkona, G ^a   Garcia Belenguer S ^a   Chacon G ^a   Rosado, B ^a   Leon M ^a   Palacio, J ^a  

^a UNIVERSIDAD DE ZARAGOZA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ANIMAL; ANIMAL BEHAVIOR; ARTICLE; CASTRATION; COGNITIVE DEFECT; CROSS-SECTIONAL STUDY; DOG; DOG DISEASE; FEMALE; HOSPITALIZATION; HUMAN; INTERVIEW; MALE; PREVALENCE; PSYCHOLOGICAL ASPECT; RISK FACTOR; SEX DIFFERENCE; STATISTICAL MODEL;

AGING; ANIMALS; BEHAVIOR, ANIMAL; CASTRATION; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; DOG DISEASES; DOGS; FEMALE; HUMANS; INTERVIEWS AS TOPIC; LOGISTIC MODELS; MALE; PREVALENCE; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SEX FACTORS;

ANIMALIA; CANIS FAMILIARIS;

EID: 59649128451     PISSN: 00224510     EISSN: 17485827     Source Type: Journal    
DOI: 10.1111/j.1748-5827.2008.00718.x     Document Type: Article

References (30)

1. Adams, B., Chan, A., Callahan, H. Milgram, N. W 2000) The canine as a model of human cognitive aging: recent developments. Progress in Neuro-Psychopharmacology and Biological Psychiatry 24, 675 692 Ruehl, W. W 2001) Predicting behavioral changes associated with age-related cognitive impairment in dogs. Journal of the American Veterinary Medical Association 218, 1792 1795
2. Barrett-Connor, E., Goodman-Gruen, D. Patay, B 1999) Endogenous sex hormones and cognitive function in older men. Journal of Clinical Endocrinology & Metabolism 84, 3681 3685
3. Borrás, D., Ferrer, I. Pumarola, M 1999) Age-related changes in the brain of the dog. Veterinary Pathology 36, 202 211
4. Chapman, B. L. Voith, V. L 1990) Behavioral problems in old dogs: 26 cases (1984-1987). Journal of the American Veterinary Medical Association 196, 944 946
5. Colle, M. A., Hauw, J. J., Crespeau, F., Akiyama, H., Checler, F., Pageat, P. Duykaerts, C 2000) Vascular and parenchymal Aß deposition in the aging dog: correlation with behaviour. Neurobiology of Aging 21, 695 704
6. Cummings, B. J., Su, J. H., Cotman, C. W., While, R. Russel, M. J 1993) ß-Amyloid accumulation in aged canine brain. A model of early plaque formation in Alzheimer's disease. Neurobiology of Aging 14, 547 560
7. 40: evidence from cats and dogs. Neurobiology of Aging 17, 653 659
8. Cummings, B. J., Head, E., Ruehl, W. W., Milgram, N. W. Cotman, C. W 1996b) The canine as an animal model of human aging dementia. Neurobiology of Aging 17, 259 268
9. Frank, D 2002) La disfunción cognitiva en perros. Consulta de difusión veterinaira 10, 71 75
10. Hao, J., Rapp, P. R., Janssen, W. G. M., Lou, W., Lasley, B. L., Hof, P. R. Morrison, J. H 2007) Interactive effects of age and estrogen on cognition and pyramidal neurons in monkey prefrantal cortex. Proceedings of the National Academy of Sciences of the United States of America 104, 11465 11470 2001) Effect of gonadectomy on subsequent development of age-related cognitive impairment in dogs. Journal of the American Veterinary Medical Association 219, 51 56
11. Head, E., Callaghan, H., Muggenburg, B. A., Cotman, C. W. Milgram, N. W 1998) Visual-discrimination learning ability and ß-amyloid accumulation in the dog. Neurobiology of Aging 19, 415 425
12. Heath, S 2002) Behaviour problems in the geriatric pet. In : BSAVA Manual of Canine and Feline Behavioural Medicine. British Small Animal Veterinary Association, Gloucester, UK. pp 109 118 Craze, P. G 2007) Nutritional supplementation in cases of canine cognitive dysfunction - a clinical trial. Applied Animal Behaviour Science 105, 284 296
13. Landsberg, G 2005) Therapeutic agents for the treatment of cognitive dysfunction syndrome in senior dogs. Progress in Neuro-Psychopharmacology and Biological Psychiatry 29, 471 479
14. Landsberg, G. Araujo, J. A 2005) Behavior problems in geriatric pets. Veterinary Clinics of North America: Small Animal Practice 35, 675 698
15. Mangone, C. A 2002) Enfermedad de Alzheimer. In : Tratado de Neurología Clínica. Ed F. E. Micheli. Médica Panamericana, Madrid, Spain. pp 712 729 Mayeux, R 2000) Endogenous estrogen levels and Alzheimer's disease among postmenopausal women. Neurology 54, 833 837
