메뉴 건너뛰기




Volumn 21, Issue 1, 2014, Pages 9-14

New treatment targets for the management of irritable bowel syndrome

Author keywords

chronic idiopathic constipation; gastrointestinal receptors; irritable bowel syndrome (IBS); linaclotide; lubiprostone; serotonin

Indexed keywords

CHLORIDE CHANNEL; FATTY ACID DERIVATIVE; GUANYLATE CYCLASE; LINACLOTIDE; LUBIPROSTONE; PEPTIDE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

EID: 84892371611     PISSN: 1752296X     EISSN: 17522978     Source Type: Journal    
DOI: 10.1097/MED.0000000000000034     Document Type: Review
Times cited : (10)

References (75)
  • 1
    • 84867754193 scopus 로고    scopus 로고
    • Irritable bowel syndrome: Diagnosis and pathogenesis
    • El-Salhy M. Irritable bowel syndrome: Diagnosis and pathogenesis. WJG 2012; 18: 5151-5163
    • (2012) WJG , vol.18 , pp. 5151-5163
    • El-Salhy, M.1
  • 2
    • 84883588093 scopus 로고    scopus 로고
    • Irritable bowel syndrome: The role of gut neuroendocrine peptides
    • El-Salhy M, Seim I, Chopin L, et al. Irritable bowel syndrome: The role of gut neuroendocrine peptides. Front Biosci (Elite Ed) 2012; 4: 2783-2800
    • (2012) Front Biosci (Elite Ed , vol.4 , pp. 2783-2800
    • El-Salhy, M.1    Seim, I.2    Chopin, L.3
  • 3
    • 84859888900 scopus 로고    scopus 로고
    • A global perspective on irritable bowel syndrome: A consensus statement of the world gastroenterology organisation summit task force on irritable bowel syndrome
    • Quigley EM, Abdel-Hamid H, Barbara G, et al. A global perspective on irritable bowel syndrome: A consensus statement of the World Gastroenterology Organisation Summit Task Force on irritable bowel syndrome. J Clin Gastroenterol 2012; 46: 356-366
    • (2012) J Clin Gastroenterol , vol.46 , pp. 356-366
    • Quigley, E.M.1    Abdel-Hamid, H.2    Barbara, G.3
  • 4
    • 42249114703 scopus 로고    scopus 로고
    • Clinical practice. Irritable bowel syndrome
    • Mayer EA. Clinical practice. Irritable bowel syndrome. N Engl J Med 2008; 358: 1692-1699
    • (2008) N Engl J Med , vol.358 , pp. 1692-1699
    • Mayer, E.A.1
  • 5
    • 79951569700 scopus 로고    scopus 로고
    • The effect of irritable bowel syndrome on healthrelated quality of life and healthcare expenditures
    • Agarwal N, Spiegel BM. The effect of irritable bowel syndrome on healthrelated quality of life and healthcare expenditures. Gastroenterol Clin North Am 2011; 40: 11-19
    • (2011) Gastroenterol Clin North Am , vol.40 , pp. 11-19
    • Agarwal, N.1    Spiegel, B.M.2
  • 6
    • 68349141680 scopus 로고    scopus 로고
    • Developing valid and reliable health utilities in irritable bowel syndrome: Results from the ibs proof cohort
    • Spiegel B, Harris L, Lucak S, et al. Developing valid and reliable health utilities in irritable bowel syndrome: Results from the IBS PROOF Cohort. Am J Gastroenterol 2009; 104: 1984-1991
    • (2009) Am J Gastroenterol , vol.104 , pp. 1984-1991
    • Spiegel, B.1    Harris, L.2    Lucak, S.3
  • 7
    • 0344413667 scopus 로고    scopus 로고
    • Utilization patterns and net direct medical cost to medicaid of irritable bowel syndrome
    • Martin BC, Ganguly R, Pannicker S, et al. Utilization patterns and net direct medical cost to Medicaid of irritable bowel syndrome. Curr Med Res Opin 2003; 19: 771-780
    • (2003) Curr Med Res Opin , vol.19 , pp. 771-780
    • Martin, B.C.1    Ganguly, R.2    Pannicker, S.3
  • 8
    • 0242584898 scopus 로고    scopus 로고
    • The economic consequences of irritable bowel syndrome: A US employer perspective
    • Leong SA, Barghout V, Birnbaum HG, et al. The economic consequences of irritable bowel syndrome: A US employer perspective. Arch Intern Med 2003; 163: 929-935
