메뉴 건너뛰기




Volumn 32, Issue 48, 2012, Pages 17391-17400

Genetic mechanisms mediating kisspeptin regulation of GnRH gene expression

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; KISSPEPTIN; TRANSCRIPTION FACTOR OTX2;

EID: 84870176736     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2438-12.2012     Document Type: Article
Times cited : (35)

References (54)
  • 1
    • 0032992524 scopus 로고    scopus 로고
    • Binding properties of the human homeodomain protein OTX2 to a DNA target sequence
    • Briata P, Ilengo C, Bobola N, Corte G (1999) Binding properties of the human homeodomain protein OTX2 to a DNA target sequence. FEBS Lett 445:160-164.
    • (1999) FEBS Lett , vol.445 , pp. 160-164
    • Briata, P.1    Ilengo, C.2    Bobola, N.3    Corte, G.4
  • 3
    • 58149178839 scopus 로고    scopus 로고
    • Basic aspects of the control of GnRH and LH secretions by kisspeptin: Potential applications for better control of fertilityin females
    • 18638120
    • Caraty A, Franceschini I (2008) Basic aspects of the control of GnRH and LH secretions by kisspeptin: potential applications for better control of fertilityin females.Reprod Domest Anim 43 [Suppl 2]:172-178.18638120
    • (2008) Reprod Domest Anim , vol.43 , Issue.2 , pp. 172-178
    • Caraty, A.1    Franceschini, I.2
  • 4
    • 0347683480 scopus 로고    scopus 로고
    • A novel AP-1 site is critical for maximal induction of the follicle-stimulating hormone beta gene by gonadotropin-releasing hormone
    • Medline
    • Coss D, Jacobs SB, Bender CE, Mellon PL (2004) A novel AP-1 site is critical for maximal induction of the follicle-stimulating hormone beta gene by gonadotropin-releasing hormone. J Biol Chem 279:152-162. Medline
    • (2004) J Biol Chem , vol.279 , pp. 152-162
    • Coss, D.1    Jacobs, S.B.2    Bender, C.E.3    Mellon, P.L.4
  • 5
    • 0141814637 scopus 로고    scopus 로고
    • Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
    • de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E (2003) Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 100:10972-10976.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10972-10976
    • de Roux, N.1    Genin, E.2    Carel, J.C.3    Matsuda, F.4    Chaussain, J.L.5    Milgrom, E.6
  • 6
    • 57349103617 scopus 로고    scopus 로고
    • A novel dominant negative mutationofOTX2 associated with combined pituitary hormone deficiency
    • Diaczok D, Romero C, Zunich J, Marshall I, Radovick S (2008) A novel dominant negative mutationofOTX2 associated with combined pituitary hormone deficiency. J Clin Endocrinol Metab 93:4351-4359.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4351-4359
    • Diaczok, D.1    Romero, C.2    Zunich, J.3    Marshall, I.4    Radovick, S.5
  • 8
    • 32644451823 scopus 로고    scopus 로고
    • Minireview: Kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion
    • Dungan HM, Clifton DK, Steiner RA (2006) Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology 147:1154-1158.
    • (2006) Endocrinology , vol.147 , pp. 1154-1158
    • Dungan, H.M.1    Clifton, D.K.2    Steiner, R.A.3
  • 9
    • 0032230256 scopus 로고    scopus 로고
    • Oct-1 binds promoter elements required for transcription of the GnRH gene
    • Eraly SA, Nelson SB, Huang KM, Mellon PL (1998) Oct-1 binds promoter elements required for transcription of the GnRH gene. Mol Endocrinol 12:469-481.
    • (1998) Mol Endocrinol , vol.12 , pp. 469-481
    • Eraly, S.A.1    Nelson, S.B.2    Huang, K.M.3    Mellon, P.L.4
  • 10
    • 84862666470 scopus 로고    scopus 로고
    • Histone deacetylases regulate gonadotropin-releasing hormone i gene expression via modulating Otx2-driven tran-scriptional activity
    • Gan L, Ni PY, Ge Y, Xiao YF, Sun CY, Deng L, Zhang W, Wu SS, Liu Y, Jiang W, Xin HB (2012) Histone deacetylases regulate gonadotropin-releasing hormone i gene expression via modulating Otx2-driven tran-scriptional activity. PLoS One 7:e39770.
