Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice

Oncology Reports

Volumn 20, Issue 4, 2008, Pages 767-772

  Kuno, Toshiya ^a   Yokohira, Masanao ^a   Matsuda, Yoko ^a   Suzuki, Satoshi ^a   Hashimoto, Nozomi ^a   Yamakawa, Keiko ^a   Saoo, Kousuke ^a   Imaida, Katsumi ^a  

^a KAGAWA UNIVERSITY   (Japan)

Author keywords

8 methoxypsoralen; Lung tumor; Post initiation

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; CYTOCHROME P450 2A5; CYTOCHROME P450 2A6; MESSENGER RNA; METHOXSALEN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DIET; EXPERIMENTAL STUDY; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG ADENOMA; LUNG CARCINOGENESIS; LUNG TUMOR; MOUSE; MOUSE STRAIN; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; DISEASE PROGRESSION; ENZYME INHIBITORS; FEMALE; LUNG NEOPLASMS; METHOXSALEN; MICE; NEOPLASM STAGING; NITROSAMINES;

EID: 54949136882     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or_00000072     Document Type: Article

References (26)

1. Boffetta P, Pershagen G, Jockel KH, Forastiere F, Gaborieau V, Heinrich J, Jahn I, Kreuzer M, Merletti F, Nyberg F, Rosch F and Simonato L: Cigar and pipe smoking and lung cancer risk: a multicenter study from Europe. J Natl Cancer Inst 91: 697-701, 1999.
2. Lubin JH and Blot WJ: Assessment of lung cancer risk factors by histologic category. J Natl Cancer Inst 73: 383-389, 1984.
3. Travis WD, Travis LB and Devesa SS: Lung cancer. Cancer 75: 191-202, 1995.
4. Hecht SS: Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem Res Toxicol 11: 559-603, 1998.
5. Imaida K, Yokohira M and Kuno T: Detection of carcinogenic and modifying potentials by test compounds using a mouse lung carcinogenesis bioassay. J Toxicol Pathol 20: 117-123, 2007.
6. Kushida H, Fujita K, Suzuki A, Yamada M, Endo T, Nohmi T and Kamataki T: Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase. Carcinogenesis 21: 1227-1232, 2000.
7. Fujieda M, Yamazaki H, Saito T, Kiyotani K, Gyamfi MA, Sakurai M, Dosaka-Akita H, Sawamura Y, Yokota J, Kunitoh H and Kamataki T: Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers. Carcinogenesis 25: 2451-2458, 2004.
8. Ariyoshi N, Miyamoto M, Umetsu Y, Kunitoh H, Dosaka-Akita H, Sawamura Y, Yokota J, Nemoto N, Sato K and Kamataki T: Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers. Cancer Epidemiol Biomarkers Prev 11: 890-894, 2002.
9. Matsuda Y, Saoo K, Yamakawa K, Yokohira M, Suzuki S, Kuno T, Kamataki T and Imaida K: Overexpression of CYP2A6 in human colorectal tumors. Cancer Sci 98: 1582-1585, 2007.
10. Matsuda Y, Yamakawa K, Saoo K, Hosokawa K, Yokohira M, Kuno T, Iwai J, Shirai T, Obika K, Kamataki T and Imaida K: CYP2A6 overexpression in human lung cancers correlates with a high malignant status. Oncol Rep 18: 53-57, 2007.
11. Takeuchi H, Saoo K, Matsuda Y, Yokohira M, Yamakawa K, Zeng Y, Miyazaki M, Fujieda M, Kamataki T and Imaida K: Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice. Cancer Lett 234: 232-238, 2006.
12. Takeuchi H, Saoo K, Yokohira M, Ikeda M, Maeta H, Miyazaki M, Yamazaki H, Kamataki T and Imaida K: Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice. Cancer Res 63: 7581-7583, 2003.
13. Miyazaki M, Yamazaki H, Takeuchi H, Saoo K, Yokohira M, L Masumura K, Nohmi T, Funae Y, Imaida K and Kamataki T: Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas. Carcinogenesis 26: 1947-1955, 2005.
14. Felicia ND, Rekha GK and Murphy SE: Characterization of cytochrome P450 2A4 and 2A5-catalyzed 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism. Arch Biochem Biophys 384: 418-424, 2000.
15. Dungworth DL, Rittinghausen S, Schwartz L, Harkema JR, Hayashi Y, Kittel B, Lewis D, Miller RA, Mohr U, Morgan KT, Rehm S and Slayter MV: Respiratory system and mesothelium. In: International Classification of Rodent Tumors: The Mouse. Mohr U (ed). Springer, Heidelberg, pp87-137, 2001.
16. Koenigs LL, Peter RM, Thompson SJ, Rettie AE and Trager WF: Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen. Drug Metab Dispos 25: 1407-1415, 1997.
17. Koenigs LL and Trager WF: Mechanism-based inactivation of P450 2A6 by furanocoumarins. Biochemistry 37: 10047-10061, 1998.
18. Scott BR, Pathak MA and Mohn GR: Molecular and genetic basis of furocoumarin reactions. Mutat Res 39: 29-74, 1976.
19. Anderson TF and Voorhees JJ: Psoralen photochemotherapy of cutaneous disorders. Annu Rev Pharmacol Toxicol 20: 235-257, 1980.
20. Parrish JA, Fitzpatrick TB, Tanenbaum L and Pathak MA: Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light. N Engl J Med 291: 1207-1211, 1974.
21. Edelson R, Berger C, Gasparro F, Jegasothy B, Heald P, Wintroub B, Vonderheid E, Knobler R, Wolff K, Plewig G, et al: Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. Preliminary results. N Engl J Med 316: 297-303, 1987.
22. Dunnick JK and Elwell MR: Toxicity studies of amphetamine sulfate, ampicillin trihydrate, codeine, 8-methoxypsoralen, alpha-methyldopa, penicillin VK and propantheline bromide in rats and mice. Toxicology 56: 123-136, 1989.
23. Sellers EM, Ramamoorthy Y, Zeman MV, Djordjevic MV and Tyndale RF: The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in vivo. Nicotine Tob Res 5: 891-899, 2003.
24. Wattenberg LW, Wiedmann TS, Estensen RD, Zimmerman CL, Steele VE and Kelloff GJ: Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice. Cancer Res 57: 5489-5492, 1997.
25. Yan Y, Cook J, McQuillan J, Zhang G, Hitzman CJ, Wang Y, Wiedmann TS and You M: Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice. Neoplasia 9: 401-405, 2007.
26. Myrdal PB, Karlage K, Kuehl PJ, Angersbach BS, Merrill BA and Wightman PD: Effects of novel 5-1ipoxygenase inhibitors on the incidence of pulmonary adenomas in the A/J murine model when administered via nose-only inhalation. Carcinogenesis 28: 957-961, 2007.