Genistein attenuates cancer stem cell characteristics in gastric cancer through the downregulation of Gli1

Oncology Reports

Volumn 31, Issue 2, 2014, Pages 673-678

  Yu, Dayeon ^a   Shin, Hyun Soo ^b   Lee, Yeo Song ^a   Lee, Doyeon ^a   Kim, Shin ^a   Lee, Yong Chan ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

Author keywords

Cancer stem cells; CD44; Gastric cancer; Genistein; Gli1

Indexed keywords

GENISTEIN; HERMES ANTIGEN; MESSENGER RNA; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ARTICLE; CANCER STEM CELL; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; GENE EXPRESSION; GLI1 GENE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH CANCER; TUMOR INVASION;

ANTICARCINOGENIC AGENTS; ANTIGENS, CD44; ATP-BINDING CASSETTE TRANSPORTERS; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; GENISTEIN; HEDGEHOG PROTEINS; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; NESTIN; OCTAMER TRANSCRIPTION FACTOR-3; POLYCOMB REPRESSIVE COMPLEX 1; PROTEIN KINASE INHIBITORS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 84892410753     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2893     Document Type: Article

References (21)

1. Taylor CK, Levy RM, Elliott JC and Burnett BP: The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies. Nutr Rev 67: 398-415, 2009.
2. Zhang Y, Li Q and Chen H: DNA methylation and histone modifications of Wnt genes by genistein during colon cancer development. Carcinogenesis 34: 1756-1763, 2013.
3. Li Y, Ahmed F, Ali S, Philip PA, Kucuk O and Sarkar FH: Inactivation of nuclear factor κB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer Res 65: 6934-6942, 2005.
4. Yanagihara K, Ito A, Toge T and Numoto M: Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract. Cancer Res 53: 5815-5821, 1993.
5. Matsukawa Y, Marui N, Sakai T, et al: Genistein arrests cell cycle progression at G2-M. Cancer Res 53: 1328-1331, 1993.
6. Guo W, Lasky JL and Wu H: Cancer stem cells. Pediatr Res 59: 59R-64R, 2006.
7. Takaishi S, Okumura T and Wang TC: Gastric cancer stem cells. J Clin Oncol 26: 2876-2882, 2008.
8. Rocco A, Compare D and Nardone G: Cancer stem cell hypothesis and gastric carcinogenesis: experimental evidence and unsolved questions. World J Gastrointest Oncol 4: 54-59, 2012.
9. Du L, Wang H, He L, et al: CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res 14: 6751-6760, 2008.
10. + gastric cancer stem cells. J Cancer Res Clin Oncol 137: 1679-1686, 2011.
11. Takaishi S, Okumura T, Tu S, et al: Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells 27: 1006-1020, 2009.
12. Akiyoshi T, Nakamura M, Koga K, et al: Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation. Gut 55: 991-999, 2006.
13. Douard R, Moutereau S, Pernet P, et al: Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer. Surgery 139: 665-670, 2006.
14. Yanai K, Nagai S, Wada J, et al: Hedgehog signaling pathway is a possible therapeutic target for gastric cancer. J Surg Oncol 95: 55-62, 2007.
15. Song Z, Yue W, Wei B, et al: Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer. PLoS One 6: e17687, 2011.
16. Pavese JM, Farmer RL and Bergan RC: Inhibition of cancer cell invasion and metastasis by genistein. Cancer Metastasis Rev 29: 465-482, 2010.
17. Ślusarz A, Shenouda NS, Sakla MS, et al: Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer. Cancer Res 70: 3382-3390, 2010.
18. Zhang L, Li L, Jiao M, et al: Genistein inhibits the stemness properties of prostate cancer cells through targeting Hedgehog-Gli1 pathway. Cancer Lett 23: 48-57, 2012.
19. Clement V, Sanchez P, de Tribolet N, Radovanovic I and Ruiz i Altaba A: HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal and tumorigenicity. Curr Biol 17: 165-172, 2007.
20. Singh A and Settleman J: EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29: 4741-4751, 2010.
21. Zhang LL, Li L, Wu DP, et al: A novel anti-cancer effect of genistein: reversal of epithelial mesenchymal transition in prostate cancer cells. Acta Pharmacol Sin 29: 1060-1068, 2008.