Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimer's disease

Acta Biochimica Polonica

Volumn 58, Issue 4, 2011, Pages 513-520

  Aly, Hanan F ^a   Metwally, Fateheya M ^a   Ahmed, Hanaa H ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Alzheimer's disease; Apoptosis; Dehydroepiandrosterone; Oxidative stress

Indexed keywords

ANIMALIA; RATTUS;

EID: 84860526369     PISSN: 0001527X     EISSN: 1734154X     Source Type: Journal    
DOI: 10.18388/abp.2011_2218     Document Type: Article

References (65)

1. Abd El-Rahman SS (2003) Neuropathology of aluminum toxicity in rats (glutamate and GABA impairment). Pharmacol Res 47: 189-194.
2. Aebi H (1984) Catalase in vitro. Methods Enzymol 105: 121-126.
3. Alleva K, Rankin J, Santucci D (1998) Neurobehavioural alteration in rodents following developmental exposure to aluminum. Toxicol Ind Health 14: 209-221.
4. Aragno M, Tamagno E, Gatto V, Brignardello E, Parola S, Danni O, Boccuzzi G (1999) Dehydroepiandrosterone protects tissues of streptozotocin-treated rats against oxidative stress. Free Radic Biol Med 26: 1467-1474.
5. Armitage P, Berry G (1987) Comparison of several groups. In: Statistical methods in medical research, 2nd edn, pp 186-213. Blockwell Significant Publication, Oxford.
6. Barakat-Walter I (1996) Brain derived neurotrophic factor like immunoreactivity is localized mainly in small sensory neurons of rat dorsal root ganglia. J Neurosci Meth 68: 281-288.
7. Barbareschi M, Caffo O, Veronese S, Leek RD, Fina P, Fox S, Bonzanini M, Girlando S, Morelli L, Eccher C, Pezzella F, Doglioni C, Palma PD, Harris A (1996) Bcl-2 and P53 expression in nodenegative breast carcinoma: a study with long-term follow-up. Human Pathol 27: 1149-1155.
8. Behl C, Moosmann B (2002) Oxidative nerve cell death in Alzheimer's disease and stroke: antioxidants as neuroprotective compounds. Biol Chem 383: 521-536.
9. Berkels R, Purol-Schnabel S, Roesen R (2004) Measurment of nitric oxide by reconversion of nitrate/nitrite to nitric oxide. Methods Mol Biol 279: 1-8.
10. Bharathi P, Vasudevaraju P, Govindaraju M, Palanisamy AP, Sambamurti K, Rao KS (2008) Molecular toxicity of aluminum in relation to neurodegeneration. Ind. J Med Res 128: 545-556.
11. Cardounel A, Regelson W, Kalimi M (1999) Dehydroepi-androsterone protects hippocampal neurons against neurotoxin-induced cell death: mechanism of action. Proc Soc Exp Bio Med 222: 145-149.
12. Charalampopoulos I, Alexaki VI, Lazaridis I, Dermitzaki E, Avlonitis N, Tsatsanis C, Calogeropoulou T, Margioris AN, Castanas E, Gravanis A, (2006) G-protein-associated, specific membrane binding sites mediate the neuroprotective effect of dehydroepiandrosterone. FASEB J 20: 577-579.
13. Den Blaauwen DH, Poppe WA, Tritschler W (1983) Acetylcholinesterase with acetylthiocholine iodide as substrate: references depending on age and sex with special reference to hormonal effects and pregnancy. J Clin Chem Clin Biochem 21: 381-386.
14. Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ, Wahli W (1996) The PPARα-leukotriene B4 pathway to inflammation control. Nature 384: 39-43.
15. Di J, Yao K,Han W, Bi S, (2006a) Study on the interaction of copper zinc superoxide dismutase with aluminum ions by electrochemical and fluorescent method. Spectrochim Acta Mol Biomol Spectr 65: 896- 900.
16. Di J, Zhang M, Yao K, Bi S (2006b) Direct voltammetery of catalase immobilized on silica sol-gel and cysteine modified gold electrode and its application. Biosen Bioelect 22: 247-252.
17. Drury RAB, Wallington EA (1980) Carleton's histological technique, 5th edn, pp 188-189, 237-240, 290-291. Oxford University Press, Oxford, New York, Toronto.
18. El-Rigal NS, Aly SA, Rizk MZ, Said,AA (2006) Effect of Ailanthus altissima and Ziziphus spina Christi extracts on some hepatic marker enzymes and antioxidants in Shistosoma mansoni infected mice. Pol J Food Nutr Sci 15/56: 199-206.
19. Erden M, Bor NM (1984) Changes in reduced glutathione, glutathione reductase and glutathione peroxidase after radiation in guinea pigs, Biochem Med 31: 217-227
