Deficiency of Thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes epithelial to mesenchymal transition

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Masaki, So ^a   Masutani, Hiroshi ^a   Yoshihara, Eiji ^a   Yodoi, Junji ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

SMAD2 PROTEIN; THIOREDOXIN INTERACTING PROTEIN; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL STRUCTURE; CONTROLLED STUDY; EMBRYO; EPITHELIAL MESENCHYMAL TRANSITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CADHERINS; CARRIER PROTEINS; CELL SHAPE; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; PHOSPHORYLATION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; THIOREDOXINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

GASTROPODA;

EID: 84863108603     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039900     Document Type: Article

References (42)

1. Pardali K, Moustakas A, (2007) Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer. Biochimica et Biophysica Acta (BBA)- Reviews on Cancer 1775: 21-62.
2. Zavadil J, Böttinger EP, (2005) TGF-β and epithelial-to-mesenchymal transitions. Oncogene 24: 5764-5774.
3. Thiery JP, Sleeman JP, (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nature Reviews Molecular Cell Biology 7: 131-142.
4. Xu J, Lamouille S, Derynck R, (2009) TGF-β-induced epithelial to mesenchymal transition. Cell Research 19: 156-172.
5. Vincent T, Neve EPA, Johnson JR, Kukalev A, Rojo F, et al. (2009) A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial-mesenchymal transition. Nature Cell Biology 11: 943-950.
6. Karen M. Hajra DY-SC, Fearon ER, (2002) The SLUG Zinc-Finger Protein Represses E-Cadherin in Breast Cancer. Cancer Research 62: 1613-1618.
7. Nieto MA, (2002) The snail superfamily of zinc-finger transcription factors. Nature reviews Molecular cell biology 3: 155-166.
8. Peinado H, Olmeda D, Cano A, (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nature Reviews Cancer 7: 415-428.
9. Bodnar JS, Chatterjee A, Castellani LW, Ross DA, Ohmen J, et al. (2002) Positional cloning of the combined hyperlipidemia gene Hyplip1. Nature Genetics 30: 110-116.
10. Chen KS, DeLuca HF, (1994) Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3. biochimica et Biophysica Acta 1219: 26-32.
11. Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, et al. (1999) Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression. The Journal of Biological Chemistory 274: 21645-21650.
12. Nishinaka Y, Masutani H, Oka Si, Matsuo Y, Yamaguchi Y, et al. (2004) Importin α1 (Rch1) Mediates Nuclear Translocation of Thioredoxin-binding Protein-2/Vitamin D3-up-regulated Protein 1. Journal of Biological Chemistry 279: 37559-37565.
13. Alvarez CE, (2008) On the origins of arrestin and rhodopsin. BMC evolutionary biology 8: 222.
14. Patwari P, Chutkow WA, Cummings K, Verstraeten VLRM, Lammerding J, et al. (2009) Thioredoxin-independent Regulation of Metabolism by the-Arrestin Proteins. Journal of Biological Chemistry 284: 24996-25003.
15. Kuljaca S, Liu T, Dwarte T, Kavallaris M, Haber M, et al. (2009) The cyclin-dependent kinase inhibitor, p21WAF1, promotes angiogenesis by repressing gene transcription of thioredoxin-binding protein 2 in cancer cells. Carcinogenesis 30: 1865-1871.
16. Chen J, Hui ST, Couto FM, Mungrue IN, Davis DB, et al. (2008) Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. The FASEB Journal 22: 3581-3594.
17. Lee KN, Kang H-S, Jeon J-H, Kim E-M, Yoon S-R, et al. (2005) VDUP1 Is Required for the Development of Natural Killer Cells. Immunity 22: 195-208.
18. Son A, Nakamura H, Okuyama H, Oka Si, Yoshihara E, et al. (2008) Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses. European Journal of Immunology 38: 1358-1367.
19. Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J, (2009) Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nature Immunology 11: 136-140.
20. Hui TY, Sheth SS, Diffley JM, Potter DW, Lusis AJ, et al. (2004) Mice Lacking Thioredoxin-interacting Protein Provide Evidence Linking Cellular Redox State to Appropriate Response to Nutritional Signals. Journal of Biological Chemistry 279: 24387-24393.