    • (2003) Arch Intern Med , vol.163 , pp. 929-935
    • Leong, S.A.1    Barghout, V.2    Birnbaum, H.G.3
  • 9
    • 0037344032 scopus 로고    scopus 로고
    • Irritable bowel syndrome, healthcare use, and costs: A U.S. Managed care perspective
    • Longstreth GF, Wilson A, Knight K, et al. Irritable bowel syndrome, healthcare use, and costs: A U.S. managed care perspective. Am J Gastroenterol 2003; 98: 600-607
    • (2003) Am J Gastroenterol , vol.98 , pp. 600-607
    • Longstreth, G.F.1    Wilson, A.2    Knight, K.3
  • 10
    • 0034012726 scopus 로고    scopus 로고
    • Economic burden of irritable bowel syndrome proposed strategies to control expenditures
    • Camilleri M, Williams DE. Economic burden of irritable bowel syndrome. Proposed strategies to control expenditures. Pharmacoeconomics 2000; 17: 331-338
    • (2000) Pharmacoeconomics , vol.17 , pp. 331-338
    • Camilleri, M.1    Williams, D.E.2
  • 12
    • 2342550581 scopus 로고    scopus 로고
    • Are there alterations of neuroendocrine and cellular immune responses to nutrients in women with irritable bowel syndrome
    • Elsenbruch S, Holtmann G, Oezcan D, et al. Are there alterations of neuroendocrine and cellular immune responses to nutrients in women with irritable bowel syndrome? Am J Gastroenterol 2004; 99: 703-710
    • (2004) Am J Gastroenterol , vol.99 , pp. 703-710
    • Elsenbruch, S.1    Holtmann, G.2    Oezcan, D.3
  • 14
    • 32044464304 scopus 로고    scopus 로고
    • Neuroendocrine and neuroimmune markers in IBS: Pathophysiological role or epiphenomenon
    • Chang L. Neuroendocrine and neuroimmune markers in IBS: Pathophysiological role or epiphenomenoñGastroenterology 2006; 130: 596-600
    • (2006) Gastroenterology , vol.130 , pp. 596-600
    • Chang, L.1
  • 15
    • 84861167356 scopus 로고    scopus 로고
    • Irritable bowel syndrome: Methods, mechanisms, and pathophysiology neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome
    • Feng B, La JH, Schwartz ES, Gebhart GF. Irritable bowel syndrome: Methods, mechanisms, and pathophysiology. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 2012; 302: G1085-G1098
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302
    • Feng, B.1    La, J.H.2    Schwartz, E.S.3    Gebhart, G.F.4
  • 16
    • 55649112489 scopus 로고    scopus 로고
    • Serotonergic agents and the irritable bowel syndrome: What goes wrong
    • Spiller R. Serotonergic agents and the irritable bowel syndrome: What goes wrong? Curr Opin Pharmacol 2008; 8: 709-714
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 709-714
    • Spiller, R.1
  • 17
    • 33744949904 scopus 로고    scopus 로고
    • Enteroendocrine cell counts correlate with visceral hypersensitivity in patients with diarrhoea-predominant irritable bowel syndrome
    • Park JH, Rhee PL, Kim G, et al. Enteroendocrine cell counts correlate with visceral hypersensitivity in patients with diarrhoea-predominant irritable bowel syndrome. Neurogastroenterol Motil 2006; 18: 539-546
    • (2006) Neurogastroenterol Motil , vol.18 , pp. 539-546
    • Park, J.H.1    Rhee, P.L.2    Kim, G.3
  • 18
    • 84867828617 scopus 로고    scopus 로고
    • Peripheral mechanisms in irritable bowel syndrome
    • Camilleri M. Peripheral mechanisms in irritable bowel syndrome. N Engl J Med 2012; 367: 1626-1635
    • (2012) N Engl J Med , vol.367 , pp. 1626-1635
    • Camilleri, M.1
  • 19
    • 80052155410 scopus 로고    scopus 로고
    • Management of irritable bowel syndrome (IBS) in adults: Conventional and complementary/alternative approaches
    • Yoon SL, Grundmann O, Koepp L, Farrell L. Management of irritable bowel syndrome (IBS) in adults: Conventional and complementary/alternative approaches. Altern Med Rev 2011; 16: 134-151
