IL-15 promotes osteoclastogenesis via the PLD pathway in rheumatoid arthritis

Immunology Letters

Volumn 139, Issue 1-2, 2011, Pages 42-51

  Park, Mi Kyung ^a   Her, Yang Mi ^a   Cho, Mi La ^a   Oh, Hye Joa ^a   Park, Eun Mi ^a   Kwok, Seung Ki ^b   Ju, Ji Hyeon ^b   Park, Kyung Su ^b   Min, Do Sik ^c   Kim, Ho Youn ^b   Park, Sung Hwan ^b  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Department of Life Science and Biotechnology   (South Korea)

Author keywords

IL 15; Osteoclastogenesis; PLD pathway; RANKL; Rheumatoid arthritis

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 15; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATIDIC ACID; PHOSPHOLIPASE D1; STAT5 PROTEIN;

ARTICLE; BONE DESTRUCTION; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FIBROBLAST; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MONOCYTE; OSTEOARTHRITIS; OSTEOCLASTOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; SYNOVIOCYTE; SYNOVIUM; UPREGULATION;

ARTHRITIS, RHEUMATOID; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-15; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NF-KAPPA B; OSTEOCLASTS; PHOSPHATIDIC ACIDS; PHOSPHOLIPASE D; RANK LIGAND; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; SYNOVIAL MEMBRANE;

EID: 79960700295     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2011.04.013     Document Type: Article

References (52)