21. Parikh H, Carlsson E, Chutkow WA, Johansson LE, Storgaard H, et al. (2007) TXNIP Regulates Peripheral Glucose Metabolism in Humans. PLoS Medicine 4: 0868-0879.
22. Hui ST, Andres AM, Miller AK, Spann NJ, Potter DW, et al. (2008) Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proceedings of the National Academy of Sciences of the United States of America 105: 3921-3926.
23. Oka Si, Yoshihara E, Bizen-Abe A, Liu W, Watanabe M, et al. (2008) Thioredoxin Binding Protein-2/Thioredoxin-Interacting Protein Is a Critical Regulator of Insulin Secretion and Peroxisome Proliferator-Activated Receptor Function. Endocrinology 150: 1225-1234.
24. Yoshihara E, Fujimoto S, Inagaki N, Okawa K, Masaki S, et al. (2010) Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity. Nature Communications 1: 127.
25. Butler LM, Zhou X, Xu WS, Scher HI, Rifkind RA, et al. (2002) The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin. Proceedings of the National Academy of Sciences 99: 11700-11705.
26. Goldberg SF, Miele ME, Hatta N, Takata M, Paquette-Straub C, et al. (2003) Melanoma Metastasis Suppression by Chromosome 6: Evidence for a Pathway Regulated by CRSP3 and TXNIP. Cancer Research 63: 432-440.
27. Han SH, Jeon JH, Ju HR, Jung U, Kim KY, et al. (2003) VDUP1 upregulated by TGF-β1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. Oncogene 22: 4035-4046.
28. Nishinaka Y, Nishiyama A, Masutani H, Oka Si, Ahsan KM, et al. (2004) Loss of Thioredoxin-Binding Protein-2/Vitamin D3 Up-Regulated Protein 1 in Human T-Cell Leukemia Virus Type I-Dependent T-Cell Transformation: Implications for Adult T-Cell Leukemia Leukemogenesis. Cancer Research 64: 1287-1292.
29. Jeon JH, Lee KN, Hwang CY, Kwon KS, You KH, et al. (2005) Tumor Suppressor VDUP1 Increases p27kip1 Stability by Inhibiting JAB1. Cancer Research 65: 4485-4489.
30. Kim SY, Shu HW, Chung JW, Yoon SR, Choi I, (2007) Diverse Functions of VDUP1 in Cell Proliferation, Differentiation, and Diseases. Cellular & Molecular Immunology 4: 345-351.
31. Ahsan MK, Masutani H, Yamaguchi Y, Kim YC, Nosaka K, et al. (2005) Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2. Oncogene 25: 2181-2191.
32. Chen Z, Lopez-Ramos DA, Yoshihara E, Maeda Y, Masutani H, et al. (2010) Thioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation. Leukemia 25: 440-448.
33. Sheth SS, Bodnar JS, Ghazalpour A, Thipphavong CK, Tsutsumi S, et al. (2006) Hepatocellular carcinoma in Txnip-deficient mice. Oncogene 25: 3528-3536.
34. Kwon HJ, Won YS, Suh HW, Jeon JH, Shao Y, et al. (2010) Vitamin D3 Upregulated Protein 1 Suppresses TNF-α-Induced NF- B Activation in Hepatocarcinogenesis. The Journal of Immunology 185: 3980-3989.
35. Nishizawa K, Nishiyama H, Matsui Y, Kobayashi T, Saito R, et al. (2011) Thioredoxin-interacting protein suppresses bladder carcinogenesis. Carcinogenesis 32: 1459-1466.
36. Kwon HJ, Won YS, Yoon YD, Yoon WK, Nam KH, et al. (2011) Vitamin D3 up-regulated protein 1 deficiency accelerates liver regeneration after partial hepatectomy in mice. Journal of Hepatology 54: 1168-1176.
37. Arai RJ, Ogata FT, Batista WL, Masutani H, Yodoi J, et al. (2008) Thioredoxin-1 promotes survival in cells exposed to S-nitrosoglutathione: Correlation with reduction of intracellular levels of nitrosothiols and up-regulation of the ERK1/2 MAP Kinases. Toxicology and applied pharmacology 233: 227-237.
38. Jin HO, Seo SK, Kim YS, Woo SH, Lee KH, et al. (2011) TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1. Oncogene 30: 3792-3801.
39. Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di Guglielmo GM, et al. (2005) Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. Molecular cell 19: 297-308.
40. Inoue Y, Imamura T, (2008) Regulation of TGF-β family signaling by E3 ubiquitin ligases. Cancer Science 99: 2107-2112.
41. Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, et al. (2000) Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGF-β Receptor for Degradation. Molecular Cell 6: 1365-1375.
42. Shi W, Sun C, He B, Xiong W, Shi X, et al. (2004) GADD34-PP1c recruited by Smad7 dephosphorylates TGF type I receptor. The Journal of Cell Biology 164: 291-300.