Early detection of renal damage caused by fumaric acid ester therapy by determination of urinary β2-microglobulin

British Journal of Dermatology

Volumn 164, Issue 3, 2011, Pages 648-651

  Haring N ^a   Mähr, H Sprenger ^a   Mundle M ^a   Strohal, R ^a   Lhotta, K ^a  

^a Academic Teaching Hospital Feldkirch   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; FUMADERM;

ADULT; ARTICLE; CLINICAL ARTICLE; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG MEGADOSE; DRUG WITHDRAWAL; EARLY DIAGNOSIS; FEMALE; HUMAN; KIDNEY INJURY; LOW DRUG DOSE; MALE; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PSORIASIS; SIDE EFFECT; URINARY EXCRETION;

ACUTE KIDNEY INJURY; ADULT; BETA 2-MICROGLOBULIN; BIOLOGICAL MARKERS; EARLY DIAGNOSIS; FEMALE; FUMARATES; HUMANS; KIDNEY FUNCTION TESTS; MALE; MIDDLE AGED; PSORIASIS;

EID: 79952417987     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2010.10171.x     Document Type: Article

References (13)

1. Hoefnagel JJ, Thio HB, Willemze R, et al. Long-term safety aspects of systemic therapy with fumaric acid esters in severe psoriasis. Br J Dermatol 2003; 149: 363-9. (Pubitemid 37100263)
2. Roodnat JI, Christiaans MH, Nugteren-Huying WM, et al. [Acute kidney insufficiency in the treatment of psoriasis using fumaric esters]. Schweiz Med Wochenschr 1989; 119: 826-30 (in German).
3. Dalhoff K, Faerber P, Arnholdt H, et al. [Acute kidney failure during psoriasis therapy with fumaric acid derivatives]. Dtsch Med Wochenschr 1990; 115: 1014-17 (in German). (Pubitemid 20204887)
4. Stühlinger W, Innerebner M, Aberer W,. [The nephrotoxic effect of therapy with fumaric acid esters in psoriasis]. Dtsch Med Wochenschr 1990; 115: 1712-15 (in German). (Pubitemid 20381668)
5. Fliegner L, Spiegel P,. [Osteomalacia as an apparently rare side effect of oral fumaric acid therapy. Secondary De Toni-Debre-Fanconi syndrome in the adult]. Hautarzt 1992; 43: 554-60 (in German).
6. Raschka C, Koch HJ,. Long term treatment of psoriasis using fumaric acid preparations can be associated with severe proximal tubular damage. Hum Exp Toxicol 1999; 18: 738-9. (Pubitemid 30077236)
7. Warzecha J, Runck A, Priepke E, et al. [Multiple pathological fractures within the scope of De Toni-Debre-Fanconi syndrome after fumarate therapy in psoriasis]. Unfallchirurg 2001; 104: 448-51 (in German). (Pubitemid 32547488)
8. Schardijn GH, Statius van Eps LW,. Beta 2-microglobulin: its significance in the evaluation of renal function. Kidney Int 1987; 32: 635-41. (Pubitemid 17152392)
9. Boesken WH, Oser B, Roth J, et al. Nephrotoxische Wirkung durch Fumarsäure-Derivate in der Behandlung der Psoriasis vulgaris. Nieren- und Hochdruckkrankheiten 1998; 27: 145-50. (Pubitemid 28182832)
10. Kaler G, Truong DM, Khandelwal A, et al. Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem 2007; 282: 23841-53. (Pubitemid 47328029)
11. Bergeron M, Dubord L, Hausser C, et al. Membrane permeability as a cause of transport defects in experimental Fanconi syndrome. A new hypothesis. J Clin Invest 1976; 57: 181-9.
12. Kellerman PS,. Exogenous adenosine triphosphate (ATP) preserves proximal tubule microfilament structure and function in vivo in a maleic acid model of ATP depletion. J Clin Invest 1993; 92: 1940-9. (Pubitemid 23304563)
13. Zager RA, Johnson AC, Naito M, et al. Maleate nephrotoxicity: mechanisms of injury and correlates with ischemic/hypoxic tubular cell death. Am J Physiol Renal Physiol 2008; 294: F187-97.