Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice

Oncology Reports

Volumn 30, Issue 6, 2013, Pages 2632-2638

  Ninomiya, Fumiko ^a   Yokohira, Masanao ^a   Kishi, Sosuke ^a   Nakano, Yuko ^a   Yamakawa, Keiko ^a   Inoue, Tatsushi ^a   Kuno, Toshiya ^a   Imaida, Katsumi ^a  

^a KAGAWA UNIVERSITY   (Japan)

Author keywords

4 (methylnitrosamino) 1 (3 pyridyl) 1 butanone; A J mouse; Gonadectomy; Lung tumorigenesis; Sex hormone

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; ESTRADIOL; SEX HORMONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHIOLOALVEOLAR HYPERPLASIA; CASTRATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; ESTRADIOL BLOOD LEVEL; FEMALE; GONADECTOMY; HORMONE ACTION; HORMONE INHIBITION; HYPERPLASIA; LUNG ADENOCARCINOMA; LUNG ADENOMA; LUNG CARCINOGENESIS; LUNG NODULE; MALE; MOUSE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; SEX DIFFERENCE; TESTOSTERONE BLOOD LEVEL;

ADENOCARCINOMA; ADENOMA; ANIMALS; CARCINOGENESIS; ESTRADIOL; FEMALE; HUMANS; HYPERPLASIA; LUNG; LUNG NEOPLASMS; MALE; MICE; NEOPLASMS, HORMONE-DEPENDENT; NITROSAMINES; ORCHIECTOMY; OVARIECTOMY; SEX CHARACTERISTICS; TESTOSTERONE;

EID: 84892410325     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2759     Document Type: Article

References (40)