20. Gao J, Sun HY, Zhu ZR, Ding Z, Zhu L (2005) Antioxidant effects of dehydroepiandrosterone are related to upregulation of thioredoxin in SH-SY5Y cells. Acta. Biochim. Biophys Sin 37: 119-125.
21. Garrel C, Lafond JL, Guiraud P, Faure P, Favier A (1994) Induction of production of nitric oxide in microglial cells by insoluble form of aluminum. Ann New York Acad. Sci 738: 455-461.
22. Goel RM, Cappola AR (2011) Dehydroepiandrosterone sulfate and postmenopausal women. Curr Opin Endocrinol Diabetes Obes (in press).
23. Grosgen S,Grimm MO, Frieb P, Hartmann T (2010) Role of amyloid- beta in lipid homeostasis. Biochim Biophys Acta 1801: 966-974.
24. Guix FX, Uribesalgo I, Coma M, Munoz FJ (2005) The physiology and pathophysiology of nitric oxide in the brain. Progress in Neurobiol 76: 126-152.
25. Huh JW, Choi M M, Lee JH, Yang SJ, Kim MJ, Choi J, Lee KH, Lee JE, Cho SW (2005) Activation of monoamine oxidase isotypes by prolonged intake of aluminum in rat brain. J Inorg Biochem 99: 2088-2091.
26. Johnson VJ, Kim S, Sharma RP (2005) Aluminum maltolate induces apoptosis and necrosis in neuro-2a cells: potential role for p53 signaling. Toxicol Sci 83: 329-339.
27. Julka D, Gill KD (1996) Effect of aluminum on regional brain antioxidant defense status in wistar rats. Res Exp Med 196: 187-194.
28. Kaizer RR,Correa MC, Gris LRS, Da Rosa CS, Bohrer D,Morsch VM, Rosa M, Schetinger C (2008) Effect of long term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes. Neurochem Res 33: 2294-2301.
29. Koracevic D,Koracevic G, Djordjevic V, Andrejevic S, Cosic V (2001) Method for the measurement of antioxidant activity in human fluids. J Clin Pathol 54: 356-361.
30. Krysiak R, Frysz-Naglak D, Okopie B (2008) Current views on the role of dehydroepiandrosterone in physiology, pathology and therapy. Pol Merk Lek 24: 66-71.
31. Kumar P, Taha A, Sharma D, Kale RK, Baquer NZ (2008) Effect of dehydroepiandrosterone (DHEA) on monoamine oxidase activity, lipid peroxidation and lipofuscin accumulation in aging rat brain regions. Biogerontol 9: 235-246.
32. Kumar V, Bal A, Gill K.D. (2009a) Susceptibility of mitochondrial superoxide dismutase to aluminum-induced oxidative damage. Toxicol 255: 117-123.
33. Kumar V, Bal A, Gill KD (2009b) Aluminum-induced oxidative DNA damage recognition and cell cycle disruption in different regions of rat brain. Toxicol 264: 137-144.
34. Kurata K, Takebayashi M, Morinobu S, Yamawaki S (2004) Beta-estradiol, dehydroepiandrosterone, and dehydroepiandrosterone sulfate protect against N-methyl-D-aspartate-induced neurotoxicity in rat hippocampal neurons by different mechanisms. J Pharmacol Exp Ther 311: 237-245.
35. Lardy H, Henwood SM, Weeks CE (1999) An acute oral gavage study of β-acetoxyandrost-5-ene-7, 17-dione (7-oxo-DHEA-acetate) in rats. Biochem Biophys Res Commun 254: 120-123.
36. Lazaridis I, Charalampopoulos I, Alexaki VI, Avlonitis N, Pediaditakis I, Efstathopoulos P, Calogeropoulou T, Castanas E, Gravanis A (2011) Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. PLoS Biol 9: 100-105.
37. Li W, Ota K, Nakamura J, Naruse K, Nakashima E, Oisa Y, Hamada Y (2008) Antiglycation effect of gliclazide on in vitro AGE formation from glucose and methylglyoxal. Exp Biol Med 23: 176-179.
38. Lowry OH, Rosebrough NJ, Farr A L, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275.
39. Luppi C, Fioravanti M, Bertolini B, Inguscio M, Grugnetti A, Guerriero F,Rovelli C, Cantoni F,Guagnano P, Marazzi E, Rolfo E, Ghianda D, Levante D,Guerrini C,Bonacasa R, Solerte SB (2009) Growth factors decrease in subjects with mild to moderate Alzheimer's disease (AD): potential correction with dehydroepiandrosterone sulphate (DHEAS). Arch Gerontol Geriat 1: 173-184.
40. Mahieu S, Contini MD, Gonzez M, Millen N (2009) Melatonin reduces oxidative damage-induced by aluminum in rat kidney. Toxicol Lett 190: 9-15.
41. Marklund SL, Westman NG, Lundgren E, Roos G (1982) Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res 42: 1955-1961.
42. Mohan PF, Jacobson MS (1993) Inhibition of macrophage superoxide generation by dehydroepiandrosterone. Am J Med. Sci 306: 10-15.