    • (2012) PLoS One , vol.7
    • Gan, L.1    Ni, P.Y.2    Ge, Y.3    Xiao, Y.F.4    Sun, C.Y.5    Deng, L.6    Zhang, W.7    Wu, S.S.8    Liu, Y.9    Jiang, W.10    Xin, H.B.11
  • 11
    • 67649524640 scopus 로고    scopus 로고
    • Isolation of active regulatory elements from eu-karyotic chromatin using FAIRE (Formaldehyde Assisted Isolation of Regulatory Elements)
    • Giresi PG, Lieb JD (2009) Isolation of active regulatory elements from eu-karyotic chromatin using FAIRE (Formaldehyde Assisted Isolation of Regulatory Elements). Methods 48:233-239.
    • (2009) Methods , vol.48 , pp. 233-239
    • Giresi, P.G.1    Lieb, J.D.2
  • 12
    • 33745916162 scopus 로고    scopus 로고
    • Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis
    • Gottsch ML, Clifton DK, Steiner RA (2006) Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis. Mol Cell Endocrinol 254-255: 91-96.
    • (2006) Mol Cell Endocrinol
    • Gottsch, M.L.1    Clifton, D.K.2    Steiner, R.A.3
  • 14
    • 34447131517 scopus 로고    scopus 로고
    • Regulation of type II collagen expression by histone deacetylase in articular chondrocytes
    • Huh YH, Ryu JH, Chun JS (2007) Regulation of type II collagen expression by histone deacetylase in articular chondrocytes. J Biol Chem 282:17123-17131.
    • (2007) J Biol Chem , vol.282 , pp. 17123-17131
    • Huh, Y.H.1    Ryu, J.H.2    Chun, J.S.3
  • 15
    • 79952123625 scopus 로고    scopus 로고
    • Dynamic chromatin modifications control GnRH gene expression during neuronal differentiation and protein kinase C signal transduction
    • Iyer AK, Brayman MJ, Mellon PL (2011) Dynamic chromatin modifications control GnRH gene expression during neuronal differentiation and protein kinase C signal transduction. Mol Endocrinol 25:460-473.
    • (2011) Mol Endocrinol , vol.25 , pp. 460-473
    • Iyer, A.K.1    Brayman, M.J.2    Mellon, P.L.3
  • 16
    • 36248998213 scopus 로고    scopus 로고
    • 17-Beta-estradiol directly regulates the expression of adrenergic receptors and kisspeptin/GPR54 system in GT1-7 GnRH neurons
    • Jacobi JS, Martin C, Nava G, Jeziorski MC, Clapp C, Martínez dela Escalera G (2007) 17-Beta-estradiol directly regulates the expression of adrenergic receptors and kisspeptin/GPR54 system in GT1-7 GnRH neurons. Neu-roendocrinology 86:260-269.
    • (2007) Neu-roendocrinology , vol.86 , pp. 260-269
    • Jacobi, J.S.1    Martin, C.2    Nava, G.3    Jeziorski, M.C.4    Clapp, C.5    Martínez dela Escalera, G.6
  • 17
    • 34848890984 scopus 로고    scopus 로고
    • Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction
    • Kauffman AS, Clifton DK, Steiner RA (2007) Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction. Trends Neurosci 30:504-511.
    • (2007) Trends Neurosci , vol.30 , pp. 504-511
    • Kauffman, A.S.1    Clifton, D.K.2    Steiner, R.A.3
  • 18
    • 0034464904 scopus 로고    scopus 로고
    • The Otx2 homeoprotein regulates expression from the gonadotropin-releasing hormone proximal promoter
    • Kelley CG, Lavorgna G, Clark ME, Boncinelli E, Mellon PL (2000) The Otx2 homeoprotein regulates expression from the gonadotropin-releasing hormone proximal promoter. Mol Endocrinol 14:1246-1256.
    • (2000) Mol Endocrinol , vol.14 , pp. 1246-1256
    • Kelley, C.G.1    Lavorgna, G.2    Clark, M.E.3    Boncinelli, E.4    Mellon, P.5
  • 19
    • 0037085359 scopus 로고    scopus 로고
    • Promoter sequences targeting tissue-specific gene expression of hypothalamic and ovarian gonadotropin-releasing hormone in vivo
    • Kim HH, Wolfe A, Smith GR, Tobet SA, Radovick S (2002) Promoter sequences targeting tissue-specific gene expression of hypothalamic and ovarian gonadotropin-releasing hormone in vivo. J Biol Chem 277:5194-5202.