16. Milgram, N. W., Head, E., Muggenburg, B., Holowachuck, D., Murphey, H., Estrada, J., Ikeda-Douglas, C. J., Zicker, S. C. Cotman, C. W 2002) Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy. Neuroscience and Biobehavioral Reviews 26, 679 695
17. Milgram, N. W., Head, E., Zicker, S. C., Ikeda-Douglas, C. J., Murphey, H., Muggenburg, B. A., Siwak, C. T., Tapp, P. D., Lowry, S. R. Cotman, C. W 2004) Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Experimental Gerontology 39, 753 765
18. Moffat, S. D., Zonderman, A. B., Metter, E. J., Blackman, M. R., Harman, S. M. Resnick, S. M 2002) Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. Journal of Clinical Endocrinology & Metabolism 87, 5001 5007
19. Nielson, J. C., Hart, B. L., Cliff, K. D. Ruehl, W. W 2001) Prevalence of behavioral changes associated with age-related cognitive impairment in dogs. Journal of the American Veterinary Medical Association 218, 1787 1791
20. Osella, M. C., Re, G., Odore, R., Girardi, C., Badino, P., Barbero, R. Bergamasco, L 2007) Canine cognitive dysfunction syndrome: prevalence, clinical signs and treatment with a neuroprotective nutraceutical. Applied Animal Behaviour Science 105, 297 310 Glickman, L. T 1997) Comparison longevity of pet dogs and humans: implications for gerontology research. Journal of Gerontology Series A: Biological Science and Medical Science 52, B171 B178
21. Ravaglia, G., Forti, P., Maioli, F., Bastagli, L., Montesi, F., Pisacane, N., Chiappelli, M., Licastro, F. Patterson, C 2007) Endogenous sex hormones as risk factors for dementia in elderly men and women. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 62, 1035 1041
22. Ruehl, W. W., Bruyette, D. S., Depaoli, A., Cotman, C. W., Head, E., Milgram, N. W. Cummings, B. J 1995) Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to l-deprenyl therapy. Progress in Brain Research 106, 217 225
23. Satou, T., Cummings, B. J., Head, E., Nielsen, K. A., Hahn, F. F., Milgram, N. W., Velazquez, P., Cribbs, D. H., Tenner, A. J. Cotman, C. W 1997) The progression of ß-amyloid deposition in the frontal cortex of the aged canine. Brain Research 774, 35 43
24. Siwak, C. T., Tapp, P. D. Milgram, N. W 2002) Behavioral correlates of age-associated cognitive changes in dogs. In : Symposium on Brain Aging and Related Behavioral Changes in Dogs. Veterinary Healthcare Communications. Orlando, FL, USA, January 11. pp 20 22 (2005) Estrogen: a neuroprotective or proinflammatory hormone? Emerging evidence from reproductive aging models. Annals of New York Academic of Sciences 1052, 75 90
25. Studzinski, C. M., Araujo, J. A. Milgram, N. W 2005) The canine model of human cognitive aging and dementia: pharmacological validity of the model for assessment of human cognitive-enhancing drugs. Progress in Neuro- Psychopharmacology and Biological Psychiatry 29, 489 498
26. Studzinski, C. M., Christie, L. A., Araujo, J. A., Burnham, W. M., Head, E., Cotman, C. W. Milgram, N. W 2006) Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Neurobiology of Learning and Memory 86, 197 204
27. Tapp, P. D. Siwak, C. T 2006) The canine model of human brain aging: cognition, behaviour and neuropathology. In : Handbook of Models for Human Aging. Ed P. M. Conn. Academic Press : San Diego, CA, USA. pp 415 434 Frankena, K 2001) Win episcope 2.0: improved epidemiological software for veterinary medicine. Veterinary Record 148, 567 572
28. WHO (2006) Burden of Mental and Behavioural Disorders: Alzheimer's disease. http://www.who.int/whr/2001/chapter2/en/index4.html Kirschbaum, C 2002) Endogenous estradiol and testosterone levels are associated with cognitive performance in older women and men. Hormones and Behavior 41, 259 266
29. Yaffe, K., Lui, L.-Y., Grady, D., Cauley, J., Kramer, J. Cummings, S. R 2000) Cognitive decline in women in relation to non-protein-bound oestradiol concentrations. Lancet 356, 708 712
30. Yaffe, K., Lui, L.-Y., Zmuda, J. Cauley, J 2002) Sex hormone and cognitive function in older men. Journal of American Geriatrics Society 50, 707