Hirsutanol A, a novel sesquiterpene compound from fungus Chondrostereum sp., induces apoptosis and inhibits tumor growth through mitochondrial-independent ROS production: Hirsutanol A inhibits tumor growth through ROS production

Journal of Translational Medicine

Volumn 11, Issue 1, 2013, Pages

  Yang, Fen ^a   Chen, Wen Dan ^a   Deng, Rong ^a   Zhang, Hui ^c   Tang, Jun ^a   Wu, Ke Wei ^a   Li, Dan Dan ^a   Feng, Gong Kan ^a   Lan, Wen Jian ^b   Li, Hou Jin ^b   Zhu, Xiao Feng ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

Apoptosis; Cancer; Hirsutanol A; JNK; Mitochondria; ROS

Indexed keywords

ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; CASPASE 3; CYTOCHROME C; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HIRSUTANOL A; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE; SESQUITERPENE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG POTENCY; DRUG STRUCTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; WESTERN BLOTTING;

AGARICALES; ANIMALS; APOPTOSIS; CELL DEATH; CELL LINE, TUMOR; CYTOCHROMES C; CYTOSOL; FLOW CYTOMETRY; HUMANS; MEMBRANE POTENTIALS; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; NEOPLASM TRANSPLANTATION; REACTIVE OXYGEN SPECIES; SESQUITERPENES; SIGNAL TRANSDUCTION; TETRAZOLIUM SALTS; THIAZOLES;

EID: 84873448363     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-11-32     Document Type: Article

References (40)