    • (2002) J Biol Chem , vol.277 , pp. 5194-5202
    • Kim, H.H.1    Wolfe, A.2    Smith, G.R.3    Tobet, S.A.4    Radovick, S.5
  • 20
    • 33846619696 scopus 로고    scopus 로고
    • In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone
    • Kim HH, Wolfe A, Cohen RN, Eames SC, Johnson AL, Wieland CN, Radovick S (2007) In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone. Mol Endocrinol 21: 457-471.
    • (2007) Mol Endocrinol , vol.21 , pp. 457-471
    • Kim, H.H.1    Wolfe, A.2    Cohen, R.N.3    Eames, S.C.4    Johnson, A.L.5    Wieland, C.N.6    Radovick, S.7
  • 21
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides T (2007) Chromatin modifications and their function. Cell 128: 693-705.
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 22
    • 78049513957 scopus 로고    scopus 로고
    • Epigenetic changes coincide with in vitro primate GnRH neuronal maturation
    • Kurian JR, Keen KL, Terasawa E (2010) Epigenetic changes coincide with in vitro primate GnRH neuronal maturation. Endocrinology 151:5359-5368.
    • (2010) Endocrinology , vol.151 , pp. 5359-5368
    • Kurian, J.R.1    Keen, K.L.2    Terasawa, E.3
  • 24
    • 67650527155 scopus 로고    scopus 로고
    • Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors
    • Larder R, Mellon PL (2009) Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors. J Biol Chem 284:16966-16978.
    • (2009) J Biol Chem , vol.284 , pp. 16966-16978
    • Larder, R.1    Mellon, P.L.2
  • 25
    • 47549106165 scopus 로고    scopus 로고
    • Specific GATA-binding elements in the GnRH promoter are required for gene expression pulse activity: Role of GATA-4 and GATA-5 in this intermittent process
    • Leclerc GM, Bose SK, Boockfor FR (2008) Specific GATA-binding elements in the GnRH promoter are required for gene expression pulse activity: role of GATA-4 and GATA-5 in this intermittent process. Neuroendocri-nology 88:1-16.
    • (2008) Neuroendocri-nology , vol.88 , pp. 1-16
    • Leclerc, G.M.1    Bose, S.K.2    Boockfor, F.R.3
  • 26
    • 30044449633 scopus 로고    scopus 로고
    • Identification of a novel OCT1 binding site that is necessary for the elaboration of pulses of rat GnRH promoter activity
    • Leclerc GM, Boockfor FR (2005) Identification of a novel OCT1 binding site that is necessary for the elaboration of pulses of rat GnRH promoter activity. Mol Cell Endocrinol 245:86-92.
    • (2005) Mol Cell Endocrinol , vol.245 , pp. 86-92
    • Leclerc, G.M.1    Boockfor, F.R.2
  • 27
    • 33847070442 scopus 로고    scopus 로고
    • The role of chromatin during transcription
    • Li B, Carey M, Workman JL (2007) The role of chromatin during transcription. Cell 128:707-719.
    • (2007) Cell , vol.128 , pp. 707-719
    • Li, B.1    Carey, M.2    Workman, J.L.3
  • 29
    • 0030218980 scopus 로고    scopus 로고
    • OTX2 ho-meoprotein in the developing central nervous system and migratory cells of the olfactory area
    • Mallamaci A, Di Blas E, Briata P, Boncinelli E, Corte G (1996) OTX2 ho-meoprotein in the developing central nervous system and migratory cells of the olfactory area. Mech Dev 58:165-178.
    • (1996) Mech Dev , vol.58 , pp. 165-178
    • Mallamaci, A.1    Di Blas, E.2    Briata, P.3    Boncinelli, E.4    Corte, G.5
  • 30
    • 0024623863 scopus 로고
    • A DNA cassette containing a trimerized SV40 polyadenylation signal which efficiently blocks spurious plasmid-initiated transcription
    • Maxwell IH, Harrison GS, Wood WM, Maxwell F (1989) A DNA cassette containing a trimerized SV40 polyadenylation signal which efficiently blocks spurious plasmid-initiated transcription. BioTechniques 7: 276-280.