1. Lee D.M., Weinblatt M.E. Rheumatoid arthritis. Lancet 2001, 358:903-911.
2. Sack U., Gunther A., Pfeiffer R., Genest M., Kinne J., Biskop M., et al. Systemic characteristics of chronic arthritis induced by transfer of human rheumatoid synovial membrane into SCID mice (human/murine SCID arthritis). J Autoimmun 1999, 13:335-346.
3. Gravallese E.M., Harada Y., Wang J.T., Gorn A.H., Thornhill T.S., Goldring S.R. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol 1998, 152:943-951.
4. Gravallese E.M., Manning C., Tsay A., Naito A., Pan C., Amento E., et al. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum 2000, 43:250-258.
5. Kong Y.Y., Feige U., Sarosi I., Bolon B., Tafuri A., Morony S., et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 1999, 402:304-309.
6. Takayanagi H., Oda H., Yamamoto S., Kawaguchi H., Tanaka S., Nishikawa T., et al. A new mechanism of bone destruction in rheumatoid arthritis: synovial fibroblasts induce osteoclastogenesis. Biochem Biophys Res Commun 1997, 240:279-286.
7. Itonaga I., Fujikawa Y., Sabokbar A., Murray D.W., Athanasou N.A. Rheumatoid arthritis synovial macrophage-osteoclast differentiation is osteoprotegerin ligand-dependent. J Pathol 2000, 192:97-104.
8. Lee H.Y., Jeon H.S., Song E.K., Han M.K., Park S.I., Lee S.I., et al. CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL-mediated osteoclastogenesis: evidence of NF-kappaB-dependent, CD40-mediated bone destruction in rheumatoid arthritis. Arthritis Rheum 2006, 54:1747-1758.
9. Kotake S., Udagawa N., Takahashi N., Matsuzaki K., Itoh K., Ishiyama S., et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 1999, 103:1345-1352.
10. D O.G., Ireland D., Bord S., Compston J.E. Joint erosion in rheumatoid arthritis: interactions between tumour necrosis factor alpha, interleukin 1, and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclasts. Ann Rheum Dis 2004, 63:354-359.
11. Romas E., Gillespie M.T., Martin T.J. Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis. Bone 2002, 30:340-346.
12. Ogata Y., Kukita A., Kukita T., Komine M., Miyahara A., Miyazaki S., et al. A novel role of IL-15 in the development of osteoclasts: inability to replace its activity with IL-2. J Immunol 1999, 162:2754-2760.
13. Ferrari-Lacraz S., Zanelli E., Neuberg M., Donskoy E., Kim Y.S., Zheng X.X., et al. Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J Immunol 2004, 173:5818-5826.
14. Miranda-Carus M.E., Benito-Miguel M., Balsa A., Cobo-Ibanez T., Perez de Ayala C., Pascual-Salcedo D., et al. Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin-15 on the cell surface and promote osteoclastogenesis in autologous monocytes. Arthritis Rheum 2006, 54:1151-1164.
15. Frohman M.A., Sung T.C., Morris A.J. Mammalian phospholipase D structure and regulation. Biochim Biophys Acta 1999, 1439:175-186.
16. Yang S.F., Freer S., Benson A.A. Transphosphatidylation by phospholipase D. J Biol Chem 1967, 242:477-484.
17. McDermott M., Wakelam M.J., Morris A.J. Phospholipase D. Biochem Cell Biol 2004, 82:225-253.
18. Liscovitch M., Czarny M., Fiucci G., Tang X. Phospholipase D: molecular and cell biology of a novel gene family. Biochem J 2000, 345:401-415.
19. Siddhanta A., Shields D. Secretory vesicle budding from the trans-Golgi network is mediated by phosphatidic acid levels. J Biol Chem 1998, 273:17995-17998.
20. Brown F.D., Thompson N., Saqib K.M., Clark J.M., Powner D., Thompson N.T., et al. Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation. Curr Biol 1998, 8:835-838.
21. Arneson L.S., Kunz J., Anderson R.A., Traub L.M. Coupled inositide phosphorylation and phospholipase D activation initiates clathrin-coat assembly on lysosomes. J Biol Chem 1999, 274:17794-17805.
22. Colley W.C., Sung T.C., Roll R., Jenco J., Hammond S.M., Altshuller Y., et al. Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol 1997, 7:191-201.
23. Rizzo M.A., Shome K., Vasudevan C., Stolz D.B., Sung T.C., Frohman M.A., et al. and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway. J Biol Chem 1999, 274:1131-1139.
24. Caumont A.S., Galas M.C., Vitale N., Aunis D., Bader M.F. Regulated exocytosis in chromaffin cells, Translocation of ARF6 stimulates a plasma membrane-associated phospholipase D. J Biol Chem 1998, 273:1373-1379.
25. Dhalla N.S., Xu Y.J., Sheu S.S., Tappia P.S., Panagia V. Phosphatidic acid: a potential signal transducer for cardiac hypertrophy. J Mol Cell Cardiol 1997, 29:2865-2871.
26. Kusner D.J., Hall C.F., Jackson S. Fc gamma receptor-mediated activation of phospholipase D regulates macrophage phagocytosis of IgG-opsonized particles. J Immunol 1999, 162:2266-2274.
27. English D., Cui Y., Siddiqui R.A. Messenger functions of phosphatidic acid. Chem Phys Lipids 1996, 80:117-132.
28. Ortmeyer J., Mohsenin V. Inhibition of phospholipase D and superoxide generation by glucose in diabetic neutrophils. Life Sci 1996, 59:255-262.
29. Kozawa O., Suzuki A., Tokuda H., Uematsu T. Prostaglandin F2alpha stimulates interleukin-6 synthesis via activation of PKC in osteoblast-like cells. Am J Physiol 1997, 272:E208-E211.
30. Cappellen D., Luong-Nguyen N.H., Bongiovanni S., Grenet O., Wanke C., Susa M. Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFkappa B. J Biol Chem 2002, 277(June):21971-21982.
31. Hsu Y.L., Hung J.Y., Ko Y.C., Hung C.H., Huang M.S., Kuo P.L., et al. Phospholipase D signaling pathway is involved in lung cancer-derived IL-8 increased osteoclastogenesis. Carcinogenesis 2010, 31:587-596.
32. Steed P.M., Chow A.H. Intracellular signaling by phospholipase D as a therapeutic target. Curr Pharm Biotechnol 2001, 2:241-256.
33. Hanahan D.J., Chaikoff I.L. The phosphorus-containing lipids of the carrot. J Biol Chem 1947, 168:233-240.
34. Sciorra V.A., Morris A.J. Sequential actions of phospholipase D and phosphatidic acid phosphohydrolase 2b generate diglyceride in mammalian cells. Mol Biol Cell 1999, 10:3863-3876.
35. Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 2007, 7:292-304.
36. Yamashita T., Yao Z., Li F., Zhang Q., Badell I.R., Schwarz E.M., et al. NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J Biol Chem 2007, 282:18245-18253.
37. Takayanagi H., Kim S., Koga T., Nishina H., Isshiki M., Yoshida H., et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 2002, 3:889-901.
38. McInnes I.B., Gracie J.A., Harnett M., Harnett W., Liew F.Y. New strategies to control inflammatory synovitis: interleukin 15 and beyond. Ann Rheum Dis 2003, 62:ii51-ii54.
39. McInnes I.B., Leung B.P., Sturrock R.D., Field M., Liew F.Y. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. Nat Med 1997, 3:189-195.
40. Ruiz C., Perez E., Garcia-Martinez O., Diaz-Rodriguez L., Arroyo-Morales M., Reyes-Botella C. Expression of cytokines IL-4, IL-12, IL-15, IL-18, and IFNgamma and modulation by different growth factors in cultured human osteoblast-like cells. J Bone Miner Metab 2007, 25:286-292.
41. Koh J.M., Oh B., Ha M.H., Cho K.W., Lee J.Y., Park B.L., et al. Association of IL-15 polymorphisms with bone mineral density in postmenopausal Korean women. Calcif Tissue Int 2009, 85:369-378.
42. Lam J., Takeshita S., Barker J.E., Kanagawa O., Ross F.P., Teitelbaum S.L. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest 2000, 106:1481-1488.
43. Hofbauer L.C., Lacey D.L., Dunstan C.R., Spelsberg T.C., Riggs B.L., Khosla S. Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells. Bone 1999, 25:255-259.
44. Harada S., Yamamura M., Okamoto H., Morita Y., Kawashima M., Aita T., et al. Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum 1999, 42:1508-1516.
45. Sethu S., Mendez-Corao G., Melendez A.J. Phospholipase D1 plays a key role in TNF-alpha signaling. J Immunol 2008, 180:6027-6034.
46. Chen M.C., Paez-Espinosa V., Welsh N., Eizirik D.L. Interleukin-1beta regulates phospholipase D-1 expression in rat pancreatic beta-cells. Endocrinology 2000, 141:2822-2828.
47. Petrovic-Rackov L., Pejnovic N. Clinical significance of IL-18, IL-15, IL-12 and TNF-alpha measurement in rheumatoid arthritis. Clin Rheumatol 2006, 25:448-452.
48. McInnes I.B., al-Mughales J., Field M., Leung B.P., Huang F.P., Dixon R., et al. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med 1996, 2:175-182.
49. Miranda-Carus M.E., Balsa A., Benito-Miguel M., Perez de Ayala C., Martin-Mola E. IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate. J Immunol 2004, 173:1463-1476.
50. Matsumoto M., Sudo T., Saito T., Osada H., Tsujimoto M. Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL). J Biol Chem 2000, 275:31155-31161.
51. Miyazaki T., Katagiri H., Kanegae Y., Takayanagi H., Sawada Y., Yamamoto A., et al. Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts. J Cell Biol 2000, 148:333-342.
52. Iotsova V., Caamano J., Loy J., Yang Y., Lewin A., Bravo R. Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med 1997, 3:1285-1289.