    • (2011) Altern Med Rev , vol.16 , pp. 134-151
    • Yoon, S.L.1    Grundmann, O.2    Koepp, L.3    Farrell, L.4
  • 20
    • 67649537590 scopus 로고    scopus 로고
    • An evidence-based position statement on the management of irritable bowel syndrome
    • Brandt LJ, Chey WD, Foxx-Orenstein AE, et al. An evidence-based position statement on the management of irritable bowel syndrome. Am J Gastroenterol 2009; 104 (Suppl 1): S1-S35
    • (2009) Am J Gastroenterol , vol.104 , Issue.SUPPL. 1
    • Brandt, L.J.1    Chey, W.D.2    Foxx-Orenstein, A.E.3
  • 21
    • 0027981172 scopus 로고
    • Antidepressant therapy in 138 patients with irritable bowel syndrome: A five-year clinical experience
    • Clouse RE, Lustman PJ, Geisman RA, Alpers DH. Antidepressant therapy in 138 patients with irritable bowel syndrome: A five-year clinical experience. Alimen Pharmacol Ther 1994; 8: 409-416
    • (1994) Alimen Pharmacol Ther , vol.8 , pp. 409-416
    • Clouse, R.E.1    Lustman, P.J.2    Geisman, R.A.3    Alpers, D.H.4
  • 22
    • 84871926401 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract
    • Gershon MD. 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract. Curr Opin Endocrinol Diab Obes 2013; 20: 14-21
    • (2013) Curr Opin Endocrinol Diab Obes , vol.20 , pp. 14-21
    • Gershon, M.D.1
  • 23
    • 33846347644 scopus 로고    scopus 로고
    • The serotonin signaling system: From basic understanding to drug development for functional GI disorders
    • Gershon MD, Tack J. The serotonin signaling system: From basic understanding to drug development for functional GI disorders. Gastroenterology 2007; 132: 397-414
    • (2007) Gastroenterology , vol.132 , pp. 397-414
    • Gershon, M.D.1    Tack, J.2
  • 24
    • 78650835708 scopus 로고    scopus 로고
    • Gastrointestinal regulatory peptides
    • Weber HC. Gastrointestinal regulatory peptides. Curr Opin Endocrinol Diab Obes 2011; 18: 33-34
    • (2011) Curr Opin Endocrinol Diab Obes , vol.18 , pp. 33-34
    • Weber, H.C.1
  • 25
    • 84880860326 scopus 로고    scopus 로고
    • Emerging receptor target in the pharmacotherapy of irritable bowel syndrome with constipation
    • Blackshaw LA, Brierley SM. Emerging receptor target in the pharmacotherapy of irritable bowel syndrome with constipation. Expert Rev Gastroenterol Hepatol 2013; 7: 15-19
    • (2013) Expert Rev Gastroenterol Hepatol , vol.7 , pp. 15-19
    • Blackshaw, L.A.1    Brierley, S.M.2
  • 26
    • 71549121350 scopus 로고    scopus 로고
    • Review article: New receptor targets for medical therapy in irritable bowel syndrome
    • Camilleri M. Review article: New receptor targets for medical therapy in irritable bowel syndrome. Alimen Pharmacol Ther 2010; 31: 35-46
    • (2010) Alimen Pharmacol Ther , vol.31 , pp. 35-46
    • Camilleri, M.1
  • 27
    • 67650455908 scopus 로고    scopus 로고
    • Efficacy of 5-HT3 antagonists and 5-HT4 agonists in irritable bowel syndrome: Systematic review and meta-Analysis
    • Ford AC, Brandt LJ, Young C, et al. Efficacy of 5-HT3 antagonists and 5-HT4 agonists in irritable bowel syndrome: Systematic review and meta-Analysis. Am J Gastroenterol 2009; 104: 1831-1843
    • (2009) Am J Gastroenterol , vol.104 , pp. 1831-1843
    • Ford, A.C.1    Brandt, L.J.2    Young, C.3
  • 28
    • 84872235011 scopus 로고    scopus 로고
    • A review of the clinical efficacy of linaclotide in irritable bowel syndrome with constipation
    • Johnston JM, Shiff SJ, Quigley EM. A review of the clinical efficacy of linaclotide in irritable bowel syndrome with constipation. Curr Med Res Opin 2013; 29: 149-160