    • (1989) BioTechniques , vol.7 , pp. 276-280
    • Maxwell, I.H.1    Harrison, G.S.2    Wood, W.M.3    Maxwell, F.4
  • 33
    • 0033734710 scopus 로고    scopus 로고
    • Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells
    • Nelson SB, Lawson MA, Kelley CG, Mellon PL (2000) Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells. Mol Endocrinol 14:1509-1522.
    • (2000) Mol Endocrinol , vol.14 , pp. 1509-1522
    • Nelson, S.B.1    Lawson, M.A.2    Kelley, C.G.3    Mellon, P.L.4
  • 34
    • 69249219124 scopus 로고    scopus 로고
    • Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines
    • Novaira HJ, Ng Y, Wolfe A, Radovick S (2009) Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines. Mol Cell Endocrinol 311:126-134.
    • (2009) Mol Cell Endocrinol , vol.311 , pp. 126-134
    • Novaira, H.J.1    Ng, Y.2    Wolfe, A.3    Radovick, S.4
  • 35
    • 79952276015 scopus 로고    scopus 로고
    • The gonadotropin-releasing hormone cell-specific element is required for normal puberty and estrous cyclicity
    • Novaira HJ, Yates M, Diaczok D, Kim H, Wolfe A, Radovick S (2011) The gonadotropin-releasing hormone cell-specific element is required for normal puberty and estrous cyclicity. J Neurosci 31:3336-3343.
    • (2011) J Neurosci , vol.31 , pp. 3336-3343
    • Novaira, H.J.1    Yates, M.2    Diaczok, D.3    Kim, H.4    Wolfe, A.5    Radovick, S.6
  • 36
    • 0346594337 scopus 로고    scopus 로고
    • Eivers E,De Robertis EM(2003)Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction
    • Pera EM, Ikeda A, Eivers E,De Robertis EM (2003) Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes Dev 17:3023-3028.
    • Genes Dev , vol.17 , pp. 3023-3028
    • Pera, E.M.1    Ikeda, A.2
  • 37
    • 0035512635 scopus 로고    scopus 로고
    • Neural and head induction by insulin-like growth factor signals
    • Pera EM, Wessely O, Li SY, De Robertis EM (2001) Neural and head induction by insulin-like growth factor signals. Dev Cell 1:655-665.
    • (2001) Dev Cell , vol.1 , pp. 655-665
    • Pera, E.M.1    Wessely, O.2    Li, S.Y.3    de Robertis, E.M.4
  • 38
    • 41549121999 scopus 로고    scopus 로고
    • Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol
    • Pielecka-Fortuna J, Chu Z, Moenter SM (2008) Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol. Endocrinology 149:1979-1986.
    • (2008) Endocrinology , vol.149 , pp. 1979-1986
    • Pielecka-Fortuna, J.1    Chu, Z.2    Moenter, S.M.3
  • 39
    • 0035051857 scopus 로고    scopus 로고
    • Cycles of transcription and translation do not comprise the gonadotropin-releasing hormone pulse generator in GT1 cells
    • Pitts GR, Nunemaker CS, Moenter SM (2001) Cycles of transcription and translation do not comprise the gonadotropin-releasing hormone pulse generator in GT1 cells. Endocrinology 142:1858-1864.
    • (2001) Endocrinology , vol.142 , pp. 1858-1864
    • Pitts, G.R.1    Nunemaker, C.S.2    Moenter, S.M.3
  • 41
    • 24744459873 scopus 로고    scopus 로고
    • The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1
    • Rave-Harel N, Miller NL, Givens ML, Mellon PL (2005) The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. J Biol Chem 280:30975-30983.
    • (2005) J Biol Chem , vol.280 , pp. 30975-30983
    • Rave-Harel, N.1    Miller, N.L.2    Givens, M.L.3    Mellon, P.L.4
  • 42
    • 37649008207 scopus 로고    scopus 로고
    • New fron-tiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function
    • Roa J, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M (2008a) New fron-tiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function. Front Neuroendocrinol 29:48-69.
    • (2008) Front Neuroendocrinol , vol.29 , pp. 48-69
    • Roa, J.1    Aguilar, E.2    Dieguez, C.3    Pinilla, L.4    Tena-Sempere, M.5
  • 43
    • 41549109864 scopus 로고    scopus 로고
    • Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: Implications for the generation of the preovulatory surge
    • Roa J, Vigo E, Castellano JM, Gaytan F, Navarro VM, Aguilar E, Dijcks FA, Ederveen AG, Pinilla L, van Noort PI, Tena-Sempere M (2008b) Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge. Endocrinology 149: 1627-1637.
