Ginkgo biloba extract individually inhibits JNK activation and induces c-jun degradation in human chondrocytes: Potential therapeutics for osteoarthritis

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Ho, Ling Jun ^a,b   Hung, Li Feng ^a   Liu, Feng Cheng ^c   Hou, Tsung Yun ^c   Lin, Leou Chyr ^c   Huang, Chuan Yueh ^a   Lai, Jenn Haung ^d,e  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^e CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; GINKGO BILOBA EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE CELL; CELL DEGENERATION; CELL MIGRATION; CHEMOTAXIS ASSAY; CHONDROPROTECTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REPRESSION; ENZYME SYNTHESIS; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; OSTEOARTHRITIS; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; UBIQUITINATION;

ARTHROPLASTY, REPLACEMENT, HIP; ARTHROPLASTY, REPLACEMENT, KNEE; CELL MOVEMENT; CHONDROCYTES; GENE EXPRESSION REGULATION; GINKGO BILOBA; HUMANS; INTERLEUKIN-1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUPEPTINS; MAP KINASE KINASE 4; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OSTEOARTHRITIS; PLANT EXTRACTS; PRIMARY CELL CULTURE; PROTEOLYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; UBIQUITINATION;

EID: 84892420297     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082033     Document Type: Article

References (42)

1. Pelletier JP, Martel-Pelletier J, Abramson SB (2001) Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum 44: 1237-1247.
2. Sohn DH, Sokolove J, Sharpe O, Erhart JC, Chandra PE, et al. (2012) Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. Arthritis Res Ther 14: R7.
3. Pelletier JP, Faure MP, DiBattista JA, Wilhelm S, Visco D, et al. (1993) Coordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis. An immunohistochemical study. Am J Pathol 142: 95-105.
4. Ismaiel S, Atkins RM, Pearse MF, Dieppe PA, Elson CJ (1992) Susceptibility of normal and arthritic human articular cartilage to degradative stimuli. Br J Rheumatol 31: 369-373.
5. Yuan GH, Masuko-Hongo K, Sakata M, Tsuruha J, Onuma H, et al. (2001) The role of C-C chemokines and their receptors in osteoarthritis. Arthritis Rheum 44: 1056-1070.
6. Borzi RM, Mazzetti I, Cattini L, Uguccioni M, Baggiolini M, et al. (2000) Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokines. Arthritis Rheum 43: 1734-1741.
7. Scanzello CR, McKeon B, Swaim BH, DiCarlo E, Asomugha EU, et al. (2011) Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms. Arthritis Rheum 63: 391-400.
8. Alaaeddine N, Olee T, Hashimoto S, Creighton-Achermann L, Lotz M (2001) Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation. Arthritis Rheum 44: 1633-1643.
9. Abramson SB (2008) Osteoarthritis and nitric oxide. Osteoarthritis Cartilage 16 Suppl 2: S15-20.
10. Melchiorri C, Meliconi R, Frizziero L, Silvestri T, Pulsatelli L, et al. (1998) Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis. Arthritis Rheum 41: 2165-2174.
11. Peng SL (2008) Transcription factors in autoimmune diseases. Front Biosci 13: 4218-4240.
12. Wolter S, Doerrie A, Weber A, Schneider H, Hoffmann E, et al. (2008) c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene. Mol Cell Biol 28: 4407-4423.
13. Zenz R, Eferl R, Scheinecker C, Redlich K, Smolen J, et al. (2008) Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease. Arthritis Res Ther 10: 201.
14. Mendes AF, Carvalho AP, Caramona MM, Lopes MC (2002) Role of nitric oxide in the activation of NF-kappaB, AP-1 and NOS II expression in articular chondrocytes. Inflamm Res 51: 369-375.
15. Yancheva S, Ihl R, Nikolova G, Panayotov P, Schlaefke S, et al. (2009) Ginkgo biloba extract EGb 761(R), donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: a randomised, double-blind, exploratory trial. Aging Ment Health 13: 183-190.
16. Weinmann S, Roll S, Schwarzbach C, Vauth C, Willich SN (2010) Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatr 10: 14.
17. Lim S, Yoon JW, Kang SM, Choi SH, Cho BJ, et al. (2011) EGb761, a Ginkgo biloba extract, is effective against atherosclerosis in vitro, and in a rat model of type 2 diabetes. PLoS One 6: e20301.
18. Amieva H, Meillon C, Helmer C, Barberger-Gateau P, Dartigues JF (2013) Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study. PLoS One 8: e52755.
