Comparative expression of thioredoxin-1 in uterine leiomyomas and myometrium

Molecular Human Reproduction

Volumn 20, Issue 2, 2014, Pages 148-154

  Hou, Ping ^a,b   Zhao, Lu ^a   Li, Ye ^a   Luo, Fucheng ^a   Wang, Shengdong ^a   Song, Junying ^a   Bai, Jie ^a  

^a KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

Cyclin D1; Cyclooxygenase 2 (COX 2); Hypoxia inducible factor 1 (HIF 1 ); Thioredoxin 1 (TRX 1); Uterine leiomyoma

Indexed keywords

CYCLIN D1; CYCLOOXYGENASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; THIOREDOXIN 1; THIOREDOXIN INTERACTING PROTEIN; TRANSCRIPTION FACTOR FKHRL1;

ARTICLE; CELL CYCLE; CELL PROLIFERATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; HYSTERECTOMY; LEIOMYOMA; LIPID PEROXIDATION; MYOMETRIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; UTERUS MYOMA; WESTERN BLOTTING;

CYCLIN D1; CYCLOOXYGENASE-2 (COX-2); HYPOXIA-INDUCIBLE FACTOR-1Α (HIF-1Α); THIOREDOXIN-1 (TRX-1); UTERINE LEIOMYOMA;

ADULT; BLOTTING, WESTERN; CYCLIN D1; CYCLOOXYGENASE 2; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LEIOMYOMA; MIDDLE AGED; MYOMETRIUM; NUCLEAR PROTEINS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TATA BOX BINDING PROTEIN-LIKE PROTEINS; THIOREDOXINS; UTERINE NEOPLASMS;

EID: 84892547070     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gat069     Document Type: Article

References (54)