    • (2008) Endocrinology , vol.149 , pp. 1627-1637
    • Roa, J.1    Vigo, E.2    Castellano, J.M.3    Gaytan, F.4    Navarro, V.M.5    Aguilar, E.6    Dijcks, F.A.7    Ederveen, A.G.8    Pinilla, L.9    van Noort, P.I.10    Tena-Sempere, M.11
  • 45
    • 33645884139 scopus 로고    scopus 로고
    • Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mu-latta): A finding with therapeutic implications
    • Seminara SB, Dipietro MJ, Ramaswamy S, Crowley WF Jr, Plant TM (2006) Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mu-latta): a finding with therapeutic implications. Endocrinology 147: 2122-2126.
    • (2006) Endocrinology , vol.147 , pp. 2122-2126
    • Seminara, S.B.1    Dipietro, M.J.2    Ramaswamy, S.3    Crowley Jr., W.F.4    Plant, T.M.5
  • 46
    • 0242348752 scopus 로고    scopus 로고
    • Histone lysine methylation: A signature for chromatin function
    • Sims 3rd
    • Sims RJ 3rd, Nishioka K, Reinberg D (2003) Histone lysine methylation: a signature for chromatin function. Trends Genet 19:629-639.
    • (2003) Trends Genet , vol.19 , pp. 629-639
    • Sims, R.J.1    Nishioka, K.2    Reinberg, D.3
  • 47
    • 0037083389 scopus 로고    scopus 로고
    • Otx2 is required to respond to signals from anterior neural ridge for forebrain specification
    • Tian E, Kimura C, Takeda N, Aizawa S, Matsuo I (2002) Otx2 is required to respond to signals from anterior neural ridge for forebrain specification. Dev Biol 242:204-223.
    • (2002) Dev Biol , vol.242 , pp. 204-223
    • Tian, E.1    Kimura, C.2    Takeda, N.3    Aizawa, S.4    Matsuo, I.5
  • 49
    • 0029832193 scopus 로고    scopus 로고
    • Cell-specific expression of the human gonadotropin-releasing hormone gene in transgenic animals
    • Wolfe AM, Wray S, Westphal H, Radovick S (1996) Cell-specific expression of the human gonadotropin-releasing hormone gene in transgenic animals. J Biol Chem 271:20018-20023.
    • (1996) J Biol Chem , vol.271 , pp. 20018-20023
    • Wolfe, A.M.1    Wray, S.2    Westphal, H.3    Radovick, S.4
  • 50
    • 0036186171 scopus 로고    scopus 로고
    • Identification of a discrete promoter region of the human GnRH gene that is sufficient for directing neuron-specific expression: Arole for POU homeodomain transcription factors
    • Wolfe A, Kim HH, Tobet S, Stafford DE, Radovick S (2002) Identification of a discrete promoter region of the human GnRH gene that is sufficient for directing neuron-specific expression: arole for POU homeodomain transcription factors. Mol Endocrinol 16:435-449.
    • (2002) Mol Endocrinol , vol.16 , pp. 435-449
    • Wolfe, A.1    Kim, H.H.2    Tobet, S.3    Stafford, D.E.4    Radovick, S.5
  • 52
    • 24944534978 scopus 로고    scopus 로고
    • Real-time PCR for mRNA quantitation
    • Wong ML, Medrano JF (2005) Real-time PCR for mRNA quantitation. Bio-Techniques 39:75-85.
    • (2005) Bio-Techniques , vol.39 , pp. 75-85
    • Wong, M.L.1    Medrano, J.F.2
  • 53
    • 0024421286 scopus 로고
    • Thyroid hormone regulates the mouse thyrotropin beta-subunit gene promoter in trans-fected primary thyrotropes
    • Wood WM, Kao MY, Gordon DF, Ridgway EC (1989) Thyroid hormone regulates the mouse thyrotropin beta-subunit gene promoter in trans-fected primary thyrotropes. J Biol Chem 264:14840-14847.
    • (1989) J Biol Chem , vol.264 , pp. 14840-14847
    • Wood, W.M.1    Kao, M.Y.2    Gordon, D.F.3    Ridgway, E.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.