Relation of IL-6, IL-13 and IL-15 gene polymorphisms to the rheumatoid factors, anti-CCP and other measures of rheumatoid arthritis activity

International Journal of Immunogenetics

Volumn 41, Issue 1, 2014, Pages 34-40

  Pavkova Goldbergova, M ^a   Nemec, P ^b   Lipkova, J ^a   Jarkovsky, J ^a   Gatterova, J ^c   Ambrozkova, D ^a   Vasku, A ^a   Soucek, M ^b   Pavek, N ^a  

^a MASARYK UNIVERSITY   (Czech Republic)

^b ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

^c INSTITUTE OF RHEUMATOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; GENOMIC DNA; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 6; RHEUMATOID FACTOR;

ADULT; ANTIBODY PRODUCTION; ARTICLE; CALCULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DAS28; DISEASE ACTIVITY; DNA POLYMORPHISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; HAND RADIOGRAPHY; HETEROZYGOTE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SCORING SYSTEM; TOTAL SHARP SCORE;

ADULT; AGED; ALLELES; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; CASE-CONTROL STUDIES; DISEASE PROGRESSION; FEMALE; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN-13; INTERLEUKIN-15; INTERLEUKIN-6; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RHEUMATOID FACTOR;

EID: 84892369498     PISSN: 17443121     EISSN: 1744313X     Source Type: Journal    
DOI: 10.1111/iji.12065     Document Type: Article

References (31)