    • (2013) Curr Med Res Opin , vol.29 , pp. 149-160
    • Johnston, J.M.1    Shiff, S.J.2    Quigley, E.M.3
  • 29
    • 65549109893 scopus 로고    scopus 로고
    • Lubiprostone: Chronic constipation and irritable bowel syndrome with constipation
    • Lacy BE, Chey WD. Lubiprostone: Chronic constipation and irritable bowel syndrome with constipation. Expert Opin Pharmacother 2009; 10: 143-152
    • (2009) Expert Opin Pharmacother , vol.10 , pp. 143-152
    • Lacy, B.E.1    Chey, W.D.2
  • 30
    • 79953315976 scopus 로고    scopus 로고
    • Treatment of irritable bowel syndrome: Beyond fiber and antispasmodic agents
    • Sainsbury A, Ford AC. Treatment of irritable bowel syndrome: Beyond fiber and antispasmodic agents. Ther Adv Gastroenterol 2011; 4: 115-127
    • (2011) Ther Adv Gastroenterol , vol.4 , pp. 115-127
    • Sainsbury, A.1    Ford, A.C.2
  • 31
    • 79751514491 scopus 로고    scopus 로고
    • Ibs in 2010: Advances in pathophysiology, diagnosis and treatment nature reviews
    • Ford AC, Talley NJ. IBS in 2010: Advances in pathophysiology, diagnosis and treatment. Nature reviews. Gastroenterol Hepatol 2011; 8: 76-78
    • (2011) Gastroenterol Hepatol , vol.8 , pp. 76-78
    • Ford, A.C.1    Talley, N.J.2
  • 32
    • 0035894575 scopus 로고    scopus 로고
    • Serotoninergic neuroenteric modulators
    • Talley NJ. Serotoninergic neuroenteric modulators. Lancet 2001; 358: 2061-2068
    • (2001) Lancet , vol.358 , pp. 2061-2068
    • Talley, N.J.1
  • 33
    • 0031959979 scopus 로고    scopus 로고
    • Actions of the 5-hydroxytryptamine 1 receptor agonist sumatriptan on interdigestive gastrointestinal motility in man
    • Tack J, Coulie B, Wilmer A, et al. Actions of the 5-hydroxytryptamine 1 receptor agonist sumatriptan on interdigestive gastrointestinal motility in man. Gut 1998; 42: 36-41
    • (1998) Gut , vol.42 , pp. 36-41
    • Tack, J.1    Coulie, B.2    Wilmer, A.3
  • 34
    • 42749097353 scopus 로고    scopus 로고
    • Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptomrelief and constipation in nonconstipated irritable bowel syndrome: A systematic review and meta-Analysis of randomized controlled trials
    • Andresen V, Montori VM, Keller J, et al. Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptomrelief and constipation in nonconstipated irritable bowel syndrome: A systematic review and meta-Analysis of randomized controlled trials. Clin Gastroenterol Hepatol 2008; 6: 545-555
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 545-555
    • Andresen, V.1    Montori, V.M.2    Keller, J.3
  • 35
    • 79953727524 scopus 로고    scopus 로고
    • Targeting the 5-HT(3) receptor in the treatment of irritable bowel syndrome
    • Spiller RC. Targeting the 5-HT(3) receptor in the treatment of irritable bowel syndrome. Curr Opin Pharmacol 2011; 11: 68-74
    • (2011) Curr Opin Pharmacol , vol.11 , pp. 68-74
    • Spiller, R.C.1
  • 36
    • 77951677635 scopus 로고    scopus 로고
    • Alosetron for severe diarrhea-predominant irritable bowel syndrome: Safety and efficacy in perspective
    • Lewis JH. Alosetron for severe diarrhea-predominant irritable bowel syndrome: Safety and efficacy in perspective. Expert Rev Gastroenterol Hepatol 2010; 4: 13-29
    • (2010) Expert Rev Gastroenterol Hepatol , vol.4 , pp. 13-29
    • Lewis, J.H.1
  • 37
    • 16444362290 scopus 로고    scopus 로고
    • The effects of the 5-HT3 antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel syndrome
    • Nakai A, Diksic M, Kumakura Y, et al. The effects of the 5-HT3 antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel syndrome. Neurogastroenterol Motil 2005; 17: 212-221
    • (2005) Neurogastroenterol Motil , vol.17 , pp. 212-221