1. Ahsan MK, Masutani H, Yamaguchi Y, Kim YC, Nosaka K, Matsuoka M, Nishinaka Y, Maeda M, Yodoi J. Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of hioredoxin-binding protein-2. Oncogene 2006;25:2181-2191.
2. Andersen CL, Jensen JL, Orntoft TF. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res 2004;64:5245-5250.
3. Antonietta RF, Antonella T, Lucia C, Maria-Paola M, Arne H, Geoffery JB, Alberto G, Andrew RM. Thioredoxin alters the matrix metalloproteinase/ tissue inhibitors of metalloproteinase balance and stimulates human SK-N-SH neuroblastoma cell invasion. Eur J Biochem 2001;268:405-413.
4. Biguet C, Wakasugi N, Mishal Z, Holmgren A, Chouaib S, Tursz T, Wakasugi H. Thioredoxin increases the proliferation of human B-cell lines through a protein kinase C-dependent mechanism. J Biol Chem 1994;269:28865-28870.
5. ChiAY,Waypa GB, Mungai PT, SchumackerPT. Prolonged hypoxia increases ROSsignaling and RhoAactivation in pulmonary artery smooth muscle and endothelial cells. Antioxid Redox Signal 2010;12:603-610.
6. Collet JF, Messens J. Structure, function, and mechanism of thioredoxin proteins. Antioxid Redox Signal 2010;13:1205-1216.
7. Csiki I, Yanagisawa K, Haruki N, Nadaf S, Morrow JD, Johnson DH, Carbone DP. Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1alpha in non-small cell lung cancer. Cancer Res 2006;66:143-150.
8. Deroo BJ, Hewitt SC, Peddada SD, Korach KS. Estradiol regulates the thioredoxin antioxidant system in the mouse uterus. Endocrinology 2004; 145:5485-5492.
9. Gillett C, Fantl V, Smith R, Fisher C, Bartek J, Dickson C, Barnes D, Peters G. Amplification and overexpression of cyclinD1in breast cancer detected by immunohistochemical staining. Cancer Res 1994;54:1812-1817.
10. Hashimoto S, Matsumoto K, Gon Y, Furuichi S, Maruoka S, Takeshita I, Hirota K, Yodoi J, Horie T. Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor necrosis factor-a. Biochem Biophys Res Commun 1999;258:443-447.
11. Ikarashi M, Takahashi Y, Ishii Y, Nagata T, Asai S, Ishikawa K. VitaminD3 up-regulated protein 1 (VDUP1) expression in gastrointestinal cancer and itsrelation to stage of disease. Anticancer Res 2002;22:4045-4048.
12. Jeon JH, Lee KN, Hwang CY, Kwon KS, You KH, Choi I. Tumor suppressor VDUP1 increases p27(kip1) stability by inhibiting JAB1. Cancer Res 2005; 65:4485-4489.
13. Jung Y, Isaacs JS, Lee S, Trepel J, Liu ZG, Neckers L. Hypoxiainducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation. Biochem J 2003a;370:1011-1017.
14. Jung YJ, Isaacs JS, Lee S,Trepel J,Neckers L. IL-1betamediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J 2003b;17:2115-2117.
15. Junn E, Han SH, Im JY, Yang Y, ChoEW, UmHD, Kim DK, LeeKW, Han PL, Rhee SG et al. VitaminD3up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J Immunol 2000;164:6287-6295.
16. Kaimul AM, Nakamura H, Masutani H, Yodoi J. Thioredoxin and thioredoxin-binding protein-2 in cancer and metabolic syndrome. Free Radic Biol Med 2007;43:861-868.
17. Kim YH, Coon A, Baker AF, Powis G. Antitumor agent PX-12 inhibits HIF-1alpha protein levels through an Nrf2/PMF-1-mediated increase in spermidine/spermine acetyl transferase. Cancer Chemother Pharmacol 2011;68:405-413.
18. Kovács KA, Oszter A, Göcze PM, Környei JL, Szabó I. Comparative analysis of cyclinD1andoestrogen receptor (alpha andbeta) levels inhumanleiomyoma and adjacent myometrium. Mol Hum Reprod 2001;7:1085-1091.
19. Lambeth JD. Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic Biol Med 2007;43:332-347. Li J, Du W, Maynard S, Andreassen PR, Pang Q. Oxidative stress-specific interaction between FANCD2 and FOXO3a. Blood 2010;115:1545-1548.
20. Li J, Du W, Maynard S, Andreassen PR, Pang Q. Oxidative stress-specific interaction between FANCD2 and FOXO3a. Blood 2010;115:1545-1548.
21. Li XN, Song J, Zhang L, LeMaire SA, Hou X, Zhang C, Coselli JS, Chen L,Wang XL, Zhang Y et al. Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin. Diabetes 2009;58:2246-2257.
22. Luo X, Ding L, Chegini N. CCNs, fibulin-1C and S100A4 expression in leiomyoma and myometrium: inverse association with TGF-beta and regulation by TGF-beta in leiomyoma and myometrial smooth muscle cells. Mol Hum Reprod 2006;12:245-256.
23. Masaki S, Masutani H, Yoshihara E, Yodoi J. Deficiency of thioredoxin binding protein-2 (TBP-2) enhances TGF-b signaling and promotes epithelial to mesenchymal transition. PLoS One 2012;7:e39900.
24. Masutani H, Bai J, Kim YC, Yodoi J. Thioredoxin as a neurotrophic cofactor and an important regulator of neuroprotection. Mol Neurobiol 2004; 29:229-242.
25. MatsumotoK,MasutaniH,NishiyamaA,Hashimoto S,GonY, HorieT,Yodoi J. C-propeptide region of human pro alpha 1 type 1 collagen interacts with thioredoxin. Biochem Biophys Res Commun 2002;295:663-667.
26. Maybin JA, Critchley HO, Jabbour HN. Inflammatory pathways in endometrial disorders. Mol Cell Endocrinol 2011;335:42-51.
27. Mayer A, Höckel M, Wree A, Leo C, Horn LC, Vaupel P. Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia. Cancer Res 2008;68:4719-4726.