43. Moron MS, Depierre JW, Mannervik B (1979) Level of glutathione, glutathione reductase and glutathion-S-transferase activities in rat lung and liver. Biochem Biophys Acta 582: 67-68.
44. Munoz-Castaneda JR, Muntane J, Munoz MC, Bujalance I, Montilla P, Tunez I (2006) Estradiol and catecholestrogens protect against adriamycin-induced oxidative stress in erythrocytes of ovariectomized rats. Toxicol Lett 160: 196-203.
45. Nagatsu T, Mogi M, Ichinose H, Togari A (2000) Changes in cytokines and neurotrophins in Parkinson's disease. J Neural Transm 20: 277- 290.
46. Nishikimi M, Appaji N, Yagi K (1972) The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem. Biophys Res Commun 46: 849-854.
47. Oswald C, Smits SH, Hoing M, Sohn-Bosser L, Dupont L, Le Rudulier D, Schmitt L, Bremer E (2008) Crystal structures of choline/acetylcholine substrate-binding protein chox from sinorhizobium meliloti in the liganded and unliganded-closed states. J Biol Chem 283: 32848-32859.
48. Ozdemir G, Ozden M, Maral H, Kuskay S, Cetinalp P (2005) Malondialdehde, glutathione, glutathione peroxidase and homocysteine levels in type 2 diabetic patients with and without microalbuminuria. Ann Clin Biochem. 42: 99-104.
49. Peters JM, Zhou YC, Ram P A, Lee SST, Gonzalez FJ, Waxman DJ (1996) Peroxisome proliferators-activated receptor α required for gene induction by dehydroepiandrosterone-3-β-sulfate. Mol Pharmacol 50: 67-74.
50. Rhodes ME, Li PK, Flood JF, Johnson DA (1996) Enhancement of hippocampal acetylcholine release by the neurosteroid dehydroepiandrosterone sulfate: an in vivo microdialysis study. Brain Res 733: 284-286.
51. Satoh K (1978) Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta 90: 37-43.
52. Schwartz AG, Whitcomb JM, Nyce JW, Lewbart ML, Pashko LL (1988) Dehydroepiandrosterone and structural analogs: a new class of cancer chemopreventive agents. Adv Cancer Res 51: 391-425.
53. Sharma K, Mehra RD (2008) Long term administration of estrogen or tamoxifen to ovariectomized rats affords neuroprote-ction to hippocampal neurons by modulating the expression of Bcl-2 and Bax. Brain Res 1204: 1-15.
54. Tabuchi A, Sakaya H, Kisukeda T, Fushiki H, Tsuda M (2002) Involvement of an upstream stimulatory factor as well as cAMP responsive element binding protein in the activation of brain derived neurotrophic factor gene promoter. J. Biol Chem 277: 35920-35931.
55. Takuma K, Matsuo A, Himeno Y, Hoshina Y, Ohno Y, Funatsu Y, Arai S, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M, Yamada K (2007) 17-β estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized rats. Neuroscience 146: 60-68.
56. 2+-ATPase activities induced by the in vitro galactosaemia. Pharmacol Res 49: 475-479.
57. Tuneva J, Chittur S, Boldyrev AA, Birman I, Carpenter DO (2006) Cerebellar granule cell death induced by aluminum. Neurotoxicol Res 9: 297-304
58. Van Groen T, Kadish I (2005) Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology. Brain Res Rev 48: 370-378.
59. Vina J, Sastre J, Pallardo FV,Gambini J, Borras C (2008) Modulation of longevity-associated genes by estrogens or phytooestrogens. Biol Chem 389: 273-277.
60. Yildirim A, Gumus M, Dalga S, Sahin YN, Akcay F (2003) Dehydroepiandrosterone improves hepatic antioxidant systems after renal ischemia-reperfusion injury in rabbits. Ann Clin Lab Sci 33: 459-464.
61. Walton JR, Wang MX (2009) APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease. J Inorg Biochem 103: 1548-1554.
62. Yousif MF, El-Rigal NS (2004) C-glycolsyl flavones O-glycosides of clerodendrum splendens G.Don. and antioxidants activity in schistosome-infected mice. Egypt J Biomed Sci 14: 128-137.
63. Yu BC, Chang CK, Ou HY, Cheng KC, Cheng JT (2008) Decreases of peroxisome proliferation-activated receptor delta expression in cardiomyopathy of streptozotocin-induced diabetic rats. Cardiovascular res 38: 257-261.
64. Zheng J, Yang JQ, He BC, Zhou QX, Yu HR, Tang Y, Liu BZ (2009) Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease. Saud Med J 30: 760-766.
65. Zheng P (2009) Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance. Progr Neurobiol 89: 134-152.