    • Nakai, A.1    Diksic, M.2    Kumakura, Y.3
  • 38
    • 0037295146 scopus 로고    scopus 로고
    • Efficacy of alosetron in irritable bowel syndrome: A meta-Analysis of randomized controlled trials
    • Cremonini F, Delgado-Aros S, Camilleri M. Efficacy of alosetron in irritable bowel syndrome: A meta-Analysis of randomized controlled trials. Neurogastroenterol Motil 2003; 15: 79-86
    • (2003) Neurogastroenterol Motil , vol.15 , pp. 79-86
    • Cremonini, F.1    Delgado-Aros, S.2    Camilleri, M.3
  • 40
    • 79958855229 scopus 로고    scopus 로고
    • The risk of ischaemic colitis in irritable bowel syndrome patients treated with serotonergic therapies
    • Lewis JH. The risk of ischaemic colitis in irritable bowel syndrome patients treated with serotonergic therapies. Drug Saf 2011; 34: 545-565
    • (2011) Drug Saf , vol.34 , pp. 545-565
    • Lewis, J.H.1
  • 41
    • 33646441324 scopus 로고    scopus 로고
    • Incidence of ischemic colitis and serious complications of constipation among patients using alosetron: Systematic review of clinical trials and postmarketing surveillance data
    • Chang L, Chey WD, Harris L, et al. Incidence of ischemic colitis and serious complications of constipation among patients using alosetron: Systematic review of clinical trials and postmarketing surveillance data. Am J Gastroenterol 2006; 101: 1069-1079
    • (2006) Am J Gastroenterol , vol.101 , pp. 1069-1079
    • Chang, L.1    Chey, W.D.2    Harris, L.3
  • 42
    • 84864653374 scopus 로고    scopus 로고
    • Randomised clinical trial: Alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea-predominant IBS
    • Cremonini F, Nicandro JP, Atkinson V, et al. Randomised clinical trial: Alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea-predominant IBS. Alimen Pharmacol Ther 2012; 36: 437-448
    • (2012) Alimen Pharmacol Ther , vol.36 , pp. 437-448
    • Cremonini, F.1    Nicandro, J.P.2    Atkinson, V.3
  • 44
    • 33846794803 scopus 로고    scopus 로고
    • Tegaserod for constipation-predominant irritable bowel syndrome
    • Kale-Pradhan PB, Wilhelm SM. Tegaserod for constipation-predominant irritable bowel syndrome. Pharmacotherapy 2007; 27: 267-277
    • (2007) Pharmacotherapy , vol.27 , pp. 267-277
    • Kale-Pradhan, P.B.1    Wilhelm, S.M.2
  • 45
    • 8544257356 scopus 로고    scopus 로고
    • Review of tegaserod in the treatment of irritable bowel syndrome
    • Patel S, Berrada D, Lembo A. Review of tegaserod in the treatment of irritable bowel syndrome. Expert Opin Pharmacother 2004; 5: 2369-2379
    • (2004) Expert Opin Pharmacother , vol.5 , pp. 2369-2379
    • Patel, S.1    Berrada, D.2    Lembo, A.3
  • 47
    • 34250007918 scopus 로고    scopus 로고
    • Desperately seeking serotonin a commentary on the withdrawal of tegaserod and the state of drug development for functional and motility disorders
    • Pasricha PJ. Desperately seeking serotonin. A commentary on the withdrawal of tegaserod and the state of drug development for functional and motility disorders. Gastroenterology 2007; 132: 2287-2290
    • (2007) Gastroenterology , vol.132 , pp. 2287-2290
    • Pasricha, P.J.1
  • 48
    • 84892373837 scopus 로고    scopus 로고
    • accessed 8 November 2013
    • http: //www.accessdata.fda.gov/drugsatfda-docs/label/2012/ 021908s010lbl.pdf [accessed 8 November 2013
  • 49
    • 33745798874 scopus 로고    scopus 로고
    • Lubiprostone (amitiza) for chronic constipation
    • Lubiprostone (amitiza) for chronic constipation. Med Lett Drugs Ther 2006; 48: 47-48
    • (2006) Med Lett Drugs Ther , vol.48 , pp. 47-48
  • 50
    • 22244449305 scopus 로고    scopus 로고
    • Review PubMed PMID: 15991886 Drugs R D.