28. Mesquita FS, Dyer SN,HeinrichDA, Bulun SE, Marsh EE,Nowak RA. Reactive oxygen species mediate mitogenic growth factor signaling pathways in human leiomyoma smooth muscle cells. Biol Reprod 2010;82:341-351.
29. MochizukiM,KwonYW,Yodoi J,MasutaniH.Thioredoxin regulates cell cycle via the ERK1/2-cyclin D1 pathway. Antioxid Redox Signal 2009;11:2957-2971.
30. Nishinaka Y, Nishiyama A, Masutani H, Oka S, Ahsan KM, Nakayama Y, Ishii Y, Nakamura H, Maeda M, Yodoi J. Loss of thioredoxin-binding protein-2/vitamin D3 up-regulated protein 1 in human T-cell leukemia virus type I-dependent T-cell transformation: implications for adult T-cell leukemia leukemogenesis. Cancer Res 2004;64:1287-1292.
31. Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J. Identification of thioredoxin-binding protein-2/vitaminD(3) up-regulated protein 1 as anegative regulator of thioredoxin function and expression. J BiolChem 1999;274:21645-21650.
32. Patwari P, Higgins LJ, ChutkowWA, Yoshioka J, Lee RT. The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange. J Biol Chem 2006;281:21884-21891.
33. Powis G, Montfort WR. Properties and biological activities of thioredoxins. Annu Rev Biophys Biomol Struct 2001;30:421-455.
34. Prabhakar NR, Kumar GK, Nanduri J. Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS. Respir Physiol Neurobiol 2010;174:230-234.
35. Rein MS, Barbieri RL, Friedman AJ. Progesterone: a critical role in the pathogenesis of uterine myomas. Am J Obstet Gynecol 1995;172:14-18.
36. Sadovsky Y, Kushner PJ, Roberts JM, Riemer RK. Restoration of estrogendependent progesterone receptor expression in a uterine myocyte cell line. Endocrinology 1993;132:1609-1613.
37. Sahlin L, Wang H, Lindblom B, Eriksson H, Holmgren A, Blanck A. Thioredoxin expression in human myometrium and fibroids. Mol Hum Reprod 2000;6:60-67.
38. Scortegagna M, Cataisson C, Martin RJ, Hicklin DJ, Schreiber RD, Yuspa SH, Arbeit JM. HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling. Blood 2008; 111:3343-3354.
39. Shimomura Y, Matsuo H, Samoto T, Maruo T. Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma. J Clin Endocrinol Metab 1998;83:2192-2198.
40. Song J, Dong X, Chen Y, Chen G, Liang H, Nakamura H, Yodoi J, Bai J. The expression of thioredoxin-1 in preterm delivery placenta. Redox Rep 2012; 17:187-193.
41. Stasinopoulos I, Shah T, Penet MF, Krishnamachary B, Bhujwalla ZM. COX-2 in cancer: Gordian knot or Achilles heel?. Front Pharmacol 2013; 4:34.
42. Stewart EA, Friedman AJ, Peck K, Nowak RA. Relative overexpression of collagen type I and collagen type III messenger ribonucleic acids by uterine leiomyomas during the proliferative phase of the menstrual cycle. J Clin Endocrinol Metab 1994;79:900-906.
43. Strawn EY Jr, Novy MJ, Burry KA, Bethea CL. Insulin-like growth factor I promotes leiomyoma cell growth in vitro. Am J Obstet Gynecol 1995; 172:1837-1843.
44. Svegliati S, Cancello R, Sambo P, Luchetti M, Paroncini P, Orlandini G, Discepoli G, Paterno R, Santillo M, Cuozzo C et al. Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblast. J BiolChem2005;280:36474-36482.
45. Takahashi Y,MasudaH, Ishii Y, Nishida Y, Kobayashi M, Asai S. Decreased expression of thioredoxin interacting protein mRNA in inflamed colonic mucosa in patients with ulcerative colitis. Oncol Rep 2007; 18:531-535.
46. Tropeano G, Amoroso S, Scambia G. Non-surgical management of uterine fibroids. Hum Reprod Update 2008;14:259-274.
47. Ushio-FukaiM,Alexander RW,AkersM, Griendling KK. p38 Mitogenactivated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy. J Biol Chem1998;273:15022-15029.
48. Varghese BV, Koohestani F, McWilliams M, Colvin A, Gunewardena S, Kinsey WH, Nowak RA, Nothnick WB, Chennathukuzhi VM. Loss of the repressor REST in uterine fibroids promotes aberrant G proteincoupledreceptor 10 expression and activates mammalian target of rapamycin pathway. Proc Natl Acad Sci USA 2013;110:2187-2192.
49. Vestergaard AL, Knudsen UB, Munk T, Rosbach H, Martensen PM. Transcriptional expression of type-I interferon response genes and stability of housekeeping genes in the human endometrium and endometriosis. Mol Hum Reprod 2011;17:243-254.
50. Walker CL, Stewart EA. Uterine fibroids: the elephant in the room. Science 2005;308:1589-1592.
51. Wegienka G. Are uterine leiomyoma a consequence of a chronically inflammatory immune system? Med Hypotheses 2012;79:226-231.
52. Welsh SJ,BellamyWT, BriehlMM, Powis G.TheRedox ProteinThioredoxin-1(TRX-1) Increases Hypoxia-Inducible Factor 1α Protein Expression: TRX-1 Overexpression Results inIncreased Vascular Endothelial Growth Factor Production and Enhanced Tumor Angiogenesis. Cancer Res 2002; 62:5089-5095.
53. Yoshioka J, Schreiter ER, Lee RT. Role of thioredoxin in cell growth through interactions with signaling molecules. Antioxid Redox Signal 2006; 8:2143-2151.
54. Yu L, Saile K, Swartz CD, He H, Zheng X, Kissling GE, Di X, Lucas S, Robboy SJ, Dixon D. Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. Mol Med 2008;14:264-275.