1. Fang J, Seki T, Maeda H. Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv Drug Deliv Rev 2009, 61(4):290-302. 10.1016/j.addr.2009.02.005, 19249331.
2. Lu FX. Reactive oxygen species in cancer, too much or too little?. Medical Hypotheses 2007, 69(6):1293-1298. 10.1016/j.mehy.2007.03.017, 17509774.
3. Schumacker PT. Reactive oxygen species in cancer cells: Live by the sword, die by the sword. Cancer Cell 2006, 10(3):175-176. 10.1016/j.ccr.2006.08.015, 16959608.
4. Pan JS, Hong MZ, Ren JL. Reactive oxygen species: A double -edged sword in oncogenesis. World J Gastroenterol 2009, 15(14):1702-1707. 10.3748/wjg.15.1702, 2668775, 19360913.
5. Rachootham D, Alexandre J, Huang P. Targeting cancer cells by ROS- mediated mechanisms: a radical therapeutic approach?. Nat Rev Drug Discovery 2009, 8(7):579-591.
6. Trachootham D, Zhou Y, Zhang H, et al. Selective killing of oncogenically transformed cells through a ROS mediated mechanism by β-phenylethyl isothiocyanate. Cancer Cell 2006, 10(3):241-252. 10.1016/j.ccr.2006.08.009, 16959615.
7. Zhang H, Trachootham D, Lu W, et al. Effective killing of Gleevec- resistant CML cells with T3151 mutation by a natural compound PEITC through redox-mediated mechanism. Leukemia 2008, 22(6):1191-1199. 10.1038/leu.2008.74, 2585768, 18385754.
8. Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell 2004, 116(2):205-219. 10.1016/S0092-8674(04)00046-7, 14744432.
9. Hang P, Oliff A. Signaling pathways in apoptosis as potential targets for cancer therapy. Trends Cell Biol 2001, 11(8):343-348. 10.1016/S0962-8924(01)02063-3, 11489640.
10. Mark GH, Catherine LD. Regulation of apoptosis: uncovering the binding determinants. Curr Opin Struct Biol 2005, 15(6):690-699. 10.1016/j.sbi.2005.10.003, 16263267.
11. Benhar M, Engelberg D, Levitzki A. ROS stress-activated kinases and stress signaling in cancer. EMBO 2002, 3(5):420-425.
12. Ricci JE, Munoz-Pinedo C, Fitzgerald P, et al. Disruption of Mitochondrial Function during Apoptosis is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport Chain. Cell 2004, 117(6):773-786. 10.1016/j.cell.2004.05.008, 15186778.
13. Lee DH, Park T, Kim HW. Induction of apoptosis by diaturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscripenol mycotoxins. Biol Pharm Bull 2006, 29(4):648-654. 10.1248/bpb.29.648, 16595895.
14. Kuwabara M, Asanuma T, Inanami O. Regulation of cell survival and death signals induced by oxidative stress. J Clin Biochem Nutr 2008, 43(2):51-57. 10.3164/jcbn.2008045, 2533719, 18818753.
15. Li DD, Wang LL, Deng R, et al. The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin1 expression during anticancer agents-induced autophagy in cancer cells. Oncogene 2009, 28(6):886-898. 10.1038/onc.2008.441, 19060920.
16. Kops GJ, Dansen TB, Polderman PE, et al. Fokhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 2002, 419(6904):316-321. 10.1038/nature01036, 12239572.
17. Wang GYS, Abrell LM, Avelar A, et al. New hirsutane-basesquiterpenes from salt water cultures of a marine sponge-derived fungus and the terrestrial fungus Coriolus consors. Tetrahedron 1998, 54(26):7335-7342.
18. Yang F, Wu KW, Li DD, et al. A novel sesquiterpene hirsutanol A induces autophagical cell death in human hepatocellular carcinoma cells by increasing reactive oxygen species. Chin J Caner 2010, 29(7):665-660.
19. Li HJ, Lan WJ, Lam CK, et al. Hirsutane sesquiterpenoids from marine-derived fungus Chondrostereum sp. Chem Biodivers 2011, 8(2):317-324. 10.1002/cbdv.201000036, 21337504.
20. Chen LM, Wu XP, Ruan JW, et al. Screening novel, potent multidrug- resistant modulators from imidazole derivatives. Oncol Res 2004, 14(7-8):355-62.19.
21. Sewell JM, Mayer I, Langdon SP, et al. The mechanism of action of Kahalalide F: variable cell permeability in human hepatoma cell lines. Eur J Cancer 2005, 41(11):1637-1644. 10.1016/j.ejca.2005.04.015, 15953713.
22. Zhang JY, Wu HY, Xia XK, et al. Anthracenedione derivative 1403P-3 induces apoptosis in KB and KBv200 cells via reactive oxygen species-independent mitochondrial pathway and death receptor pathway. Cancer Biol Ther 2007, 6(9):1413-1421. 10.4161/cbt.6.9.4543, 17786034.
23. Zhou JM, Zhu XF, Lu YJ, et al. Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines. Oncogene 2006, 25(4):503-511.
24. Liu JN, Deng R, Guo JF, et al. Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells. Leukemia 2007, 21(6):1300-1302. 10.1038/sj.leu.2404652, 17392822.
25. Deng R, Li W, Guan Z, et al. Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis. Oncogene 2006, 25(53):7070-7077. 10.1038/sj.onc.1209686, 16715131.
26. Kristian T. Isolation of mitochondria from the CNS. Curr Protoc Neurosci 2010, 7(7):22. 2908900, 20578034.
27. Deng R, Tang J, Xia LP, et al. Excisanin A, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway. Mol Cancer Ther 2009, 8(4):873-882. 10.1158/1535-7163.MCT-08-1080, 19372560.
28. Li DD, Wu XQ, Tang J, Wei XY, Zhu XF, et al. ON-III inhibits erbB-2 tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast cancer cells. Cancer Biol Ther 2009, 8(8):739-743. 10.4161/cbt.8.8.7917, 19242112.
29. Darzynkiewicz Z, Juan G, Li X, et al. Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry 1997, 27(1):1-20. 10.1002/(SICI)1097-0320(19970101)27:1<1::AID-CYTO2>3.0.CO;2-L, 9000580.
30. Oyama Y, Hayashi A, Ueha T, et al. Characterization of 2′,7′-dichlorofluorescin fluorescence in dissociated mammalian brain neurons: estimation on intracellular content of hydrogen peroxide. Brain Res 1994, 635(1-2):113-117.
31. Bindokas VP, Jordan J, Lee CC, et al. Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J Neurosci 1996, 16(4):1324-1336.
32. Al-Gubory KH, Fowler PA, Garrel C. The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. Int J Biochem Cell Biol 2010, 42(10):1634-1650. 10.1016/j.biocel.2010.06.001, 20601089.
33. Chen FH, Zhang LB, Qiang L, et al. Reactive oxygen species-mitochondria pathway involved in LYG-202-induced apoptosis in human hepatocellular carcinoma HepG2 cells. Cancer Lett 2010, 296(1):96-105. 10.1016/j.canlet.2010.04.004, 20580989.
34. Bennett DT, Sasaki BW, Murray EC, et al. SP600125, an anthrapyrazole inhibitor of jun N-terminal kinase. Proc Natl Acad Sci USA 2001, 98(24):13681-13686. 10.1073/pnas.251194298, 61101, 11717429.
35. Huang P, Feng L, Elizabeth A, et al. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 2000, 407(6802):390-395. 10.1038/35030140, 11014196.
36. Alexandre J, Hu Y, Lu WQ, et al. Novel Action of Paclitaxel against Cancer Cells; Bystander Effect Mediated by Reactive Oxygen Species. Cancer Res 2007, 67(8):3512-3517. 10.1158/0008-5472.CAN-06-3914, 17440056.
37. Marchi S, Giorgi C, Suski JM, et al. Mitochondria-ros crosstalk in the control of cell death and aging. J Signal Transduct 2012, 2012:329635. 10.1155/2012/329635, 3235816, 22175013.
38. Han YH, Park WH. The effects of N-acetyl cysteine, buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on antimycin A-treated Calu-6 lung cells in relation to cell growth, reactive oxygen species and glutathione. Oncol Rep 2009, 22(2):385-391.
39. Pelicano H, Carney D, Huang P. ROS stress in cancer cells and therapeutic implication. Drug Resist Updat 2004, 7(2):97-110. 10.1016/j.drup.2004.01.004, 15158766.
40. Valko M, Rhodes CJ, Moncol J, et al. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006, 160(1):1-40. 10.1016/j.cbi.2005.12.009, 16430879.