    • Lubiprostone: RU 0211, SPI 0211. Drugs R D. 2005;6(4): 245-8. Review. PubMed PMID: 15991886
    • (2005) Lubiprostone: RU 0211 SPI 0211 , vol.6 , Issue.4 , pp. 245-248
  • 51
    • 58149103805 scopus 로고    scopus 로고
    • Clinical trial: Lubiprostone in patients with constipation-Associated irritable bowel syndrome-results of two randomized, placebo-controlled studies
    • Drossman DA, Chey WD, Johanson JF, et al. Clinical trial: Lubiprostone in patients with constipation-Associated irritable bowel syndrome-results of two randomized, placebo-controlled studies. Alimen Pharmacol Ther 2009; 29: 329-341
    • (2009) Alimen Pharmacol Ther , vol.29 , pp. 329-341
    • Drossman, D.A.1    Chey, W.D.2    Johanson, J.F.3
  • 52
    • 34248595894 scopus 로고    scopus 로고
    • Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: A double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety
    • Johanson JF, Ueno R. Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: A double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety. Alimen Pharmacol Ther 2007; 25: 1351-1361
    • (2007) Alimen Pharmacol Ther , vol.25 , pp. 1351-1361
    • Johanson, J.F.1    Ueno, R.2
  • 53
    • 79955897225 scopus 로고    scopus 로고
    • Efficacy and safety of oral lubiprostone in constipated patients with or without irritable bowel syndrome: A randomized, placebo-controlled and dose-finding study
    • 544-e205
    • Fukudo S, Hongo M, Kaneko H, Ueno R. Efficacy and safety of oral lubiprostone in constipated patients with or without irritable bowel syndrome: A randomized, placebo-controlled and dose-finding study. Neurogastroenterol Motil 2011; 23: 544-e205
    • (2011) Neurogastroenterol Motil , vol.23
    • Fukudo, S.1    Hongo, M.2    Kaneko, H.3    Ueno, R.4
  • 54
    • 84856707088 scopus 로고    scopus 로고
    • Safety and patient outcomes with lubiprostone for up to 52 weeks in patients with irritable bowel syndrome with constipation
    • Chey WD, Drossman DA, Johanson JF, et al. Safety and patient outcomes with lubiprostone for up to 52 weeks in patients with irritable bowel syndrome with constipation. Alimen Pharmacol Ther 2012; 35: 587-599
    • (2012) Alimen Pharmacol Ther , vol.35 , pp. 587-599
    • Chey, W.D.1    Drossman, D.A.2    Johanson, J.F.3
  • 55
    • 84894543194 scopus 로고    scopus 로고
    • An open-label, multicenter, safety and effectiveness study of lubiprostone for the treatment of functional constipation in children
    • Epub ahead of print]. PubMed PMID: 24048162
    • Hyman PE, Di Lorenzo C, Prestridge LL, et al. An open-label, multicenter, safety and effectiveness study of lubiprostone for the treatment of functional constipation in children. J Pediatr Gastroenterol Nutrition 2013. [Epub ahead of print]. PubMed PMID: 24048162
    • (2013) J Pediatr Gastroenterol Nutrition
    • Hyman, P.E.1    Di Lorenzo, C.2    Prestridge, L.L.3
  • 56
    • 80052863525 scopus 로고    scopus 로고
    • Lubiprostone does not influence visceral pain thresholds in patients with irritable bowel syndrome
    • Whitehead WE, Palsson OS, Gangarosa L, et al. Lubiprostone does not influence visceral pain thresholds in patients with irritable bowel syndrome. Neurogastroenterol Motil 2011; 23: 944-e400
    • (2011) Neurogastroenterol Motil , vol.23
    • Whitehead, W.E.1    Palsson, O.S.2    Gangarosa, L.3
  • 57
    • 84860379170 scopus 로고    scopus 로고
    • Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors
    • Cuppoletti J, Blikslager AT, Chakrabarti J, et al. Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors. BMC Pharmacol 2012; 12: 3
    • (2012) BMC Pharmacol , vol.12 , pp. 3
    • Cuppoletti, J.1    Blikslager, A.T.2    Chakrabarti, J.3