1. Afzali, B., Lombardi, G., Lechler, R.I. & Lord, G.M. (2007) The role of T helper 17 (Th17) and regulatory (Treg) in human organ transplantation and autoimmune disease. Clinical and Experimental Immunology, 148, 32.
2. Badolato, R., Ponzi, A.N., Millesimo, M., Notarangelo, L.D. & Musso, T. (1997) Interleukin 15 (IL-15) induces IL-8 and monocyte chemotactic protein 1 production in human monocytes. Blood, 7, 2804.
3. Bamford, R.N., Grant, A.J., Burton, J.D., Peters, C., Kurys, G., Goldman, C.K., Brennan, J., Roessler, E. & Waldmann, T.A. (1994) The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proceedings of the National Academy of Sciences of the United States of America, 91, 4940.
4. Becknell, B. & Caligiuri, M.A. (2005) Interleukin-2, interleukin-15, and their roles in human natural killer cells. Advances in Immunology, 86, 209.
5. Bernasconi, N.L., Traggiai, E. & Lanzavecchia, A. (2002) Maintenance of serological memory by polyclonal activation of human memory B cells. Science, 298, 2199.
6. Bierbaum, S., Nickel, R., Zitnik, S., Ahlert, I., Lau, S., Deichmann, K.A. et al. (2006) Confirmation of association of IL-15 with pediatric asthma and comparison of different controls. Allergy, 61, 576.
7. Brombacher, F. (2000) The role of interleukin-13 in infectious diseases and allergy. BioEssays, 22, 646.
8. Budagian, V., Bulanova, E., Paus, R. & Bulfone-Paus, S. (2006) IL-15/IL-15 receptor biology: a guided tour through an expanding universe. Cytokine & Growth Factor Reviews, 17, 259.
9. Cameron, L., Webster, R.B., Strempel, J.M., Kiesler, P., Kabesch, M., Ramachandran, H. et al. (2006) Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammation. The Journal of Immunology, 177, 8633.
10. Esen, M., Forster, J., Ajua, A., Spänkuch, I., Paparoupa, M., Mordmüller, B. & Kremsner, P.G. (2012) Effect of IL-15 on IgG versus IgE antibody-secreting cells in vitro. Journal of Immunological Methods, 375, 7.
11. Firestein, S. (2003) Evolving concepts of rheumatoid arthritis. Nature, 423, 356.
12. Fishman, D., Faulds, G., Jeffery, R., Mohamed-Ali, V., Yudkin, J.S., Humphries, S. & Woo, P. (1998) The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. The Journal of Clinical Investigation, 102, 1369.
13. Hegedus, C.M., Skibola, C.F., Bracci, P., Holly, E.A. & Smith, M.T. (2007) Screening the human serum proteome for genotype-phenotype associations: an analysis of the IL6 -174G>C polymorphism. Proteomics, 7, 548.
14. Kacani, L., Stoiber, H. & Dierich, M.P. (1997) Role of IL-15 in HIV-1-associated hypergammaglobulinaemia. Clinical and Experimental Immunology, 108, 14.
15. Kurz, T., Strauch, K., Dietrich, H., Braun, S., Hierl, S., Jerkic, S.P., Wienker, T.F., Deichmann, K.A. & Heinzmann, A. (2004) Multilocus haplotype analyses reveal association between 5 novel IL-15 polymorphisms and asthma. The Journal of Allergy and Clinical Immunology, 113, 896.
16. Lim, C.S., Yoon, H.J., Kim, Y.S., Ahn, C., Han, J.S., Kim, S., Lee, J.S., Lee, H.S. & Chae, D.W. (2003) Clinicopathological correlation of intrarenal cytokines and chemokines in IgA nephropathy. Nephrology, 8, 21.
17. Marinou, I., Till, S.H., Moore, D.J. & Wilson, A.G. (2008) Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis. Arthritis Research & Therapy, 10, R80.
18. McInnes, I.B. & Liew, F.Y. (1998) Interleukin-15: a proinflammatory role in rheumatoid arthritis synovitis. Immunology Today, 19, 75.
19. Mori, A., Suko, M., Kaminuma, O., Inoue, S., Ohmura, T., Nishizaki, Y. et al. (1996) IL-15 promotes cytokine production of human T helper cells. The Journal of Immunology, 156, 2400.
20. Oppenheimer-Marks, N., Brezinschek, R.I., Mohamadzadeh, M., Vita, R. & Lipsky, P.E. (1998) Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivo. The Journal of Clinical Investigation, 101, 1261.
21. Park, M.K., Her, Y.M., Cho, M.L., Oh, H.J., Park, E.M., Kwok, S.K. et al. (2011) IL-15 promotes osteoclastogenesis via the PLD pathway in rheumatoid arthritis. Immunology Letters, 139, 42.
22. Pavkova Goldbergova, M., Pavek, N., Lipkova, J., Stouracova, M., Gatterova, J., Vasku, A., Soucek, M. & Nemec, P. (2012) Circulating cytokine pattern and factors describing rheumatoid arthritis: IL-15 as one of the biomarkers for RA? Biomarkers, 17, 655.
23. Pawlik, A., Wrzesniewska, J., Florczak, M., Gawronska-Szklarz, B. & Herczynska, M. (2005) The -590 IL-4 promoter polymorphism in patients with rheumatoid arthritis. Rheumatology International, 26, 48.
24. Rückert, R., Asadullah, K., Seifert, M., Budagian, V.M., Arnold, R., Trombotto, C., Paus, R. & Bulfone-Paus, S. (2000) Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis? The Journal of Immunology, 165, 2240.
25. Rueda, B., López-Nevot, M.A., González-Gay, M.A., Balsa, A., Pascual-Salcedo, D., Garcia, A., Gonzalez, A. & Martin, J. (2007) Molecular screening and association study of IL-15 gene polymorphisms in rheumatoid arthritis. Cytokine, 38, 84.
26. Schlüter, B., Raufhake, C., Erren, M., Schotte, H., Kipp, F., Rust, S., Van Aken, H., Assmann, G. & Berendes, E. (2002) Effect of the interleukin-6 promoter polymorphism (-174 G/C) on the incidence and outcome of sepsis. Critical Care Medicine, 30, 32.
27. Stephens, M., Smith, N.J. & Donnely, P. (2001) A new statistical method for haplotype reconstruction from population data. American Journal of Human Genetics, 68, 978.
28. Stephens, M. & Donnely, P. (2003) A comparison of bayesian methods for haplotype reconstruction from population genotype data. American Journal of Human Genetics, 73, 1162.
29. Terry, C.F., Loukaci, V. & Green, F.R. (2000) Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. Journal of Biological Chemistry, 275, 18138.
30. Thompson, E.A., Deeb, S., Walker, D. & Motulsky, A.G. (1998) The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes. American Journal of Human Genetics, 42, 113.
31. Zhang, X.J., Yan, K.L., Wang, Z.M., Yang, S., Zhang, G.L., Fan, X. et al. (2007) Polymorphisms in Interleukin-15 Gene on Chromosome 4q31.2 Are Associated with Psoriasis Vulgaris in Chinese Population. The Journal of Investigative Dermatology, 127, 2544.