19. Cybulska-Heinrich AK, Mozaffarieh M, Flammer J (2012) Ginkgo biloba: an adjuvant therapy for progressive normal and high tension glaucoma. Mol Vis 18: 390-402.
20. Zadoyan G, Rokitta D, Klement S, Dienel A, Hoerr R, et al. (2012) Effect of Ginkgo biloba special extract EGb 761(R) on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers. Eur J Clin Pharmacol 68: 553-560.
21. Herrschaft H, Nacu A, Likhachev S, Sholomov I, Hoerr R, et al. (2012) Ginkgo biloba extract EGb 761(R) in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg. J Psychiatr Res 46: 716-723.
22. Cheng SM, Yang SP, Ho LJ, Tsao TP, Juan TY, et al. (2003) Down-regulation of c-jun N-terminal kinase-activator protein-1 signaling pathway by Ginkgo biloba extract in human peripheral blood T cells. Biochem Pharmacol 66: 679-689.
23. Ho LJ, Lin LC, Hung LF, Wang SJ, Lee CH, et al. (2005) Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes. Biochem Pharmacol 70: 200-208.
24. Huang CY, Hung LF, Liang CC, Ho LJ (2009) COX-2 and iNOS are critical in advanced glycation end product-activated chondrocytes in vitro. Eur J Clin Invest 39: 417-428.
25. Wu WL, Ho LJ, Chang DM, Chen CH, Lai JH (2009) Triggering of DC migration by dengue virus stimulation of COX-2-dependent signaling cascades in vitro highlights the significance of these cascades beyond inflammation. Eur J Immunol 39: 3413-3422.
26. Liu FC, Hung LF, Wu WL, Chang DM, Huang CY, et al. (2010) Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes. Arthritis Res Ther 12: R167.
27. Hashimoto S, Takahashi K, Amiel D, Coutts RD, Lotz M (1998) Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum 41: 1266-1274.
28. Ishibashi Y, Takahashi N, Tokumaru A, Karino K, Sugamori T, et al. (2008) Activation of inducible NOS in peripheral vessels and outcomes in heart failure patients. J Card Fail 14: 724-731.
29. Ou HC, Lee WJ, Lee IT, Chiu TH, Tsai KL, et al. (2009) Ginkgo biloba extract attenuates oxLDL-induced oxidative functional damages in endothelial cells. J Appl Physiol 106: 1674-1685.
30. Hung LF, Lai JH, Lin LC, Wang SJ, Hou TY, et al. (2008) Retinoid acid inhibits IL-1-induced iNOS, COX-2 and chemokine production in human chondrocytes. Immunol Invest 37: 675-693.
31. Fanning PJ, Emkey G, Smith RJ, Grodzinsky AJ, Szasz N, et al. (2003) Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage. J Biol Chem 278: 50940-50948.
32. Abulencia JP, Gaspard R, Healy ZR, Gaarde WA, Quackenbush J, et al. (2003) Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells. J Biol Chem 278: 28388-28394.
33. Chu CR, Kaplan LD, Fu FH, Crossett LS, Studer RK (2004) Recovery of articular cartilage metabolism following thermal stress is facilitated by IGF-1 and JNK inhibitor. Am J Sports Med 32: 191-196.
34. Papachristou DJ, Papachroni KK, Papavassiliou GA, Pirttiniemi P, Gorgoulis VG, et al. (2009) Functional alterations in mechanical loading of condylar cartilage induces changes in the bony subcondylar region. Arch Oral Biol 54: 1035-1045.
35. Nishitani K, Ito H, Hiramitsu T, Tsutsumi R, Tanida S, et al. (2010) PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes. J Cell Biochem 109: 425-433.
36. Manning AM, Davis RJ (2003) Targeting JNK for therapeutic benefit: from junk to gold? Nat Rev Drug Discov 2: 554-565.
37. Arkin MR, Whitty A (2009) The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions. Curr Opin Chem Biol 13: 284-290.
38. Musti AM, Treier M, Bohmann D (1997) Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases. Science 275: 400-402.
39. Nateri AS, Riera-Sans L, Da Costa C, Behrens A (2004) The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science 303: 1374-1378.
40. Gao M, Labuda T, Xia Y, Gallagher E, Fang D, et al. (2004) Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science 306: 271-275.
41. Nakayama K, Furusu A, Xu Q, Konta T, Kitamura M (2001) Unexpected transcriptional induction of monocyte chemoattractant protein 1 by proteasome inhibition: involvement of the c-Jun N-terminal kinase-activator protein 1 pathway. J Immunol 167: 1145-1150.
42. Joshi-Barve S, Barve SS, Butt W, Klein J, McClain CJ (2003) Inhibition of proteasome function leads to NF-kappaB-independent IL-8 expression in human hepatocytes. Hepatology 38: 1178-1187.