  • 58
    • 84873654410 scopus 로고    scopus 로고
    • Lubiprostone induced ischemic colitis
    • Sherid M, Sifuentes H, Samo S, et al. Lubiprostone induced ischemic colitis. WJG 2013; 19: 299-303
    • (2013) WJG , vol.19 , pp. 299-303
    • Sherid, M.1    Sifuentes, H.2    Samo, S.3
  • 59
    • 84876669771 scopus 로고    scopus 로고
    • Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota
    • Musch MW, Wang Y, Claud EC, Chang EB. Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota. Dig Dis Sci 2013; 58: 668-677
    • (2013) Dig Dis Sci , vol.58 , pp. 668-677
    • Musch, M.W.1    Wang, Y.2    Claud, E.C.3    Chang, E.B.4
  • 60
    • 84865498099 scopus 로고    scopus 로고
    • Safety evaluation of lubiprostone in the treatment of constipation and irritable bowel syndrome
    • Chamberlain SM, Rao SS. Safety evaluation of lubiprostone in the treatment of constipation and irritable bowel syndrome. Expert Opin Drug Saf 2012; 11: 841-850
    • (2012) Expert Opin Drug Saf , vol.11 , pp. 841-850
    • Chamberlain, S.M.1    Rao, S.S.2
  • 61
    • 84872821705 scopus 로고    scopus 로고
    • Linaclotide (Linzess) for constipation. PubMed PMID: 23183319
    • Linaclotide (Linzess) for constipation. Med Letter Drugs Ther 2012; 54: 91-92; PubMed PMID: 23183319
    • (2012) Med Letter Drugs Ther , vol.54 , pp. 91-92
  • 62
    • 77249162216 scopus 로고    scopus 로고
    • Taking a lesson from microbial diarrheagenesis in the management of chronic constipation
    • Bharucha AE, Waldman SA. Taking a lesson from microbial diarrheagenesis in the management of chronic constipation. Gastroenterology 2010; 138: 813-817
    • (2010) Gastroenterology , vol.138 , pp. 813-817
    • Bharucha, A.E.1    Waldman, S.A.2
  • 63
    • 84870565183 scopus 로고    scopus 로고
    • Guanylate cyclase-C receptor activation: Unexpected biology
    • Brierley SM. Guanylate cyclase-C receptor activation: Unexpected biology. Curr Opin Pharmacol 2012; 12: 632-640
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 632-640
    • Brierley, S.M.1
  • 64
    • 78049283798 scopus 로고    scopus 로고
    • Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit
    • Busby RW, Bryant AP, Bartolini WP, et al. Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit. Eur J Pharmacol 2010; 649: 328-335
    • (2010) Eur J Pharmacol , vol.649 , pp. 328-335
    • Busby, R.W.1    Bryant, A.P.2    Bartolini, W.P.3
  • 65
    • 84871682733 scopus 로고    scopus 로고
    • Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation
    • Busby RW, Kessler MM, Bartolini WP, et al. Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. J Pharmacol Exp Ther 2013; 344: 196-206
    • (2013) J Pharmacol Exp Ther , vol.344 , pp. 196-206
    • Busby, R.W.1    Kessler, M.M.2    Bartolini, W.P.3
  • 66
    • 34548500315 scopus 로고    scopus 로고
    • Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome
    • Andresen V, Camilleri M, Busciglio IA, et al. Effect of 5 days linaclotide on transit and bowel function in females with constipation- predominant irritable bowel syndrome. Gastroenterology 2007; 133: 761-768
    • (2007) Gastroenterology , vol.133 , pp. 761-768
    • Andresen, V.1    Camilleri, M.2    Busciglio, I.A.3
  • 67
    • 78649690668 scopus 로고    scopus 로고
    • Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    • e1872
    • Johnston JM, Kurtz CB, Macdougall JE, et al. Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation. Gastroenterology 2010; 139: 1877-1886 e1872
    • (2010) Gastroenterology , vol.139 , pp. 1877-1886
    • Johnston, J.M.1    Kurtz, C.B.2    Macdougall, J.E.3
  • 68
    • 80051640525 scopus 로고    scopus 로고
    • Two randomized trials of linaclotide for chronic constipation