1. Balbo S, Upadhyaya P, Villalta PW, Qian X and Kassie F: DNA adducts in aldehyde dehydrogenase-positive lung stem cells of A/J mice treated with the tobacco specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chem Res Toxicol: Mar 12, 2013 (Epub ahead of print).
2. Akopyan G and Bonavida B: Understanding tobacco smoke carcinogen NNK and lung tumorigenesis (Review). Int J Oncol 29: 745-752, 2006.
3. Chen RJ, Chang LW, Lin P and Wang YJ: Epigenetic effects and molecular mechanisms of tumorigenesis induced by cigarette smoke: an overview. J Oncol 2011: 654931, 2011.
4. Belinsky SA, Devereux TR, Foley JF, Maronpot RR and Anderson MW: Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse. Cancer Res 52: 3164-3173, 1992.
5. Imaida K, Yokohira M and Kuno T: Detection of carcinogenic and modifying potentials by test compounds using a mouse lung carcinogenesis bioassay (Review). J Toxicol Pathol 20: 117-123, 2007.
6. Takeuchi H, Saoo K, Matsuda Y, et al: 8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice. Mol Med Rep 2: 585-588, 2009.
7. Takeuchi H, Saoo K, Matsuda Y, et al: Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice. Cancer Lett 234: 232-238, 2006.
8. Takeuchi H, Saoo K, Yokohira M, et al: Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice. Cancer Res 63: 7581-7583, 2003.
9. Yokohira M, Takeuchi H, Saoo K, et al: Establishment of a bioassay model for lung cancer chemoprevention initiated with 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone (NNK) in female A/J mice. Exp Toxicol Pathol 60: 469-473, 2008.
10. Kuno T, Yokohira M, Matsuda Y, et al: Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice. Oncol Rep 20: 767-772, 2008.
11. Matsuda Y, Saoo K, Hosokawa K, et al: Post-initiation chemopreventive effects of dietary bovine lactoferrin on 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone-induced lung tumorigenesis in female A/J mice. Cancer Lett 246: 41-46, 2007.
12. Yamakawa K, Kuno T, Hashimoto N, et al: Molecular analysis of carcinogen-induced rodent lung tumors: Involvement of microRNA expression and Kras or Egfr mutations. Mol Med Rep 3: 141-147, 2010.
13. Yokohira M, Hashimoto N, Yamakawa K, Saoo K, Kuno T and Imaida K: Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer. Exp Toxicol Pathol 63: 181-185, 2011.
14. Yokohira M, Hashimoto N, Yamakawa K, et al: Lack of modifying effects of intratracheal instillation of quartz or dextran sulfate sodium (DSS) in drinking water on lung tumor development initiated with 4-(Methylnitrosamino)-1-(3- pyridyl)-1-butanone (NNK) in female A/J mice. J Toxicol Pathol 22: 179-185, 2009.
15. Miyazaki M, Yamazaki H, Takeuchi H, et al: Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone-induced mouse lung adenomas. Carcinogenesis 26: 1947-1955, 2005.
16. Igarashi M, Watanabe M, Yoshida M, et al: Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1- butanone by Ogg1 gene deficiency in female, but not male, mice. J Toxicol Sci 34: 163-174, 2009.
17. Morita T: A statistical study of lung cancer in the annual of pathological autopsy cases in Japan, from 1958 to 1997, with reference to time trends of lung cancer in the world. Jpn J Cancer Res 93: 15-23, 2002.
18. Sobue T, Ajiki W, Tsukuma H, Oshima A, Hanai A and Fujimoto I: Trends of lung cancer incidence by histologic type: a population-based study in Osaka, Japan. Jpn J Cancer Res 90: 6-15, 1999.
19. Zang EA and Wynder EL: Differences in lung cancer risk between men and women: examination of the evidence. J Natl Cancer Inst 88: 183-192, 1996.
20. Belani CP, Marts S, Schiller J and Socinski MA: Women and lung cancer: epidemiology, tumor biology, and emerging trends in clinical research. Lung Cancer 55: 15-23, 2007.
21. Nishio M, Ohyanagi F, Horiike A, et al: Gefitinib treatment affects androgen levels in non-small-cell lung cancer patients. Br J Cancer 92: 1877-1880, 2005.
22. Mohr U (ed): International Classification of Rodent Tumors: The Mouse. 1st edition. Springer-Verlag, Berlin, 2001.
23. de Kretser DM: The Testis. In: Reproduction in Mammals: Hormonal Control of Reproduction. Austin CR and Short RV (eds). Vol 3. 2nd edition. Cambridge University Press, Cambridge, pp76-90, 1984.
24. Baird DT: The Ovary. In: Reproduction in Mammals: Hormonal Control of Reproduction. Austin CR and Short RV (eds). Vol 3. 2nd edition. Cambridge University Press, Cambridge, pp91-114, 1984.
25. Pelletier G, Luu-The V, Li S and Labrie F: Localization of type 5 17β-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization. Cell Tissue Res 320: 393-398, 2005.
26. Matsuura S and Suzuki K: Morphological changes in the submandibular glands and in the X zone of the adrenal gland following ovariectomy in mice. Cell Tissue Res 246: 549-556, 1986.
27. Kamei Y, Suzuki M, Miyazaki H, et al: Ovariectomy in mice decreases lipid metabolism-related gene expression in adipose tissue and skeletal muscle with increased body fat. J Nutr Sci Vitaminol 51: 110-117, 2005.
28. Wu J, Wang X, Chiba H, et al: Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice. Metabolism 53: 942-948, 2004.
29. Yamaguchi M, Katoh S, Morimoto C, et al: The hormonal responses of lipoprotein lipase activity and lipolysis in adipose tissue differ depending on the stage of the estrous cycle in female rats. Int J Obes Relat Metab Disord 26: 610-617, 2002.
30. Duffel MW, Graham JM and Ziegler DM: Changes in dimethylaniline N-oxidase activity of mouse liver and kidney induced by steroid sex hormones. Mol Pharmacol 19: 134-139, 1981.
31. Kamataki T, Fujita KI, Nakayama K, Yamazaki Y, Miyamoto M and Ariyoshi N: Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP. Drug Metab Rev 34: 667-676, 2002.
32. Wiener D, Doerge DR, Fang JL, Upadhyaya P and Lazarus P: Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl) -1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4. Drug Metab Dispos 32: 72-79, 2004.
33. Benowitz NL, Lessov-Schlaggar CN, Swan GE and Jacob P III: Female sex and oral contraceptive use accelerate nicotine metabolism. Clinl Pharmacol Ther 79: 480-488, 2006.
34. Miners JO, Grgurinovich N, Whitehead AG, Robson RA and Birkett DJ: Influence of gender and oral contraceptive steroids on the metabolism of salicytic acid and acetylsalicylic acid. Br J Clin Pharmacol 22: 135-142, 1986.
35. Mitchell MC, Hanew T, Meredith CG and Schenker S: Effects of oral contraceptive steroids on acetaminophen metabolism and elimination. Clin Pharmacol Ther 34: 48-53, 1983.
36. Stoehr GP, Kroboth PD, Juhl RP, Wender DB, Phillips JP and Smith RB: Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics. Clin Pharmacol Ther 36: 683-690, 1984.
37. Balogh A, Klinger G, Henschel L, Börner A, Vollanth R and Kuhnz W: Influence of ethinylestradiol-containing combination oral contraceptives with gestodene or levonorgestrel on caffeine elimination. Eur J Clin Pharmacol 48: 161-166, 1995.
38. Laine K, Tybring G and Bertilsson L: No sex-related differences but significant inhibition by oral contraceptives of CYP2C19 activity as measured by the probe drugs mephenytoin and omeprazole in healthy Swedish white subjects. Clin Pharmacol Ther 68: 151-159, 2000.
39. Slayter KL, Ludwig EA, Lew KH, Middleton E Jr, Ferry JJ and Jusko WJ: Oral contraceptive effects on methylprednisolone pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther 59: 312-321, 1996.
40. Mikkonen L, Pihlajamaa P, Sahu B, Zhang FP and Jänne OA: Androgen receptor and androgen-dependent gene expression in lung. Mol Cell Endocrinol 317: 14-24, 2010.