Synthesis of hydrophilic intra-articular microspheres conjugated to ibuprofen and evaluation of anti-inflammatory activity on articular explants

International Journal of Pharmaceutics

Volumn 459, Issue 1-2, 2014, Pages 51-61

  Bédouet, Laurent ^a   Moine, Laurence ^b   Pascale, Florentina ^c   Nguyen, Van Nga ^b   Labarre, Denis ^b   Laurent, Alexandre ^a,c  

^a Occlugel SAS   (France)

^b IPSIT   (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

DDS; Hydrogel; Ibuprofen; Microspheres; Osteoarthritis; Prodrug

Indexed keywords

BUFFER; CARBOXYLIC ACID; IBUPROFEN; LIPOPOLYSACCHARIDE; MICROSPHERE; PROSTAGLANDIN E2; SODIUM CHLORIDE;

ADULT; ALKALINITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ARTICULAR CARTILAGE; DRUG DEGRADATION; DRUG RELEASE; EXPLANT; HYDROLYSIS; HYDROPHILICITY; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; SYNOVIUM;

DDS; HYDROGEL; IBUPROFEN; MICROSPHERES; OSTEOARTHRITIS; PRODRUG;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARTILAGE, ARTICULAR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE INHIBITORS; DELAYED-ACTION PREPARATIONS; DIALYSIS; DINOPROSTONE; HYDROLYSIS; IBUPROFEN; INJECTIONS, INTRA-ARTICULAR; L-LACTATE DEHYDROGENASE; LACTIC ACID; LIPOPOLYSACCHARIDES; MAGNETIC RESONANCE SPECTROSCOPY; MICROSPHERES; ORGAN CULTURE TECHNIQUES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SHEEP; SYNOVIAL MEMBRANE;

EID: 84892440805     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.11.004     Document Type: Article

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