    • Lembo AJ, Schneier HA, Shiff SJ, et al. Two randomized trials of linaclotide for chronic constipation. N Engl J Med 2011; 365: 527-536
    • (2011) N Engl J Med , vol.365 , pp. 527-536
    • Lembo, A.J.1    Schneier, H.A.2    Shiff, S.J.3
  • 69
    • 84869493876 scopus 로고    scopus 로고
    • A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation
    • Rao S, Lembo AJ, Shiff SJ, et al. A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation. Am J Gastroenterol 2012; 107: 1714-1724
    • (2012) Am J Gastroenterol , vol.107 , pp. 1714-1724
    • Rao, S.1    Lembo, A.J.2    Shiff, S.J.3
  • 70
    • 84869491248 scopus 로고    scopus 로고
    • Linaclotide for irritable bowel syndrome with constipation: A 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety
    • Chey WD, Lembo AJ, Lavins BJ, et al. Linaclotide for irritable bowel syndrome with constipation: A 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety. Am J Gastroenterol 2012; 107: 1702-1712
    • (2012) Am J Gastroenterol , vol.107 , pp. 1702-1712
    • Chey, W.D.1    Lembo, A.J.2    Lavins, B.J.3
  • 71
    • 84892366820 scopus 로고    scopus 로고
    • Effect of linaclotide on severe abdominal symptoms in patients with irritable bowel syndrome with constipation
    • Rao SS, Quigley EM, Shiff SJ, et al. Effect of linaclotide on severe abdominal symptoms in patients with irritable bowel syndrome with constipation. Clin Gastroenterol Hepatol 2013; 11: 1984-1092
    • (2013) Clin Gastroenterol Hepatol , vol.11 , pp. 1984-1092
    • Rao, S.S.1    Quigley, E.M.2    Shiff, S.J.3
  • 72
    • 84870601331 scopus 로고    scopus 로고
    • Randomised clinical trials: Linaclotide phase 3 studies in ibs-c-A prespecified further analysis based on european medicines agency-specified endpoints
    • Quigley EM, Tack J, Chey WD, et al. Randomised clinical trials: Linaclotide phase 3 studies in IBS-C-A prespecified further analysis based on European Medicines Agency-specified endpoints. Alimen Pharmacol Ther 2013; 37: 49-61
    • (2013) Alimen Pharmacol Ther , vol.37 , pp. 49-61
    • Quigley, E.M.1    Tack, J.2    Chey, W.D.3
  • 73
    • 84882775844 scopus 로고    scopus 로고
    • Effects of linaclotide in patients with irritable bowel syndrome with constipation or chronic constipation: A metaanalysis
    • 1083
    • Videlock EJ, Cheng V, Cremonini F. Effects of linaclotide in patients with irritable bowel syndrome with constipation or chronic constipation: A metaanalysis. Clin Gastroenterol Hepatol 2013; 11: 1084-1092e 1083
    • (2013) Clin Gastroenterol Hepatol , vol.11
    • Videlock, E.J.1    Cheng, V.2    Cremonini, F.3
  • 74
    • 84878471844 scopus 로고    scopus 로고
    • Activation of guanylate cyclase-C attenuates stretch responses and sensitization of mouse colorectal afferents
    • Feng B, Kiyatkin ME, La JH, et al. Activation of guanylate cyclase-C attenuates stretch responses and sensitization of mouse colorectal afferents. J Neurosci 2013; 33: 9831-9839
    • (2013) J Neurosci , vol.33 , pp. 9831-9839
    • Feng, B.1    Kiyatkin, M.E.2    La, J.H.3
  • 75
    • 84888293106 scopus 로고    scopus 로고
    • Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-c and extracellular cyclic guanosine 30,50-monophosphate
    • doi: 10.1053/j.gastro.2013.08.017. [Epub ahead of print
    • Castro J, Harrington AM, Hughes PA, et al. Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-c and extracellular cyclic guanosine 30,50-monophosphate. Gastroenterology 2013. doi: 10.1053/j.gastro.2013.08.017. [Epub ahead of print
    • (2013) Gastroenterology
    • Castro, J.1    Harrington, A.M.2    Hughes, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.